Pathogenic neisseriae: Complexity of pathogen - Host cell interplay

Clinical Infectious Diseases

Volumn 28, Issue 3, 1999, Pages 433-441

  Meyer, Thomas F ^a,b  

^a MAX PLANCK INST FÜR BIOLOGIE   (Germany)

^b Max Planck Insitut F I   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL COLONIZATION; BACTERIUM PILUS; CELL ADHESION; CONFERENCE PAPER; CYTOKINE RELEASE; HOST CELL; IMMUNE RESPONSE; NEISSERIA; NONHUMAN; PATHOGENICITY; PERIODONTAL DISEASE; PHAGOCYTOSIS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

EID: 0033051472     PISSN: 10584838     EISSN: None     Source Type: Journal    
DOI: 10.1086/515160     Document Type: Conference Paper

References (50)

1. 1. Kallstrom H, Liszewski MK, Atinkson JP, Jonsson A-B. Membrane cofactor protein (MCP or CD46) is a cellular pilus receptor for pathogenic Neisseria. Mol Microbiol 1997;25:619-38.
2. 1a. Dehio C, Gray-Owen SD, Meyer TF. The role of neisserial Opa proteins in interactions with host cells. Trends Microbiol 1998;6:489-95.
3. 2. Parge HE, Forest KT, Hickey MJ, Christensen DA, Getzoff ED, Tainer JA. Structure of the fibre-forming protein pilin at 2.6 Å resolution. Nature 1995;378:32-8.
4. 3. Haas R, Meyer TF. The repertoire of silent pilus genes in Neisseria gonorrhoeae: evidence for gene conversion. Cell 1986;44:107-15.
5. 4. Jonsson AB, Nyberg G, Normark S. Phase variation of gonococcal pili by frameshift mutation in pilC, a novel gene for pilus assembly. EMBO J 1991;10:477-88.
6. 5. Rudel T, Facius D, Barten R, Scheuerpflug I, Nonnenmacher E, Meyer TF. Role of pili and the phase-variable PilC protein in natural competence for transformation of Neisseria gonorrhoeae. Proc Natl Acad Sci USA 1995;92:7986-990.
7. 6. Rudel T, Scheuerpflug I, Meyer TF. Neisseria PilC protein identified as type-4 pilus tip-located adhesin. Nature 1995;373:357-9.
8. 7. Fussenegger M, Rudel T, Barten R, Ryll R, Meyer TF. Transformation competence and type-4 pilus biogenesis in Neisseria gonorrhoeae. Gene 1997;192:125-34.
9. 8. Makino S, van Putten JPM, Meyer TF. Phase variation of the opacity outer membrane protein controls invasion by Neisseria gonorrhoeae into human epithelial cells. EMBO J 1991;10:1307-15.
10. 9. van Putten JPM. Phase variation of lipopolysaccharide directs interconversion of invasive and immuno-resistant phenotypes of Neisseria gonorrhoeae. EMBO J 1993;12:4043-51.
11. 10. McGee DJ, Rest RF. Regulation of gonococcal sialyltransferase, lipooligosaccharide, and serum resistance by glucose, pyruvate, and lactate. Infect Immun 1996;64:4630-7.
12. 11. Apicella MA, Ketterer M, Lee FKN, Zhuo D, Rice PA, Blake MS. The pathogenesis of gonococcal urethritis in men: confocal and immunoelectron microscopic analysis of urethral exudates from men infected with Neisseria gonorrhoeae. J Infect Dis 1996;173:636-46.
13. 12. McGee ZA, Johnson AP, Taylor-Robinson D. Pathogenic mechanisms of Neisseria gonorrhoeae: observations on damage to human fallopian tubes in organ culture by gonococci of colony type I or type 4. J Infect Dis 1981;143:413-22.
