An extract of Polypodium leucotomos appears to minimize certain photoaging changes in a hairless albino mouse animal model: A pilot study

Photodermatology Photoimmunology and Photomedicine

Volumn 15, Issue 3-4, 1999, Pages 120-126

  Alcaraz, M V ^a   Pathak, M A ^a   Rius, F ^b   Kollias, N ^a   González, Salvador ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b NONE

Author keywords

Hairless albino mouse; Polypodium leucotomos; Skin cancer; Skin photoaging; Ultraviolet radiation

Indexed keywords

POLYPODIUM LEUCOTOMOS EXTRACT;

ANIMAL MODEL; ARTICLE; CANCER RISK; MOUSE; NONHUMAN; NUDE MOUSE; PHOTODERMATOSIS; PRIORITY JOURNAL; RADIATION EXPOSURE; SKIN TUMOR; ULTRAVIOLET B RADIATION;

POLYPODIUM LEUCOTOMOS;

EID: 0033059479     PISSN: 09054383     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0781.1999.tb00071.x     Document Type: Article

References (28)

1. Tedesco AC, Martínez LM, González S. Photochemistry and photobiology of actinic erythema: defensive and reparative cutaneous mechanisms. Braz J Med Biol Res 1997: 30: 561-575.
2. Kligman LH. The ultraviolet-irradiated hairless mouse: A model for photoaging. J Am Acad Dermatol 1989: 21: 623-31.
3. Bissett DL, Hannon DP, Orr TV. An animal model of solar-aged skin: histological, physical, and visible changes in UV-irradiated hairless mouse skin. Photochem Photobiol 1987: 46: 367-378.
4. Chatterjee R, Benzinger MJ, Ritter JL, Bissett DL. Chronic ultraviolet B radiation-induced biochemical changes in the skin of hairless mice. Photochem Photobiol 1990: 51: 91-97.
5. Kligman LH, Gebre M. Biochemical changes in hairless mouse skin collagen after chronic exposure to ultraviolet-A radiation. Photochem Photobiol 1991: 54: 233-237.
6. Fisher MS, Menter JM, Willis I. Ultraviolet radiation-induced suppression of contact hypersensitivity in relation to Padimate O and Oxybenzone. J Invest Dermatol 1989: 92: 337-341.
7. Ho KKL, Halliday GM, Barnetson RS. Sunscreens protect epidermal Langerhans cells and Thy-1+ cells but not local contact sensitization from the effects of ultraviolet light. J Invest Dermatol 1992: 98: 720-724.
8. Reeve RE, Bosnic M, Boehm-Wilcox C, Ley RD. Differential protection by two sunscreens from UV radiation-induced immunosuppression. J Invest Dermatol 1991: 97: 624-628.
9. Kligman AM, Kligman LH. Photoaging. In: Fitzpatrick TB et al., ed. Dermatology in general medicine. New York: McGraw-Hill, Inc, 1993: 2972-2979.
10. Kaaresn LL, Poulsen TD, de Fine Olivarius F, Wulf HC. Mast cells and elastosis in ultraviolet-irradiated hairless mice. Photodermatol Photoimmunol Photomed 1995: 11: 1-5.
11. Poulsen JT, Staberg B, Wulf HC, Brodthagen H. Dermal elastosis in hairless mice after UVB and UVA applied simultaneously, separately or sequentially. Br J Dermatol 1984: 110: 531-538.
12. Gilchrest BA. A review of skin ageing and its medical therapy. Br J Dermatol 1996: 135: 867-875.
13. Kang S, Voorhees JJ. Photoaging therapy with topical tretinoin: an evidence-based analysis. J Am Acad Dermatol 1998: 39 (2 Pt 3): S55-S61.
14. Snyder DS, May M. Ability of PABA to protect mamalian skin from ultraviolet light-induced skin tumors and actinic damage. J Invest Dermatol 1975: 65: 543-546.
15. Kligman LH, Akin FJ, Kligman AM. Prevention of ultraviolet damage to the dermis of hairless mice by sunscreens. J Invest Dermatol 1982: 78: 181-189.
16. Kligman LH, Akin PP, Sayre RM. Broad-spectrum sunscreens with UVA I and UVA II absorbers provide increased protection against solar-simulating radiation induced dermal damage in hairless mice. J Soc Cosmet Chem 1996: 47: 129-155.
17. Bissett DL, McBride JF, Hannon DP, Patrick LF. Time-dependent decrease in susncreen protection against chronic photodamage in UVB-irradiated hairless mouse skin. J Photochem Photobiol B Biol 1991: 9: 323-334.
18. Huang MT, Xie J-G, Wang ZY et al. Effects of tea, decaffeinated tea and caffeine on UVB light-induced complete carcinogenesis in SKH-1 mice: Demonstration of caffeine as a biologically important constituent of tea. Cancer Res 1997: 57: 2623-2629.
19. Ruiz H. Disertaciones sobre la raiz de la rat-nhia de la calaguala y de la china y acerca de la yerba llamada cauchalagua. Imprenta Real, Madrid 1796. Cited in : Biblioteca de Clá;sicos de la Farmacia Española, 1992.
20. Horvarth A, Alvarado F, Szocs J, Ney de Alvarado Z, Padilla G. Metabolic effects of calagualina, and antitumoral saponine of Polypodium leucotomos. Nature 1967: 214: 1256-1258.
21. González S, Pathak MA. Inhibition of ultraviolet-induced formation of reactive oxygen species, lipid peroxidation, erythema and skin photosensitization by Polypodium leucotomos. Photodermatol Photoimmunol Photomed 1996: 12: 45-56.
22. González S, Pathak MA, Cuevas J, Villarrubia VG, Fitzpatrick TB. Topical or oral administration with an extract of Polypodium leucotomos prevents acute sunburn and psoralen-induced phototoxic reactions as well as depletion of Langerhans cells in human skin. Photodermatol Photoimmunol Photomed 1997: 13: 50-60.
23. Kochevar IE, Moran M, Lyon N, Flotte T, Siebert E, Gange RW. Effects of systemic indomethacin, meclizine and BW755C on chronic ultraviolet B-induced effects in hairless mouse skin. J Invest Dermatol 1993: 100: 186-193.
24. Berger H, Tsambaos D, Mahrle G. Experimental elastosis induced by chronic ultraviolet exposure. Arch Dermatol Res 1980: 269: 39-49.
25. Mera SL, Lowell CR, Jones RR, Davies JD. Elastic fibers in normal and sun-damaged skin: an immunohistochemical study. Br J Dermatol 1987: 117: 21-27.
26. Wulf HC, Poulsen T, Davies RE, Urbach F. Narrow-band UV radiation and induction of dermal elastosis and skin cancer. Photodermatology 1989: 6: 44-51.
27. Kligman LH, Akin FJ, Kligman AM. Sunscreens promote repair of ultraviolet radiation-induced dermal damage. J Invest Dermatol 1983: 81: 98-102.
28. Danno K, Horio T, Takigawa M, Imamura S. Role of oxygen intermediates in UV-induced epidermal cell injury. J Invest Dermatol 1984: 83: 305-310.