-
1
-
-
0023932431
-
Oxygen distribution in squamous cell carcinoma metastases and its relationship to outcome of radiation therapy
-
Gatenby RA, Kessler HB, Rosenblum JS, Coia LR, Moldofsky PJ, Hartz WH. Oxygen distribution in squamous cell carcinoma metastases and its relationship to outcome of radiation therapy. Int J Radiat Oncol Biol Phys 1988;14:831-838.
-
(1988)
Int J Radiat Oncol Biol Phys
, vol.14
, pp. 831-838
-
-
Gatenby, R.A.1
Kessler, H.B.2
Rosenblum, J.S.3
Coia, L.R.4
Moldofsky, P.J.5
Hartz, W.H.6
-
2
-
-
0029955072
-
Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck
-
Nordsmark M, Overgaard M, Overgaard J. Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck. Radiother Oncol 1996;41:31-40.
-
(1996)
Radiother Oncol
, vol.41
, pp. 31-40
-
-
Nordsmark, M.1
Overgaard, M.2
Overgaard, J.3
-
3
-
-
0030742027
-
Tumor hypoxia adversely affects the prognosis of carcinoma of the head and neck
-
Brizel DM, Sibley GS, Prosnitz LR, Scher RL, Dewhirst MW. Tumor hypoxia adversely affects the prognosis of carcinoma of the head and neck. Int J Radiat Oncol Biol Phys 1997;38:285-289.
-
(1997)
Int J Radiat Oncol Biol Phys
, vol.38
, pp. 285-289
-
-
Brizel, D.M.1
Sibley, G.S.2
Prosnitz, L.R.3
Scher, R.L.4
Dewhirst, M.W.5
-
4
-
-
0028632781
-
Clinical evaluation of nitroimidazoles as modifiers of hypoxia in solid tumors
-
Overgaard J. Clinical evaluation of nitroimidazoles as modifiers of hypoxia in solid tumors. Oncol Res 1994; 6:509-518.
-
(1994)
Oncol Res
, vol.6
, pp. 509-518
-
-
Overgaard, J.1
-
5
-
-
0031716020
-
Oxygenation predicts radiation response and survival in patients with cervix cancer
-
Fyles AW, Milosevic M, Wong R, Kavanagh MC, Pintilie M, Sun A, Chapman W, Levin W, Manchul L, Keane TJ, Hill RP. Oxygenation predicts radiation response and survival in patients with cervix cancer. Radiother Oncol 1998;48:149-156.
-
(1998)
Radiother Oncol
, vol.48
, pp. 149-156
-
-
Fyles, A.W.1
Milosevic, M.2
Wong, R.3
Kavanagh, M.C.4
Pintilie, M.5
Sun, A.6
Chapman, W.7
Levin, W.8
Manchul, L.9
Keane, T.J.10
Hill, R.P.11
-
6
-
-
0029065105
-
Hypoxic cell radiosensitizers: The end of an era? Regarding Lee et al., IJROBP 1995;32:567-576
-
Brown JM. Hypoxic cell radiosensitizers: the end of an era? Regarding Lee et al., IJROBP 1995;32:567-576 [editorial]. Int J Radiat Oncol Biol Phys 1995;32:883-885.
-
(1995)
Int J Radiat Oncol Biol Phys
, vol.32
, pp. 883-885
-
-
Brown, J.M.1
-
7
-
-
0024563098
-
Tumor radiosensitization by nicotinamide: A result of improved blood perfusion and oxygenation
-
Horsman MR, Chaplin DJ, Brown JM. Tumor radiosensitization by nicotinamide: a result of improved blood perfusion and oxygenation. Radiat Res 1989;118: 139-150.
