Opioids and the immune system;Opioides y sistema inmune

Revista Medica de Chile

Volumn 127, Issue 3, 1999, Pages 341-348

  Núñez U, Gastón ^a   Urzúa, Jorge ^a,b  

^a PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

^b NONE   (Chile)

Author keywords

Immune system; Immune tolerance; Morphine; Opioid peptides

Indexed keywords

NARCOTIC AGENT;

B LYMPHOCYTE; HUMAN; IMMUNE SYSTEM; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; IMMUNOMODULATION; NATURAL KILLER CELL; PHYSIOLOGY; REVIEW; T LYMPHOCYTE;

B-LYMPHOCYTES; HUMANS; IMMUNE SYSTEM; IMMUNE TOLERANCE; KILLER CELLS, NATURAL; NARCOTICS; NEUROIMMUNOMODULATION; T-LYMPHOCYTES;

EID: 0033088682     PISSN: 00349887     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (53)

1. DANTZER R, KELLEY KW. Stress and immunity: an integrated view of relationships between the brain and the immune system. Life Sci 1989, 44: 1995-2008.
2. LEWIS JW, SHAVIT Y, TERMAN GW, GALE RP, LIEBESKIND JC. Stress and morphine effect survival of rats challenged with a mammary ascites tumor (MAT 13762B). Nat Immun Cell Growth Regul 1983-84; 3: 43-50.
3. ABBAS AK, LICHTMAN AH, POBER JS. Cellular and Molecular Immunology. 2nd Edition. WB Saunders Company, 1994.
4. AUPHAN N, DIDONATO JA, ROSETTE C, HELMBERG A, KARIN M. Immunosuppression by glucocorticoids: inhibition of NF-κB activity through induction of IκB synthesis. Science 1995, 270: 286-90.
5. CARR DJJ. The role of endogenous opioids and their receptors in the immune system. Proc Soc Exp Biol Med 1991; 198: 710-20.
6. HERNÁNDEZ M, FLORES LR, BAYER BM. Immunosuppression by morphine is mediated by central pathways. J Pharmacol Exp Ther 1993; 267: 1336-41.
7. PRUETT SB, HAN YC, FUCHS BA. Morphine suppresses primary humoral immune responses by a predominantly indirect mechanism. J Pharmacol Exp Ther 1992; 262: 923-8.
8. BAYER BM, DAUSSIN S, HERNÁNDEZ M, IRVIN L. Morphine inhibition of lymphocyte activity is mediated by an opioid dependent mechanism. Neuropharmacology 1990; 29: 369-74.
9. YEAGER MP, COLACCHIO TA, YU CT, HILDEBRANDT L, HOWELL AL, WEISS J, GUYRE PM. Morphine inhibits spontaneous and cytokine-enhanced natural killer cell cytotoxicity in volunteers. Anesthesiology 1995; 83: 500-8.
10. FREIER DO, FUCHS BA. A mechanism of action for morphine-induced immunosuppression: corticosterone mediates morphine-induced suppression of natural killer cell activity. J Pharmacol Exp Ther 1994; 270: 1127-33.
11. BRYANT HU, BERNTON EW, KENNER JR, HOLADAY JW. Role of adrenal cortical activation in the immunosuppressive effects of chronic morphine treatment. Endocrinology 1991; 128: 3253-8.
12. CARR DJJ, FRANCE CP. Immune alterations in morphine-treated Rhesus monkeys. J Pharmacol Exp Ther 1993; 267: 9-15.
13. CARPENTER GW, GARZA HHJR, GEBHARDT BM, CARR DJ. Chronic morphine treatment suppresses CTL-mediated cytolysis, granulation, and cAMP responses to alloantigen. Brain Behav Immunol 1994; 8: 185-203.
14. SIMON RH, ARBO TE. Morphine increases metastatic tumor growth. Brain Res Bull 1986; 16: 363-7.
15. JANKOVIC BD, MARIC D. Enkephalins and Immunity, I: In vivo suppression and potentiation of humoral immune response. Ann NY Acad Sci 1987; 496: 115-25.
