Decreased expression of retinoic acid receptors, transforming growth factor β, involucrin, and cornifin in cervical intraepithelial neoplasia

Clinical Cancer Research

Volumn 5, Issue 6, 1999, Pages 1503-1508

  Xu, Xiao Chun ^a   Mitchell, Michele F ^a   Silva, Elvio ^a   Jetten, Anton ^b   Lotan, Reuben ^a  

^a UNIVERSITY OF TEXAS   (United States)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CORNIFIN; INVOLUCRIN; RETINOIC ACID RECEPTOR; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2;

ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; RECEPTOR DOWN REGULATION; UTERINE CERVIX CARCINOMA IN SITU;

CERVICAL INTRAEPITHELIAL NEOPLASIA; DOWN-REGULATION; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MEMBRANE PROTEINS; PROTEIN PRECURSORS; RECEPTORS, RETINOIC ACID; RNA, MESSENGER; TRANSFORMING GROWTH FACTOR BETA; TUMOR MARKERS, BIOLOGICAL; UTERINE CERVICAL NEOPLASMS;

EID: 0033052303     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (48)

1. Morrow, C. P., and Cozen, W. Perspective on cervical cancer: why prevent? J. Cell. Biochem. Suppl., 23: 61-70, 1995.
2. Morris, M., Tortolero-Luna, G., Malpica, A., Baker, V. V., Cook, E., Johnson, E., and Pollen Mitchell, M. Cervical intraepithelial neoplasia and cervical cancer. Obstet. Gynecol. Clin. N. Am., 23: 347-410, 1996.
3. Landis, S. H., Murray, T., Bolden, S., and Wingo, P. A. Cancer statistics 1999. CA Cancer J. Clin., 49: 8-31, 1999.
4. Hong, W. K., and Sporn, M. B. Recent advances in chemoprevention of cancer. Science (Washington DC), 278: 1073-1077, 1997.
5. Kelloff, G. J., Boone, C. W., Crowell, J. A., Nayfield, S. G., Hawk, E., Steele, V. E., Lubet, R. A., and Sigman, C. C. Strategies for phase II cancer chemoprevention trials: cervix, endometrium, and ovary. J. Cell. Biochem. Suppl., 23: 1-9, 1995.
6. Mitchell, M. F., Hittelman, W. N., Lotan, R., Nishioka, K., Tortolero-Luna, G., Richards-Kortum, R., and Hong, W. K. Chemoprevention trials in the cervix: design, feasibility, and recruitment. J. Cell. Biochem. Suppl., 23: 104-112, 1995.
7. Mitchell, M. F., Tortolero-Luna, G., Wright, T., Sarkar, A., Richards-Kortum, R., Hong, W. K., and Schottenfeld, D. Cervical human papillomavirus infection and intraepithelial neoplasia: a review. J. Natl. Cancer Inst. Monogr., 21: 17-25, 1996.
8. Moon, R. C., and Mehta, R. G. Cancer chemoprevention by retinoids: animal models. Methods Enzymol., 190: 395-406, 1990.
9. Lippman, S. M., Kavanagh, J. J., Paredes-Espinoza, M., Delgadillo-Madrueno, F., Paredes-Casillas, P., Hong, W. K., Holdener, E., and Krakoff, I. H. 13-cis-Retinoic acid plus interferon α-2a: highly active systemic therapy for squamous cell carcinoma of the cervix [see comments]. J. Natl. Cancer Inst., 84: 241-245, 1992.
10. Lippman, S. M., Kavanagh, J. J., Paredes-Espinoza, M., Delgadillo-Madrueno, F., Paredes-Casillas, P., Hong, W. K., Massimini, G., Holdener, E. E., and Krakoff, I. H. 13-cis-Retinoic acid plus interferon-α 2a in locally advanced squamous cell carcinoma of the cervix. J. Natl. Cancer Inst., 85: 499-500, 1993.
11. Batova, A., Danielpour, D., Pirisi, L., and Creek, K. E. Retinoic acid induces secretion of latent transforming growth factor β1 and β2 in normal and human papillomavirus type 16-immortalized human keratinocytes. Cell Growth Differ., 3: 763-772, 1992.
12. Boone, C. W., and Kelloff, G. J. Intraepithelial neoplasia, surrogate endpoint biomarkers, and cancer chemoprevention. J. Cell. Biochem. Suppl., 17F: 37-48, 1993.
13. Hong, W. K., and Itri, L. M. Retinoids and human cancer. In: M. B. Sporn, A. B. Roberts, and D. S. Goodman (eds.), The Retinoids, pp. 597-658. New York: Raven Press, 1994.
14. Meyskens, F. L., Jr., Surwit, E., Moon, T. E., Childers, J. M., Davis, J. R., Dorr, R. T., Johnson, C. S., and Alberts, D. S. Enhancement of regression of cervical intraepithelial neoplasia II (moderate dysplasia) with topically applied all-trans-retinoic acid: a randomized trial [see comments]. J. Natl. Cancer Inst., 86: 539-543, 1994.
