Polymorphisms in IL-β and IL-1 receptor antagonist genes are associated with myasthenia gravis

Journal of Neuroimmunology

Volumn 81, Issue 1-2, 1998, Pages 76-81

  Huang, Deren ^a   Pirskanen, Ritva ^b   Hjelmström, Peter ^b   Lefvert, Ann Kari ^a  

^a Center for Molecular Medicine   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

HLA; IL 1 receptor antagonist; IL 1 ; Myasthenia gravis

Indexed keywords

INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 1BETA; ENDODEOXYRIBONUCLEASE TAQI; HLA B8 ANTIGEN; IL1RN PROTEIN, HUMAN; SIALOGLYCOPROTEIN; TYPE II SITE SPECIFIC DEOXYRIBONUCLEASE;

ADULT; ALLELE; ARTICLE; FEMALE; GENETIC LINKAGE; GENETIC POLYMORPHISM; HLA TYPING; HUMAN; MAJOR CLINICAL STUDY; MALE; MARKER GENE; MYASTHENIA GRAVIS; PATHOGENESIS; PRIORITY JOURNAL; TANDEM REPEAT; AUTOIMMUNE DISEASE; CASE CONTROL STUDY; COMPARATIVE STUDY; DISEASE PREDISPOSITION; GENETIC MARKER; GENETICS; GENOTYPE; MIDDLE AGED; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; VARIABLE NUMBER OF TANDEM REPEAT;

ADULT; ALLELES; AUTOIMMUNE DISEASES; CASE-CONTROL STUDIES; DEOXYRIBONUCLEASES, TYPE II SITE-SPECIFIC; DISEASE SUSCEPTIBILITY; FEMALE; GENETIC MARKERS; GENOTYPE; HLA-B8 ANTIGEN; HUMANS; INTERLEUKIN 1 RECEPTOR ANTAGONIST PROTEIN; MALE; MIDDLE AGED; MINISATELLITE REPEATS; MYASTHENIA GRAVIS; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; SIALOGLYCOPROTEINS;

EID: 0031594245     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-5728(97)00161-6     Document Type: Article

References (27)

