The epithelium as a target of glucocorticoid action in the treatment of asthma

American Journal of Respiratory and Critical Care Medicine

Volumn 154, Issue 2 SUPPL., 1996, Pages

  Schwiebert, Lisa M ^a   Stellato, Cristiana ^a   Schleimer, Robert P ^a  

^a JOHNS HOPKINS ASTHMA AND ALLERGY CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTHELIN 1; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 6; PROSTAGLANDIN E2; PROSTAGLANDIN F2 ALPHA; RANTES; TRANSCRIPTION FACTOR AP 1;

ASTHMA; BRONCHUS HYPERREACTIVITY; DRUG MECHANISM; HUMAN; HUMAN CELL; IMMUNOMODULATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; RESPIRATORY EPITHELIUM; REVIEW; STEROID THERAPY;

EID: 0029763302     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm/154.2_pt_2.s16     Document Type: Review

References (35)

1. Barnes, P. J. 1996. Inhaled glucocorticoids in asthma: current understanding and future directions. In R. P. Schleimer, W. W. Busse, and P. M. O'Byrne, editors. Topical Glucocorticoids in Asthma: Mechanisms and Clinical Actions. Marcel Dekker, New York. (In press)
2. Miesfeld, R. 1996. Glucocorticoid receptor structure and function. In R. P. Schleimer, W. W. Busse, and P. M. O'Byrne, editors. Topical Glucocorticoids in Asthma: Mechanisms and Clinical Actions. Marcel Dekker, New York. (In press)
3. Karin, M., and F. Saatcioglu. 1996. Negative transcriptional regulation by the glucocorticoid receptor is responsible for the antiinflammatory activity of glucocorticoids. In R. P. Schleimer, W. W. Busse, and P. M. O'Byrne, editors. Topical Glucocorticoids in Asthma: Mechanisms and Clinical Actions. Marcel Dekker, New York. (In press)
4. Lee, T. H., and A. R. Sousa. 1994. Immunoflammatory role of the airway epithelial cell in asthma. Eur. Respir. Rev. 4:368-370.
5. Nakano, J., H. Takizawa, T. Ohtoshi, S. Shoji, M. Yamaguchi, A. Ishii, M. Yanagisawa, and K. Ito. 1994. Endotoxin and pro-inflammatory cytokines stimulate endothelin-1 expression and release by airway epithelial cells. Clin. Exp. Allergy 24:330-336.
6. Kharitonov, S. A., D. Yates, and P. J. Barnes. 1995. Increased nitric oxide in exhaled air of normal human subjects with upper respiratory tract infections. Eur. Respir. J. 8045:295-297.
7. Guo, F., H. R. De Raeve, T. W. Rice, D. J. Stuehr, F. B. Thunnissen, and S. C. Erzurum. 1995. Continuous nitric oxide synthesis by inducible nitric oxide synthase in normal human airway epithelium in vivo. Proc. Natl. Acad. Sci. U.S.A. 92:7809-7813.
8. Levine, S. J. 1995. Bronchial epithelial cell-cytokine interactions in airway inflammation. J. Invest. Med. 43:241-249.
9. Schwiebert, L. M., C. Stellato, L. A. Beck, B. Bochner, and R. P. Schleimer. 1996. Glucocorticosteroid inhibition of cytokine production: relevance to antiallergic actions. J. Allergy Clin. Immunol. (In press)
10. Sousa, A. R., S. J. Lane, J. A. Nakhosteen, T. Yoshirmura, T. H. Lee, and R. N. Poston. 1994. Increased expression of the monocyte chemoattractant protein-1 in bronchial tissue from asthmatic subjects. Am. J. Respir. Cell Mol. Biol. 10:142-147.
11. Sousa, A. R., R. N. Poston, S. J. Lane, J. A. Nakhosteen, and T. H. Lee. 1993. Detection of GM-CSF in asthmatic bronchial epithelium and decrease by inhaled corticosteroids. Am. Rev. Respir. Dis. 147: 1557-1561.
12. Ohno, I., R. Lea, S. Finotto, J. Marshall, J. Denburg, J. Dolovich, J. Gauldie, and M. Jordana. 1991. Granulocyte/macrophage colony-stimulating factor (GM-CSF) gene expression by eosinophils in nasal polyposis. Am. J. Respir. Cell Mol. Biol. 5:505-510.
13. Bellini, A., E. Vittori, M. Marini, V. Ackerman, and S. Mattoli, 1993. Intraepithelial dendritic cells and selective activation of Th2-like lymphocytes in patients with atopic asthma. Chest 103:997-1005.
14. Cambrey, A. D., O. J. Kwon, and R. J. McAnulty. 1993. Release of fibroblast proliferative activity from cultured human airway epithelial cells: a role for insulin-like growth factor-1 (IGF-1) (abstract). Am. Rev. Respir. Dis. 147:A272.