15. Lancillotti, F., Giandomenico, V., Affabris, E., Fiorucci, G., Romeo, G., and Rossi, G. B. Interferon α-2b and retinoic acid combined treatment affects proliferation and gene expression of human cervical carcinoma cells. Cancer Res., 55: 3158-3164, 1995.
16. Eckert, R. L., Agarwal, C., Hembree, J. R., Choo, C. K., Sizemore, N., Andreatta-van Leyen, S., and Rorke, E. A. Human cervical cancer. Retinoids, interferon and human papillomavirus. Adv. Exp. Med. Biol., 375: 31-44, 1995.
17. Lotan, R., Dawson, M. I., Zou, C. C., Jong, L., Lotan, D., and Zou, C. P. Enhanced efficacy of combinations of retinoic acid- and retinoid X receptor-selective retinoids and α-interferon in inhibition of cervical carcinoma cell proliferation. Cancer Res., 55: 232-236, 1995.
18. Behbakht, K., DeGeest, K., Turyk, M. E., and Wilbanks, G. D. All-trans-retinoic acid inhibits the proliferation of cell lines derived from human cervical neoplasia. Gynecol. Oncol., 61: 31-39, 1996.
19. Mangelsdorf, D. J., Umesono, K., and Evans, R. M. The retinoid receptors. In: M. B. Sporn, A. B. Roberts, and D. S. Goodman (eds.), The Retinoids, pp. 319-350. New York: Raven Press, 1994.
20. Chambon, P. A decade of molecular biology of retinoic acid receptors. FASEB J., 10: 940-954, 1996.
21. Kelloff, G. J., Boone, C. W., Crowell, J. A., Steele, V. E., Lubet, R., and Doody, L. A. Surrogate endpoint biomarkers for phase II cancer chemoprevention trials. J. Cell. Biochem. Suppl., 19: 1-9, 1994.
22. Ruffin, M. T. T., Ogaily, M. S., Johnston, C. M., Gregoire, L., Lancaster, W. D., and Brenner, D. E. Surrogate endpoint biomarkers for cervical cancer chemopreventive trials. J. Cell. Biochem. Suppl., 23: 113-124, 1995.
23. Mitchell, M. F., Hittelman, W. K., Lotan, R., Nishioka, K., Tortolero-Luna, G., Richards-Kortum, R., Wharton, J. T., and Hong, W. K. Chemoprevention trials and surrogate end point biomarkers in the cervix. Cancer (Phila.), 76: 1956-1977, 1995.
24. Xu, X. C., Ro, J. Y., Lee, J. S., Shin, D. M., Hong, W. K., and Lotan, R. Differential expression of nuclear retinoid receptors in normal, premalignant, and malignant head and neck tissues. Cancer Res., 54: 3580-3587, 1994.
25. Lotan, R., Xu, X. C., Lippman, S. M., Ro, J. Y., Lee, J. S., Lee, J. J., and Hong, W. K. Suppression of retinoic acid receptor-β in premalignant oral lesions and its up-regulation by isotretinoin. N. Engl. J. Med., 332: 1405-1410, 1995.
26. Lotan, R., Xu, X-C., Zou, C., and Hong, W-K. Retinoids and their receptors in modulation of differentiation, development, and prevention of head and neck cancer. Ann. Oncol., 5 (Suppl. 9): S23-S28, 1994.
27. Xu, X. C., Clifford, J. L., Hong, W. K., and Lotan, R. Detection of nuclear retinoic acid receptor mRNA in histological tissue sections using nonradioactive in situ hybridization histochemistry. Diagn. Mol. Pathol., 3: 122-131, 1994.
28. Xu, X. C., Lee, J. S., Lippman, S. M., Ro, J. Y., Hong, W. K., and Lotan, R. Increased expression of cytokeratins CK8 and CK19 is associated with head and neck carcinogenesis. Cancer Epidemiol. Biomark. Prev., 4: 871-876, 1995.
29. Park, T. K., Lee, J. P., Kim, S. N., Choi, S. M., Kudelka, A. P., and Kavanagh, J. J. Interferon-α2a, 13-cis-retinoic acid and radiotherapy for locally advanced carcinoma of the cervix: a pilot study. Eur. J. Gynaecol. Oncol., 19: 353-358, 1998.
30. Darwiche, N., Celli, G., Sly, L., Lancillotti, F., and De Luca, L. M. Retinoid status controls the appearance of reserve cells and keratin expression in mouse cervical epithelium. Cancer Res., 53: 2287-2299, 1993.
31. Zou, C. P., Clifford, J. L., Xu, X. C., Sacks, P. G., Chambon, P., Hong, W. K., and Lotan, R. Modulation by retinoic acid (RA) of squamous cell differentiation, cellular RA-binding proteins, and nuclear RA receptors in human head and neck squamous cell carcinoma cell lines. Cancer Res., 54: 5479-5487, 1994.
