Towards the development of peptide mimotopes of carbohydrate antigens as cancer vaccines

Hybridoma

Volumn 18, Issue 1, 1999, Pages 103-112

  Qiu, Jianping ^a   Luo, Ping ^a   Wasmund, Kelly ^b   Steplewski, Zenon ^c   Kieber Emmons, Thomas ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b Research Genetics   (United States)

^c THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER VACCINE; CARBOHYDRATE ANTIGEN; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; IMMUNOGLOBULIN M ANTIBODY; MONOCLONAL ANTIBODY; QS 21;

AMINO ACID SEQUENCE; ANIMAL CELL; ANTIGEN DETECTION; BLOOD GROUP LEWIS SYSTEM; CANCER IMMUNOTHERAPY; CARCINOMA; COMPLEMENT DEPENDENT CYTOTOXICITY; CONFERENCE PAPER; ENZYME LINKED IMMUNOSORBENT ASSAY; FIBROSARCOMA; IMMUNE RESPONSE; IMMUNOGENICITY; MELANOMA; MINIMAL RESIDUAL DISEASE; NONHUMAN; PEPTIDE ANALYSIS; PEPTIDE MAPPING; PRIORITY JOURNAL;

ANIMALIA; MURINAE;

EID: 0033062668     PISSN: 0272457X     EISSN: None     Source Type: Journal    
DOI: 10.1089/hyb.1999.18.103     Document Type: Conference Paper

References (59)