-
(1989)
Radiat Res
, vol.118
, pp. 139-150
-
-
Horsman, M.R.1
Chaplin, D.J.2
Brown, J.M.3
-
8
-
-
0028278267
-
Reducing acute and chronic hypoxia in tumours by combining nicotinamide with carbogen breathing
-
Horsman MR, Nordsmark M, Khalil AA, Hill SA, Chaplin DJ, Siemann DW, Overgaard J. Reducing acute and chronic hypoxia in tumours by combining nicotinamide with carbogen breathing. Acta Oncol 1994;33:371-376.
-
(1994)
Acta Oncol
, vol.33
, pp. 371-376
-
-
Horsman, M.R.1
Nordsmark, M.2
Khalil, A.A.3
Hill, S.A.4
Chaplin, D.J.5
Siemann, D.W.6
Overgaard, J.7
-
9
-
-
0029057395
-
Perfusion changes in the RIF-1 tumour and normal tissues after carbogen and nicotinamide, individually and combined
-
Honess DJ, Bleehen NM. Perfusion changes in the RIF-1 tumour and normal tissues after carbogen and nicotinamide, individually and combined. Br J Cancer 1995;71:1175-1180.
-
(1995)
Br J Cancer
, vol.71
, pp. 1175-1180
-
-
Honess, D.J.1
Bleehen, N.M.2
-
10
-
-
0028856360
-
Noninvasive monitoring of carbogen-induced changes in tumor blood flow and oxygenation by functional magnetic resonance imaging
-
see comments
-
Robinson SP, Howe FA, Griffiths JR. Noninvasive monitoring of carbogen-induced changes in tumor blood flow and oxygenation by functional magnetic resonance imaging [see comments]. Int J Radiat Oncol Biol Phys 1995;33:855-859.
-
(1995)
Int J Radiat Oncol Biol Phys
, vol.33
, pp. 855-859
-
-
Robinson, S.P.1
Howe, F.A.2
Griffiths, J.R.3
-
11
-
-
0030065653
-
Carbogen and nicotinamide as radiosensitizers in a murine mammary carcinoma using conventional and accelerated radiotherapy
-
Rojas A, Hirst VK, Calvert AS, Johns H. Carbogen and nicotinamide as radiosensitizers in a murine mammary carcinoma using conventional and accelerated radiotherapy. Int J Radiat Oncol Biol Phys 1996;34:357-365.
-
(1996)
Int J Radiat Oncol Biol Phys
, vol.34
, pp. 357-365
-
-
Rojas, A.1
Hirst, V.K.2
Calvert, A.S.3
Johns, H.4
-
12
-
-
0029123236
-
Nicotinamide and other benzamide analogs as agents for overcoming hypoxic cell radiation resistance in tumours. A review
-
Horsman MR. Nicotinamide and other benzamide analogs as agents for overcoming hypoxic cell radiation resistance in tumours. A review. Acta Oncol 1995;34: 571-587.
-
(1995)
Acta Oncol
, vol.34
, pp. 571-587
-
-
Horsman, M.R.1
-
13
-
-
0029061380
-
Carbogen breathing with nicotinamide improves the oxygen status of tumours in patients
-
Laurence VM, Ward R, Dennis IF, Bleehen NM. Carbogen breathing with nicotinamide improves the oxygen status of tumours in patients. BrJ Cancer 1995;72: 198-205.
-
(1995)
BrJ Cancer
, vol.72
, pp. 198-205
-
-
Laurence, V.M.1
Ward, R.2
Dennis, I.F.3
Bleehen, N.M.4
-
14
-
-
18844482218
-
The effect of combined nicotinamide and carbogen treatments in human tumour xenografts: Oxygenation and tumour control studies
-
Stuben G, Stuschke M, Knuhmann K, Horsman MR, Sack H. The effect of combined nicotinamide and carbogen treatments in human tumour xenografts: oxygenation and tumour control studies. Radiother Oncol 1998;48:143-148.
