Granulocyte-macrophage colony-stimulating factor protects dendritic cells from liposome-encapsulated dichloromethylene diphosphonate-induced apoptosis through a Bcl-2-mediated pathway

European Journal of Immunology

Volumn 29, Issue 2, 1999, Pages 563-570

  Rabinovich, Gabriel A ^a   Riera, Clelia M ^a   Iribarren, Pablo ^a  

^a UNIVERSIDAD NACIONAL DE CÓRDOBA   (Argentina)

Author keywords

Apoptosis; Bcl 2; Dendritic cell; Granulocyte macrophage colony stimulating factor; Liposome encapsulated dichloromethylene diphosphonate

Indexed keywords

CELL DNA; CLODRONIC ACID; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; PROTEIN BCL 2;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CULTURE; CELL ULTRASTRUCTURE; CONTROLLED STUDY; DENDRITIC CELL; DNA CLEAVAGE; DNA STRAND BREAKAGE; ENCAPSULATION; FEMALE; NONHUMAN; NUCLEOSOME; PRIORITY JOURNAL; RAT; WESTERN BLOTTING;

ANALGESICS, NON-NARCOTIC; ANIMALS; APOPTOSIS; CELLS, CULTURED; CLODRONIC ACID; DENDRITIC CELLS; DRUG CARRIERS; FEMALE; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; LIPOSOMES; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION;

EID: 0033060650     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-4141(199902)29:02<563::AID-IMMU563>3.0.CO;2-A     Document Type: Article

References (43)

