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Volumn 83, Issue 2, 1999, Pages 537-548

Restorative gene therapy approaches to Parkinson's disease

Author keywords

[No Author keywords available]

Indexed keywords

VIRUS VECTOR;

EID: 0033058906     PISSN: 00257125     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0025-7125(05)70119-X     Document Type: Article
Times cited : (8)

References (55)
  • 1
    • 0027408530 scopus 로고
    • Transfer of a foreign gene into the brain using adenovirus vectors
    • S. Akli C. Caillaud E. Vigne Transfer of a foreign gene into the brain using adenovirus vectors Nat Genet 3 1993 221 228
    • (1993) Nat Genet , vol.3 , pp. 221-228
    • Akli, S.1    Caillaud, C.2    Vigne, E.3
  • 2
    • 0027477148 scopus 로고
    • Direct in vivo gene transfer to ependymal cells in the central nervous system using recombinant adenovirus vectors
    • G. Bajocchi S.H. Feldman R.G. Crystal Direct in vivo gene transfer to ependymal cells in the central nervous system using recombinant adenovirus vectors Nat Genet 3 1993 229 234
    • (1993) Nat Genet , vol.3 , pp. 229-234
    • Bajocchi, G.1    Feldman, S.H.2    Crystal, R.G.3
  • 3
    • 9544226495 scopus 로고
    • Recovery of herpes-simplex virus from human trigeminal ganglions
    • J.R. Baringer P. Sworeland Recovery of herpes-simplex virus from human trigeminal ganglions N Engl J Med 228 1973 9593 9596
    • (1973) N Engl J Med , vol.228 , pp. 9593-9596
    • Baringer, J.R.1    Sworeland, P.2
  • 4
    • 0016195894 scopus 로고
    • Evidence that neurons harbor latent herpes simplex virus
    • M.L. Cook U.B. Bastone J.G. Stevens Evidence that neurons harbor latent herpes simplex virus Infect Immun 9 1974 946 951
    • (1974) Infect Immun , vol.9 , pp. 946-951
    • Cook, M.L.1    Bastone, U.B.2    Stevens, J.G.3
  • 5
    • 0027522920 scopus 로고
    • A model system for in vivo gene transfer into the central nervous system using an adenoviral vector
    • B.L. Davidson E.D. Allen K.F. Kozarsky A model system for in vivo gene transfer into the central nervous system using an adenoviral vector Nat Genet 3 1993 219 223
    • (1993) Nat Genet , vol.3 , pp. 219-223
    • Davidson, B.L.1    Allen, E.D.2    Kozarsky, K.F.3
  • 6
    • 0011244578 scopus 로고
    • Neuroprotection and neuroregeneration in rodent and primate parkinsonian models using an AAV vector expressing GDNF
    • M.J. During D. Choi-Lundberg P. Leone Neuroprotection and neuroregeneration in rodent and primate parkinsonian models using an AAV vector expressing GDNF Abstr Soc Neurosci 21 1995 225.9
    • (1995) Abstr Soc Neurosci , vol.21 , pp. 225.9
    • During, M.J.1    Choi-Lundberg, D.2    Leone, P.3
  • 7
    • 0031104731 scopus 로고    scopus 로고
    • Targets for gene therapy of Parkinson's disease: Growth factors, signal transduction, and promoters
    • M.J. During P. Leone Targets for gene therapy of Parkinson's disease: Growth factors, signal transduction, and promoters Exp Neurol 144 1997 74 81
    • (1997) Exp Neurol , vol.144 , pp. 74-81
    • During, M.J.1    Leone, P.2
  • 8
    • 0028559601 scopus 로고
    • Long-term behavioral recovery in parkinsonian rats by an HSV vector expressing tyrosine hydroxylase
    • M.J. During J.R. Naegele K.L. O'Malley Long-term behavioral recovery in parkinsonian rats by an HSV vector expressing tyrosine hydroxylase Science 266 1994 1399 1403
    • (1994) Science , vol.266 , pp. 1399-1403
    • During, M.J.1    Naegele, J.R.2    O'Malley, K.L.3
  • 9
    • 0031875751 scopus 로고    scopus 로고
    • In vivo expression of therapeutic human genes for dopamine production in the caudates of MPTP-treated monkeys using an AAV vector