14. 13. Mosleh I, Boxberger H-J, Sessler MJ, Meyer TF. Experimental infection of native human ureteral tissue with Neisseria gonorrhoeae: adhesion, invasion, intracellular fate, exocytosis, and passage through a stratified epithelium. Infect Immun 1997;65:3391-8.
15. 14. Wang J, Gray-Owen SG, Knorre A, Meyer TF, Dehio C. Opa binding to cellular CD66 receptors mediates the transcellular traversal of Neisseria gonorrhoeae across polarized T84 epithelial cell monolayers. Mol Microbiol 1998;30:657-71.
16. 15. Stern A, Brown M, Nickel P, Meyer TF. Opacity genes in Neisseria gonorrhoeae control of phase and antigenic variation. Cell 1986;47: 61-71.
17. 16. Connell TD, Black WJ, Kawula TH, et al. Recombination among protein II genes of Neisseria gonorrhoeae generates new coding sequences and increases structural variability in the protein II family. Mol Microbiol 1988;2:227-36.
18. 17. Kupsch E-M, Knepper B, Kuroki T, Heuer I, Meyer TF. Variable opacity (Opa) outer membrane proteins account for the cell tropisms displayed by Neisseria gonorrhoeae for human leukocytes and epithelial cells. EMBO J 1993;12:650.
19. 18. van Putten JPM, Paul SM. Binding of syndecan-like cell surface proteoglycan receptors is required for Neisseria gonorrhoeae entry into human mucosal cells. EMBO J 1995;14:2144-54.
20. 19. Chen T, Belland R, Wilson J, Swanson J. Adherence of pilus-Opa+ gonococci to epithelial cells in vitro involves heparan sulfate. J Exp Med 1995;182:511-7.
21. 20. Chen T, Gotschlich EC. CGM1a antigen of neutrophils, a receptor of gonococcal opacity proteins. Proc Natl Acad Sci USA 1996;93: 14851-6.
22. 21. Gray-Owen SD, Dehio C, Haude A, Grunert F, Meyer TF. CD66 carcinoembryonic antigens mediate interactions between Opa-expressing Neisseria gonorrhoeae and human polymorphonuclear phagocytes. EMBO J 1997;16:3435-45.
23. 22. Bos MP, Grunert F, Belland RJ. Differential recognition of members of the carcinoembryonic antigen family by Opa variants of Neisseria gonorrhoeae. Infect Immun 1997;65:2353-61.
24. 23. Virji M, Makepeace K, Ferguson DJP, Watt SM. Carcinoembryonic antigens (CD66) on epithelial cells and neutrophils are receptors for Opa proteins of pathogenic neisseriae. Mol Microbiol 1996;22: 941-50.
25. 24. David G. Integral membrane heparan sulfate proteoglycans. FASEB J 1993;7:1023-30.
26. 25. Thompson JA, Grunert F, Zimmermann W. Carcinoembryonic antigen gene family: molecular biology and clinical perspectives. J Clin Lab Anal 1991;5:344-66.
27. 26. Grassmé H, Gulbins E, Brenner B, et al. Acidic sphingomyelinase mediates entry of N. gonorrhoeae into nonphagocytic cells. Cell 1997;91:605-15.
28. 27. Gómez-Duarte OG, Dehio M, Guzmán CA, Chhatwal GS, Dehio C, Meyer TF. Binding of vitronectin to Opa-expressing Neisseria gonorrhoeae mediates invasion of HeLa cells. Infect Immun 1997;65:3857-66.
29. 28. Schafer WM, Rest RF. Interactions of gonococci with phagocytic cells. Annu Rev Microbiol 1989;43:121-45.
30. 29. van Putten JPM, Duensing TD, Cole RL. Entry of OpaA+ gonococci into HEp-2 cells requires concerted action of glycosaminoglycans, fibronectin and integrin receptors. Mol Microbiol 1998;29:369-79.
31. 30. Preissner KT. Structure and biological role of vitronectin. Annual Review of Cell Biology 1991;7:275-310.
32. v integrin receptors. FEBS Lett 1998;424:84-8.