-
(1998)
Radiother Oncol
, vol.48
, pp. 143-148
-
-
Stuben, G.1
Stuschke, M.2
Knuhmann, K.3
Horsman, M.R.4
Sack, H.5
-
15
-
-
0031670159
-
Accelerated radiotherapy with carbogen and nicotinamide (ARCON) for laryngeal cancer
-
Kaanders JH, Pop LA, Marres HA, Liefers J, van den Hoogen FJ, van Daal WA, van der Kogel AJ. Accelerated radiotherapy with carbogen and nicotinamide (ARCON) for laryngeal cancer. Radiother Oncol 1998; 48:115-122.
-
(1998)
Radiother Oncol
, vol.48
, pp. 115-122
-
-
Kaanders, J.H.1
Pop, L.A.2
Marres, H.A.3
Liefers, J.4
Van Den Hoogen, F.J.5
Van Daal, W.A.6
Van Der Kogel, A.J.7
-
16
-
-
0022493495
-
SR-4233: A new bioreductive agent with high selective toxicity for hypoxic mammalian cells
-
Zeman EM, Brown JM, Lemmon MJ, Hirst VK, Lee WW. SR-4233: a new bioreductive agent with high selective toxicity for hypoxic mammalian cells. Int J Radiat Oncol Biol Phys 1986;12:1239-1242.
-
(1986)
Int J Radiat Oncol Biol Phys
, vol.12
, pp. 1239-1242
-
-
Zeman, E.M.1
Brown, J.M.2
Lemmon, M.J.3
Hirst, V.K.4
Lee, W.W.5
-
17
-
-
0028235953
-
Reoxygenation and rehypoxiation in the SCCVII mouse tumor
-
Kim IH, Brown JM. Reoxygenation and rehypoxiation in the SCCVII mouse tumor. Int J Radiat Oncol Biol Phys 1994;29:493-497.
-
(1994)
Int J Radiat Oncol Biol Phys
, vol.29
, pp. 493-497
-
-
Kim, I.H.1
Brown, J.M.2
-
18
-
-
0030669672
-
Physiological and cytotoxic effects of tirapazamine in tumor-bearing mice
-
Durand RE, Olive PL. Physiological and cytotoxic effects of tirapazamine in tumor-bearing mice. Radiat Oncol Invest 1997;5:213-219.
-
(1997)
Radiat Oncol Invest
, vol.5
, pp. 213-219
-
-
Durand, R.E.1
Olive, P.L.2
-
19
-
-
84965808588
-
Tumor-specific, schedule-dependent interaction between tirapazamine (SR 4233) and cisplatin
-
Dorie MJ, Brown JM. Tumor-specific, schedule-dependent interaction between tirapazamine (SR 4233) and cisplatin. Cancer Res 1993;53:4633-4636.
-
(1993)
Cancer Res
, vol.53
, pp. 4633-4636
-
-
Dorie, M.J.1
Brown, J.M.2
-
20
-
-
0001488812
-
Survival benefit from tirazone (tirapazamine) and cisplatin in advanced nonsmall cell lung cancer (NSCLC) patients: Final results from the international phase III CATAPULT 1 trial
-
Abstr #1749
-
von Pawel J, von Roemeling R. Survival benefit from tirazone (tirapazamine) and cisplatin in advanced nonsmall cell lung cancer (NSCLC) patients: final results from the international phase III CATAPULT 1 trial. Proc Am Soc Clin Oncol 1998;17:454a Abstr #1749.
-
(1998)
Proc Am Soc Clin Oncol
, vol.17
-
-
Von Pawel, J.1
Von Roemeling, R.2
-
21
-
-
0025646401
-
Potentiation by the hypoxic cytotoxin SR 4233 of cell killing produced by fractionated irradiation of mouse tumors
-
Brown JM, Lemmon MJ. Potentiation by the hypoxic cytotoxin SR 4233 of cell killing produced by fractionated irradiation of mouse tumors. Cancer Res 1990;50: 7745-7749.