    • M.J. During R.J. Samulski J.D. Elsworth In vivo expression of therapeutic human genes for dopamine production in the caudates of MPTP-treated monkeys using an AAV vector Gene Ther 5 1998 820 827
    • (1998) Gene Ther , vol.5 , pp. 820-827
    • During, M.J.1    Samulski, R.J.2    Elsworth, J.D.3
  • 10
    • 85119790103 scopus 로고    scopus 로고
    • Freese A. Gene therapy for Parkinson's disease: Rationale, prospects and limitations Exp Neurol vol 144 1997
    • (1997) Exp Neurol , vol.vol 144
  • 11
    • 9544224212 scopus 로고
    • Expression of tyrosine hydroxylase in striatal cells with a HSV-1 vector causes stable production and regulated release of dopa and dopamine: Potential gene therapy for Parkinson's disease
    • A. Freese M.J. During K. O'Malley Expression of tyrosine hydroxylase in striatal cells with a HSV-1 vector causes stable production and regulated release of dopa and dopamine: Potential gene therapy for Parkinson's disease Abstr Soc Neurosci 17 1991 424.15
    • (1991) Abstr Soc Neurosci , vol.17 , pp. 424.15
    • Freese, A.1    During, M.J.2    O'Malley, K.3
  • 12
    • 0026336511 scopus 로고
    • Infection of cultured striatal neurons with a defective HSV-1 vector: Implications for gene therapy
    • A. Freese A.I. Geller Infection of cultured striatal neurons with a defective HSV-1 vector: Implications for gene therapy Nucl Acids Res 19 1991 7219 7223
    • (1991) Nucl Acids Res , vol.19 , pp. 7219-7223
    • Freese, A.1    Geller, A.I.2
  • 13
    • 0030872521 scopus 로고    scopus 로고
    • Direct gene transfer into human epileptogenic hippocampal tissue with an adeno-associated virus vector: Implications for a gene therapy approach to epilepsy
    • A. Freese M.G. Kaplitt M.J. O'Connor Direct gene transfer into human epileptogenic hippocampal tissue with an adeno-associated virus vector: Implications for a gene therapy approach to epilepsy Epilepsia 38 1997 759 766
    • (1997) Epilepsia , vol.38 , pp. 759-766
    • Freese, A.1    Kaplitt, M.G.2    O'Connor, M.J.3
  • 14
    • 0025054649 scopus 로고
    • HSV-1 vector-mediated neuronal gene delivery: Strategies for neuroscience and neurology
    • A. Freese R. Neve A.I. Geller HSV-1 vector-mediated neuronal gene delivery: Strategies for neuroscience and neurology Biochem Pharm 40 1990 2189 2199
    • (1990) Biochem Pharm , vol.40 , pp. 2189-2199
    • Freese, A.1    Neve, R.2    Geller, A.I.3
  • 15
    • 0029838423 scopus 로고    scopus 로고
    • Prospects for gene therapy in Parkinson's disease
    • A. Freese M. Stern M.G. Kaplitt Prospects for gene therapy in Parkinson's disease Mov Disord 11 1996 469 488
    • (1996) Mov Disord , vol.11 , pp. 469-488
    • Freese, A.1    Stern, M.2    Kaplitt, M.G.3
  • 16
    • 0028276809 scopus 로고
    • Implanted fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevent 1-methyl-4-phenylpyridium toxicity to dopamine neurons in the rat
    • D.M. Frim T.A. Uhler W.R. Galpern Implanted fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevent 1-methyl-4-phenylpyridium toxicity to dopamine neurons in the rat Proc Natl Acad Sci U S A 91 1994 5104 5108
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 5104-5108
    • Frim, D.M.1    Uhler, T.A.2    Galpern, W.R.3
  • 17
    • 0023784651 scopus 로고
    • A defective HSV-1 vector expresses Escherichia coli B-galactosidase in cultured peripheral neurons
    • A.I. Geller X.O. Breakefield A defective HSV-1 vector expresses Escherichia coli B-galactosidase in cultured peripheral neurons Science 241 1988 1667 1669
    • (1988) Science , vol.241 , pp. 1667-1669
    • Geller, A.I.1    Breakefield, X.O.2
  • 18
    • 0027182757 scopus 로고
