Reduced retention of cadmium in the liver of metallothionein-null mice

Environmental Toxicology and Pharmacology

Volumn 1, Issue 3, 1996, Pages 213-216

  Tohyama, Chiharu ^a   Satoh, Masahiko ^a   Kodama, Naomi ^a   Nishimura, Hisao ^b   Choo, Andy ^c   Michalska, Anna ^c   Kanayama, Yoshitaka ^d   Naganuma, Akira ^d  

^a NATIONAL INSTITUTE FOR ENVIRONMENTAL STUDIES   (Japan)

^b Japan   (Japan)

^c ROYAL CHILDREN'S HOSPITAL   (Australia)

^d TOHOKU UNIVERSITY   (Japan)

Author keywords

Cadmium; Metallothionein; Metallothionein null mice

Indexed keywords

CADMIUM CHLORIDE; METALLOTHIONEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; BLOOD SAMPLING; CADMIUM POISONING; CONTROLLED STUDY; GENE MUTATION; MALE; METAL METABOLISM; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFECT; RADIOIMMUNOASSAY; SPECTROMETRY; TISSUE DISTRIBUTION; TISSUE HOMOGENATE; TRANSGENIC MOUSE;

ANIMALIA; MUS MUSCULUS;

EID: 0029937179     PISSN: 13826689     EISSN: None     Source Type: Journal    
DOI: 10.1016/1382-6689(96)00014-2     Document Type: Article

References (18)

1. Bremner, I., 1979, Mammalian absorption, transport and excretion of cadmium, in: The Chemistry, Biochemistry and Biology of Cadmium, ed. M. Webb (Elsevier, Amsterdam) p. 175.
2. Cherian, M.G. and Z.A. Shaikh, 1975, Metabolism of intravenously injected cadmium binding protein. Biochem. Biophys. Res. Commun. 65, 863.
3. Eaton, D.L. and M.G. Cherian, 1991, Determination of metallothionein in tissues by cadmium-hemoglobin affinity assay. Methods Enzymol. 205, 83.
4. Elinder, C.-G. and G.F. Nordberg, 1986, Metallothionein, in: Cadmium and Health: A Toxicological and Epidemiological Appraisal. Vol. 1, eds. L. Friberg, C.-G. Elinder, T. Kjellstrom and G.F. Nordberg (CRC Press, Boca Raton, FL) p. 73.
5. Friberg, L., C.-G. Elinder, T. Kjellstrom and G.F. Nordberg, 1986, Cadmium and Health: A Toxicological and Epidemiological Appraisal, Vol. 2 (CRC press, Boca Raton, FL) p. 307.
6. Hoshi, F., M. Satoh, S. Koyama, K. Nakadaka, M. Chiba, N. Ikeda, R. Hakamada, S. Higuchi and S. Kawamura, 1994, Application to cows and horses of Spotchem, a dry-chemistry blood analyzer for use in veterinary clinics, J. Vet. Med. A 41, 22.
7. Kägi, J.H.R. and Y. Kojima, 1986, Metallothionein II, Experientia 52 (suppl.), 755.
8. Masters, B.A., E.J. Kelly, C.J. Quaife, R.L. Brinster and R.D. Palmiter, 1994, Targeted disruption of metallothionein I and II genes increases sensitivity to cadmium, Proc. Natl Acad. Sci. USA 91, 584.
9. Michalska, A.E. and K.H. Choo, 1993, Targeting and germ-line transmission of a null mutation at the metallothionein I and II loci in mouse, Proc. Natl. Acad. Sci. USA 90, 8088.
10. Nishimura, H., N. Nishimura and C. Tohyama, 1990, Localization of metallothionein in the genital organs of the male rat, J. Histochem. Cytochem. 38, 927.
11. Nordberg, G.F., T. Kjellstrom and M. Nordberg, 1985, Kinetics and metabolism, in: Cadmium and Health: A Toxicological and Epidemiological Appraisal. Vol. 1, eds. L. Friberg, C.-G. Elinder, T. Kjellstrom and G.F. Nordberg (CRC Press, Boca Raton, FL) p. 103.
12. Palmiter, R.D., S.D. Findley, T.E. Whitemore and D.M. Durnam, 1992, MT-III, a brain-specific member of the metallothionein gene family, Proc. Natl. Acad. Sci. USA 89, 6333.
13. Quaife, C.J., S.D. Findley, G.J. Erickson, E.J. Kelly, B.W. Zambrowicz and R.D. Palmiter, 1994, Induction of a new metallothionein isoform (MT-IV) occurs during differentiation of stratified squamous epithelia, Biochemistry 33, 7250.
14. Suzuki, K.T., 1982, Induction and degradation of metallothionein and their relation to the toxicity of cadmium, Biological Roles of Metallothionein. ed. E.C. Foulkes (Elsevier, Amsterdam) p. 215.
15. 109Cd-labeled metallothionein in rats, Toxicol. Appl. Pharmacol. 33, 258.
16. Tohyama, C., J.S. Suzuki, S.T. Homma, N. Nishimura and H. Nishimura, 1993. Regulation of metallothionein biosynthesis in genital organs of male rats, in: Metallothionein III: Biological Roles and Medical Implications, eds. K.T. Suzuki, N. Imura and M. Kimura (Birkhauser, Basel) p. 443.
17. Uchida, Y., K. Takio, K. Titani, Y. Ihara and M. Tomonaga, 1991, The growth inhibitory factor that is deficient in the Alzheimer's disease brain is a 68 amino acid metallothionein-like protein, Neuron 7, 337.
18. Webb, M., 1979, The metallothioneins, in: The Chemistry, Biochemistry and Biology of Cadmium, ed. M. Webb (Elsevier, Amsterdam) p. 195.