Enhancement of urinary bladder carcinogenesis in nullizygous p53- deficient mice by N-butyl-N-(4-hydroxybutyl)nitrosamine

Cancer Letters

Volumn 135, Issue 2, 1999, Pages 137-144

  Yamamoto, Shinji ^a   Min, Wei ^a   Lee, Chyi Chia R ^a   Salim, Elsayed I ^a   Wanibuchi, Hideki ^a   Sukata, Tokuo ^a,b   Fukushima, Shoji ^a  

^a OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b SUMITOMO CHEMICAL CO LTD   (Japan)

Author keywords

N Butyl N (4 hydroxybutyl)nitrosamine; p53 Deficient mouse; Tumor susceptibility; Urinary bladder carcinogenesis; Vascular tumor

Indexed keywords

N BUTYL N (4 HYDROXYBUTYL)NITROSAMINE; PROTEIN P53;

ALLELE; ANGIOSARCOMA; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLADDER CARCINOGENESIS; CONTROLLED STUDY; HETEROZYGOTE; MALE; MUTATION; NONHUMAN; PATHOLOGY; PRIORITY JOURNAL;

ANIMALS; BUTYLHYDROXYBUTYLNITROSAMINE; CARCINOGENICITY TESTS; CARCINOGENS; CARCINOMA IN SITU; CARCINOMA, TRANSITIONAL CELL; COCARCINOGENESIS; GENE DELETION; GENES, P53; GENOTYPE; MALE; MICE; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; URINARY BLADDER NEOPLASMS;

EID: 0033060842     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(98)00288-2     Document Type: Article

References (30)