1. Banchereau, J. and Steinman, R. M., Dendritic cells and the control of immunity. Nature 1998. 392: 245-252.
2. Hart, D. N. J., Dendritic cells: unique leukocyte populations which control the primary immune response. Blood 1997. 90: 3245-3287.
3. Steinman, R. M., Pack, M. and Inaba, K., Dendritic cells in the T-cell areas of lymphoid organs. Immunol. Rev. 1997. 156: 25-37.
4. Girolomoni, G. and Ricciardi-Castagnoli, P., Dendritic cells hold promise for immunotherapy. Immunol. Today 1997. 18: 102-104.
5. Inaba, K., Inaba, M., Romani, N., Aya, H., Deguchi, M., Ikehara, S., Muramatsu, S. and Steinman, R. M., Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/ macrophage colony-stimulating factor. J. Exp. Med. 1992. 176: 1693-1702.
6. Chen-Woan, M., Delaney, C. P., Fournier, V., Wakizaka, Y., Murase, N., Fung, J., Starzl, T. E. and Demetris, A. J., A new protocol for the propagation of dendritic cells from rat bone marrow using recombinant GM-CSF, and their quantification using the mAb OX-62. J. Immunol. Methods 1995. 178: 157-171.
7. Inaba, K., Steinman, R. M., Pack, M. W., Aya, H., Inaba, M., Sudo, T., Wolpe, S. and Schuler, G., Identification of proliferating dendritic cell precursors in mouse blood. J. Exp. Med. 1992. 175: 1157-1167.
8. Lu, L., Woo, J., Rao, A. S. S., Li, Y., Watkins, S. C., Qian, S., Starzl, T. E., Demetris, A. J. and Thomson, A. W., Propagation of dendritic cell progenitors from normal mouse liver using GM-CSF and their maturational development in the presence of type-1 collagen. J. Exp. Med. 1994. 179: 1823-1834.
9. Lu, L., Hsieh, M., Oriss, T. B., Morel, P. A., Starzl, T. E., Rao, A. S. and Thomson, A. W., Generation of DC from mouse spleen cell cultures in response to GM-CSF: immunophenotypic and functional analyses, Immunology 1995. 84: 127-134.
10. Stingl, G. and Bergstresser, P. R., Dendritic cells: a major story unfolds. Immunol. Today 1995. 16: 330-333.
11. Baixeras, E., Bosca, L., Stauber, C., Gonzalez, A., Carrera, A. C., Gonzalo, J. A. and Martinez, A. C., From apoptosis to autoimmunity: insights from the signaling pathways leading to proliferation or to programmed cell death. Immunol. Rev. 1994. 142: 53-91.
12. Colotta, F., Fabio, R., Polentarutti, N., Sozzani, S. and Mantovani, A., Modulation of granulocyte survival and programmed cell death by cytokines and bacterial products. Blood 1992. 80: 2012-2020.
13. Ludewing, B., Graf, D., Gelderblom, H. R., Becker, Y., Kroczek, R. A. and Pauli, C., Spontaneous apoptosis of dendritic cells is efficiently inhibited by TRAP (CD40-ligand) and TNF-α, but strongly enhanced by interleukin-10. Eur. J. Immunol. 1995. 25: 1943-1950.
14. Munn, D. H., Beall, A. C., Song, D., Wrenn, R. and Throckmorton, D. C., Activation-induced apoptosis in human macrophages: Developmental regulation of a novel cell death pathway by macrophage colony stimulating factor and Interferon γ. J. Exp. Med. 1995. 181: 127-136.
15. Colter, T. G., Fernandes, R. S., Verhaegen, S. and McCarthy, J. V., Cell death in the myeloid lineage. Immunol. Rev. 1994. 142: 93-112.
16. Cowling, G. J. and Dexter, T. M., Apoptosis in haemopoietic system. Phil. Trans. R. Soc. Lond. 1994. 345: 257-263.
17. Man, J. H., Gileadi, C., Rajapaksa, R., Kosek, J. and Greenberg, P. L., Modulation of apoptosis in human myeloid leukemic cells by GM-CSF. Exp. Hematol. 1995. 23: 265-272.
18. Collins, M. K. L., Perkins, G. R., Rodriguez-Tarduchy, G., Nieto, M. A. and Lopez-Rivas, A., Growth factors as survival factors: Regulation of apoptosis. Bioessays 1994. 16: 133-138.
19. Huitinga, I., van Rooijen, N., de Groot, C. J. A., Uitdehaag, B. M. J. and Dijkstra, C. D., Suppression of experimental allergic encephalomyelitis in Lewis rats after elimination of macrophages. J. Exp. Med. 1990. 172: 1025-1033.
20. Pouvreau, I., Zech, J. C., Thillayne-Goldenberg, B., Naud, M. C., van Rooijen, N. and Kozak, Y., Effect of macrophage depletion by liposomes containing dichloromethylene-diphosphonate on endotoxininduced uveitis. J. Neumimmunol. 1998. 86: 171-181.
21. Berra, A., Rodriguez, A., Heiligenhaus, A., Pazos, B., van Rooijen, N. and Foster, S., The role of macrophages in the pathogenesis of HSV-1 induced chorioretinitis in BALB/c mice. Invest. Ophthalmol. Vis. Sci. 1994. 35: 2990-2998.
22. Camilleri, J. P., Willams, A. S., Amos, N., Douglas-Jones, A. G., Love, W. G. and Willams, B. D., The effect of free and liposome-encapsulated clodronate on the hepatic mononuclear phagocyte system in the rat. Clin. Exp. Immunol. 1995. 99: 269-275.
