Optimization of formulations and conditions for the aerosol delivery of functional cationic lipid: DNA complexes

Human Gene Therapy

Volumn 8, Issue 3, 1997, Pages 313-322

  Eastman, Simon J ^a   Tousignant, Jennifer D ^a   Lukason, Michael J ^a   Murray, Heather ^a   Siegel, Craig S ^a   Constantino, Paul ^a   Harris, David J ^a   Cheng, Seng H ^a   Scheule, Ronald K ^a  

^a GENZYME CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; LIPID; PLASMID DNA; SODIUM CHLORIDE;

AEROSOL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CLONING VECTOR; CONTROLLED STUDY; DNA DEGRADATION; DOSE RESPONSE; DRUG DELIVERY SYSTEM; FEMALE; GENE ACTIVITY; GENE TARGETING; INHALATIONAL DRUG ADMINISTRATION; LUNG; MOUSE; NEBULIZATION; NEBULIZER; NONHUMAN; REPORTER GENE; TISSUE CULTURE CELL; ZETA POTENTIAL;

ANIMALIA;

EID: 0030754344     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/hum.1997.8.3-313     Document Type: Article

References (18)

1. AIDA, Y., and PABST, M.J. (1990). Removal of endotoxin from protein solutions by phase separation using Triton X-114. J. Immunol. Mem. 132, 191-195.
2. ALTON, E.W.F.W., MIDDLETON, P.G., CAPLEN, N.J., SMITH, S.N., STEEL, D.M., MUNKONGE, F.M., JEFFERY, P.K., GEDDES, D.M., HART, S.L., WILLIAMSON, R., FASOLD, K.I., MILLER, A.D., DICKINSON, P., STEVENSON, B.J., MCLACHLAN, G., DORIN, J.R., and PORTEOUS, D.J. (1993). Non-invasive liposome-mediated gene delivery can correct the ion transport defect in cystic fibrosis mutant mice. Nature Genet. 5, 135-142.
3. BATES, D.V., FISH, B.R., HATCH, T.F., MERCER, T.T., and MORROW, P.E. (1966). Deposition and retention models for internal dosimetry of the human respiratory tract. Health Physics 12, 173-207.
4. BLIGH, E.G., and DYER, W.J. (1959). A rapid method of total lipid extraction and purification. Can. J. Biochem. Physiol. 37, 911-937.
5. CANONICO, A.E., CONARY, J.T., MEYRICK, B.O., and BRIGHAM, K.L. (1994). Aerosol and intravenous transfection of human α1-antitrypsin gene to lungs of rabbits. Am. J. Respir. Cell Moll. Biol. 10, 24-29.
6. CONARY, J.T., PARKER, R.E., CHRISTMAN, B.W., FAULKS, R.D., KING, G.A., MEYRICK, B.O., and BRIGHAM, K.L. (1994). Protection of rabbit lungs from endotoxin injury by in vivo hyperexpression of the prostaglandin G/H synthase gene. J. Clin. Invest. 93, 1834-1840.
7. FASBENDER, A.J., ZABNER, J., and WELSH, M.J. (1995). Optimization of cationic lipid-mediated gene transfer to airway epithelia. Am. J. Physiol. 269, L45-L51.
8. FELGNER, P.L., GADEK, T.R., HOLM, M., ROMAN, R., CHAN, H.W., WENZ, M., NORTHROP, J.P., RINGOLD, G.M., and DANIELSON, M. (1987). Lipofectin: A highly efficient, lipid-mediated DNA-transfection procedure. Proc. Natl. Acad. Sci. USA 84, 7413-7417.
9. FELGNER, J.H., KUMAR, R., SRIDHAR, C.N., WHEELER, C.J., TSAI, Y.J., BORDER, R., RAMSEY, P., MARTIN, M., and FELGNER, P.L. (1994). Enhanced gene delivery and mechanism studies with a novel series of cationic lipid formulations. J. Biol. Chem. 269, 2550-2561.
10. LEE, E.R., MARSHALL, J., SIEGEL, C.S., JIANG, C., YEW, N.S., NICHOLS, M.R., NIETUPSKI, J.B., ZIEGLER, R.J., LANE, M.B., WANG, K.X., WAN, N.C., SCHEULE, R.K., HARRIS, D.J., SMITH, A.E., and CHENG, S.H. (1996). Detailed analysis of structures and formulations of cationic lipids for efficient gene transfer to the lung. Hum. Gene Ther. 7, 1701-1717.
11. LIU, Y., LIGGITT, D., ZHONG, W., GUANHUAN, T., GAENSLER, K., and DEBS, R. (1995). Cationic liposome-mediated intravenous gene delivery. J. Biol. Chem. 270, 24864-24870.
12. LOGAN, J.J., BEBOK, Z., WALKER, L.C., PENG, S., FELGNER, P.L., SIEGAL, G.P., FRIZZELL, R.A., DONG, J., HOWARD, M., MATALON, S., LINDSEY, J.R., DUVALL, M., and SORSCHER, E.J. (1995). Cationic lipids for reporter gene and CFTR transfer to rat pulmonary epithelium. Gene Ther. 2, 38-49.
13. MCLACHLAN, G., DAVIDSON, D.J., STEVENSON, B.J., DICKINSON, P., DAVIDSON-SMITH, H., DORIN, J.R., and PORTEOUS, D.J. (1995). Evaluation in vitro and in vivo of cationic liposome-expression construct complexes for cystic fibrosis gene therapy. Gene Ther. 2, 614-622.
14. SCHWARZ, L.A., JOHNSON, J.L., BLACK, M., CHENG, S.H., HOGAN, M.E., and WALDREP, J.C. (1996). Delivery of DNA-cationic liposome complexes by small-particle aerosol. Hum. Gene Ther. 7, 731-741.
15. SOLODIN, I., BROWN, C.S., BRUNO, M.S., CHOW, C-Y., JANG, E-H., DEBS, R.J., and HEATH, T.D. (1995). A novel series of amphiphilic imidazolium compounds for in vitro and in vivo gene delivery. Biochemistry 35, 13537-13544.
16. STRIBLING, R., BRUNETTE, E., LIGGITT, D., GAENSLER, K., and DEBS, R. (1992). Aerosol gene delivery in vivo. Proc. Natl. Acad. Sci. USA 89, 11277-11281.
17. YANKASKAS, J.R., HAIZLIP, J.E., CONRAD, M., KOVAL, D., SARKADI, B., SCHLEGEL, R., and BOUCHER, R.C. (1993). Papilloma virus immortalized tracheal epithelial cells retain a well-differentiated phenotype. Am. J. Physiol. 264 (Cell Physiol. 33), C1219-C1230.
18. YOSHIMURA, K., ROSENFELD, M.A., NAKAMURA, H., SCHERER, E.M., PAVIRANI, A., LECOCQ, J-P., and CRYSTAL, R.G. (1992). Expression of the human cystic fibrosis transmembrane conductance regulator gene in the mouse lung after in vivo intratracheal plasmid-mediated gene transfer. Nucleic Acids Res. 20, 3233-3240.