Modulation of experimental autoimmune neuritis in Lewis rats by oral application of myelin antigens

Journal of Neuroimmunology

Volumn 79, Issue 2, 1997, Pages 129-137

  Gaupp, Stefanie ^a   Hartung, Hans Peter ^a   Toyka, Klaus ^a   Jung, Stefan ^a  

^a Department of Neurology   (Germany)

Author keywords

Adjuvant; Antigen therapy; GBS; Immunomodulation; Oral tolerance

Indexed keywords

ANTIGEN; MYELIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN SPECIFICITY; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; IMMUNOGENICITY; IMMUNOLOGICAL TOLERANCE; IMMUNOMODULATION; NEURITIS; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR DOWN REGULATION; SPLEEN CELL;

ADJUVANTS, IMMUNOLOGIC; ADMINISTRATION, ORAL; ADOPTIVE TRANSFER; ANIMALS; ANTIGENS; CATTLE; CHOLERA TOXIN; DRUG COMBINATIONS; FEMALE; IMMUNE TOLERANCE; MALE; MYELIN SHEATH; NEURITIS, AUTOIMMUNE, EXPERIMENTAL; PERIPHERAL NERVES; RATS; RATS, INBRED LEW;

EID: 0030813627     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-5728(97)00115-X     Document Type: Article

References (46)

