Neuroendocrinology of the human growth hormone-insulin-like growth factor I axis during ageing

Growth Hormone and IGF Research

Volumn 9, Issue SUPPL. A, 1999, Pages 111-115

  Arvat, E ^a   Giordano, R ^a   Gianotti, L ^a   Broglio, F ^a   Camanni, F ^a   Ghigo, E ^a  

^a MOLINETTE HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; ARGININE; CATECHOLAMINE; CORTICOTROPIN RELEASING FACTOR; GALANIN; GROWTH HORMONE; NEUROTRANSMITTER; SOMATOMEDIN C; THYROTROPIN;

AGED; CONFERENCE PAPER; ENDOCRINE FUNCTION; EXERCISE; GROWTH HORMONE RELEASE; HUMAN; NEUROENDOCRINOLOGY; NUTRITION; OBESITY; PRIORITY JOURNAL; SLEEP; SOMATIC CELL;

EID: 0033058506     PISSN: 10966374     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1096-6374(99)80022-7     Document Type: Conference Paper

References (55)

1. Veldhuis J.D. Randall J.U. Lizarralde G. Johnson M. Iranmanesh S.H. Attenuation of luteinizing hormone secretory burst amplitude as a proximate basis for the hypoandrogenism of healthy aging in men J Clin Endocrinol Metab 75 1992 52 58
2. Mariotti S. Franceschi C. Cossarizza A. Pinchera A. The aging thyroid Endocr Rev 16 1995 686 715
3. Corpas E. Harman S.M. Blackman M.R. Human growth hormone and human aging Endocr Rev 14 1993 20 39
4. Ghigo E. Arvat E. Gianotti L. Human aging and the GH-IGF-I axis J Pediatr Endocrinol Metab 9 1996 271 278
5. Muller E.E. Cella S.G. Parenti M. Somatotropic dysregulation in old mammals Horm Res 43 1995 39 45
6. Demarest K.T. Reigle G.D. Moore K.E. Characteristics of dopaminergic neurons in the aged animals Neuroendocrinology 31 1980 222 248
7. Gudelsky G.A. Nansel D.D. Porter J.C. Dopaminergic control of prolactin secretion in the aging male rat Brain Res 204 1981 446 450
8. Sapolsky R.M. Krey L.C. McEwen B. The neuroendocrinology of stress and aging: the glucocorticoid cascade hypothesis Endocr Rev 7 1986 284 301
9. Jacobson L. Sapolsky R. The role of the hippocampus in feedback regulation of the hypothalamic-pituitary-adrenocortical axis Endocr Rev 12 1991 118 134
10. Takahasthi Y. Kipnis D.M. Daughaday W.H. Growth-hormone secretion during sleep J Clin Invest 47 1968 2079 2090
11. Quabbe H.J. Schilling E. Helge H. Pattern of growth hormone secretion during a 24-hour fast in normal adults J Clin Endocrinol Metab 26 1966 1173 1177
12. Pohelman E.T. Copeland K.C. Influence of physical activity on insulin-like growth factor-I levels in healthy younger and older men J Clin Endocrinol Metab 71 1990 1468 1473
13. Clemmons D.R. Van Wyk J.J. Factors controlling blood concentration of somatomedin J Clin Endocrinol Metab 13 1984 113 143
14. Chatelain P. Claris O. Lapillone A. Dimayo M. Salle B. Fetal and neonatal somatotroph function Front Paediatr Neuroendocrinol 20 1994 127 130
15. Rose S.R. Municchi G. Barnes K.M. Spontaneous growth hormone secretion increases during puberty in normal girls and boys J Clin Endocrinol Metab 73 1991 428 435
16. Ho K.Y. Evans W.S. Blizzard R.M. Effects of sex and age on the 24-hour profile of growth hormone secretion in man: importance of endogenous estradiol concentrations J Clin Endocrinol Metab 64 1987 51 58
17. Iranmanesh A. Lizzardle G. Veldhuis J.D. Age and relative adiposity are specific negative determinants of the frequency and amplitude of GH secretory burst and half-life of endogenous GHin healthy men J Clin Endocrinol Metab 73 1991 1081 1088
