Kinetics of competitive binding with application to thrombin complexes

Analytical Biochemistry

Volumn 248, Issue 1, 1997, Pages 130-140

  Wedemeyer, William J ^a   Ashton, Robert W ^a   Scheraga, Harold A ^a  

^a Department of Obstetrics Gynecology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; DISSOCIATION; ENZYMES; FREE ENERGY; NUMERICAL METHODS;

BINDING FREE ENERGY; COMPETITIVE BINDING; DISSOCIATION CONSTANT; NUMERICAL INTEGRATIONS; TRADITIONAL APPROXIMATION;

RATE CONSTANTS;

HIRUDIN; THROMBIN;

ARTICLE; BINDING COMPETITION; BINDING KINETICS; DIAGNOSTIC ACCURACY; DISSOCIATION CONSTANT; MATHEMATICAL ANALYSIS; PRIORITY JOURNAL; PROTEIN BINDING; STRUCTURE ANALYSIS;

EID: 0031570362     PISSN: 00032697     EISSN: None     Source Type: Journal    
DOI: 10.1006/abio.1997.2087     Document Type: Article

References (15)

1. Fersht A. Enzyme Structure and Mechanism. 1985;Freeman, New York.
2. Lauffenburger D. A., Linderman J. J. Receptors: Models for Binding, Trafficking and Signaling. 1993;Oxford University Press, Oxford.
3. Duggleby R. G. Methods Enzymol. 249:1995;61-90.
4. Beeson C., McConnell H. M. J. Am. Chem. Soc. 117:1995;10429-10433.
5. Cha S. Biochem. Pharmacol. 24:1975;2177-2185.
6. Hijazi N. H., Laidler K. J. Can. J. Biochem. Physiol. 51:1973;815-821.
7. Ince E. L. Ordinary Differential Equations. 1956;Dover, New York.
8. Vincent J., Lazdunski M. Biochemistry. 11:1972;2967-2977.
9. Nayfeh A. H. Perturbation Methods. 1973;Wiley, New York. p. 110-114.
10. Ashton R. W., Scheraga H. A. Biochemistry. 34:1995;6454-6463.
11. Rydel T. J., Ravichandran K. G., Tulinsky A., Bode W., Huber R., Riotsch C., Fenton J. W. II. Science. 249:1990;277-280.
12. Press W., Teukolsky S. A., Vetterling W. T., Flannery B. P. Numerical Recipes in C. 1994;Cambridge Univ. Press, Cambridge.
13. Stone S. R., Hofsteenge J. Biochemistry. 25:1986;4622-4628.
14. Braun P. J., Dennis S., Hofsteenge J., Stone S. R. Biochemistry. 27:1988;6517-6522.
15. Zwillinger D. Handbook of Differential Equations. 1992;Academic Press, San Diego. p. 46-49.