-
(1990)
Cancer Res
, vol.50
, pp. 7745-7749
-
-
Brown, J.M.1
Lemmon, M.J.2
-
22
-
-
0025968030
-
SR 4233: A tumor specific radiosensitizer active in fractionated radiation regimes
-
Brown JM, Lemmon MJ. SR 4233: a tumor specific radiosensitizer active in fractionated radiation regimes. Radiother Oncol 1991;20:151-156.
-
(1991)
Radiother Oncol
, vol.20
, pp. 151-156
-
-
Brown, J.M.1
Lemmon, M.J.2
-
23
-
-
0025972731
-
Tumor hypoxia can be exploited to preferentially sensitize tumors to fractionated irradiation
-
Brown JM, Lemmon MJ. Tumor hypoxia can be exploited to preferentially sensitize tumors to fractionated irradiation. Int J Radiat Oncol Biol Phys 1991;20:457-461.
-
(1991)
Int J Radiat Oncol Biol Phys
, vol.20
, pp. 457-461
-
-
Brown, J.M.1
Lemmon, M.J.2
-
24
-
-
0031743190
-
Concurrent tirapazamine and radiotherapy for advanced head and neck carcinomas: A phase II study
-
Lee D-J, Trotti A, Spencer S, Rostock R, Fisher C, von Roemeling R, Harvey E, Groves E. Concurrent tirapazamine and radiotherapy for advanced head and neck carcinomas: a phase II study. Int J Radiat Oncol Biol Phys 1998;42:811-815.
-
(1998)
Int J Radiat Oncol Biol Phys
, vol.42
, pp. 811-815
-
-
Lee, D.-J.1
Trotti, A.2
Spencer, S.3
Rostock, R.4
Fisher, C.5
Von Roemeling, R.6
Harvey, E.7
Groves, E.8
-
25
-
-
0026417645
-
Therapeutic advantage of hypoxic cells in tumors: A theoretical study
-
Brown JM, Koong A. Therapeutic advantage of hypoxic cells in tumors: a theoretical study. J Natl Cancer Inst 1991;83:178-185.
-
(1991)
J Natl Cancer Inst
, vol.83
, pp. 178-185
-
-
Brown, J.M.1
Koong, A.2
-
26
-
-
0028079669
-
Comparison of the enhancement of tumor responses to fractionated irradiation by SR 4233 (tirapazamine) and by nicotinamide with carbogen
-
Dorie MJ, Menke D, Brown JM. Comparison of the enhancement of tumor responses to fractionated irradiation by SR 4233 (tirapazamine) and by nicotinamide with carbogen. Int J Radiat Oncol Biol Phys 1994;28: 145-150.
-
(1994)
Int J Radiat Oncol Biol Phys
, vol.28
, pp. 145-150
-
-
Dorie, M.J.1
Menke, D.2
Brown, J.M.3
-
27
-
-
0030009223
-
Tirapazamine-induced DNA damage measured using the comet assay correlates with cytotoxicity towards hypoxic tumour cells in vitro
-
Sum BG, van Zijl PL, Brown JM. Tirapazamine-induced DNA damage measured using the comet assay correlates with cytotoxicity towards hypoxic tumour cells in vitro. Br J Cancer 1996;73:952-960.
-
(1996)
Br J Cancer
, vol.73
, pp. 952-960
-
-
Sum, B.G.1
Van Zijl, P.L.2
Brown, J.M.3
-
28
-
-
0028200683
-
Muscle cramping in phase I clinical trials of tirapazamine (SR 4233) with and without radiation
-
Doherty N, Hancock SL, Kaye S, Coleman CN, Shulman L, Marquez C, Mariscal C, Rampling R, Senan S, Roemeling RV. Muscle cramping in phase I clinical trials of tirapazamine (SR 4233) with and without radiation. Int J Radiat Oncol Biol Phys 1994;29:379-382.