16. TUBARO E, BORELLI G, CROCE C, CAVALLO G, SANTIANGELI C. Effect of morphine on resistance to infection. J Infect Dis 1983; 148: 656-66.
17. Fowler CJ, FRASER GL. Mu-, delta-, kappa-opioids receptors and their subtypes. A critical review with emphasis on radioligand binding experiments. Neurochem Int 1994; 24: 401-26.
18. MANSOUR A, HOVERSTEN MT, TAYLOR LP, WATSON SJ, AKIL H. The clone mu, delta and kappa receptors and their endogenous ligands: Evidence for two opioid peptide recognition cores. Brain Res 1995; 700: 89-98.
19. ZADINA JE, HACKLER L, GE LJ, KASTIN AJ. A potent and selective endogenous agonist for the opiate receptor. Nature 1997; 386: 499-502.
20. JANKOVIC BD, RADULOVIC J. Enkephalins, brain and immunity: modulation of immune responses by methionine-enkephalin injected into the cerebral cavity. Int J Neurosci 1992; 67: 241-70.
21. KUSNECOV AW, HUSBAND AJ, KING MG, PANG G, SMITH R. In vivo effects of β-endorphin on lymphocyte proliferation and interleukine-2 production. Brain Behav Immunol 1987; 1: 88-97.
22. KUSNECOV AW, HUSBAND AJ, KING MG, SMITH R. Modulation of mitogen-induced spleen cell proliferation and antibody-forming cell response by β-endorphin in vivo. Peptides 1989; 10: 473-9.
23. HSUEH CM, HIRAMOTO RN, GHANTA VK. The central effect of methionine-enkephalin on NK cell activity. Brain Res 1992; 578: 142-8.
24. SHAVIT Y, DEPAULIS A, MARTIN FC, TERMAN GW, PECHNICK RN, ZANE CJ, GALE RP, LIEBESKIND JC. Involvement of brain opiate receptors in the immune-suppressive effect of morphine. Proc Natl Acad Sci USA 1986; 83: 7114-7.
25. NELSON CJ, DYKSTRA LA, LYSLE DT. Comparison of the time course of morphine's analgesic and immunologic effects. Anesth Analg 1997; 85: 620-7.
26. PALM S, LEHZEN S, MIGNAT C, STEINMANN J, LEIMENSTOLL G, MAIER C. Does Prolonged oral treatment with sustained-release morphine tablets influence immune function? Anesth Analg 1998; 86: 166-72.
27. FLORES LR, SHARON MW, BAYER BM. Mechanisms of morphine-induced immunosuppression: Effect of acute morphine administration on lymphocyte trafficking. J Pharmacol Exp Ther 1995; 272: 1246-51.
28. PANERAI AE, MANFREDI B, LOCATELLI L, RUBBOLI F, SACERDOTE P. Age-related changes of β-endorphin and cholecystokinin in peripheral blood mononuclear cells. Ann N Y Acad Sci 1991; 621: 174-8.
29. CARR DJJ. The role of endogenous opioids and their receptors in the immune system. Proc Soc Exp Biol Med 1991; 198: 710-20.
30. KAVELAARS A, BALLIEUX RE, HEIJNEN CJ. Two different signaling pathways for the induction of immunoreactive β-endorphin secretion by human peripheral blood mononuclear cells. Endocrinology 1991; 128: 765-70.
31. SIBINGA NES, GOLDSTEIN A. Opioid peptides and opioid receptors in cells of the immune system. Ann Rev Immunol 1988; 6: 219-49.
32. KAY NE, MORLEY JE, ALLEN JI. Interaction between endogenous opioids and IL-2 on PHA-stimulated human lymphocytes. Immunology 1990; 70: 485-91.
33. 2+ modulation in human B cell lines. J Immunol 1992; 149: 4074-81.
34. GAVÉRIAUX C, PELUSO J, SIMONIN F, LAFORED J, KIEFFER B. Identification of kappa- and delta-opioid receptor transcripts in immune cells. FEBS Lett 1995; 369: 272-6.
