Failure to detect antiviral activity in serum and plasma of healthy individuals displaying high activity in ELISA for IFN-α and IFN-β

Journal of Interferon and Cytokine Research

Volumn 19, Issue 5, 1999, Pages 463-469

  Jabs, Wolfram J ^a   Hennig, Christian ^a   Zawatzky, Rainer ^b   Kirchner, Holger ^a  

^a UNIVERSITY OF LÜBECK   (Germany)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; BETA INTERFERON;

ANTIVIRAL ACTIVITY; ARTICLE; BLOOD SAMPLING; CELL PROLIFERATION; CROSS REACTION; DRUG BLOOD LEVEL; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; IMMUNOREACTIVITY; MOLECULAR CLONING; PRIORITY JOURNAL; RECEPTOR BINDING;

ANTIVIRAL AGENTS; BIOLOGICAL ASSAY; BLOOD DONORS; CRYOPRESERVATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; IMMUNOASSAY; INTERFERON-ALPHA; INTERFERON-BETA; REFERENCE VALUES;

ENCEPHALOMYOCARDITIS VIRUS;

EID: 0033047408     PISSN: 10799907     EISSN: None     Source Type: Journal    
DOI: 10.1089/107999099313901     Document Type: Article

References (36)

1. KIRCHNER, H. (1986). The interferon system as an integral part of the defense system against infections. Antiviral Res. 70, 1-17.
2. PESTKA, S. (1986). Interferon. Methods Enzymol. 119, 3-23.
3. DIAZ, M.O., BOHLANDER, S., and ALLEN, G. (1996). Nomenclature of the human interferon genes. J. Interferon Cytokine Res. 16, 179-180.
4. GREENWAY, A.L., OVERALL, M.L., SATTAYASAI, N., ROWLEY, M.I. HERTZOG, P.J., McMULLEN, G.L., CHEETHAM, B.F., and MARZUKI, S. (1992). Selective production of interferon-alpha subtypes by cultured peripheral blood mononuclear cells and lymphoblastoid cell lines. Immunology 75, 182-188.
5. CUTRONE, E.C., and LANGER, J. (1997). Contributions of cloned type I interferon receptor subunits to differential ligand binding. FEBS Lett. 404, 197-202.
6. FINTER, N.B. (1991). Why are there so many subtypes of alpha-interferons? J. Interferon Res. 11, 185-194.
7. GREEN, J.A., CHARETTE, R.P., YEH, T.H., and SMITH, C.B. (1982). Presence of interferon in acute- and convalescent-phase sera of humans with influenza or an influenza-like illness of undetermined etiology. J. Infect. Dis. 145, 837-841.
8. BERNIER, J., REUTER, A., VRINDTS-GEVAERT, Y., and GRANCHIMONT, P. (1984). Radioimmunoassay of leukocyte (alpha) interferon and its application to some clinical conditions. J. Nucl. Med. 25, 765-772.
9. SCOTT, G.M., WARD, R.J., WRIGHT, D.J., ROBINSON, J.A., ONWUBALILI, J.K., and GAUCI, C.L. (1983). Effects of cloned interferon α2 in normal volunteers: febrile reactions and changes in circulating corticosteroids and trace metals. Antimicrob. Agents Chemother. 23, 589-592.
10. LINDE, A., ANDERSSON, B., SVENSON, S.B., AHRNE, A., CARLSSON, M., FORSBERG, P., HUGO, H., KARSTORP, A., LENKEI, R., LINDWALL, A., LOFTENIUS, A., SÄLL, C., and ANDERSSON, J. (1992). Serum levels of lymphokines and soluble cellular receptors in primary Epstein-Barr virus infection and in patients with chronic fatigue syndrome. J. Infect. Dis. 165, 994-1000.
11. KAKUMU, S., FUJI, A., YOSHIOKA, K., and TAHARA, H. (1989). Serum levels of α-interferon and γ-interferon in patients with acute and chronic viral hepatitis. Hepatogastroenterology 36, 97-102.
12. ABB, J. (1987). Interferon-alpha in sera of HIV-infected patients. Lancet 2, 1092-1093.
13. SHIOZAWA, S., CHIHARA, K., SHIOZAWA, K., FUJITA, T., IKEGAMI, H., KOYAMA, S., and KURIMOTO, M. (1986). A sensitive radioimmunoassay for alpha-interferon: ciculating α-interferon-like substance in the plasma of healthy individuals and rheumatoid arthritis patients. Clin. Exp. Immunol. 66, 77-87.
14. FORTI, R.L., MOLDOVAN, R.A., MITCHELL, W.M., CALLICOAT, P., SCHUFFMAN, S.S., DAVIES, H.A., and SMITH, D.M. (1985). Application of an objective biological assay of human interferons to clinical specimens and a survey of a normal population. J. Clin. Microbiol. 21, 689-693.