-
(1994)
Int J Radiat Oncol Biol Phys
, vol.29
, pp. 379-382
-
-
Doherty, N.1
Hancock, S.L.2
Kaye, S.3
Coleman, C.N.4
Shulman, L.5
Marquez, C.6
Mariscal, C.7
Rampling, R.8
Senan, S.9
Roemeling, R.V.10
-
29
-
-
0026008168
-
Radiosensitization with normobaric oxygen and carbogen
-
Rojas A. Radiosensitization with normobaric oxygen and carbogen. Radiother Oncol 1991;20(Suppl. I): 65-70.
-
(1991)
Radiother Oncol
, vol.20
, Issue.1 SUPPL.
, pp. 65-70
-
-
Rojas, A.1
-
30
-
-
0018842376
-
A new mouse tumor model system (RIF-1) for comparison of end-point studies
-
Twentyman PR, Brown JM, Gray JW, Franko AJ, Scoles MA, Kallman RF. A new mouse tumor model system (RIF-1) for comparison of end-point studies. J Natl Cancer Inst 1980;64:595-604.
-
(1980)
J Natl Cancer Inst
, vol.64
, pp. 595-604
-
-
Twentyman, P.R.1
Brown, J.M.2
Gray, J.W.3
Franko, A.J.4
Scoles, M.A.5
Kallman, R.F.6
-
31
-
-
0027288316
-
SR 4233 (tirapazamine): A new anticancer drug exploiting hypoxia in solid tumours
-
Brown JM. SR 4233 (tirapazamine): a new anticancer drug exploiting hypoxia in solid tumours. Br J Cancer 1993;67:1163-1170.
-
(1993)
Br J Cancer
, vol.67
, pp. 1163-1170
-
-
Brown, J.M.1
-
32
-
-
0030871773
-
Tirapazamine-induced cytotoxicity and DNA damage in transplanted tumors: Relationship to tumor hypoxia
-
Siim BG, Menke DR, Done MJ, Brown JM. Tirapazamine-induced cytotoxicity and DNA damage in transplanted tumors: relationship to tumor hypoxia. Cancer Res 1997;57:2922-2928.
-
(1997)
Cancer Res
, vol.57
, pp. 2922-2928
-
-
Siim, B.G.1
Menke, D.R.2
Done, M.J.3
Brown, J.M.4
-
33
-
-
0026098826
-
Nicotinamide, fluosol DA and carbogen: A strategy to reoxygenate acutely and chronically hypoxic cells in vivo
-
Chaplin DJ, Horsman MR, Aoki D. Nicotinamide, fluosol DA and carbogen: a strategy to reoxygenate acutely and chronically hypoxic cells in vivo. Br J Cancer 1991;63:109-113.
-
(1991)
Br J Cancer
, vol.63
, pp. 109-113
-
-
Chaplin, D.J.1
Horsman, M.R.2
Aoki, D.3
-
34
-
-
0025939872
-
A therapeutic benefit from combining normobaric carbogen or oxygen with nicotinamide in fractionated X-ray treatments
-
Kjellen E, Joiner MC, Collier JM, Johns H, Rojas A. A therapeutic benefit from combining normobaric carbogen or oxygen with nicotinamide in fractionated X-ray treatments. Radiother Oncol 1991;22:81-91.
-
(1991)
Radiother Oncol
, vol.22
, pp. 81-91
-
-
Kjellen, E.1
Joiner, M.C.2
Collier, J.M.3
Johns, H.4
Rojas, A.5
-
35
-
-
0030890096
-
Administration of nicotinamide during a five- To seven-week course of radiotherapy: Pharmacokinetics, tolerance, and compliance
-
Kaanders JH, Stratford MR, Liefers J, Dennis MF, van der Kogel AJ, van Daal WA, Rojas A. Administration of nicotinamide during a five- to seven-week course of radiotherapy: pharmacokinetics, tolerance, and compliance. Radiother Oncol 1997;43:67-73.