1. Al-Sabbagh A., Miller A., Santos L.M.B., Weiner H.L. Antigen-driven tissue-specific suppression following oral tolerance: Orally administrated myelin basic protein suppresses proteolipid protein-induced experimental autoimmune encephalomyelitis in the SJL mouse. Eur. J. Immunol. 24:1994;2104-2109.
2. Bitar D.M., Whitacre C.C. Suppression of experimental autoimmune encephalomyelitis by the oral administration of myelin basic protein. Cell. Immunol. 112:1988;364-370.
3. Brod S.A., Al-Sabbagh A., Sobel R.A., Hafler D.A., Weiner H.L. Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin antigens: IV. Suppression of chronic relapsing disease in the Lewis rat and strain 13 guinea pig. Ann. Neurol. 29:1991;615-622.
4. Chen Y., Kuchroo V.K., Inobe J.-I., Hafler D.A., Weiner H.L. Regulatory T cell clones induced by oral tolerance: Suppression of autoimmune encephalomyelitis. Science. 265:1994;1237-1240.
5. Chen Y., Inobe J., Marks R., Gonella P., Kuchroo V.K., Weiner H.L. Peripheral deletion of antigen-reactive T cells in oral tolerance. Nature. 376:1995;177-180.
6. Elson C.O., Ealding W. Cholera toxin feeding did not induce oral tolerance in mice and abrogated oral tolerance to an unrelated protein antigen. J. Immunol. 133:1984;2892-2897.
7. Friedman A., Weiner H.L. Induction of anergy or active suppression following oral tolerance is determined by antigen dosage. Proc. Natl. Acad. Sci. USA. 91:1994;6688-6692.
8. Fukaura H., Kent S.C., Pietrusewicz M.J., Khoury S.J., Weiner H.L., Hafler D.A. Induction of circulating myelin basic protein and proteolipid protein-specific transforming growth factor-beta-1-secreting Th3 T cells by oral administration of myelin in multiple sclerosis patients. J. Clin. Invest. 98:1996;70-77.
9. Gregerson D.S., Obritsch W.F., Donoso L.A. Oral tolerance in experimental autoimmune uveoretinitis: Distinct mechanism of resistance are induced by low versus high dose feeding. J. Immunol. 151:1993;5751-5761.
10. Hartung H.P., Schaefer B., Heininger K., Stoll G., Toyka K.V. The role of macrophages and eicosanoids in the pathogenesis of experimental allergic neuritis. Serial clinical, electrophysiological, biochemical and morphological observations. Brain. 111:1988;1039-1059.
11. Hartung, H.P., Stoll, G., Toyka, K.V. (1993). Immune reactions in the peripheral nervous system. In: Dyck, P.J., Thomas, P.K., Griffin, J.W., Low, P.A., Poduslo, J.F., (Eds.), Peripheral Neuropathies. Saunders, Philadelphia, PA, pp. 418-444.
12. Jung S., Kraemer S., Schluesener H.J., Huenig T., Toyka K., Hartung H.P. Prevention and therapy of experimental autoimmune neuritis by an antibody against T cell receptors-alpha/beta. J. Immunol. 148:1992;3768-3775.
13. Jung S., Toyka K., Hartung H.-P. T cell mediated immunotherapy of inflammatory demyelination in the peripheral nervous system. Potent suppression of the effector phase of experimental autoimmune neuritis by anti-CD2 antibodies. Brain. 119:1996;1079-1090.
14. Kadlubowski M., Hughes R.A.C. Identification of the neuritogen for experimental allergic neuritis. Nature. 277:1979;140-141.
15. Khoruts A., Miller S.D., Jenkins M.K. Neuroantigen-specific Th2 cells are inefficient suppressors of experimental autoimmune encephalomyelitis induced by effector Th1 cells. J. Immunol. 155:1995;5011-5017.
16. Khoury S.J., Lider O., Al-Sabbagh A., Weiner H.L. Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein. III. Synergistic effect of lipopolysaccharide. Cell. Immunol. 131:1990;302-310.
17. Khoury S.J., Hancock W.W., Weiner H.L. Oral tolerance to myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with downregulation of inflammatory cytokines and differential upregulation of transforming growth factor b, interleukin 4, and prostaglandin E expression in the brain. J. Exp. Med. 176:1992;1355-1364.
18. Kitamura K., Suzuki M., Uyemura K. Purification and partial characterization of two glycoproteins in bovine peripheral nerve myelin membrane. Biochem. Biophys. Acta. 455:1976;806-816.
19. Lider O., Santos L.M., Lee C.S., Higgins P.J., Weiner H.L. Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein. II. Suppression of disease and in vitro immune responses is mediated by antigen-specific CD8+ T lymphocytes. J. Immunol. 142:1989;748-752.
20. Lycke N., Holmgren J. Intestinal mucosal memory and presence of memory cells in Lamina propria and Peyer's patches in mice 2 years after immunization with cholera toxin. Scand. J. Immunol. 23:1986;611-616.
21. McGee D.W., Elson C.O., McGhee J. Enhancing effect of cholera toxin on interleukin-6 secretion by IEC-6 intestinal epithelial cells: Mode of action and augmenting effects of inflammatory cytokines. Infect. Immunol. 61:1993;4637-4644.