32. Jetten, A. M., De Luca, L. M., Nelson, K., Schroeder, W., Burlingame, S., and Fujimoto, W. Regulation of cornifin a expression in the vaginal and uterine epithelium by estrogen and retinoic acid. Mol. Cell. Endocrinol., 123: 7-15, 1996.
33. Sabichi, A. L., Hendricks, D. T., Bober, M. A., and Birrer, M. J. Retinoic acid receptor pi expression and growth inhibition of gynecologic cancer cells by the synthetic retinoid N-(4-hydroxyphenyl) retinamide. J. Natl. Cancer Inst., 90: 597-605, 1998.
34. de The, H. Altered retinoic acid receptors. FASEB J., 10: 955-960, 1996.
35. Darwiche, N., Celli, G., and De Luca, L. M. Specificity of retinoid receptor gene expression in mouse cervical epithelia. Endocrinology, 134: 2018-2025, 1994.
36. Bartsch, D., Boye, B., Baust, C., zur Hausen, H., and Schwarz, E. Retinoic acid-mediated repression of human papillomavirus 18 transcription and different ligand regulation of the retinoic acid receptor β gene in non-tumorigenic and tumorigenic HeLa hybrid cells. EMBO J., 11: 2283-2291, 1992.
37. Celli, G., Darwiche, N., and De Luca, L. M. Estrogen induces retinoid receptor expression in mouse cervical epithelia. Exp. Cell Res., 226: 273-282, 1996.
38. Geisen, C., Denk, C., Gremm, B., Baust, C., Karger, A., Bollag, W., and Schwarz, E. High-level expression of the retinoic acid receptor β gene in normal cells of the uterine cervix is regulated by the retinoic acid receptor a and is abnormally down-regulated in cervical carcinoma cells. Cancer Res., 57: 1460-1467, 1997.
39. Sporn, M. B., Roberts, A. B., Wakefield, L. M., Click, A. B., and Danielpour, D. Transforming growth factor-β and suppression of carcinogenesis. Princess Takamatsu Symp., 20: 259-266, 1989.
40. Click, A. B., Sporn, M. B., and Yuspa, S. H. Altered regulation of TGF-β1 and TGF-α in primary keratinocytes and papillomas expressing v-Ha-ras. Mol. Carcinog., 4: 210-219, 1991.
41. Click, A. B., Kulkarni, A. B., Tennenbaum, T., Hennings, H., Flanders, K. C., O'Reilly, M., Sporn, M. B., Karlsson, S., and Yuspa, S. H. Loss of expression of transforming growth factor β in skin and skin tumors is associated with hyperproliferation and a high risk for malignant conversion. Proc. Natl. Acad. Sci. USA. 90: 6076-6080, 1993.
42. Comerci, J. T., Jr., Runowicz, C. D., Flanders, K. C., De Victoria, C., Fields, A. L., Kadish, A. S., and Goldberg, G. L. Altered expression of transforming growth factor-β1 in cervical neoplasia as an early biomarker in carcinogenesis of the uterine cervix. Cancer (Phila.), 77: 1107-1114, 1996.
43. Lorincz, A. T., Reid, R., Jenson, A. B., Greenberg, M. D., Lancaster, W., and Kurman, R. J. Human papillomavirus infection of the cervix: relative risk associations of 15 common anogenital types. Obstet. Gynecol., 79: 328-337, 1992.
44. Woodworth, C. D., Notario, V., and DiPaolo, J. A. Transforming growth factors β1 and 2 transcriptionally regulate human papillomavirus (HPV) type 16 early gene expression in HPV-immortalized human genital epithelial cells. J. Virol., 64: 4767-4775, 1990.
45. Sassoon, A. F., Said, J. W., Nash, G., Shintaku, I. P., and Banks-Schlegel, S. Involucrin in intraepithelial and invasive squamous cell carcinomas of the cervix: an immunohistochemical study. Hum. Pathol., 16: 467-470, 1985.
46. Marvin, K. W., George, M. D., Fujimoto, W., Saunders, N. A., Bernacki, S. H., and Jetten, A. M. Cornifin, a cross-linked envelope precursor in keratinocytes that is down-regulated by retinoids. Proc. Natl. Acad. Sci. USA, 89: 11026-11030, 1992.
47. Auersperg, N., Kruk, P. A., MacLaren, I. A., Watt, F. M., and Mydral, S. E. Heterogeneous expression of keratin, involucrin, and extracellular matrix among subpopulations of a poorly differentiated human cervical carcinoma: possible relationships to patterns of invasion. Cancer Res., 49: 3007-3014, 1989.
48. Nair, S. A., Nair, M. B., Jayaprakash, P. G., Rajalekshmy, T. N., Nair, M. K., and Pillai, M. R. Involucrin and tumor progression in the uterine cervix. Pathobiology, 64: 333-338, 1996.