Genetic instability and p53 mutations in metastatic foci of mouse urinary bladder carcinomas induced by N-butyl-N- (4-hydroxybutyl)nitrosamine

Carcinogenesis

Volumn 18, Issue 10, 1997, Pages 1877-1882

  Yamamoto, Shinji ^a   Chen, Tianxin ^a   Murai, Takashi ^a,b   Mori, Satoru ^a,b   Morimura, Keiichirou ^a   Oohara, Tadao ^b   Makino, Susumu ^b   Tatematsu, Masae ^c   Wanibuchi, Hideki ^a   Fukushima, Shoji ^a  

^a OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b SHIONOGI AND CO LTD   (Japan)

^c AICHI CANCER CENTER HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

N BUTYL N (4 HYDROXYBUTYL)NITROSAMINE; PROTEIN P53;

ALLELE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLADDER CARCINOMA; CANCER GROWTH; CONTROLLED STUDY; DRUG INDUCED CANCER; GENE MUTATION; GENETIC HETEROGENEITY; MALE; METASTASIS; MOLECULAR CLONING; MOUSE; NONHUMAN; ONCOGENE H RAS; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SINGLE STRAND CONFORMATION POLYMORPHISM; TUMOR SUPPRESSOR GENE;

ANIMALS; BUTYLHYDROXYBUTYLNITROSAMINE; CARCINOGENS; CARCINOMA, SQUAMOUS CELL; CARCINOMA, TRANSITIONAL CELL; DNA, COMPLEMENTARY; DNA, NEOPLASM; GENES, P53; MALE; MICE; POINT MUTATION; POLYMERASE CHAIN REACTION; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; URINARY BLADDER NEOPLASMS;

EID: 0031417554     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/18.10.1877     Document Type: Article

References (24)

1. Fearon, E.R. and Vogelstein, B. (1990) A genetic model for colorectal tumorigenesis. Cell, 61, 759-767.
2. Sidransky, D., Mikkelsen, T., Schwechheimer, K., Rosenblum, M.L., Cavanee, W. and Vogelstein, B. (1992) Clonal expansion of p53 mutant cells is associated with brain tumour progression. Nature, 355, 846-847.
3. Kastrinakis, W.V., Ramchurren, N., Rieger, K.M., Hess, D.T., Loda, M., Steele, G. and Summerhayes, I.C. (1995) Increased incidence of p53 mutations is associated with hepatic metastasis in colorectal neoplastic progression. Oncogene, 11, 647-652.
4. Maruyama, K., Tanaka, T., Baba, S., Nakamura, S., Endo, Y. and Sugimura, H. (1996) p53 accumulation in colorectal cancer with hepatic metastasis. Jpn. J. Cancer Res., 87, 368-376.
5. Bookstein, R., MacGrogan, D., Hilsenbeck, S.G., Sharkey, F. and Allred, D.C. (1993) p53 is mutated in a subset of advanced-stage prostate cancers. Cancer Res., 53, 3369-3373.
6. Oda, H., Nakatsuru, Y. and Ishikawa, T. (1995) Mutations of the p53 gene and p53 protein overexpression are associated with sarcomatoid transformation in renal cell carcinomas. Cancer Res., 55, 658-662.
7. Sidransky, D., von Eschenbach, A., Tsai, Y.C., Jones, P., Summerhayes, I., Marshall, F., Paul, M., Green, R. Hamilton, S.R., et al. (1991) Identification of p53 gene mutations in bladder cancers and urine samples. Science, 252, 706-709.
8. Fujimoto, K., Yamada, Y., Okajima, E., Kakizoe, T., Sasaki, H., Sugimura, T. and Terada, M. (1992) Frequent association of p53 gene mutation in invasive bladder cancer. Cancer Res., 52, 1393-1398.
9. Spruck, C.H., III., Ohneseit, P.F., Gonzalez, Z.M., Esrig, D., Miyao, N., Tsai, Y.C., Lerner, S.P., Schmutte, C., Yang, A.S., et al. (1994) Two molecular pathways to transitional cell carcinoma of the bladder. Cancer Res., 54, 784-788.
10. Miyao, N., Tsai, Y.C., Lerner, S.P., Olumi, A.F., Spruck, C.H., Gonzalez-Zulueta, M., Nichols, P.W., Skinner, D.G. and Jones, P.A. (1993) Role of chromosome 9 in human bladder cancer. Cancer Res., 53, 4066-4070.
11. Yin, Y., Tainsky, M.A., Bischoff, F.Z., Strong, L.C. and Wahl, G.M. (1992) Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles. Cell, 70, 937-948.
12. Eyfjörd, J.E., Thorlacius, S., Steinarsdottir, M., Valgardsdottir, R., Ögmundsdottir, H.M. and Anamthawat-Jonsson, K. (1995) p53 abnormalities and genomic instability in primary human breast carcinomas. Cancer Res., 55, 646-651.
13. Murai, T., Mori, S., Hosono, M., Takeuchi, Y. Ohara, T., Makino, S., Takeda, R., Hayashi, Y. and Fukushima, S. (1991) Renal pelvic carcinoma which shows metastatic potential to distant organs, induced by N-butyl-N-(4-hydroxybutyl)nitrosamine in NON/Shi mice. Jpn. J. Cancer Res., 82, 1371-1377.
14. Murai, T., Mori, S., Hosono, M., Takeuchi, Y. Ohara, T., Makino, S., Hayashi, Y. Takeda, R. and Fukushima, S. (1994) Influence of aging and sex on renal pelvic carcinogenesis by N-butyl-N-(4-hydroxybutyl)nitrosamine in NON/Shi mice. Cancer Lett., 76, 147-153.
15. Yamamoto, S., Masui, T., Murai, T., Mori, S., Oohara, T., Makino, S., Fukushima, S. and Tatematsu, M. (1995) Frequent mutations of the p53 gene and infrequent H-and K-ras mutations in urinary bladder carcinomas of NON/Shi mice treated with N-butyl-N-(4-hydroxybutyl)nitrosamine. Carcinogenesis, 16, 2363-2368.
16. Chirgwin, J.M., Przyhyla, A.E., MacDonald, R.J. and Rutter, W.J. (1979) Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry, 18, 5294-5299.
17. Mostofi, F.K., Torloni, H. and Sobin, L.H. (1974) Histological Typing of Bladder Tumors. International Histological Classification of Tumours, no. 10. WHO, Geneva.
18. Hermanek, P. and Sobin, L.H. (1987) Urinary Bladder. TNM Classification of Malignant Tumours.
19. Mount, S.M. (1982) A catalogue of splice junction sequences. Nucleic Acids Res., 10, 459-472.
20. Moch, H., Sauter, G., Moore, D., Mihatsch, M.J., Gudat, F. and Waldman, F. (1993) p53 and erbB-2 protein overexpression are associated with early invasion and metastasis in bladder cancer. Virchows Arch. A, 423, 329-334.
21. Sauter, G., Moch, H., Gasser, T.C., Mihatsch, M.J. and Waldman, F.M. (1995) Heterogeneity of chromosome 17 and erbB-2 gene copy number in primary and metastatic bladder cancer. Cytometry, 21, 40-46.
22. Nowell, P.C. (1976) The clonal evolution of tumour cell populations. Science, 194, 23-28.
23. Asamoto, M., Mann, A.M., Macatee, T.L. and Cohen, S.M. (1994) Mutations and expression of the p53 gene in rat bladder carcinomas and cell lines. Mol. Carcinogenesis, 9, 236-244.
24. Lane, D.P. (1992) p53, guardian of the genome. Nature, 358, 15-16.