22. Meyer A.L., Benson J.M., Gienapp I.E., Whitacre C.C. Suppression of murine chronic relapsing experimental autoimmune encephalomyelitis by the oral administration of myelin basic protein. J. Immunol. 157:1996;4230-4238.
23. Miller A., Lider O., Weiner H.L. Antigen-driven bystander suppression after oral administration of antigens. J. Exp. Med. 174:1991;791-798.
24. Miller A., Al-Sabbagh A., Santos L.M., Das M.P., Weiner H.L. Epitopes of myelin basic protein that trigger TGF-beta release after oral tolerization are distinct from encephalitogenic epitopes and mediate epitope-driven bystander suppression. J. Immunol. 151:1993;7307-7315.
25. Mowat A.M. The regulation of immune resonses to dietary protein antigens. Immunol. Today. 8:1987;93-98.
26. Munoz E., Zubiaga A.M., Merrow M., Sauter N.P., Huber B.T. Cholera toxin discriminates between T helper 1 and 2 cells in T cell receptor-mediated activation: Role of cAMP in T cell proliferation. J. Exp. Med. 172:1990;95-103.
27. Norton W.T., Poduslo S.E. Myelination in rat brain: Method of myelin isolation. J. Neurochem. 21:1973;749-757.
28. Okumura S., McIntosh K.R., Drachman D.B. Oral administration of acetylcholin receptor: Effects on experimental myasthenia gravis. Ann. Neurol. 36:1994;704-713.
29. Olee T., Powers J.M., Brostoff S.W. A T cell epitope for experimental allergic neuritis. J. Neuroimmunol. 19:1988;167-173.
30. Pierre P., Denis O., Bazin H., Mbella E.M., Vaerman J.-P. Modulation of oral tolerance to ovalbumin by cholera toxin and its B subunit. Eur. J. Immunol. 22:1992;3179-3182.
31. Rostami A., Cronkhite R.I. Prevention of experimental allergic neuritis (EAN) by oral induction of immunological tolerance. Neurology. 42:1992;171.
32. Singh V.K., Kalra H.K., Yamaki K., Shinohara T. Suppression of experimental autoimmune uveitis in rats by the oral administration of the uveitopathogenic S-antigen fragment or a cross-reactive homologous peptide. Cell. Immunol. 139:1992;81-90.
33. Smith M.E., Forno L.S., Hofmann W.W. Experimental allergic neuritis in the Lewis rat. J. Neuropathol. Exp. Neurol. 38:1979;377-391.
34. Spangler B.D. Structure and function of cholera toxin and the related Escherichia coli heat-labile enterotoxin. Microbiol. Rev. 56:1992;622-647.
35. Sun J.-B., Holmgren J., Czerkinsky C. Cholera toxin B subunit: An efficient transmucosal carrier-delivery system for induction of peripheral immunological tolerance. Proc. Natl. Acad. Sci. USA. 91:1994;10795-10799.
36. Sun J.B., Rask C., Olsson T., Holmgren J., Czerkinsky C. Treatment of experimental autoimmune encephalomyelitis by feeding myelin basic protein conjugated to cholera toxin B subunit. Proc. Natl. Acad. Sci. USA. 93:1996;7196-7201.
37. Trentham D.E., Dynesius-Trentham R.A., Orav E.J., Combitchi D., Lorenzo C., Sewell K.L., Hafler D.A., Weiner H.L. Effects of oral administration of type II collagen in rheumatoid arthritis. Science. 261:1993;1727-1730.
38. Vajdy M., Lycke N.Y. Cholera toxin adjuvant promotes long-term immunological memory in the gut mucosa to unrelated immunogens after oral tolerance. Immunology. 75:1992;488-492.
39. Wang Z.-Y., Link H., Ljungdahl A., Höjeberg B., Link J., He B., Qiao J., Melms A., Olsson T. Induction of interferon-γ, interleukin-4, and transforming growth factor-β in rats orally tolerized against experimental autoimmune myasthenia gravis. Cell. Immunol. 157:1994;353-368.
40. Weiner H.L. Oral tolerance. Proc. Natl. Acad. Sci. USA. 91:1994;10762-10765.
41. Weiner H.L., Friedman A., Miller A., Khoury S.J., Al-Sabbagh A., Santos L., Sayegh M., Nussenblatt R.B., Trentham D.E., Hafler D. Oral tolerance: Immunologic mechanisms and treatment of animal and human organ-specific autoimmune diseases by oral administration of autoantigens. Annu. Rev. Immunol. 12:1994;809-837.
42. Whitacre C.C., Gienapp I.E., Orosz C.G., Bitar D.M. Oral tolerance in experimental autoimmune encephalomyelitis III. Evidence for clonal anergy. J. Immunol. 147:1991;2155-2163.
43. Wildner G., Thurau S.R. Orally induced bystander suppression in experimental autoimmune uveoretinitis occurs only in the periphery and not in the eye. Eur. J. Immunol. 25:1995;1292-1297.
44. Xu-Amano J., Kiyono H., Jackson R.J., Staats H.F., Fujihashi K., Burrows P.D., Elson C.O., Pillai S., McGhee J.R. Helper T cells subsets for immunoglobulin A responses: Oral immunisation with tetanus toxin and cholera toxin as adjuvant selectively induces Th2 cells in mucosa associated tissues. J. Exp. Med. 178:1993;1309-1320.
45. Yoshino S. Antigen-induced arthritis in rats is suppressed by the inducing antigen administrated orally before, but not after immunization. Cell. Immunol. 163:1995;55-58.
46. Zhang Z.J., Lee C.S., Lider O., Weiner H.L. Suppression of adjuvant arthritis in Lewis rats by oral administration of type II collagen. J. Immunol. 145:1990;2489-2493.