1. Ravindranath MH, Amiri AA, Bauer PM, Kelley MC, Essner R, and Morton DL: Endothelial-selectin ligands sialyl Lewis(x) and sialyl Lewis(a) are differentiation antigens immunogenic in human melanoma. Cancer 1997;79:1686-1697.
2. Livingston PO, and Ragupathi G: Carbohydrate vaccines that induce antibodies against cancer. 2. Previous experience and future plans. Cancer Immunol Immunother 1997;45:10-19.
3. Mond JJ, Lees A, and Snapper CM: T cell-independent antigens type 2. Annu Rev Immunol 1995;13:655-692.
4. Diakun KR, and Matta KL: Synthetic antigens as immunogens: Part III. Specificity analysis of an anti-anti-idiotypic antibody to a carbohydrate tumor-associated antigen. J Immunol 1989;142: 2037-2040.
5. Hutchins W, Adkins A, Kieber-Emmons T, and Westerink MAJ: Molecular characterization of a monoclonal antibody produced in response to a group-C Meningococcal polysaccharide peptide mimic. Mol Immunol 1996;33:503-510.
6. Olsson L: Molecular mimicry of carbohydrate and protein structures by hybridoma antibodies. Bioessays 1987;7:116-9.
7. Tsuyuoka K, Yago K, Hirashima K, Ando S, Hanai N, Saito H, Yamasaki M, Takahashi K, Fukuda Y, Nakano K, and Kannagi R: Characterization of a T-cell line specific to an anti-Id antibody related to the carbohydrate antigen, sialyl ssea-1, and the immunodominant T-cell antigenic site of the antibody. J Immunol 1996;157:661-669.
8. Furuya A, Yoshida H, and Hanai N: Development of anti-idiotype monoclonal antibodies for Sialyl Le(a) antigen. Anticancer Res 1992;12:27-31.
9. Schmolling J, Reinsberg J, Wagner U, and Krebs D: Antiidiotypic antibodies in ovarian cancer patients treated with the monoclonal antibody B72.3. Hybridoma 1995;14:183-186.
10. Viale G, Grassi F, Pelagi M, Alzani R, Menard S, Miotti S, Buffa R, Gini A, and Siccardi AG: Anti-human tumor antibodies induced in mice and rabbits by "internal image" anti-idiotypic monoclonal immunoglobulins. J Immunol 1987;139:4250-4255.
11. Sen G, Chakraborty M, Foon KA, Reisfeld RA, and Bhattacharya CM: Induction of IgG antibodies by an anti-idiotype antibody mimicking disialoganglioside GD2. J Immunother 1998;21:75-83.
12. Cheung NK, Canete A, Cheung IY, Ye JN, and Liu C: Disialoganglioside GD2 anti-idiotypic monoclonal antibodies. Int J Cancer 1993;54:499-505.
13. Cheung NK, Cheung IY, Canete A, Yeh SJ, Kushner B, Bonilla MA, Heller G, and Larson SM: Antibody response to murine antiGD2 monoclonal antibodies: correlation with patient survival. Cancer Res 1994;54:2228-2233.
14. Saleh MN, Khazaeli MB, Wheeler RH, Dropcho E, Liu T, Urist M, Miller DM, Lawson S, Dixon P, Russell CH, et al.: Phase I trial of the murine monoclonal anti-GD2 antibody 14G2a in metastatic melanoma. Cancer Res 1992;52:4342-4347.
15. Saleh MN, Khazaeli MB, Wheeler RH, Allen L, Tilden AB, Grizzle W, Reisfeld RA, Yu AL, Gillies SD, and LoBuglio AF: Phase I trial of the chimeric anti-GD2 monoclonal antibody ch14.18 in patients with malignant melanoma. Hum Antibodies Hybridomas 1992;3:19-24.
16. Saleh MN, Stapleton JD, Khazaeli MB, and LoBuglio AF: Generation of a human anti-idiotypic antibody that mimics the GD2 antigen. J Immunol 1993;151:3390-3398.
17. Handgretinger R, Baader P, Dopfer R, Klingebiel T, Reuland P, Treuner J, Reisfeld RA, and Niethammer D: A phase I study of neuroblastoma with the anti-ganglioside GD2 antibody 14.G2a. Cancer Immunol Immunother 1992;35:199-204.
18. Chapman PB, and Houghton AN: Induction of IgG antibodies against GD3 ganglioside in rabbits by an anti-idiotypic monoclonal antibody. J Clin Invest 1991;88:186-192.
19. Minasian LM, Yao TJ, Steffens TA, Scheinberg DA, Williams L, Riedel E, Houghton AN, and Chapman PB: A phase I study of anti-GD3 ganglioside monoclonal antibody R24 and recombinant human macrophage-colony stimulating factor in patients with metastatic melanoma. Cancer 1995;75:2251-2257.
20. Kanda S, Takeyama H, Kikumoto Y, Morrison SL, Morton DL, and Irie RF: Both VH and VL regions contribute to the antigenicity of anti-idiotypic antibody that mimics melanoma associated ganglioside GM3. Cell Biophys 1994;25:65-74.