18. Kerrigan J. Rogol A.D. The impact of gonadal steroid hormone action on growth hormone secretion during childhood and adolescence Endocr Rev 13 1992 299 308
19. Dawson-Hughens B. Stern D. Goldman J. Reichlin S. Regulation of growth hormone and somatomedin-C secretion in postmenopausal women: effect of physiological estrogen replacement J Clin Endocrinol Metab 63 1986 424 432
20. Ceda G.P. Valenti G. Butturini U. Hoffman A.R. Diminished pituitary responsiveness to growth hormone-releasing factor in aging male rats Endocrinology 118 1986 2109 2114
21. Ghigo E. Arvat E. Muccioli G. Camanni F. Growth hormonereleasing peptides Eur J Endocrinol 136 1997 445 460
22. Thompson J.L. Butterfield G.E. Marcus R. The effects of recombinant human insulin-like growth factor-I and growth hormone on body composition in elderly women J Clin Endocrinol Metab 80 1995 1845 1852
23. Chapman I.M. Hartman M.L. Pezzoli S.S. Effect of aging on the sensitivity of growth hormone secretion to insulin-like growth factor-I negative feedback J Clin Endocrinol Metab 82 1997 2996 3004
24. Jorgensen J.O.L. Vahl N. Fisker S. Somatopause and adiposity Horm Res 48 Suppl 5 1997 101 104
25. Coiro V. Volpi R. Cavazzini U. Restoration of normal growth hormone responsiveness to GHRH in normal aged men by infusion of low amounts of theophylline J Gerontol 46 1991 M155 M158
26. Degli Uberti E.C. Ambrosio M.R. Cella S.C. Defective hypothalamic growth hormone (GH)-releasing hormone activity may contribute to declining GH secretion with age in man J Clin Endocrinol Metab 82 1997 2885 2888
27. Arvat E. Ceda G.P. Di Vito L. Age-related variations in the neuroendocrine control, more than impaired receptor sensitivity, cause the reduction in the GH-releasing activity of GHRPs in human aging Pituitary 1 1998 51 58
28. Frohman L.A. Jansson J.O. Growth hormone-releasing hormone Endocr Rev 7 1986 223 231
29. Vermeulen A. Nyctohemeral growth hormone profiles in young and aged men: correlation with somatomedin-C levels J Clin Endocrinol Metab 64 1987 884 888
30. Zadik Z. Chalew S.A. McCarter R.J. Meistas M. Kowarski A.A. The influence of age on the 24-hour integrated concentration of growth hormone in normal individuals J Clin Endocrinol Metab 60 1985 513 516
31. Muller E.E. Nisticò G. Brain messengers and the pituitary 1989 Academic Press San Diego
32. Ghigo E. Neurotransmitter control of growth hormone secretion de la Cruz L.F. Regulation of growth hormone and somatic growth 1992 Excerpta Medica Amsterdam 103 136
33. Grossman A. Costa A. Forsling M.L. Gaseous neurotransmitters in the hypothalamus. The roles of nitric oxide and carbon monoxide in neuroendocrinology Horm Metab Res 29 1997 477 482
34. Alba-Roth J. Albrecht Muller O. Schopohl J. Von Werder K. Arginine stimulates GH secretion by suppressing endogenous somatostatin secretion J Clin Endocrinol Metab 67 1988 1186 1192
35. Ghigo E. Goffi S. Nicolosi M. GH responsiveness to combined administration of arginine and GHRH does not vary with age in man J Clin Endocrinol Metab 71 1990 1481 1485
36. Ghigo E. Goffi S. Arvat E. A neuroendocrinological approach to evidence of an impairment of central cholinergic function in aging J Endocrinol Invest 15 1992 665 670
