Validation of intratracheal instillation as an alternative for aerosol inhalation toxicity testing

Journal of Applied Toxicology

Volumn 19, Issue 2, 1999, Pages 133-140

  Sabaitis, C P ^a   Leong, B K J ^a   Rop, D A ^a   Aaron, C S ^a  

^a PFIZER INC   (United States)

Author keywords

Ingestion; Inhalation; Instillation; Intratracheal; Intravenous injection; Nebulization; Rats

Indexed keywords

ANTILIPEMIC AGENT; CEPHALOSPORIN; GROWTH HORMONE; PESTICIDE; RNA DIRECTED DNA POLYMERASE INHIBITOR;

AEROSOL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREATHING RATE; DOSE RESPONSE; DYSPNEA; INHALATION TEST; INTRANASAL DRUG ADMINISTRATION; INTRATRACHEAL DRUG ADMINISTRATION; INTRAVENOUS ADMINISTRATION; LD 50; MALE; NEBULIZATION; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; TOXICITY TESTING; WEIGHT REDUCTION;

ADMINISTRATION, INHALATION; ADMINISTRATION, INTRANASAL; ADMINISTRATION, ORAL; AEROSOLS; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; EVALUATION STUDIES; HAZARDOUS SUBSTANCES; INJECTIONS, INTRAVENOUS; INTUBATION, INTRATRACHEAL; LETHAL DOSE 50; LUNG; MALE; NEBULIZERS AND VAPORIZERS; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; RESPIRATORY SOUNDS; TOXICITY TESTS;

ANIMALIA;

EID: 0033063314     PISSN: 0260437X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-1263(199903/04)19:2<133::AID-JAT549>3.0.CO;2-9     Document Type: Article

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