21. Raychaudhuri S, Kang CY, Kaveri SV, Kieber-Emmons T, and Kohler H: Tumor idiotype vaccines. VII. Analysis and correlation of structural, idiotypic, and biologic properties of protective and nonprotective Ab2. J Immunol 1990;145:760-767.
22. Burritt JB, Bond CW, Doss KW, and Jesaitis AJ: Filamentous phage display of oligopeptide libraries. Analy Biochem 1996; 238:1-13.
23. Cortese R, Monaci P, Nicosia A, Luzzago A, Felici F, Galfre G, Pessi A, Tramontano A, and Sollazzo M: Identification of biologically active peptides using random libraries displayed on phage. Curr Opin Biotechnol 1995;6:73-80.
24. Cwirla SE, Peters EA, Barrett RW, and Dower WJ: Peptides on phage: a vast library of peptides for identifying ligands. Proc Nat Acad Sci USA 1990;87:6378-6382.
25. Harris SL, Craig L, Mehroke JS, Rashed M, Zwick MB, Kenar K, Toone EJ, Greenspan N, Auzanneau FI, Marino AJ, Pinto BM, and Scott JK: Exploring the basis of peptide-carbohydrate crossreactivity: evidence for discrimination by peptides between closely related anti-carbohydrate antibodies. Proc Nat Acad Sci USA 1997;94:2454-1459.
26. Hoess R, Brinkmann U, Handel T, and Pastan I: Identification of a peptide which binds to the carbohydrate-specific monoclonal antibody B3. Gene 1993;128:43-49.
27. Lane DP, and Stephen CW: Epitope mapping using bacteriophage peptide libraries. Curr Opin Immunol 1993;5:268-271.
28. Oldenburg KR, Loganathan D, Goldstein LJ, Schultz PG, and Gallop MA: Peptide ligands for a sugar-binding protein isolated from a random peptide library. Proc Nat Acad Sci USA 1992;89:5393-5397.
29. Scott JK, Loganathan D, Easley RB, Gong X, and Goldstein IJ: A family of concanavalin A-binding peptides from a hexapeptide epitope library. Proc Nat Acad Sci USA 1992;89:5398-5402.
30. Scott JK: Discovering peptide ligands using epitope libraries. Trends Biochem Sci 1992;17:241-245.
31. Smith GP, and Scott JK: Libraries of peptides and proteins displayed on filamentous phage. Meth Enzymol 1993;217:228-257.
32. Valadon P, Nussbaum G, Boyd LF, Margulies DH, and Scharff MD: Peptide libraries define the fine specificity of anti-polysaccharide antibodies to Cryptococcus neoformans. J Mol Biol 1996;261:11-22.
33. Zhang H, Zhong Z, and Pirofski LA: Peptide epitopes recognized by a human anti-cryptococcal glucuronoxylomannan antibody. Infect Immun 1997;65:1158-1164.
34. Taki T, Ishikawa D, Hamasaki H, and Handa S: Preparation of peptides which mimic glycosphingolipids by using phage peptide library and their modulation on beta-galactosidase activity. FEBS Lett 1997;418:219-223.
35. Pinilla C, Appel JR, Blanc P, and Houghten RA: Rapid identification of high affinity peptide ligands using positional scanning synthetic peptide combinatorial libraries. Biotechniques 1992;13:901-905.
36. Pincus SH, Smith MJ, Jennings HJ, Burritt JB, and Glee PM: Peptides that mimic the group B streptococcal type III capsular polysaccharide antigen. J Immunol 1998;160:293-298.
37. Phalipon A, Folgori A, Arondel J, Sgaramella G, Fortugno P, Cortese R, Sansonetti PJ, and Felici F: Induction of anti-carbohydrate antibodies by phage library-selected peptide mimics. Eur J Immunol 1997;27:2620-2625.
38. Murali R, and Kieber-Emmons T: Molecular recognition of a peptide mimic of the Lewis Y antigen by an anti-Lewis Y antibody. J Mol Recognit 1997;10:269-276.
39. Young AC, Valadon P, Casadevall A, Scharff MD, and Sacchettini JC: The three-dimensional structures of a polysaccharide binding antibody to Cryptococcus neoformans and its complex with a peptide from a phage display library: implications for the identification of peptide mimotopes. J Mol Biol 1997;274:622-634.
40. McLean GW, Cross AM, Munns MS, and Marsden HS: Rapid attachment of a helper T cell epitope to branched peptides by fragment condensation to give enhanced immunogenicity. J Immunol Meth 1992;155:113-120.
41. Rajadhyaksha M, Yang YF, and Thanavala YM: Immunological evaluation of three generations of anti-idiotype vaccine: study of B and T cell responses following priming with anti-idiotype, antiidiotype peptide and its MAP structure. Vaccine 1995;13:1421-1426.