    • Long term increases in neurotransmitter release from neuronal cells expressing a constitutively active adenylate cyclase from a herpes simplex virus type 1 vector
    • A.I. Geller M.J. During J.W. Haycock Long term increases in neurotransmitter release from neuronal cells expressing a constitutively active adenylate cyclase from a herpes simplex virus type 1 vector Proc Natl Acad Sci U S A 90 1993 7603 7607
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 7603-7607
    • Geller, A.I.1    During, M.J.2    Haycock, J.W.3
  • 19
    • 0025883935 scopus 로고
    • Molecular analysis of neuronal physiology by gene transfer into neurons with herpes simplex virus vectors
    • A.I. Geller M.J. During R.L. Neve Molecular analysis of neuronal physiology by gene transfer into neurons with herpes simplex virus vectors Trends Neurosci 14 1991 428 432
    • (1991) Trends Neurosci , vol.14 , pp. 428-432
    • Geller, A.I.1    During, M.J.2    Neve, R.L.3
  • 20
    • 0025128689 scopus 로고
    • Transfection of cultured central nervous system neurons with a defective HSV-1 vector which expresses B-galactosidase
    • A.I. Geller A. Freese Transfection of cultured central nervous system neurons with a defective HSV-1 vector which expresses B-galactosidase Proc Natl Acad Sci U S A 87 1990 1149 1153
    • (1990) Proc Natl Acad Sci U S A , vol.87 , pp. 1149-1153
    • Geller, A.I.1    Freese, A.2
  • 21
    • 9544237203 scopus 로고
    • A helper virus-free packaging system for HSV-1 plasmid vectors that supports efficient gene transfer in the rat brain
    • A. Geller S. Song F. Lim A helper virus-free packaging system for HSV-1 plasmid vectors that supports efficient gene transfer in the rat brain Abstr Soc Neurosci 21 1995 330.1
    • (1995) Abstr Soc Neurosci , vol.21 , pp. 330.1
    • Geller, A.1    Song, S.2    Lim, F.3
  • 22
    • 0028352807 scopus 로고
    • Gene transfer to brain using herpes simplex virus vectors
    • J.C. Glorioso W.F. Goins C.A. Meaney Gene transfer to brain using herpes simplex virus vectors Ann Neurol 35 1994 28 34
    • (1994) Ann Neurol , vol.35 , pp. 28-34
    • Glorioso, J.C.1    Goins, W.F.2    Meaney, C.A.3
  • 23
    • 0023855585 scopus 로고
    • Brain-derived neurotrophic factor prevents neuronal death in vivo
    • Hofer M.M. Barde Y.-A. Brain-derived neurotrophic factor prevents neuronal death in vivo Nature 331 1988 261 262
    • (1988) Nature , vol.331 , pp. 261-262
    • Hofer, M.M.1    Barde, Y.-A.2
  • 24
    • 85119798002 scopus 로고    scopus 로고
    • Horrelou P, Sabate O, Buc-Caron M-H, et al: In vivo and ex vivo gene therapy in a rat model of Parkinson's disease. Proceedings of the International Conference on Gene Therapy for CNS Disorders, Philadelphia, 1996, p 3.15
  • 25
    • 0028606905 scopus 로고
    • Direct intracerebral gene transfer of an adenoviral vector expressing tyrosine hydroxylase in a rat model of Parkinson's disease
    • P. Horrelou E. Vigne Castel M.-N. Direct intracerebral gene transfer of an adenoviral vector expressing tyrosine hydroxylase in a rat model of Parkinson's disease Neuroreport 6 1994 49 53
    • (1994) Neuroreport , vol.6 , pp. 49-53
    • Horrelou, P.1    Vigne, E.2    Castel, M.-N.3
  • 26
    • 85119785846 scopus 로고    scopus 로고
    • Jacoby DR, Breakefield XO, Latchman DS: Construction of an HSV-1 amplicon with an inducible Oct-2 operon to modulate cytopathic effect. Proceedings of the International Conference on Gene Therapy for CNS Disorders, Philadelphia, 1996, p 1.31
  • 27
    • 0027399705 scopus 로고
    • Long-term correction of a rat model of Parkinson's disease by gene therapy
