The prevalence of antibody to CagA in children is not a marker for specific disease

Journal of Pediatric Gastroenterology and Nutrition

Volumn 28, Issue 1, 1999, Pages 71-75

  Mitchell, Hazel M ^a   Hazell, Stuart L ^a   Bohane, Timothy D ^b   Hu, Pinjin ^c   Chen, Minhu ^c   Li, Yu Yuan ^c  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

^b SYDNEY CHILDREN'S HOSPITAL   (Australia)

^c SUN YAT SEN UNIVERSITY   (China)

Author keywords

Antibody; CagA; Children; Helicobacter pylori; Peptic ulcer disease

Indexed keywords

BIOCHEMICAL MARKER; CYTOTOXIN;

ANTIBODY RESPONSE; ANTIBODY SPECIFICITY; ANTIGEN SPECIFICITY; ARTICLE; BACTERIAL VIRULENCE; GEOGRAPHIC DISTRIBUTION; HELICOBACTER PYLORI; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOGENICITY; PEPTIC ULCER; PREVALENCE; PRIORITY JOURNAL; SEROPREVALENCE;

ADOLESCENT; ANTIBODIES, BACTERIAL; ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; CHILD; CHILD, PRESCHOOL; GASTROINTESTINAL DISEASES; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; IMMUNOBLOTTING; INFANT; SEROEPIDEMIOLOGIC STUDIES;

BACTERIA (MICROORGANISMS); HELICOBACTER PYLORI;

EID: 0033051351     PISSN: 02772116     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005176-199901000-00016     Document Type: Article

References (31)

