Radiosensitization of HeLa-cells by gemcitabine;Verstarkung der radiotherapeutischen wirkung auf HeLa-zellen durch gemcitabine

Strahlentherapie und Onkologie

Volumn 175, Issue 2, 1999, Pages 78-83

  Mose, Stephan ^a   Karapetian, Martin ^a   Jüling Pohlit, Lotte ^a   Taborski, Brigitte ^a   Ramm, Ulla ^a   Damrau, Marc ^a   Rahn, Angelika ^a   Böttcher, Heinz D ^a,b  

^a GOETHE UNIVERSITY   (Germany)

^b UNIVERSITY HOSPITAL FRANKFURT   (Germany)

Author keywords

Cancer of the cervix; Gemcitabine; HeLa cell line; Radiosensitization

Indexed keywords

GEMCITABINE; DEOXYCYTIDINE; DRUG DERIVATIVE; RADIOSENSITIZING AGENT;

ARTICLE; CANCER RADIOTHERAPY; CELL SURVIVAL; CONTROLLED STUDY; ELECTRON BEAM; HELA CELL; HUMAN; HUMAN CELL; RADIATION DOSE; RADIOSENSITIZATION; CELL DIVISION; CLONOGENIC ASSAY; CYTOLOGY; DOSE RESPONSE; DRUG EFFECT; RADIATION EXPOSURE; RADIATION RESPONSE; STATISTICAL MODEL; TIME;

CELL DIVISION; CELL SURVIVAL; COLONY-FORMING UNITS ASSAY; DEOXYCYTIDINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DOSE-RESPONSE RELATIONSHIP, RADIATION; HELA CELLS; HUMANS; LINEAR MODELS; RADIATION TOLERANCE; RADIATION-SENSITIZING AGENTS; TIME FACTORS;

EID: 0033071528     PISSN: 01797158     EISSN: None     Source Type: Journal    
DOI: 10.1007/bf02753847     Document Type: Article

References (20)

1. Arning M, Blatter J. Gemcitabine in solid tumors - Present status and further development. Onkologie 1997;20:297-304.
2. Eisbruch A, Shewach DS, Urba S, et al. Phase I trial of radiation concurrent with low-dose gemcitabine for head and neck cancer: high mucosal and pharyngeal toxicity. Proc Am Soc Clin Oncol 1997;16:A1377.
3. Fertil B, Dertinger H, Courdi A, et al. Mean inactivation dose: A useful concept for intercomparison of human cell survival curves. Radiat Res 1984;99:73-84.
4. Fleckenstein K, Latz D, Blatter J, et al. Combined effects on ionizing radiation and gemcitabine (GEM) in different cell lines. Eur J Cancer 1997;33:A105.
5. Heinemann V, Schulz L, Issels RD, et al. Gemcitabine: A modulator of intracellular nucleotide and deoxynucleotide metabolism. Semin Oncol 1995;22:11-8.
6. Latz D, Fleckenstein K, Eble M, et al. Radiosensitizing potential of gemcitabine (2′,2′-difluoro-2′-deoxycytidine) within the cell cycle in vitro. Int J Radiat Oncol Biol Phys 1998;41:875-82.
7. Lawrence TS, Chang EY, Hahn TM, et al. Radiosensitization of pancreatic cancer cells by 2′,2′-difluoro-2′-deoxycytidine. Int J Radiat Oncol Biol Phys 1996;34:867-72.
8. Merlano M, Benasso M, Corvò R, et al. Gemcitabine, cisplatin and radiotherapy in squamous cell carcinoma of the head and neck. Proc Am Soc Clin Oncol 1997;16:A1445.
9. Mohideen MN, McCall A, Kamradt M, et al. Activity of gemcitabine and its radiosensitization of human cervical cancer cells. Proc Am Soc Clin Oncol 1997;16:A865.
10. Mose S, Jüling-Pohlit L, Karapetian M, et al. Radiosensibilisierung von humanen Plattenepithelkarzinomzellen durch Gemcitabine. Exp Strahlenther Klin Strahlenbiol 199S;7:138-42.
11. Ostruszka LJ, Shewach DS. Cytotoxicity and radiosensitization of gemcitabine in human glioblastoma cell lines. Proc Am Soc Clin Oncol 1997; 16:A683.
12. Peters HD, Blatter J, Ermisch S. Gemcitabin - Pharmakologisches Profil und klinische Anwendung. Onkologe 1995;l:367-82.
13. Plunkett W, Huang P, Xu YZ, et al. Gemcitabine: Metabolism, mechanism of action and self-potentiation. Semin Oncol 1995;22:3-10.
14. Robertson JM, Shewach DS, Lawrence TS. Preclinical studies of chemotherapy and radiation therapy for pancreatic carcinoma. Cancer 1996;78: 674-9.
15. Rosier JF, Beauduin M, Bruniaux M, et al. The role of gemcitabine-induced cell cycle synchronization in radiosensitization of SCC61 human head&neck squamous carcinoma cell (HNSCC) line. Eur J Cancer 1997;33:A89.
16. Rosier JF, Beauduin M, De Bast M, et al. Radiosensitization by gemcitabine (dFdC) of radiosensitive (RS) and radioresistant (RR) human head and neck carcinoma (HNSC) cell lines. Proc Am Soc Clin Oncol 1997; 16:A298.
17. Shewach DS, Hahn TM, Chang EY, et al. Metabolism of 2′,2′-difluoro-2′-deoxycytidine and radiation sensitization of human colon carcinoma cells. Cancer Res 1994;54:3218-23.
18. Shewach DS, Lawrence TS. Radiosensitization of human tumor cells by gemcitabine in vitro. Semin Oncol 1995;22:68-71.
19. Wallwiener D, Kurek R, Angioli R, et al. Radiation enhancement of gemcitabine in three human cervical cancer cell lines. Eur J Cancer 1997; 33:A923.
20. Webster LK, Joscko MA, Groves J, et al. Radioenhancement by gemcitabine with accelerated fractionated radiotherapy in a human tumor xenograft. Proc Am Soc Clin Oncol 1997;16:A1665.