35. BUCHNER RR, VOGEN SM, FICHER W, THOMAN ML, SANDERSON SD, MORGAN EL. Anti-human κ opioid receptor antibodies. Characterization of site-directed neutralizing antibodies specific for a peptide κR(33-52) derived from the predicted amino terminal region of the human κ receptor. J Immunol 1997; 158: 1670-80.
36. i1-phospholipase C activation in Xenopus oocytes. J Neurosci 1995; 15: 7485-99.
37. i1-mediated phospholipase C activity in the guinea pig cerebellum. FEBS Lett 1995; 361: 106-10.
38. GUTSTEIN HB, RUBIE EA, MANSOUR A, AKIL H, WOODGETT JR. Opioid effects on mitogen-activated protein kinase signaling cascades. Anesthesiology 1997; 87: 1118-26.
39. REISINE T. Review: Neurotrasmitter receptors V: Opiate receptors. Neuropharmacol 1995; 34: 463-72.
40. PAUL WE. T Lymphocyte Activation, in: Fundamental Immunology. Third Edition, Raven Press Ltd. 1993; 467-504.
41. TAMIR A, GRAMOT Y, ISAKOV N. Inhibition of T lymphocyte activation by cAMP is associated with down-regulation of two parallel mitogen-activated protein kinase pathway, the extracellular signal-related kinase and c-jun N-terminal kinase. J Immunol 1996; 157: 1514-22.
42. TING AT, SCHOON RA, ABRAHAM RT, LEIBSON PJ. Interaction between protein kinase C dependent and G protein-dependent pathway in regulation of natural killer cell granule exocytosis. J Biol Chem 1992; 267: 239-57.
43. BROWN SL, VAN EPPS DE. Opioid peptides modulate production of interferon gamma by human mononuclear cells. Cell Immunol 1986; 103: 19-26.
44. GILMAN SC, SCHWARTZ JM, MILNER RJ, BLOOM FE, FELDMAN JD. β-endorphin enhances lymphocyte proliferative responses. Proc Natl Acad Sci USA 1982; 79: 4226-30.
45. MANDLER RN, BIDDISON WE, MANDLER R, SERRATE SA. β-endorphin augments the cytolytic and interferon production of natural killer cells. J Immunol 1986; 136: 934-9.
46. VAN DEN BERGH P, ROZING J, NAGELKERKEN L. Two opposing modes of action of β-endorphin on lymphocyte function. Immunology 1991; 72: 537-43.
47. + T cells. Cell Immunol 1994, 154: 109-22.
48. HAZUM E, CHANG KJ, CUATRECASAS P. Specific nonopioid receptors for β-endorphin. Science 1979; 205: 1033-5.
49. PETERSON PK, SHARP B, GEKKER G, BRUMMITT C, KEANE WF. Opioid-mediated suppression of interferon-gamma production by cultured peripheral blood mononuclear cells. J Clin Invest 1987; 80: 824-31.
50. BRYANT HU, BERNTON EW, HOLADY JH. Immunosuppressive effects of chronic morphine treatment in mice. Life Sci 1987; 41: 1731-38.
51. SHAVTT Y, TERMAN GW, LEWIS JW, ZANE CJ, GALE RP, LIEBESKIND JC. Effects of footshock stress and morphine on natural killer lymphocyte in rat: studies of tolerance and cross-tolerance. Brain Res 1986; 372: 382-5.
52. HAMRA JG, YAKSH TL. Equianalgesic doses of subcutaneous but not intrathecal morphine alter phenotypic expression of cell surface markers and mitogen-induced proliferation in rat lymphocytes. Anesthesiology 1996; 85: 355-65.
53. WICK MJ, MINNERRATH SR, ROY S, RAMAKRISHNAN S, LOH HH. Expression of alternate forms of brain opioid "orphan" receptor mRNA in activated human peripheral blood lymphocytes and lymphocytic cell lines. Brain Res Mol Brain Res 1995; 32: 342-7.