Synthesis of 4-phenylpyrimidine from acetophenone and formamide

Heterocycles

Volumn 51, Issue 3, 1999, Pages 611-615

  Heiland, Irene ^a   Lejon, Tore ^a  

^a UNIVERSITY OF TROMSØ   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

ACETOPHENONE; FORMAMIDE; PYRIMIDINE DERIVATIVE;

ARTICLE; CATALYST; CHEMICAL ANALYSIS; CHEMICAL REACTION; MOLECULAR RECOGNITION; REACTION ANALYSIS; SYNTHESIS;

EID: 0033102299     PISSN: 03855414     EISSN: None     Source Type: Journal    
DOI: 10.3987/com-98-8411     Document Type: Article

References (14)

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10. R. Carlson, 'Design and Optimization in Organic Synthesis,' Elsevier, Amsterdam, 1992.
11. 'Modde for Windows, version 4.0,' Umetri AS.
12. Analysis of optimum conditions by canonical analysis led to approximately the same result.
13. Cuprous chloride and formamide were used at both high and low level.
14. Monitoring the reaction by GLC showed that all starting material was consumed within 6 hours and there was no indication that the product decomposed over time. It was also observed that 2 is formed parallel to 4, which probably explains why the yield does not exceed 60%.