23. Naito, N., Nagai, H., Kawano, S., Umezu, H., Zhu, H., Moriyama, H., Yamamoto, T., Takatsuka, H. and Takei, Y., Liposome-encapsulated dichloromethylene diphosphonate induces macrophage apoptosis in vivo and in vitro. J. Leukoc. Biol. 1996. 60: 337-344.
24. Oltvai, Z. N., Milliman, C. L. and Korsmeyer, S. J., Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 1993. 74: 609-619.
25. van Rooijen, N., Kors, N., v.d. Ende, M. and Dijkstra, C. D., Depletion and repopulation of macrophages in spleen and liver of rat after intravenous treatment with liposome-encapsulated dichloromethylene diphosphonate. Cell Tissue Res. 1990. 260: 215-222.
26. Jung, S., Huitinga, I., Schmidth, B., Zielasek, J., Dijkstra, C. D., Toyka, K. V. and Hartung, H. P., Selective elimination of macrophages by dichloromethylene diphosphonate-containing liposomes suppresses experimental autoimmune neuritis. J. Neurol. Sci. 1993. 119: 195-202.
27. van Lent, P. L. E. M., van den Hoek, A. E., van der Bersselaar, L. A. M., Spanjaards, M. F., van Rooijen, N., Dijkstra, C. D., van de Putte, L. B. A. and van den Berg, W. B., In vivo role of phagocytic synovial lining cells in onset of experimental arthritis. Am. J. Pathol. 1993. 143: 1226-1237.
28. Vaux, D. L., Haecker, G. and Strasser, A., An evolutionary perspective on apoptosis. Cell 1994. 76: 777-779.
29. Steller, H., Mechanisms and genes of cellular suicide. Science 1995. 267: 1445-1449.
30. Kelly, M. L., Tang, Y., Rosensweig, N., Clejan, S. and Beckman, B. S., Granulocyte-macrophage colony-stimulating factor rescues TF-1 leukemia cells from ionizing radiation-induced apoptosis through a pathway mediated by protein kinase C alpha. Blood 1998. 92: 416-424.
31. Sweeney, J. F., Nguyen, P. K., Omann, G. M. and Hinshaw, D. B., Ultraviolet irradiation accelerates apoptosis in human polymorphonuclear leukocytes: protection by LPS and GM-CSF. J. Leukoc. Biol. 1997. 62: 517-523.
32. Chao, J. R., Wang, J. M., Lee, S. F., Peng, H. W., Lin, Y. H., Chou, C. H., Li, J. C., Huang, H. M., Chou, C. K., Kuo, M. L., Yen, J. J. and Yang-yen, H. F., Mcl-1 is an immediate-early gene activated by the granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling pathway and is one component of the GM-CSF viability response. Mol. Cell. Biol. 1998. 18: 4883-4898.
33. L in delayed eosinophil apoptosis mediated by granulocyte-macrophage colony-stimulating factor and interleukin-5. Blood 1998. 92: 778-783.
34. Simon, H. U., Yousefi, S., Dibbert, B., Levi-Schaffer, F. and Blaser, K., Anti-apoptotic signals of granulocyte-macrophage colony-stimulating factor are transduced via Jak2 tyrosine kinase in eosinophils. Eur. J. Immunol. 1997. 27: 3536-3539.
35. Sakai, I. and Kraft, A. S., The kinase domain of Jak2 mediates induction of Bcl-2 and delays cell death in hematopoietic cells. J. Biol. Chem. 1997. 272: 12350-12358.
36. Santiago-Schwartz, F., Borrero, M., Tucci, J., Palaia, T. and Carsons, S. E., In vitro expansion of CD13+ CD33+ dendritic cell precursors from multipotent progenitors is regulated by a discrete fas-mediated apoptotic schedule. J. Leukoc. Biol. 1997. 62: 493-502.
37. Canque, B., Camus, S., Yagello, M. and Gluckman, J. C., Special susceptibility to apoptosis of CD1a+ dendritic cell precursors differentiating from cord blood CD34+ progenitors. Stem Cells 1998. 16: 218-228.
38. Correa, S. G. and Riera, C. M., Adjuvant effect of liposomes in the autoimmune response to rat male accessory glands. Immunol. Lett. 1991. 28: 39-46.
39. Correa, S. G., Riera, C. M. and Iribarren, P., Involvement of peritoneal dendritic cells in the induction of autoimmune prostatitis. J. Autoimmun. 1997. 10: 107-113.
40. Rabinovich, G. A., Iglesias, M. M., Modesti, N. M., Castagna, L. F., Wolfenstein-Todel, C., Riera, C. M. and Sotomayor, C. E., Activated rat macrophages procedure a Galectin-1-like protein that induces apoptosis of T cells: biochemical and functional characterization. J. Immunol. 1998. 160: 4831-4840.
41. Gorczyca, W., Gong, J., Ardelt, B., Traganos, F. and Darzynkiewicz, Z., The cell cycle related differences in susceptibility of HL-60 cells to apoptosis induced by various antitumor agents. Cancer Res. 1993. 53: 3186-3196.
42. Bradford, M. M., A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 1976. 72: 248-254.
43. Laemmli, U. K., Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970. 227: 680-685.