-
(1997)
Radiother Oncol
, vol.43
, pp. 67-73
-
-
Kaanders, J.H.1
Stratford, M.R.2
Liefers, J.3
Dennis, M.F.4
Van Der Kogel, A.J.5
Van Daal, W.A.6
Rojas, A.7
-
36
-
-
0023222372
-
Radiosensitization by nicotinamide in vivo: A greater enhancement of tumor damage compared to that of normal tissues
-
Horsman MR, Chaplin DJ, Brown JM. Radiosensitization by nicotinamide in vivo: a greater enhancement of tumor damage compared to that of normal tissues. Radiat Res 1987;109:479-489.
-
(1987)
Radiat Res
, vol.109
, pp. 479-489
-
-
Horsman, M.R.1
Chaplin, D.J.2
Brown, J.M.3
-
37
-
-
0031281939
-
Nicotinamide as a radiosensitizer in tumours and normal tissues: The importance of drug dose and timing
-
Horsman MR, Siemann DW, Chaplin DJ, Overgaard J. Nicotinamide as a radiosensitizer in tumours and normal tissues: the importance of drug dose and timing. Radiother Oncol 1997;45:167-174.
-
(1997)
Radiother Oncol
, vol.45
, pp. 167-174
-
-
Horsman, M.R.1
Siemann, D.W.2
Chaplin, D.J.3
Overgaard, J.4
-
38
-
-
0026708072
-
Carbogen and nicotinamide: Expectations too high?
-
Brown JM. Carbogen and nicotinamide: expectations too high? Radiother Oncol 1992;24:75-76.
-
(1992)
Radiother Oncol
, vol.24
, pp. 75-76
-
-
Brown, J.M.1
-
39
-
-
0027524919
-
Pharmacokinetics and bioreductive metabolism of the novel benzotriazine di-N-oxide hypoxic cell cytotoxin tirapazamine (WIN 59075; SR 4233; NSC 130181) in mice
-
Walton MI, Workman P. Pharmacokinetics and bioreductive metabolism of the novel benzotriazine di-N-oxide hypoxic cell cytotoxin tirapazamine (WIN 59075; SR 4233; NSC 130181) in mice. J Pharmacol Exp Ther 1993;265:938-947.
-
(1993)
J Pharmacol Exp Ther
, vol.265
, pp. 938-947
-
-
Walton, M.I.1
Workman, P.2
-
40
-
-
8244234465
-
Pharmacokinetics of the hypoxic cell cytotoxic agent tirapazamine and its major bioreductive metabolites in mice and humans: Retrospective analysis of a pharmacokinetically guided dose escalation strategy in a phase I trial
-
Graham MA, Senan S, Robin H, Eckhardt N, Lendrem D, Hincks J, Greenslade D, Rampling R, Kaye SB, von Roemeling R, Workman P. Pharmacokinetics of the hypoxic cell cytotoxic agent tirapazamine and its major bioreductive metabolites in mice and humans: retrospective analysis of a pharmacokinetically guided dose escalation strategy in a phase I trial. Cancer Chemother Pharmacokinet 1997;40:1-10.
-
(1997)
Cancer Chemother Pharmacokinet
, vol.40
, pp. 1-10
-
-
Graham, M.A.1
Senan, S.2
Robin, H.3
Eckhardt, N.4
Lendrem, D.5
Hincks, J.6
Greenslade, D.7
Rampling, R.8
Kaye, S.B.9
Von Roemeling, R.10
Workman, P.11
-
41
-
-
0027372557
-
Should carbogen and nicotinamide be given throughout the full course of fractionated radiotherapy regimens?
-
Rojas AM, Johns H, Fiat PR. Should carbogen and nicotinamide be given throughout the full course of fractionated radiotherapy regimens? Int J Radiat Oncol Biol Phys 1993;27:1101-1105.
-
(1993)
Int J Radiat Oncol Biol Phys
, vol.27
, pp. 1101-1105
-
-
Rojas, A.M.1
Johns, H.2
Fiat, P.R.3
|