General numerical treatment of competitive binding kinetics: Application to thrombin-dehydrothrombin-hirudin

Analytical Biochemistry

Volumn 267, Issue 1, 1999, Pages 17-23

  Kuzmič, Petr ^a  

^a BioKin Consulting   (United States)

Author keywords

Competitive binding; Differential equations; Enzyme inhibition; Enzyme kinetics; Hirudin; Progress curves; Rate constants; Slow binding; Thrombin; Tight binding

Indexed keywords

ALGEBRA; DIFFERENTIAL EQUATIONS; ENZYME INHIBITION; ENZYME KINETICS; KINETICS; RATE CONSTANTS;

COMPETITIVE BINDING; HIRUDIN; PROGRESS CURVES; SLOW BINDING; THROMBIN; TIGHT BINDING;

NUMERICAL METHODS;

DEHYDROTHROMBIN; HIRUDIN; MUTANT PROTEIN; THROMBIN; THROMBIN DERIVATIVE; UNCLASSIFIED DRUG;

ACCURACY; ARTICLE; BLOOD CLOTTING; COMPUTER PROGRAM; ENZYME INHIBITION; ENZYME MECHANISM; LIGAND BINDING; PRIORITY JOURNAL;

EID: 0033081685     PISSN: 00032697     EISSN: None     Source Type: Journal    
DOI: 10.1006/abio.1998.2670     Document Type: Article

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