HSV gene functions: What have we learned that could be generally applicable to its near and distant cousins?

Acta Virologica

Volumn 43, Issue 2-3, 1999, Pages 75-80

  Roizman, B ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; CYCLIN D3; DNA; ELONGATION FACTOR 1; MESSENGER RNA; PROTEIN KINASE; VIRUS PROTEIN;

CELL CYCLE S PHASE; CONFERENCE PAPER; GENE ACTIVATION; GENE FUNCTION; GENETIC TRANSFECTION; HERPES SIMPLEX VIRUS 1; NONHUMAN; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; SPLICEOSOME; VIRION; VIRUS ASSEMBLY; VIRUS INFECTION; VIRUS REPLICATION;

GENE EXPRESSION; GENOME, VIRAL; HERPES SIMPLEX; HERPESVIRUS 1, HUMAN; HUMANS; VIRAL PROTEINS; VIRUS LATENCY;

ANIMALIA; DNA VIRUSES; HERPES; HUMAN HERPESVIRUS 1;

EID: 0033060102     PISSN: 0001723X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (12)

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2. 134.5 genes preclude shutoff of protein synthesis by blocking the phosphorylation of eIF-2α. J. Virol. 72, 7005-7011.
3. 1 34.5 gene if present before activation of protein kinase R by precluding its phosphorylation and that of the a subunit of translation initiation factor eIF-2. J. Virol. 72, 8620-8626.
4. Everett RD, Meredith M, Orr A, Cross A, Kathoria M, Parkinson J (1997): A novel ubiquitin-specific protease is dynamically associated with the PML nuclear domain and binds to a herpesvirus regulatory protein. EMBO J. 16, 566-577.
5. 134.5 protein of herpes simplex virus 1 complexes with protein phosphatase 1α to dephosphorylate the a subunit of the eIF-2 translation initiation factor and preclude the shutoff of protein synthesis by double stranded RNA activated protein kinase (PKR). Proc. Natl. Acad. Sci. USA 94, 843-848.
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8. Randall G, Lagunoff M, Roizman B (1997): The product of ORF O located within the domain of herpes simplex virus 1 genome transcribed during latent infection binds to and inhibits in vitro binding of ICP4 to its cognate DNA site. Proc. Natl. Acad. Sci. USA 94, 10379-10384.
9. McGeoch DJ, Dalrymple MA, Davison AJ, Dolan A, Frame MC, McNab D, Perry, LJ, Scott JE, Taylor P (1988): The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1. J. Gen. Virol. 69, 1531-1574.
10. Mohr I, Gluzman Y (1996): A herpesvirus genetic element which affects translation in the absence of viral GADD34 function. EMBO J. 15, 4759-4766.
11. Roizman B, Sears AE (1996): The replication of Herpes simplex viruses. In Fields, BN, Knipe DM, Howley P, Chanock RM, Hirsch MS, Melnick JL, Monath TP, Roizman B (Eds): Fields' Virology. 3rd ed. Lippincott-Raven Press, New York, pp. 2231-2295.
12. Roizman B (1996): The function of herpes simplex virus genes: a primer for genetic engineering of novel vectors. Proc. Natl. Acad. Sci. USA 93, 11307-11312.