42. Luo P, Agadjanyan M, Qiu J-P, Westerink MAJ, Steplewski Z, and Kieber-Emmons T: Antigenic and immunological mimicry of peptide mimotopes of adenocarcinoma associated carbohydrate antigens. Mol Immunol 1998;17:3125-3135.
43. Westerink MAJ, Giardina PC, Apicella MA, and Kieber-Emmons T: Peptide mimicry of the meningococcal group C capsular polysaccharide. Proc Natl Acad Sci 1995;92:4021-4025.
44. Agadjanyan M, Luo P, Westerink MAJ, Carey LA, Hutchins W, Steplewski Z, Weiner DB, and Kieber-Emmons T: Peptide mimicry of carbohydrate epitopes on human immunodeficiency virus. Nature Biotechnol 1997;15:547-551.
45. Scholz D, Lubeck M, Loibner H, McDonald SJ, Kimoto Y, Koprowski H, and Steplewski Z: Biological activity in the human system of isotype variants of oligosaccharide-Y-specific murine monoclonal antibodies. Cancer Immunol Immunother 1991;33:153-157.
46. Steplewski Z, Blaszczyk TM, Lubeck M, Loibner H, Scholz D, and Koprowski H: Oligosaccharide Y specific monoclonal antibody and its isotype switch variants. Hybridoma 1990;9:201-210.
47. Iliopoulos D, Ernst C, Steplewski Z, Jambrosic JA, Rodeck U, Herlyn M, Clark WJ, Koprowski H, and Herlyn D: Inhibition of metastases of a human melanoma xenograft by monoclonal antibody to the GD2/GD3 gangliosides. J Nat Cancer Inst 1989; 81:440-444.
48. Qiu J, Zhou H, Aceto JF, and Kieber-Emmons T: Cycle sequencing of filamentous phage DNA using a biotinylated primer and delta Taq DNA polymerase. Biotechniques 1997;23:125-127.
49. Kitamura K, Stockert E, Garin CP, Welt S, Lloyd KO, Armour KL, Wallace TP, Harris WJ, Carr FJ, and Old LJ: Specificity analysis of blood group Lewis-y (Le(y)) antibodies generated against synthetic and natural Le(y) determinants. Proc Nat Acad Sci USA 1994;91:12957-12961.
50. Murai H, Hara S, Ikenaka T, Goto A, Arai M, and Murao S: Amino acid sequence of protein alpha-amylase inhibitor from Streptomyces griseosporeus YM-25. J Biochem 1985;97:1129-1133.
51. Mirkov TE, Evans SV, Wahlstrom J, Gomez L, Young NM. and Chrispeels MJ: Location of the active site of the bean alpha-amylase inhibitor and involvement of a Trp, Arg, Tyr triad. Glycobiology 1995;5:45-50.
52. Kieber-Emmons T, Luo P, Qiu J, Agadjanyan M, Carey L, Hutchins W, Westerink MAJ, and Steplewski Z: Peptide mimicry of adenocarcinoma-associated carbohydrate antigens. Hybridoma 1997;16: 3-10.
53. Thurin-Blaszczyk M, Murali R, Westerink MAJ, Steplewski Z, Co M-S, and Kieber-Emmons T: Molecular recognition of the Lewis Y antigen by monoclonal antibodies. Protein Eng 1996;9:101-113.
54. Spohr U, and Lemieux RU: Synthetic, conformational, and immunochemical studies of modified Lewis b and Y human blood-group determinants to serve as probes for the combining site of the lectin IV of Griffonia simplicifolia. Carbohydr Res 1988;174: 211-237.
55. Thurin J, Thurin M, Kimoto Y, Herlyn M, Lubeck MD, Elder DE, Smereczynska M, Karlsson KA, Clark WMJ, and Steplewski Z: Monoclonal antibody-defined correlations in melanoma between levels of GD2 and GD3 antigens and antibody-mediated cytotoxicity. Cancer Res 1987;47:1229-1233.
56. Pichla S, Murali R, and Burnett R: Preliminary crystallographic data for an fab to the melanoma-associated gd2 ganglioside, and the purification of a soluble form of this antigen. Acta Crystallogr D 1995;51:124-126.
57. Shikhman AR, Greenspan NS, and Cunningham MW: Cytokeratin peptide SFGSGFGGGY mimics N-acetyl-beta-D-glucosamine in reaction with antibodies and lectins, and induces in vivo anti-carbohydrate antibody response. J Immunol 1994;153:5593-5606.
58. Mayer P, Handgretinger R, Bruchelt G, Schaber B, Rassner G, and Fierlbeck G: Activation of cellular cytotoxicity and complement-mediated lysis of melanoma and neuroblastoma cells in vitro by murine antiganglioside antibodies MB 3.6 and 14.G2a. Melanoma Res 1994;4:101-106.
59. Ravindranath MH, Kelley MC, Jones RC, Amiri AA, Bauer PM, and Morton DL: Ratio of IgG:IgM antibodies to sialyl Lewis(x) and GM3 correlates with tumor growth after immunization with melanoma-cell vaccine with different adjuvants in mice. Int J Cancer 1998;75:117-124.