15. DiCosmo, B. F., G. P. Geba, D. Picarella, J. A. Elias, J. A. Rankin, B. R. Stripp, J. A. Whitsett, and R. A. Flavell. 1994. Airway epithelial cell expression of interleukin-6 in transgenic mice: uncoupling of airway inflammation and bronchial hyperreactivity. J. Clin. Invest. 94:2028-2035.
16. Ray, A., K. S. Laforge, and P. B. Sehgal. 1990. On the mechanisms for efficient repression of the interleukin-6 promoter by glucocorticoids: enhancer TATA box and RNA start site (1nr motif) occlusion. Mol. Cell. Biol. 10:5736-5746.
17. Adcock, I. M., H. Shirasaki, C. M. Gelder, M. J. Peters, C. R. Brown, and P. J. Barnes. 1994. The effects of glucocorticoids on phorbol ester and cytokine stimulated transcription factor activation in human lung. Life Sci. 55:1147-1153.
18. Barnes, P. J. 1994. Airway epithelial receptors. Eur. Respir. Rev. 4: 371-379.
19. Hamid, Q. A., J. C. Mak, M. N. Sheppard, B. Corrin, J. C. Venter, and P. J. Barnes. 1991. Localization of beta 2-adrenoreceptor messenger RNA in human and rat lung using in situ hydridization: correlation with receptor autoradiography. Eur. J. Pharmacol. 206:133-138.
20. Devalia, J. L., R. J. Sapsford, C. Rusznak, M. J. Toumbis, and R. J. Davies. 1992. The effects of salmeterol and salbutamol on ciliary beat frequency of cultured human bronchial epithelial cells in vitro. Pulm. Pharmacol. 5:257-263.
21. Pavia, D., J. R. M. Bateman, and S. W. Clarke. 1980. Deposition and clearance of inhaled particles. Clin. Respir. Physiol. 16:335-366.
22. DeRose, V., L. A. Robbins, and J. R. Spurzem. 1994. Substance P increases neutrophil adhesion to bronchial epithelial cells. Am. Rev. Respir. Dis. 145:A681.
23. Frossard, N., K. J. Rhoden, and P. J. Barnes. 1989. Influence of epithelium on guinea-pig airway responses to tachykinins: role of endopeptidase and cyclo-oxygenase. J. Pharmacol. Exp. Ther. 248: 292-298.
24. Piedimonte, G., D. M. McDonald, and J. A. Nadel. 1991. Neutral endopeptidase and kininase II mediate glucocorticoid inhibition of neurogenic inflammation in the rat trachea. J. Clin. Invest. 88:40-44.
25. Proud, D., M. C. Subauste, and R. E. Ward. 1994. Glucocorticoids do not alter peptidase expression on a human bronchial epithelial cell line. Am. J. Respir. Cell Mol. Biol. 11:57-65.
26. Albeda, S. M. 1991. Endothelial and epithelial cell adhesion molecules. Am. J. Respir. Cell Mol. Biol. 4:195-203.
27. Manning, P. J., and P. M. O'Byrne. 1988. Histamine bronchoconstriction reduces airway responsiveness in asthmatic subjects. Am. Rev. Respir. Dis. 137:1323-1335.
28. Bramley, A. M., M. N. Samhoun, and P. J. Piper. 1990. The role of epithelium in modulating the responses of guinea-pig trachea induced by bradykinin in vitro. Br. J. Pharmacol. 99:762-766.
29. Leikhauf, G. D., I. F. Ueki, J. A. Nadel, and J. H. Widdicombe. 1985. Bradykinin stimulates chloride secretion and prostaglandin E2 release by canine tracheal epithelium. Am. J. Physiol. 248:F48-F55.
30. Laitinen, L. A., and A. Laitinen. 1994. Structural and cellular changes in asthma. Eur. Respir. Rev. 23:348-351.
31. Lundgren, R., M. Söderberg, P. Hörstedt, and R. Stenling. 1988. Morphological studies of bronchial mucosal biopsies from asthmatics before and after ten years of treatment with inhaled steroids. Eur. Respir. J. 1:883-889.
32. 2-agonist, terbutaline, on airway inflammation in newly diagnosed asthma: a randomized, double-blind, parallel-group controlled trial. J. Allergy Clin. Immunol. 90:32-42.
33. Trigg, C. J., N. D. Manolistas, and J. Wang. 1994. Placebo-controlled immunopathological studies of four months inhaled corticosteroids in asthma. Am. J. Respir. Crit. Care Med. 150:17-22.
34. O'Byrne, P. M. 1993. Airway hyperresponsiveness. In E. Middleton, Jr., C. Reed, N. F. Adkinson, J. W. Yunginger, and W. W. Busse, editors. Allergy: Principles and Practice, 4th ed. Mosby, St. Louis. 1203-1213.
35. Casale, T. B., D. Wood, H. B. Richerson, S. Trapp, W. J. Metzger, D. Zavala, and G. W. Hunninghake. 1987. Elevated bronchoalveolar lavage fluid histamine levels in allergic asthmatics are associated with methacholine bronchial hyperresponsiveness. J. Clin. Invest. 79:1197-1203.