Identification of truncated human glutamate transporter

Tohoku Journal of Experimental Medicine

Volumn 187, Issue 2, 1999, Pages 173-182

  Matsumoto, Yasuhiro ^a   Enomoto, Takemi ^a   Masuko, Takashi ^a  

^a TOHOKU UNIVERSITY   (Japan)

Author keywords

EAAC1; EAAT3; Glutamate transporter; RT PCR

Indexed keywords

CARRIER PROTEIN; COTRANSPORTER; EXCITATORY AMINO ACID TRANSPORTER 3; GLUTAMATE TRANSPORTER; MESSENGER RNA; PEPTIDE FRAGMENT; SLC1A1 PROTEIN, HUMAN; SLC1A1 PROTEIN, MOUSE; SLC1A1 PROTEIN, RAT;

AMINO ACID SEQUENCE; ANIMAL; ARTICLE; BAGG ALBINO MOUSE; CELL LINE; GENE DELETION; GENETICS; HUMAN; MALE; METABOLISM; MOLECULAR GENETICS; MOUSE; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

AMINO ACID SEQUENCE; AMINO ACID TRANSPORT SYSTEM X-AG; ANIMALS; BASE SEQUENCE; CARRIER PROTEINS; CELL LINE; EXCITATORY AMINO ACID TRANSPORTER 3; GENE DELETION; GLUTAMATE PLASMA MEMBRANE TRANSPORT PROTEINS; HUMANS; MALE; MICE; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; POLYMERASE CHAIN REACTION; RATS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SYMPORTERS;

EID: 0033072841     PISSN: 00408727     EISSN: None     Source Type: Journal    
DOI: 10.1620/tjem.187.173     Document Type: Article

References (16)

1. Arriza, J.L., Eliasof, S., Kavanaugh, M.P. & Amara, S.G. (1997) Excitatory amino acid transporter 5, a retinal glutamate transporter coupled to a chloride conductance. Proc. Natl. Acad. Sci. USA, 94, 4155-4160.
2. Bertran, J., Magagnin, S., Werner, A., Markovich, D., Biber, J., Testar, X., Zorzano, A., Kuhn, L.C., Palacin, M. & Murer, H. (1992) Stimulation of system y(+)-like amino acid transport by the heavy chain of human 4F2 surface antigen in Xenopus laevis oocytes. Proc. Natl. Acad. Sci. USA, 89, 5606-5610.
3. Chen, S., Meredith, D. & Boyd, C.A. (1996) Both the H13 gene product and 4F2 antigen are involved in the induction of system y+ cationic amino-acid trans port following activation of human peripheral blood mononuclear cells(PBM). Biochim. Biophys. Acta, 1284, 1-3.
4. Chomczynski, P. & Sacchi, N. (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem., 162, 156-159.
5. Fonnum, P. (1984) Glutamate: A neurotransmitter in mammalian brain. J. Neurochem., 42, 1-11.
6. Kanai, Y. & Hediger, M.A. (1992) Primary structure and functional characterization of a high-affinity glutamate transporter. Nature, 360, 467-471.
7. Kanai, Y., Stelzner, M., Nussberger, S., Khawaja, S., Hebert, S.C., Smith, C.P. & Hediger, M.A. (1994) The neuronal and epithelial human high affinity glutamate transporter. Insights into structure and mechanism of transport. J. Biol. Chem., 269, 20599-20606.
8. Li, Y.S., Hayakawa, K. & Hardy, R.R. (1993) The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver. J. Exp. Med., 178, 951-960.
9. Lin, C.L., Bristol, L.A., Jin, L., Dykes-Hoberg, M., Crawford, T., Clawson, L. & Rothstein, J.D. (1998) Aberrant RNA processing in a neurodegenerative disease: The cause for absent EAAT2, a glutamate transporter, in amyotrophic lateral sclerosis. Ann. Neurol., 43, 645-653.
10. +-independent neutral and basic amino acid transporter on amino acid transport in Xenopus oocytes. J. Biol. Chem., 271, 16758-16763.
11. Nagai, M., Abe, K., Okamoto, K. & Itoyama, Y. (1998) Identification of alternative splicing forms of GLT-1 mRNA in the spinal cord of amyotrophic lateral sclerosis patients. Neurosci. Lett., 244, 165-168.
12. Nicholls, D. & Attwell, D. (1990) The release and uptake of excitatory amino acids. Trends Pharmacol. Sci., 11, 462-468.
13. Pines, G., Danbolt, N.C., Bjoras, M., Zhang, Y., Bendahan, A., Eide, L., Koepsell, H., Storm-Mathisen, J., Seeberg, E. & Kanner, B.I. (1992) Cloning and expression of a rat brain L-glutamate transporter. Nature, 360, 464-467.
14. Storck, T., Schulte, S., Hofmann, K. & Stoffel, W. (1992) Structure, expression, and functional analysis of a Na(+)-dependent glutamate/aspartate transporter from rat brain. Proc. Natl. Acad. Sci. USA, 89, 10955-10959.
15. Wells, R.G. & Hediger, M.A. (1992) Cloning of a rat kidney cDNA that stimulates dibasic and neutral amino acid transport and has sequence similarity to glucosidases. Proc. Natl. Acad. Sci. USA, 89, 5596-5600.
16. Wells, R.G., Lee, W.S., Kanai, Y., Leiden, J.M. & Hediger, M.A. (1992) The 4F2 antigen heavy chain induces uptake of neutral and dibasic amino acids in Xenopus oocytes. J. Biol. Chem., 267, 15285-15288.