1. Graham DY. Campylobacter pylori and peptic ulcer disease. Gastroenterology 1989;96:615-25.
2. Mitchell HM, Bohane TD, Tobias V, et al. Helicobacter pylori infection in children: Potential clues to pathogenesis. J Pediat Gastroenterol Nutr 1993;16:120-5.
3. Drumm B, Sherman P, Cutz E, Karmali M. Association of Campylobacter pylori on the gastric mucosa with antral gastritis in children. N Engl J Med 1987;316:1557-61.
4. Lee A, Axon ATR, Dixon MF, O'Connor HJ, Solcia E, Sipponen P. Helicobacter pylori and its role in gastritis, peptic ulcer and gastric cancer: Discussion. Scand J Gastroenterol 1994;29(Suppl 201):35-7.
5. Dooley CP, Cohen H, Fitzgibbons PL, et al. Prevalence of Helicobacter pylori infection and histologic gastritis in asymptomatic persons. N Engl J Med 1989;321:1562-6.
6. Mitchell HM, Lee A. Are there ulcerogenic strains of H. pylori? J Gastroenterol Hepatol 1994;6(Suppl 1):S11-S16.
7. Covacci A, Censini S, Bugnoli M, et al. Molecular characterisation of the 128 KDa immunodominant antigen of Helicobacter pylori associated with cytotoxicity and duodenal ulcer. Proc Natl Acad Sci 1993;90:5791-95.
8. Blaser MJ. Helicobacter pylori phenotypes associated with peptic ulceration. Scand J Gastroenterol 1994;29(Suppl 205):1-5.
9. Xiang ZY, Censini S, Bayeli PF, et al. Analysis of expression of CagA and VacA virulence factors in 43 strains of Helicobacter pylori reveals that clinical isolates can be divided into two major types and that CagA is not necessary for expression of the vacuolating cytotoxin. Infect Immun 1995;63:94-8.
10. Hazell SL, Andrews RH, Mitchell HM, Daskalopoulous G. Genetic relationship among isolates of Helicobacter pylori: Evidence for the existence of a Helicobacter pylori species-complex. FEMS Microbiol Lett 1997;150:27-32.
11. Crabtree JE, Taylor JD, Wyatt JI, et al. Mucosal IgA recognition of Helicobacter pylori 120 kDa protein, peptic ulceration, and gastric pathology. Lancet 1991;338:332-5.
12. Covacci A, Censini S, Bugnoli M, et al. Molecular characterization of the 128-kDa immunodominant antigen of Helicobacter pylori associated with cytotoxicity and duodenal ulcer. Proc Natl Acad Sci USA 1993;90:5791-5.
13. Crabtree JE, Wyatt JI, Sobala GM, et al. Systemic and mucosal humoral responses to Helicobacter pylori in gastric cancer. Gut 1993;34:1339-43.
14. Parsonnet J, Friedman GD, Orentreich N, Vogelman H. Risk for gastric cancer in people with cagA positive or cagA negative Helicobacter pylori infection. Gut 1997;40:297-301.
15. Peek RM, Miller GG, Tham KT, et al. Detection of Helicobacter pylori gene expression in human gastric mucosa. J Clin Microbiol 1995;33:28-32.
16. Cover TL, Glupczynski Y, Lage AP, et al. Serologic detection of infection with cagA(+) Helicobacter pylori strains. J Clin Microbiol 1995;33:1496-500.
17. Husson MO, Gottrand F, Vachee A, et al. Importance in diagnosis of gastritis of detection by PCR of the caga gene in Helicobacter pylori strains isolated from children. J Clin Microbiol 1995;33: 3300-3.
18. Mitchell HM, Li YY, Hu PJ, et al. Epidemiology of Helicobacter pylori in Southern China: Identification of early childhood as the critical period for acquisition. J Infect Dis 1992;166:149-53.
19. Hu PJ, Li YY, Mitchell HM, et al. Oxyntic and antral gastritis in the People's Republic of China: Diagnosis and relationship to Helicobacter pylori. Am J Gastroenterol 1992;87:741-5.
20. Mitchell HM, Lee A, Berkowicz J, Borody T. The use of serology to diagnose active Campylobacter pylori infection. Med J Aust 1988;149:604-9.
21. Price AB. The Sydney System: Histological division. J Gastroenterol Hepatol 1991;6:209-22.
22. Mitchell HM, Hazell SL, Li YY, Hu PJ. Serological response to specific Helicobacter pylori antigens: Antibody against cagA antigen is not predictive of gastric cancer in a developing country. Am J Gastroenterol 1996;91:1785-8.
23. Mitchell HM, Hazell SL, Kolesnikow T, Mitchell J, Frommer D. Antigen recognition during progression from acute to chronic infection with a cagA-positive strain of Helicobacter pylori. Infect Immun 1996;64:1166-72.
24. Glupczynski Y, Van den Borre C, Goutier S, Butzler JP. Evaluation of HelicoBlot 2.0 - a new commercial western blot test for the serological diagnosis of Helicobacter pylori infection (abstract). Gut 1995;37:A233.
25. Cover TL, Dooley CP, Blaser MJ. Characterization of and human serologic response to proteins in Helicobacter pylori broth culture supernatants with vacuolizing cytotoxin activity. Infect Immun 1990;58:603-10.
26. Ching CK, Wong B, Kwok E, Ong L, Covacci A, Lam SK. Prevalence of CagA-bearing Helicobacter pylori strains detected by the anti-CagA assay in patients with peptic ulcer disease and in control subjects. Am J Gastroenterol 1996;91:949-53.
27. Miehlke S, Kibler K, Kim JG, et al. Allelic variation in the cagA gene of Helicobacter pylori obtained from Korea compared to the United States. Am J Gastroenterol 1996;91:1322-5.
28. Pan ZJ, Vanderhulst RWM, Feller M, et al. Equally high prevalences of infection with cagA-positive Helicobacter pylori in Chinese patients with peptic ulcer disease and those with chronic gastritis-associated dyspepsia. J Clin Microbiol 1997;35:1344-7.
29. Van den Borre C, Cadranel S, Butzler JP, Glupczynski Y. Serum reactivity to Helicobacter pylori antigens assessed by HelicoBlot 2.0 in H. pylori positive children from different ethic groups (abstract). Gut 1995;37:A315.
30. Lage AP, Godfroid E, Fauconnier A, et al. Frequency of cagA in Helicobacter pylori strains isolated from Belgian and Moroccan patients (abstract). Gut 1995;37:A69.
31. Parsonnet J, Replogle M, Yang SF, Hiatt R. Seroprevalence of cagA-positive strains among Helicobacter pylori-infected, healthy young adults. J Infect Dis 1997;175:1240-2.