Biotransformation of acrolein in rat: Excretion of mercapturic acids after inhalation and intraperitoneal injection

Toxicology and Applied Pharmacology

Volumn 136, Issue 1, 1996, Pages 155-160

  Linhart, I ^a   Frantik E ^a   Vodickova L' ^a   Vosmanska M ^a   Smejkal J ^a   Mitera, J ^a  

^a NATIONAL INSTITUTE OF PUBLIC HEALTH   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE DERIVATIVE; ACROLEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOTRANSFORMATION; CONTROLLED STUDY; INHALATION; INTRAPERITONEAL DRUG ADMINISTRATION; LUNG FUNCTION; LUNG MINUTE VOLUME; MALE; METABOLITE; NONHUMAN; RAT; URINARY EXCRETION;

EID: 0030065406     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.1996.0019     Document Type: Article

References (25)

1. Babiuk, C., Steinhagen, W. H., and Barrow, C. S. (1985). Sensory irritation response to inhaled aldehydes after formaldehyde pretreatment. Toxicol. Appl. Pharmacol. 79, 143-149.
2. Ballantyne, B., Dodd, D. E., Pritts, I. M., Nachreimer, D. J., and Fowler, E. H. (1989). Acute vapour inhalation toxicity of acrolein and its influence as a trace contaminant in 2-methoxy-3,4-dihydro-2H-pyran. Hum. Toxicol. 8, 229-235.
3. Beauchamp, R. O., D. A. Andjelkovich, D. A., Kligerman, A. D., Morgan, K. T., and d'A. Heck, H. (1985). A critical review of the literature on acrolein toxicity. CRC Crit. Rev. Toxicol. 14, 309-380.
4. Catilina, P., Thieblot, L., and Champeix, J. (1966). Lesions respiratoires expérimentales par inhalation d'acroleine chez le rat. Arch. Mal. Prof. Med. Trav. Sécur. Soc. (Paris) 27, 857-867.
5. Chaviano, A. H., Gill, W. B., Ruggiero, U. J., and Vermeulen, C. W. (1985). Experimental cytoran cystitis and prevention by acetylcysteine. J. Urol. 134, 598-600.
6. de Bethizy, J. D., Udinsky, J. R., Scribner, H. E., and Frederick, C. B. (1987). The disposition and metabolism of acrylic acid and ethyl acrylate in male Sprague-Dawley rats. Fundam. Appl. Toxicol. 8, 549-561.
7. Delbressine, L. P. C., Seutter-Berlage, F., and Seutter, E. (1981). Identification of urinary mercapturic acids formed from acrylate, methacrylate and crotonate. Xenobiotica 11, 241-247.
8. Draminski, W., Eder, E., and Henschler, D. (1983). A new pathway of acrolein metabolism in rats. Arch. Toxicol. 52, 243-247.
9. Egle, J. L. (1972). Retention of inhaled formaldehyde, propionaldehyde, and acrolein in the dog. Arch. Environ. Health 25, 119-124.
10. EHC (1992). Environmental Health Criteria 127: Acrolein. World Health Organization, Geneva.
11. Kaye, C. M. (1973). Biosynthesis of mercapturic acids from allyl alcohol, allyl esters and acrolein. Biochem. J. 134, 1093-1101.
12. Kaye, C. M., Clapp, J. J., and Young, L. (1972). The metabolic formation of mercapturic acids from allyl halides. Xenobiotica 2, 129-139.
13. Leach, C. L., Hatoum, N. S., Ratajczak, H. V., and Gerhart, J. M. (1987). The pathologic and immunologic effects of inhaled acrolein in rats. Toxicol. Lett. 39, 189-198.
14. Lyon, J. P., Jemkins, L. J., Jones, R. A., Coon, R. A., and Siegel, J. (1970). Repeated and continuous exposure of laboratory animals to acrolein. Toxicol. Appl. Pharmacol. 17, 726-732.
15. Manita, M. D., and Goldberg, E. K. (1970). Spectrophotometric analysis of airborne acrolein using the semithiocarbazide reagent. Gig. Sanit. 35, 63-65. [in Russian]
16. Marinello, A. J., Bansal, S. K., Paul, B., Koser, P. L., Love, J., Struck, R. F., and Gurtoo, H. L. (1984). Metabolism and binding of cyclophosphamide and its metabolite acrolein to rat hepatic microsomal cytochrome P-450. Cancer Res. 44, 4615-4621.
17. Patel, J. M., Wood, J. C., and Leibman, K. C. (1980). The biotransformation of allyl alcohol and acrolein in rat liver and lung preparations. Drug Metab. Dispos. 8, 305-308.
18. Potts, W. J., Lederer, T. S., and Quast, J. F. (1978). A study of the inhalation toxicity of smoke produced upon pyrolysis and combustion of polyethylene foams. I. Laboratory studies. J. Combust. Toxicol. 5, 408-433.
19. Philippin, C., Gilgen, A., and Grandjean, E. (1970). Etude toxicologique et physiologique de l'acroleine chez la souris. Int. Arch. Arbeitsmed. 26, 281-305.
20. Sakata, T., Smith, R. A., Garland, E. M., and Cohen, S. M. (1989). Rat urinary bladder epithelial lesions induced by acrolein. J. Environ. Pathol. Toxicol. 9, 159-170.
21. Seutter-Berlage, F., van Dorp, H. L., Kosse, H. G. J., and Henderson, P. T. (1977). Urinary mercapturic acid excretion as a biological parameter of exposure to alkylating agents. Int. Arch. Occup. Environ. Health 39, 45-51.
22. Smyth, H. F., Carpenter, C. P., and Weil, C. S. (1951). Range-finding toxicity data: List IV. Arch. Ind. Hyg. Occup. Med. 4, 119-122.
23. Spector, W. S. (Ed.) (1956). Handbook of Biological Data, p. 267. Saunders, Philadelphia/London.
24. van Bladeren, P. J., Buys, W., Breimer, D. D., and van der Gen, A. (1980). The synthesis of mercapturic acids and their esters. Eur. J. Med. Chem. 15, 495-497.
25. 13C nuclear magnetic resonance spectroscopy. Drug Metab. Dispos. 20, 655-672.