Effect of topical antioxidants on UV-induced erythema formation when administered after exposure

Dermatology

Volumn 198, Issue 1, 1999, Pages 52-55

  Dreher, F ^a   Denig, N ^a   Gabard, B ^c   Schwindt, D A ^a,b   Maibach, Howard I ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

^c Spirig Pharma Ltd   (Switzerland)

Author keywords

tocopherol; Aftersun lotion; Ascorbic acid; N acetyl 5 methoxytryptamine; Oxidative stress

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; MELATONIN; PLACEBO;

ADULT; ARTICLE; CONTROLLED STUDY; ERYTHEMA; FEMALE; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PRIORITY JOURNAL; RADIATION EXPOSURE; SKIN BLOOD FLOW; SKIN COLOR; TOPICAL DRUG ADMINISTRATION; ULTRAVIOLET RADIATION;

ADMINISTRATION, CUTANEOUS; ADULT; ANTIOXIDANTS; ASCORBIC ACID; DOUBLE-BLIND METHOD; ERYTHEMA; FEMALE; HUMANS; MALE; MELATONIN; MIDDLE AGED; REGIONAL BLOOD FLOW; SKIN; ULTRAVIOLET RAYS; VITAMIN E;

EID: 0033048735     PISSN: 10188665     EISSN: None     Source Type: Journal    
DOI: 10.1159/000018064     Document Type: Article

References (35)