33. 32. Newton AC. Regulation of protein kinase C. Curr Opin Cell Biol 1997; 9:161-7.
34. 33. Dehio C, Freissler E, Lanz C, Gómez-Duarte OG, David G, Meyer TF. Ligation of cell surface-associated heparan sulfate proteoglycans by antibody-coated beads stimulates phagocytic uptake into epithelial cells: a model for cellular invasion by Neisseria gonorrhoeae. Exp Cell Res 1998;30:657-71.
35. 34. Blake MS, Gotschlich EC. Functional and immunological properties of pathogenic Neisseria surface proteins. In: Inouye M, ed. Bacterial outer membranes as model systems. New York: John Wiley & Sons, Inc., 1987:377-400.
36. 35. Rudel T, Schmid A, Benz R, Kolb H-A, Lang F, Meyer TF. Modulation of neisseria porin (PorB) by cytosolic ATP/GTP of target cells: parallels between pathogen accommodation and mitochondrial endosymbiosis. Cell 1996;85:391-402.
37. 35a. Bauer FJ, Rudel T, Stein M, Meyer TF. Mutagenesis of the Neisseria gonorrhoeae porin reduces invasion in epithelial cells and increases uptake by phagocytes. Mol Microbiol 1998 (in press).
38. 35b. Müller A, Günther D, Düx F, Naumann M, Meyer TF, Rudel T. Neisserial porin (PorB) causes rapid calcium influx in target cells and induces apoptosis by the activation of cysteine proteases. EMBO J 1999 (in press).
39. 36. Fussenegger M, Kahrs AF, Facius D, Meyer TF. Tetrapac (tpc), a novel genotype of Neisseria gonorrhoeae affecting epithelial cell invasion, natural transformation competence and cell separation. Mol Microbiol 1996;19:1357-72.
40. 37. Naumann M, Wessler S, Bartsch C, Wieland B, Meyer TF. Neisseria gonorrhoeae epithelial cell interaction leads to the activation of the transcription factors NF-kB and AP1 and the induction of inflammatory cytokines. J Exp Med 1997;186:247-58.
41. 38. Duensing TD, van Putten JPM. Vitronectin mediates internalization of Neisseria gonorrhoeae by Chinese hamster ovary cells. Infect Immun 1997;65:964-70.
42. 39. Hauck CR, Lorenzen D, Saas J, Meyer TF. An in vitro-differentiated human cell line as a model system to study the interaction of Neisseria gonorrhoeae with phagocytic cells. Infect Immun 1997;65: 1863-9.
43. 52 Neisseria gonorrhoeae requires a Src-like tyrosine kinase-and Rac 1-dependent signalling pathway. EMBO J 1998;17: 443-54.
44. 2 generation. J Biol Chem 1988;263:945-51.
45. 41a. Mosleh IM, Huber LA, Steinlein P, Pasquali C, Günther D, Meyer TF. Neisseria gonorrhoeae porin modulates phagosome maturation. J Biol Chem 1998;273:35332-8.
46. 42. Hauck CR, Meyer TF. The lysomal/phagosomal membrane protein h-lamp-1 is a target of the IgA1 protease of Neisseria gonorrhoeae. FEBS Lett 1997;405:86-90.
47. 42a. Lin L, Ayala P, Larson J, et al. The Neisseria type 2 IgA1 protease cleaves lamp1 and promotes survival of bacteria within epithelial cells. Mol Microbiol 1997;24:1083-94.
48. 43. Finlay BB, Falkow S. Common themes in microbial pathogenicity revisited. Microbiol Mol Biol Rev 1997;61:136-69.
49. 44. Meyer TF, Pohlner J, van Putten JPM. Biology of the pathogenic Neisseria. Curr Top Microbiol Immunol 1994;192:283-309.
50. 45. Seifert HS. Questions about gonococcal pilus phase and antigenic variation. Mol Microbiol 1996;21:433-40.