    • S. Jiao V. Gurevich J.A. Wolff Long-term correction of a rat model of Parkinson's disease by gene therapy Nature 362 1993 450 453
    • (1993) Nature , vol.362 , pp. 450-453
    • Jiao, S.1    Gurevich, V.2    Wolff, J.A.3
  • 28
    • 0026550189 scopus 로고
    • Intracerebral transplants of primary muscle cells: A potential ‘platform’ for transgene expression in the brain
    • S. Jiao E. Schultz J.A. Wolff Intracerebral transplants of primary muscle cells: A potential ‘platform’ for transgene expression in the brain Brain Res 575 1992 143 147
    • (1992) Brain Res , vol.575 , pp. 143-147
    • Jiao, S.1    Schultz, E.2    Wolff, J.A.3
  • 29
    • 0026597613 scopus 로고
    • Long-term survival of autologous muscle grafts in rat brain
    • S. Jiao J.A. Wolff Long-term survival of autologous muscle grafts in rat brain Neurosci Lett 137 1992 207 210
    • (1992) Neurosci Lett , vol.137 , pp. 207-210
    • Jiao, S.1    Wolff, J.A.2
  • 30
    • 85119804155 scopus 로고    scopus 로고
    • Kang UJ, Benecsics C, Cahill AL, et al: Regulation of l -dopa production by 5,6,7,8-tetrahydro-L-biopterin in genetically modified cells. Proceedings of the International Conference on Gene Therapy for CNS Disorders, Philadelphia, 1996, p 3.11
  • 31
    • 0028169741 scopus 로고
    • Long-term gene expression and phenotypic correction using adeno-associated virus vectors in the mammalian brain
    • M.G. Kaplitt P. Leone R.J. Samulski Long-term gene expression and phenotypic correction using adeno-associated virus vectors in the mammalian brain Nat Genet 8 1994 148 154
    • (1994) Nat Genet , vol.8 , pp. 148-154
    • Kaplitt, M.G.1    Leone, P.2    Samulski, R.J.3
  • 32
    • 0026579276 scopus 로고
    • Morphological and neurochemical features of cultured primary skin fibroblasts of Fischer 344 rats following striatal implantation
    • M.D. Kawaja F.H. Gage Morphological and neurochemical features of cultured primary skin fibroblasts of Fischer 344 rats following striatal implantation J Comp Neurol 317 1992 102 116
    • (1992) J Comp Neurol , vol.317 , pp. 102-116
    • Kawaja, M.D.1    Gage, F.H.2
  • 33
    • 0024452271 scopus 로고
    • The herpes simplex virus virion host shutoff function
    • D. Kwong N. Frenkel The herpes simplex virus virion host shutoff function J Virol 63 1989 487 496
    • (1989) J Virol , vol.63 , pp. 487-496
    • Kwong, D.1    Frenkel, N.2
  • 34
    • 0027457561 scopus 로고
    • An adenovirus vector for gene transfer into neurons and glia in the brain
    • Le Gal La Salle G. J.J. Robert An adenovirus vector for gene transfer into neurons and glia in the brain Science 259 1993 988 990
    • (1993) Science , vol.259 , pp. 988-990
    • Le Gal La Salle, G.1    Robert, J.J.2
  • 35
    • 0027285510 scopus 로고
    • GDNF: A glial cell-line derived neurotrophic factor for midbrain dopaminergic neurons
    • Lin L.-F.H. D.H. Doherty J.D. Lile GDNF: A glial cell-line derived neurotrophic factor for midbrain dopaminergic neurons Science 260 1993 1130 1132
    • (1993) Science , vol.260 , pp. 1130-1132
    • Lin, L.-F.H.1    Doherty, D.H.2    Lile, J.D.3
  • 36
    • 9544233610 scopus 로고
    • Adenoviral (Ad)-mediated gene transfer of GDNF and B-galactosidase (lac Z) to the rat nigrostriatal system in vitro and in vivo
    • O. Lin D.L. Choi-Lundberg J. Ravenell Adenoviral (Ad)-mediated gene transfer of GDNF and B-galactosidase (lac Z) to the rat nigrostriatal system in vitro and in vivo Abstr Soc Neurosci 21 1995 224.12
    • (1995) Abstr Soc Neurosci , vol.21 , pp. 224.12
    • Lin, O.1    Choi-Lundberg, D.L.2    Ravenell, J.3
  • 37
    • 0028815823 scopus 로고
    • Neuron saving schemes
    • R.M. Lindsay Neuron saving schemes Nature 273 1995 289 290