37. Ghigo E. Nicolosi M. Arvat E. Growth hormone secretion in Alzheimer's disease: studies with growth hormone-releasing hormone alone and combined with pyridostigmine or arginine Dementia 4 1993 315 320
38. Barthus R.T. Dean R.L. Beer B. Lippa A.S. The cholinergic hypothesis of geriatric memory dysfunction Science 217 1982 408 417
39. Gibson G.E. Peterson C. Jender D.J. Brain acetylcholine synthesis declines with senescence Science 213 1981 675 678
40. Cella S.G. Arce V.M. Pieretti F. Locatelli V. Settembrini B.P. Muller E.E. Combined administration of growth hormone-releasing hormone and clonidine restores defective growth hormone secretion in old dogs Neuroendocrinology 57 1993 432 438
41. Gil-Ad I. Gurewitz R. Marcovici O. Rosenfeld J. Laron Z. Effects of aging on human plasma growth hormone response to clonidine Mech Ageing Dev 27 1984 97 100
42. Vrontakis M.E. Torsello A. Friesen H.G. Galanin J Endocrinol Invest 14 1991 785 794
43. Giustina A. Bussi A.R. Conti C. Comparative effect of galanin and pyridostigmine on the growth hormone response to growth hormone-releasing hormone in normal aged subjects Horm Res 37 1992 165 170
44. Giusti M. Giovale M. Grossman A. Opioid analogue metenkephalin does not potentiate GH release after GHRH in elderly men J Endocrinol Invest 15 Suppl 4 1992 119
45. Smith R.G. Van der Ploeg L.X.T. Howard A.D. Peptidomimetic regulation of growth hormone secretion Endocr Rev 18 1997 621 645
46. 125I p-benzoyl-phenylalanine hexarelinderivative Endocrinology 139 1998 432 435
47. Muccioli G. Ghe C. Ghigo M.C. GHRP receptors in pituitary, central nervous system and peripheral human tissues J Endocrinol Invest 20 Suppl 4 1997 52
48. Howard A.D. Feighner S.D. Cully D.F. A receptor in pituitary and hypothalamus that functions in growth hormone release Science 273 1996 974 977
49. Bowers C.Y. Sartor A.O. Reynolds G.A. Badger T.M. On the action of the growth hormone-releasing hexapeptide, GHRP Endocrinology 128 1991 2027 2035
50. Dickson S.L. Luckman S.M. Induction of c-fos messenger ribonucleic acid in neuropeptide Y and growth hormone (GH)-releasing factor neurons in the rat arcuate nucleusfollowing systemic injection of the GH segretagogue, GH-releasing peptide-6 Endocrinology 138 1997 771 777
51. Fairhall K.M. Mynett A. Robinson I.C.A.F. Central effects of growth hormone-releasing hexapeptide (GHRP-6) on growth hormone release are inhibited by central somatostatin action J Endocrinol 144 1995 555 560
52. Arvat F. Gianotti L. Di Vito L. Modulation of growth hormone-releasing activity of hexarelin in man Neuroendocrinology 61 1995 51 56
53. Ghigo E. Arvat F. Gianotti L. Growth hormone-releasing activity of hexarelin, a new synthetic hexapeptide, after intravenous, subcutaneous, intranasal and oral administration inman J Clin Endocrinol Metab 78 1994 693 698
54. Arvat E. Camanni F. Ghigo E. Age-related growth hormone-releasing activity of growth hormone secretagogues in humans Acta Paediatr Suppl 423 1997 92 96
55. Chapman I.M. Bach M.A. Van Canter E. Stimulation of the growth hormone (GH)-insulin-like growth factor I axis by daily oral administration of a GH secretagogue (MK-677) in healthy elderly subjects J Clin Endocrinol Metab 81 1996 4249 4257