RTD analysis of a novel Taylor-Couette flow device for blood detoxification

AIChE Journal

Volumn 45, Issue 3, 1999, Pages 633-638

  Ameer, G A ^b   Grovender, E A ^b   Obradovic, B ^b   Cooney, C L ^a   Langer, R ^a  

^a Massachusetts Institute of Technology Cambridge   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

DETOXIFICATION; DRUG SAFETY; FLOW KINETICS; HEPARIN LYASE; HEPARIN; IMMOBILIZED ENZYME; MODEL; NEUTRALIZATION; PROCESS OPTIMIZATION; REACTOR; SEPARATION TECHNIQUE;

BLOOD; DRUG PRODUCTS; ENZYME IMMOBILIZATION; ERROR ANALYSIS; FLUID DYNAMICS; HEMODYNAMICS; MATHEMATICAL MODELS; SEPARATION;

ANTICOAGULANT; BLOOD DETOXIFICATION; HEPARIN; HEPARINASE; TAYLOR-COUETTE FLOW;

BIOREACTORS;

BLOOD FLOW; TAYLOR-COUETTE FLOW;

ANALYTIC METHOD; ARTICLE; BLEEDING; DETOXIFICATION; DEVICE; FLOW KINETICS; HEMODIALYSIS; HEPARINIZATION; OPEN HEART SURGERY; REACTOR;

EID: 0033103720     PISSN: 00011541     EISSN: None     Source Type: Journal    
DOI: 10.1002/aic.690450320     Document Type: Article

References (19)

1. Ameer, G. A., S. Raghavan, R. Sasisekharan, W. Harmon, C. L. Cooney, and R. Langer, "Regional Heparinization via Simultaneous Separation and Reaction in a Novel Taylor-Couette Flow Device," Biotechnol. Bioeng., 63 (1999a).
2. Ameer, G. A., W. Harmon, R. Sasisekharan, and R. Langer, "Investigation of a Whole Blood Fluidized Bed Taylor-Couette Flow Device for Enzymatic Heparin Neutralization," Biotechnol. Bioeng., 62, 602 (1999b).
3. Ameer, G. A., G. Barabino, R. Sasisekharan, W. Harmon, C. Cooney, and R. Langer, "Ex vivo Evaluation of a Novel Taylor-Couette Flow, Immobilized Heparinase I Device for Clinical Application," Proc. Nat. Acad. Sci. USA, 96, 2350 (1999c).
4. Beaudoin, G., and M. Y. Jaffrin, "High Efficiency Plasmapheresis using Rotating Membrane Device," Life Support Syst., 5, 273 (1987).
5. Ernst, S., G. Venkataraman, S. Winkler, R. Godavarti, R. Langer, C. L. Cooney, and R. Sasisekharan, "Expression in Escherichia Coli, Purification and Characterization of Heparinase I from Flavobacterium Heparinum," Biochem. J., 315, 589 (1996).
6. Fischel, R. J., H. Fischer, A. Shatzel, W. P. Lange, D. Cahill, D. Gervail, and N. L. Ascher, "Couette Membrane Filtration with Constant Shear Stress," Trans. Amer. Soc. Artif. Intern. Organs, 34, 375 (1988).
7. Heuser, G., and R. Opitz, "A Couette Viscometer for Short Time Shearing of Blood," Rheology, 17, 17 (1980).
8. Holeschovsky, U. B., and C. L. Cooney, "Quantitative Description of Ultrafiltration in a Rotating Filtration Device," AIChE J., 37, 1219 (1991).
9. Horrow, J. C., "Protamine: A Review of Its Toxicity," Anesth. Analg., 64, 348 (1985).
10. Iosilevskii, G., H. Brenner, C. M. V. Moore, and C. L. Cooney, "Mass Transport and Chemical Reaction in Taylor-Vortex Flows with Entrained Catalytic Particles: Application to a Novel Class of Immobilized Enzyme Biochemical Reactors," Philos. Trans. Roy. Soc. London, A234, 259 (1993).
11. Kroner, K. H., and V. Nissinen, "Dynamic Filtration of Microbial Suspensions Using an Axially Rotating Filter," J. Membrane Sci., 36, 85 (1988).
12. Lam, L. H., J. E. Silbert, and R. D. Rosenberg, "The Separation of Active and Inactive Forms of Heparin," Biochem. Biophys. Res. Commun., 69, 570 (1976).
13. Langer, R., R. J. Linhardt, S. Hoffberg, A. K. Larsen, C. L. Cooney, D. Tapper, and M. Klein, "An Enzymatic System for Removing Heparin in Extracorporeal Therapy," Science, 217, 261 (1982).
14. Levenspiel, O., Chemical Reaction Engineering, Wiley, New York (1972).
15. Mehta, R. L., "Anticoagulation During Continuous Renal Replacement Therapy," ASAIO J., 40, 931 (1994).
16. Miller, R. L., A. G. Fredrickson, A. H. Brown, and H. M. Tsuchiya, "Hydromechanical Method to Increase Efficiency of Algal Photosynthesis," Ind. Eng. Chem. Process Des. Dev., 3, 134 (1964).
17. Ohashi, K., K. Tashiro, F. Kushiya, T. Matsumoto, S. Yoshida, M. Endo, T. Horio, K. Ozawa, and K. Sakai, "Rotation-Induced Taylor Vortex Enhances Filtrate Flux in Plasma Separation," Trans. Amer. Soc. Artif. Intern. Organs, 34, 300 (1988).
18. Pudjiono, P. I., N. S. Tavare, J. Garside, and D. P. Nigam, "Residence Time Distribution from a Continuous Couette Flow Device," Chem. Eng. J., 48, 101 (1992).
19. Taylor, G. I., "Stability of a Viscous Liquid Contained Between Two Rotating Cylinders," Philos. Trans. Roy. Soc. London, A223, 289 (1923).