    • (1995) Nature , vol.273 , pp. 289-290
    • Lindsay, R.M.1
  • 38
    • 0028135308 scopus 로고
    • Recent progress in immunoisolated cell therapy
    • M.J. Lysaght B. Frydel F. Gentile Recent progress in immunoisolated cell therapy J Cell Biochem 56 1994 196 203
    • (1994) J Cell Biochem , vol.56 , pp. 196-203
    • Lysaght, M.J.1    Frydel, B.2    Gentile, F.3
  • 39
    • 0025864440 scopus 로고
    • Experimental therapy of human glioma by means of a genetically engineered virus mutant
    • R.L. Martuza A. Malick J.M. Markert Experimental therapy of human glioma by means of a genetically engineered virus mutant Science 252 1991 854 856
    • (1991) Science , vol.252 , pp. 854-856
    • Martuza, R.L.1    Malick, A.2    Markert, J.M.3
  • 40
    • 85119794690 scopus 로고    scopus 로고
    • Morassutti DJ, Atasoy E, Staines WA, et al: Characterization of murine P19 EC-derived neurons expressing foreign rat TH cDNA-in vitro and in vivo. Proceedings of the International Conference on Gene Therapy for CNS Disorders, Philadelphia, 1995, p 3.12
  • 41
    • 0026525713 scopus 로고
    • Use of adeno-associated virus as a general transduction vector for mammalian cells
    • N. Muzyczka Use of adeno-associated virus as a general transduction vector for mammalian cells Curr Top Microbiol Immunol 158 1992 97 129
    • (1992) Curr Top Microbiol Immunol , vol.158 , pp. 97-129
    • Muzyczka, N.1
  • 42
    • 0012060204 scopus 로고
    • Gene therapy in neurology: Potential application to Parkinson's disease
    • K. O'Malley A.I. Geller Gene therapy in neurology: Potential application to Parkinson's disease Vecsei L. Freese E. Swartz K.J. Neurological Disorders: Novel Experimental and Therapeutic Strategies 1992 Ellis Horwood Limited West Sussex 223 248
    • (1992) , pp. 223-248
    • O'Malley, K.1    Geller, A.I.2
  • 43
    • 0024362609 scopus 로고
    • Expression of human HPRT mRNA in brains of mice infected with a recombinant herpes simplex virus-1 vector
    • T.D. Palella Y. Hidaka L.J. Silverman Expression of human HPRT mRNA in brains of mice infected with a recombinant herpes simplex virus-1 vector Gene 80 1989 137 144
    • (1989) Gene , vol.80 , pp. 137-144
    • Palella, T.D.1    Hidaka, Y.2    Silverman, L.J.3
  • 44
    • 0025976935 scopus 로고
    • Genetically modified skin fibroblasts persist long after transplantation but gradually inactivate introduced genes
    • T.D. Palmer G.J. Rosman W.R.A. Osborne Genetically modified skin fibroblasts persist long after transplantation but gradually inactivate introduced genes Proc Natl Acad Sci U S A 88 1991 1330 1334
    • (1991) Proc Natl Acad Sci U S A , vol.88 , pp. 1330-1334
    • Palmer, T.D.1    Rosman, G.J.2    Osborne, W.R.A.3
  • 45
    • 0026727791 scopus 로고
    • Gene transfer into established and primary fibroblast cell lines: Comparison of transfection methods and promoters
    • J. Ray F.H. Gage Gene transfer into established and primary fibroblast cell lines: Comparison of transfection methods and promoters Biotechniques 13 1992 598 603
    • (1992) Biotechniques , vol.13 , pp. 598-603
    • Ray, J.1    Gage, F.H.2
  • 46
    • 0031105522 scopus 로고    scopus 로고
    • Application of ex vivo gene therapy in the treatment of Parkinson's disease
    • H.K. Raymon S. Thode F.H. Gage Application of ex vivo gene therapy in the treatment of Parkinson's disease Exp Neurol 144 1997 82 91
    • (1997) Exp Neurol , vol.144 , pp. 82-91
    • Raymon, H.K.1    Thode, S.2    Gage, F.H.3
  • 47
    • 0024311525 scopus 로고
    • Helper-free stocks of adeno-associated viruses: Normal integration does not require viral gene expression