1. Åhlberg R., Yi Q., Pirskanen R., Matell G., Swerup C., Rieber E.P., Riethmuller G., Holm G., Lefvert A.K. Treatment of myasthenia gravis with anti-CD4 antibody: Improvement correlates to decreased T-cell autoreactivity. Neurology. 44:1994;1732-1737.
2. Askanas, V., Engel, W.K., 1997. Fourteen newly recognized proteins of the muscle endplate Abstract IXth International Conference on Myasthenia Gravis and Related Disorders. California, 7 pp.
3. Bioque G., Crusius J.B.A., Koutroubakis I., Bouma G., Kostense P.J., Meuwissen S.G.M., Pena A.S. Allelic polymorphism in IL-1β and IL-1 receptor antagonist (IL-1Ra) genes in inflammatory bowel disease. Clin. Exp. Immunol. 102:1995;379-383.
4. Blakemore A.I.F., Tarlow J.K., Cork M.J., Gordon C., Emery P., Duff G.W. Interleukin-1 receptor antagonist gene polymorphism as a disease severity factor in systemic lupus erythematosus. Arthritis Rheum. 37:1994;1380-1385.
5. Crucius J.B.A., Pena A.S., van Osten B.W., Bioque G., Garcia A., Dijkstra C.D., Polman C.H. Interleukin-1 receptor antagonist gene polymorphism and multiple sclerosis. Lancet. 346:1995;979-980.
6. Danis V.A., Millington M., Hyland V.J., Grennan D. Cytokine production by normal human monocytes: inter-subject variation and relationship to an IL-1 receptor antagonist (IL-1Ra) gene polymorphism. Clin. Exp. Immunol. 99:1995;303-310.
7. Dinarello C.A. Biologic basis for interleukin-1 in disease. Blood. 87:1996;2095-2147.
8. Drachman D.B. Myasthenia gravis. N. Eng. J. Med. 330:1994;1797-1810.
9. Emilie D., Crevon M.C., Cohen-Kaminsky S., Peuchnaur M., Devergne O., Berrih-Aknin S., Galanaud P. In situ production of interleukins in hyperplastic thymus from myasthenia gravis patients. Hum. Pathol. 22:1991;461-468.
10. Firestein G.S., Boyle D.L., Yu C., Paine M.M., Whisenand T.D., Zvaifler N.J., Arend W.P. Synovial interleukin-1 receptor antagonist and interleukin-1 balance in rheumatoid arthritis. Arthritis Rheum. 37:1994;644-652.
11. Hirsch E., Irikura V.M., Paul S.M., Hirsh D. Functions of interleukin 1 receptor antagonist in gene knockout and overproducing mice. Proc. Natl. Acad. Sci. USA. 93:1996;11008-11013.
12. Hjelmström P., Giscombe R., Lefvert A.K., Pirskanen R., Kockum I., Landin-Olsson M., Sanjeevi C.B. Different HLA-DQ are positive and negative associated in Swedish patients with myasthenia gravis. Autoimmunity. 22:1995;59-65.
13. Hohfeld R., Heininger K., Gross-Wilde H., Kalies I. Autoimmune human T lymphocytes specific for acetylcholine receptor. Nature. 310:1984;244-246.
14. Huang W.X., He B., Hillert J. An interleukin 1-receptor-antagonist gene polymorphism is not associated with multiple sclerosis. J. Neuroimmunol. 67:1996;143-144.
15. Levert A.K., Bergström K., Matell G., Osterman P.O., Pirskanen R. Determination of acetylcholine receptor antibody in myasthenia gravis: clinical usefulness and pathogenetic implications. J. Neurol. Neurosurg. Psychiat. 41:1978;394-403.
16. Mandrup-Poulsen T., Pociot F., Molvig J., Shapiro L., Nilsson P., Emdal T., Roder M., Kjems L.L., Dinarello C.A., Nerup J. Monokine antagonism is reduced in patients with IDDM. Diabetes. 43:1994;1242-1247.
17. Mansfield J.C., Holden H., Tarow J.K., Francesco S., Glovine D., McDowell D.L., Wilson A.G., Holdsworth C.D. Novel genetic association between ulcerative colitis and the anti-inflammatory cytokine interleukin-1 receptor antagonist. Gastroenterology. 106:1994;637-642.
18. Maselli R.A., Richman D.P., Wollmann R.L. Inflammation at the neuromuscular juncton in myasthenia gravis. Neurology. 41:1991;1497-1504.
19. Murphy J., Murphy S.F. Myasthenia gravis in identical twins. Neurology. 36:1986;78-80.
20. Olerup O., Zetterquist H. HLA-DR typing by PCR amplification with sequence-specific primers (PCR-SSP) in 2 hours: An alternative to serological DR typing in clinical practice including donor-recipient matching in cadaveric transplantation. Tissue Antigens. 39:1992;225-235.
21. Pirskanen R., Tiilikainen A., Hokkanen E. Histocompatibity (HLA) antigens associated with myasthenia gravis. Ann. Clin. Rev. 4:1972;304-306.
22. Pociot F., Molvig J., Wogensen L., Worsaae H., Nerup J. A TaqI polymorphism in the human interleukin-1β (IL-1β) gene correlates with IL-1β secretion in vitro. Eur. J. Clin. Invest. 22:1992;396-402.
23. Pociot, F., Ronningen, K.S., Bergholdt, R., Lorenzen, T., Johannesen, J., Ye, K., Dinarello, C.A., Nerup, J., The Danish Study Group of Diabetes in Childhood, 1994. Genetic susceptibility markers in Danish patients with type 1 (insulin-dependent) diabetes - evidence for polygenicity in man. Autoimmunity 19, 169-178.
24. Schreuder H., Tardif C., Trump-Kallmeyer S., Soffientini A., Sarubbi E., Akeson A., Bowlin T., Yanofsky S., Barrett R.W. A new cytokine-receptor binding mode revealed by the crystal structure of the IL-1 receptor with an antagonist. Nature. 386:1997;194-200.
25. Tarlow J.K., Blakemore A.I.F., Lennard A., Solari R., Hughes H.N., Steinkasserer A., Duff G.W. Polymorphism in human IL-1 receptor antagonist gene intron 2 is caused by variable numbers of an 86-bp tandem repeat. Human Genet. 91:1993;403-404.
26. Vieira M.L., Caillat-Zucman S., Gajdos P., Cohen-Kaminsky S., Casteur A., Bach J.F. Identification by genomic typing of non-DR3 HLA class II genes associated with myasthenia gravis. J. Neuroimmunol. 47:1993;115-122.
27. Vigers G.P.A., Anderson L.J., Caffes P., Brandhuber B.J. Crystal structure of the type-1 interleukin-1 receptor complexed with interleukin-1β Nature. 386:1997;190-194.