1. Greenblatt M.S., Bennett W.P., Hollstein M., Harris C.C. Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis. Cancer Res. 54:1994;4855-4878.
2. Donehower L.A., Harvey M., Slagle B.L., McArthur M.J., Montgomery C.A., Butel J.S., Bradley A. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature. 356:1992;215-221.
3. Harvey M., McArthur M.J., Montgomery C.A. Jr., Butel J.S., Bradley A., Donehower L.A. Spontaneous and carcinogen-induced tumorigenesis in p53-deficient mice. Nat. Genet. 5:1993;225-229.
4. Tennant R.W., French J.E., Spalding J.W. Identifying chemical carcinogens and assessing potential risk in short-term bioassays using transgenic mouse models. Environ. Health Perspect. 103:1995;942-950.
5. Kemp C.J., Donehower L.A., Bradley A., Balmain A. Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors. Cell. 74:1993;813-822.
6. Kemp C.J. Hepatocarcinogenesis in p53-deficient mice. Mol. Carcinogenesis. 12:1995;132-136.
7. Oda H., Zhang S., Tsurutani N., Shimizu S., Nakatsuru Y., Aizawa S., Ishikawa T. Loss of p53 is an early event in induction of brain tumors in mice by transplacental carcinogen exposure. Cancer Res. 57:1997;646-650.
8. Sidransky D., von Eschenbach A., Tsai Y.C., Jones P., Summerhayes I., Marshall F., Paul M., Green P., Hamilton S.R., Frost P., Vogelstein B. Identification of p53 gene mutations in bladder cancers and urine samples. Science. 252:1991;706-709.
9. Fujimoto K., Yamada Y., Okajima E., Kakizoe T., Sasaki H., Sugimura T., Terada M. Frequent association of p53 gene mutation in invasive bladder cancer. Cancer Res. 52:1992;1393-1398.
10. Masui T., Don I., Takada N., Ogawa K., Shirai T., Fukushima S. p53 mutations in early neoplastic lesions of the urinary bladder in rats treated with N-butyl-N-(4-hydroxybutyl)nitrosamine. Carcinogenesis. 15:1994;2379-2381.
11. Masui T., Dong I., Yamamoto S., Takada N., Nakanishi H., Inada K., Fukushima S., Tatematsu M. p53 mutations in transitional cell carcinomas of the urinary bladder in rats treated with N-butyl-N-(4-hydroxybutyl)nitrosamine. Cancer Lett. 105:1996;105-112.
12. Yamamoto S., Masui T., Murai T., Mori S., Oohara T., Makino S., Fukushima S., Tatematsu M. Frequent mutations of the p53 gene and infrequent H- and K-ras mutations in urinary bladder carcinomas of NON/Shi mice treated with N-butyl-N-(4-hydroxybutyl)nitrosamine. Carcinogenesis. 16:1995;2363-2368.
13. Yamamoto S., Chen T., Murai T., Mori S., Morimura K., Ohara T., Makino S., Tatematsu M., Wanibuchi H., Fukushima S. Genetic instability and p53 mutations in metastatic foci of mouse urinary bladder carcinomas induced by N-butyl-N-(4-hydroxybutyl)nitrosamine. Carcinogenesis. 18:1997;1877-1882.
14. SpruckIII C.H., Ohneseit P.F., Gonzalez Z.M., Esrig D., Miyao N., Tsai Y.C., Lerner S.P., Schmutte C., Yang A.S., Cote R., Dubeau L., Nichols P.W., Hermann G.G., Steven K., Horn T., Skinner D.G., Jones P.A. Two molecular pathways to transitional cell carcinoma of the bladder. Cancer Res. 54:1994;784-788.
15. K. Ozaki, T. Sukata, S. Yamamoto, S. Uwagawa, T. Seki, H. Kawasaki, A. Yoshitake, H. Wanibuchi, A. Koide, Y. Mori, S. Fukushima, High susceptibility of p53 (+/-) knockout mice in N-butyl-N-(4-hydroxybutyl)nitrosamine urinary bladder carcinogenesis and lack of frequent mutation in residual allele, Cancer Res. (1998) in press.
16. Yamamoto S., Tatematsu M., Yamamoto M., Fukami H., Fukushima S. Clonal analysis of urothelial carcinomas in C3H/HeN ↔ BALB/c chimeric mice treated with N-butyl-N-(4-hydroxybutyl)nitrosamine. Carcinogenesis. 19:1998;855-860.
17. Ohtani M., Kakizoe T., Nishio Y., Sato S., Sugimura T., Fukushima S., Niijima T. Sequential changes of mouse bladder epithelium during induction of invasive carcinomas by N-butyl-N-(4-hydroxybutyl)nitrosamine. Cancer Res. 46:1986;2001-2004.
18. F.K. Mostofi, H. Torloni, L.H. Sobin, Histological Typing of Bladder Tumors. International Histological Classification of Tumours, no. 10 WHO, Geneva, 1974.
19. P. Hermanek, L.H. Sobin,Urinary Bladder. TNM Classification of Malignant Tumors, 1987.
20. Jacks T., Shane Shih T., Schmitt E.M., Bronson R.T., Bernards A., Weinberg R.A. Tumour predisposition in mice heterozygous for a targeted mutation in Nf1. Nat. Genet. 7:1994;353-361.
21. Kobayashi T., Hirayama Y., Kobayashi E., Kubo Y., Hino O. A germline insertion in the tuberous sclerosis (Tsc2) gene gives rise to the Eker rat model of dominantly inherited cancer. Nat. Genet. 9:1995;70-74.
22. Oshima H., Oshima M., Kobayashi M., Tsutsumi M., Taketo M.M. Morphological and molecular processes of polyp formation in Apc(delta716) knockout mice. Cancer Res. 57:1997;1644-1649.
23. Yamamoto S., Fukushima S. Alterations of cell cycle regulators in rat and mouse urinary bladder carcinogenesis models. J. Toxicol. Pathol. 10:1997;125-127.
24. Lee C.C.R., Yamamoto S., Wanibuchi H., Wada S., Sugimura K., Kishimoto T., Fukushima S. Cyclin D1 overexpression in rat two-stage bladder carcinogenesis and its relationship with oncogenes, tumor suppressor genes, and cell proliferation. Cancer Res. 57:1997;4765-4776.
25. Suzuki E., Mochizuki M., Okada M. Relationship of urinary N-butyl-N-(3-carboxypropyl)nitrosamine to susceptibility of animals to bladder carcinogenesis by N-butyl-N-(4-hydroxybutyl)nitrosamine. Gann. 74:1983;360-364.
26. Ohtani M., Kakizoe T., Sato S., Sugimura T., Fukushima S. Strain differences in mice with invasive bladder carcinomas induced by N-butyl-N-(4-hydroxybutyl)nitrosamine. J. Cancer Res. Clin. Oncol. 112:1986;107-110.
27. Tamano S., Hagiwara A., Suzuki E., Okada M., Shirai T., Fukushima S. Time- and dose-dependent induction of invasive urinary bladder cancers by N-ethyl-N-(4-hydroxybutyl)nitrosamine in B6C3F1 mice. Jpn. J. Cancer Res. 82:1991;650-656.
28. Booth C.J., Sundberg J.P. Hemangiomas and hemangiosarcomas in inbred laboratory mice. Lab. Anim. Sci. 45:1995;497-502.
29. Naka N., Tomita Y., Nakanishi H., Araki N., Hongyo T., Ochi T., Aozasa K. Mutations of p53 tumor-suppressor gene in angiosarcoma. Int. J. Cancer. 71:1997;952-955.
30. Esrig D., Spruck C.H. III, Nichols P.W., Chaiwum B., Steven K., Groshen S., Chen S.C., Skinner D.G., Jones P.A., Cote R.J. p53 nuclear protein accumulation correlates with mutations in the p53 gene, tumor grade, and stage in bladder cancer. Am. J. Pathol. 143:1993;1389-1397.