    • Samulski R.J. Chang L.-S. T. Shenk Helper-free stocks of adeno-associated viruses: Normal integration does not require viral gene expression J Virol 63 1989 3822 3828
    • (1989) J Virol , vol.63 , pp. 3822-3828
    • Samulski, R.J.1    Chang, L.-S.2    Shenk, T.3
  • 48
    • 0025753128 scopus 로고
    • Long-term in vivo expression of retrovirus-mediated gene transfer in mouse fibroblast implants
    • R. Scharfmann J.H. Axelrod I.M. Verma Long-term in vivo expression of retrovirus-mediated gene transfer in mouse fibroblast implants Proc Natl Acad Sci U S A 88 1991 4626 4630
    • (1991) Proc Natl Acad Sci U S A , vol.88 , pp. 4626-4630
    • Scharfmann, R.1    Axelrod, J.H.2    Verma, I.M.3
  • 49
    • 0020451027 scopus 로고
    • The herpes simplex virus amplicon: A new eucaryotic defective virus cloning-amplifying vector
    • R.R. Spaete N. Frenkel The herpes simplex virus amplicon: A new eucaryotic defective virus cloning-amplifying vector Cell 30 1982 295 304
    • (1982) Cell , vol.30 , pp. 295-304
    • Spaete, R.R.1    Frenkel, N.2
  • 50
    • 0031104813 scopus 로고    scopus 로고
    • Parkinson's disease: The case for novel treatment strategies
    • M.B. Stern A. Freese Parkinson's disease: The case for novel treatment strategies Exp Neurol 144 1997 2 3
    • (1997) Exp Neurol , vol.144 , pp. 2-3
    • Stern, M.B.1    Freese, A.2
  • 51
    • 0028834063 scopus 로고
    • Protection and repair of the nigrostriatal dopaminergic system by GDNF in vivo
    • A. Tomac E. Lindqvist Lin L.-F.H. Protection and repair of the nigrostriatal dopaminergic system by GDNF in vivo Nature 373 1995 335 339
    • (1995) Nature , vol.373 , pp. 335-339
    • Tomac, A.1    Lindqvist, E.2    Lin, L.-F.H.3
  • 52
    • 0025069974 scopus 로고
    • Tetrahydrobiopterin-dependent production of l-dopa in NRK fibroblasts transfected with tyrosine hydroxylase cDNA: Future use for intracerebral grafting
    • K. Uchida A. Ishii N. Kaneda Tetrahydrobiopterin-dependent production of l -dopa in NRK fibroblasts transfected with tyrosine hydroxylase cDNA: Future use for intracerebral grafting Neurosci Lett 109 1990 282 286
    • (1990) Neurosci Lett , vol.109 , pp. 282-286
    • Uchida, K.1    Ishii, A.2    Kaneda, N.3
  • 53
    • 0019454926 scopus 로고
    • Replication of herpes simplex virus DNA: Localization of replication recognition signals within defective virus genomes
    • D.A. Vlazny N. Frenkel Replication of herpes simplex virus DNA: Localization of replication recognition signals within defective virus genomes Proc Natl Acad Sci U S A 78 1981 742 746
    • (1981) Proc Natl Acad Sci U S A , vol.78 , pp. 742-746
    • Vlazny, D.A.1    Frenkel, N.2
  • 54
    • 0020327471 scopus 로고
    • Site-specific cleavage/packaging of herpes simplex virus DNA and the selective maturation of nucleocapsids containing full-length viral DNA
    • D.A. Vlazny A. Kwong N. Frenkel Site-specific cleavage/packaging of herpes simplex virus DNA and the selective maturation of nucleocapsids containing full-length viral DNA Proc Natl Acad Sci U S A 79 1979 1423 1427
    • (1979) Proc Natl Acad Sci U S A , vol.79 , pp. 1423-1427
    • Vlazny, D.A.1    Kwong, A.2    Frenkel, N.3
  • 55
    • 0024326943 scopus 로고
    • Grafting fibroblasts genetically modified to produce l-dopa in a rat model of Parkinson disease
    • J.A. Wolff L.J. Fisher L. Xu Grafting fibroblasts genetically modified to produce l -dopa in a rat model of Parkinson disease Proc Natl Acad Sci U S A 86 1989 9011 9014
    • (1989) Proc Natl Acad Sci U S A , vol.86 , pp. 9011-9014
    • Wolff, J.A.1    Fisher, L.J.2    Xu, L.3


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