1. Darr D, Fridovich I: Free radicals in cutaneous biology. J Invest Dermatol 1994;102:671-675.
2. Fuchs J, Huflejt ME, Rothfuss LM, Wilson DS, Carcamo G, Packer L: Impairment of enzymic and nonenzymic antioxidants in skin by UVB irradiation. J Invest Dermatol 1989;93:769-773.
3. Shindo Y, Witt E, Packer L: Antioxidant defense mechanisms in murine epidermis and dermis and their responses to ultraviolet light. J Invest Dermatol 1993;100:260-265.
4. Briviba K, Sies H: Nonenzymatic antioxidant defense systems: in Frei B (ed): Natural Antioxidants in Human Health and Disease. San Diego, Academic Press, 1994, pp 107-128.
5. Fryer MJ: Evidence for the photoprotective effects of vitamin E. Photochem Photobiol 1993;58:304-312.
6. Darr D, Pinnell SR: Reactive oxygen species and antioxidant protection in photodermatology: in Lowe NJ, Shaath NA, Pathak MA (eds): Sunscreens - Development, Evaluation and Regulatory Aspects, ed 2. New York, Dekker, 1997, pp 155-173.
7. Roshchupkin DI, Pistsov MY, Potapenko AY: Inhibition of ultraviolet light-induced erythema by antioxidants. Arch Dermatol Res 1979;266: 91-94.
8. Bissett DL, Chatterjee R, Hannon DP: Photoprotective effect of superoxide-scavenging antioxidants against ultraviolet radiation-induced chronic skin damage in the hairless mouse. Photodermatol Photoimmunol Photomed 1990; 7:56-62.
9. Gensler HL, Magdaleno M: Topical vitamin E inhibition of immunosuppression and tumorigenesis induced by ultraviolet irradiation. Nutr Cancer 1991;15:97-106.
10. Darr D, Combs S, Dunston S, Manning T, Pinnell S: Topical vitamin C protects porcine skin from ultraviolet radiation-induced damage. Br J Dermatol 1992;127:247-253.
11. Jurkiewicz BA, Bissett DL, Buettner GR: Effect of topically applied tocopherol on ultraviolet radiation-mediated free radical damage in skin. J Invest Dermatol 1995;104:484-488.
12. Darr D, Dunston S, Faust H, Pinnell S: Effectiveness of antioxidants (vitamin C and E) with and without sunscreens as topical photoprotectants. Acta Derm Venereol (Stockh) 1996;76: 264-268.
13. Trevithick JR, Xiong H, Lee S, Shum DT, Sanford SE, Karlik SJ, Norley C, Dilworth GR: Topical tocopherol acetate reduces post-UVB, sunburn-associated erythema, edema, and skin sensitivity in hairless mice. Arch Biochem Biophys 1992;296:575-582.
14. Trevithick JR, Shum DT, Redae S, Mitton KP, Norley C, Karlik SJ, Groom AC, Schmidt EE: Reduction of sunburn damage to skin by topical application of vitamin E acetate following exposure to ultraviolet B radiation: Effect of delaying application or of reducing concentration of vitamin E acetate applied. Scanning Microsc 1993;7:1269-1281.
15. Montenegro L, Bonina F, Rigano L, Giogilli S, Sirigu S: Protective effect evaluation of free radical scavengers on UVB induced human cutaneous erythema by skin reflectance spectrophotometry. Int J Cosmet Sci 1995;17: 91-103.
16. Potapenko AY, Abijev GA, Pistsov MY, Roshchupkin DI, Vladimirov YA, Pliquett F, Ermolayev AV, Sarycheva IK, Evstigneeva RP: PUVA-induced erythema and changes in mechanoelectrical properties of skin: Inhibition by tocopherols. Arch Dermatol Res 1984;276:12-16.
17. Yuen KS, Halliday GM: α-Tocopherol, an inhibitor of epidermal lipid peroxidation, prevents ultraviolet radiation from suppressing the skin immune system. Photochem Photobiol 1997;65:587-592.
18. Reiter RJ, Melchiorri D, Sewerynek E, Poeggeler B, Barlow-Walden L, Chuang J, Ortiz GG, Acuna-Castroviejo D: A review of the evidence supporting melatonin's role as an antioxidant. J Pineal Res 1995;18:1-11.
19. Bangha E, Elsner P, Kistler GS: Suppression of UV-induced erythema by topical treatment with melatonin (N-acelyl-5-methoxytryptamine): A dose response study. Arch Dermatol Res 1996;288:522-526.
20. Bangha E, Elsner P, Kistler GS: Suppression of UV-induced erythema by topical treatment with melatonin (N-acetyl-5-methoxytryptamine). Influence of the application time point. Dermatology 1997;195:248-252.
21. Learn DB, Beard J, Moloney SJ: The ultraviolet C energy emitted from FS lamps contributes significantly to the induction of human erythema and murine ear edema. Photodermatol Photoimmunol Photomed 1993;9:147-153.
22. Frosch PJ, Kligman AM: The soap chamber test - A new method for assessing the irritancy of soaps. J Am Acad Dermatol 1979:1:35-41.
23. Westerhof W, van Hasselt BAAM, Kammeijer A: Quantification of UV-induced erythema with a portable computer controlled chromameter. Photodermatology 1986;3:310-314.
24. Dreher F, Gabard B, Schwindt DA, Maibach HI: Topical melatonin in combination with vitamins E and C protects skin from ultraviolet-induced erythema: A human study in vivo. Br J Dermatol 1998;139:332-339.
25. 2 synthesis and enhances the immune response of aged mice. Mech Ageing Dev 1986;34: 191-201.
26. 2. Biochim Biophys Acta 1986;876:639-645.
27. Traber MG, Packer L: Vitamin E: Beyond antioxidant function. Am J Clin Nutr 1995;62 (suppl):1501S-1509S.
28. Franchi AM, Gimeno MF, Cardinali DP, Vacas MI: Melatonin, 5-methoxytryptamine and some of their analogs as cyclo-oxygenase inhibitors in rat medial basal hypothalamus. Brain Res 1987;405:384-388.
29. Martinuzzo M, del Zar MM, Cardinali DP, Carreras LO, Vacas MI: Melatonin effect on arachidonic acid metabolism to cyclooxygenase derivatives in human platelets. J Pineal Res 1991;11:111-115.
30. Snyder DS, Eaglstein WH: Topical indomethacin and sunburn. Br J Dermatol 1974;90:91-93.
31. Kaidbey KH, Kurban AK: The influence of corticosteroids and topical indomethacin on sunburn erythema. J Invest Dermatol 1976;66: 153-156.
32. Farr PM, Diffey BL: A quantitative study of the effect of topical indomethacin on cutaneous erythema induced by UVB and UVC radiation. Br J Dermatol 1986;115:453-166.
33. Andersen PH, Abrams K, Maibach H: Ultraviolet B dose-dependent inflammation in humans: A reflectance spectroscopic and laser Doppler flowmetric study using topical pharmacologic antagonists on irradiated skin. Photodermatol Photoimmunol Photomed 1992;9: 17-23.
34. Juhlin L, Shroot B: Effect of drugs on the early and late phase UV erythema. Acta Derm Venereol (Stockh) 1992;72:222-223.
35. Ibbotson SH, Diffey BL, Farr PM: The effect of topical indomethacin on ultraviolet-radiation-induced erythema. Br J Dermatol 1996; 135:523-527.