15. PREBLE, O.T., BLACK, R.J., and FRIEDMAN, R.M. (1982). Systemic lupus erythematosus: presence in human serum of an unusual acid-labile leukocyte interferon. Science 216, 429-431.
16. GRAU, G.E., ROUX-LOMBARD, P., GYSLER, C., LAMBERT, C., LAMBERT, P.H., DAYER, J.M., and GUILLEVIN, L. (1989). Serum cytokine changes in systemic vasculitis. Immunology 68, 196-198.
17. DUC-OIRAN, P., ROBERT-GALLIOT, B., LOPEZ, J., and CHANY, C. (1985). Unusual apparently constitutive interferons and antagonists in human placental blood. Proc. Natl. Acad. Sci. USA 82, 5010-5014.
18. TOVEY, M.G., STREULI, M., GRENZER, I., GEGENHEIM, J., BLANCHARD, B., GUYMARKO, J., VIGNAUX, F., and GIGOU, M. (1987). Interferon messenger RNA is produced constitutively in the organs of normal individuals. Proc. Natl. Acad. Sci. USA 84, 5038-5042.
19. VITI, A., MUSCETTOLA, M., PAULESCU, L., BOCCI, V., and ALMI, A. (1985). Effect of exercise on plasma interferon levels. J. Appl. Physiol. 59, 426-428.
20. LEVIN, S., and HAHN, T. (1981). Evaluation of the human interferon system in viral diseases. Clin. Exp. Immunol. 46, 475-483.
21. BELARDELLI, F., and GRESSER, I. (1996). The neglected role of type I interferon in the T-cell response: implications for its clinical use. Immunol. Today 17, 369-372.
22. EINHORN, S., and GRANDER, D. (1996). Why do so many cancer patients fail to respond to interferon therapy? J. Interferon Cytokine Res. 16, 275-281.
23. PUNG, Y.H., VETRO, S.W., and BELLANTI, J.A. (1993). Use of interferons in atopic (IgE-mediated) diseases. Ann. Allergy 71, 234-238.
24. HASLER, F. (1990). Immunoreactive circulating alpha-interferon in rheumatoid arthritis. Br. J. Rheumatol. 29, 315-316.
25. MATHUR, A., KAMAT, D.M., FILIPOVICH, A.H., STEINBUCH, M., and SHAPIRO, R.S. (1994). Immunoregulatory abnormalities in patients with Epstein-Barr virus-associated B cell lymphoproliferative disorders. Transplantation 57, 1042-1045.
26. DOLEN, J.G., and MATHUR, A. (1995). Undetectable interferon-α serum levels in a patient with atopic dermatitis. J. Interferon Cytokine Res. 15, 973-975.
27. CHU, C.M., SHEEN, I.S., YEH, C.T., HSIEH, S.Y., TSAI, S.L., and LIAW, Y.F. (1995). Serum levels of interferon-α and -γ in acute and chronic hepatitis B virus infection. Dig. Dis. Sci. 40, 2107-2112.
28. PRABHU, A., WARWICK, M., and MATHUR, A. (1996). Decreased levels of circulating IFN-α and increased sCD23 in patients with acute infectious mononucleosis. Viral Immunol. 9, 45-50.
29. PIRISI, M., FABRIS, C., TONIUTTO, P., FALLETI, E., TISMINETZKY, S.G., GEROTTO, M., SOARDO, G., VITULLI, D., DEL FORNO, M., BARALLE, F., and BARTOLI, E. (1997). Endogenous interferon-α concentration and outcome of interferon treatment in patients with chronic hepatitis C. Dig. Dis. Sci. 42, 767-771.
30. DORR, R.T., SALMON, S.E., ROBERTONE, A., and BONNEM, E. (1988). Phase I-II trial of interferon-α2b by continuous subcutaneous infusion over 28 days. J. Interferon Cytokine Res. 8, 717-725.
31. O'KELLY, P., THOMSON, L., TILLES, J.G., and CESARIO, T. (1985). Inactivation of interferon by serum and synovial fluids. Proc. Soc. Exp. Biol. Med. 178, 407-411.
32. NOVICK, D., COHEN, B., and RUBINSTEIN, M. (1992). Solu ble interferon-α receptor molecules are present in body fluids. FEBS Lett. 314, 445-448.
33. THAVASU, P.W., LONGHURST, S., JOEL, S.P., SLEVIN, M.L., and BALKWILL, F.R. (1992). Measuring cytokine levels in blood. Importnce of anticoagulants, processing, and storage conditions. J. Immunol. Methods 153, 115-124.
34. GALLATI, H. (1982). Interferon: Wesentlich vereinfachte, enzymimmunologische Bestimmung mit zwei monoklonalen Antikörpern. J. Clin. Chem. Clin. Biochem. 20, 907-914.
35. WALKER, J.R., NAGINGTON, J., SCOTT, G.M., and SECHER, D.S. (1982). An immunoradiometric assay of serum interferon using a monoclonal antibody. J. Gen. Virol. 62, 181-185.
36. RÖNNBLOM, L.E., PERERS, A., SVENSSON VALLIN, H., ERIKSSON, I., ÖSTERLIND, A., CEDERBLAD, B., and ALM, G. (1997). Detection of serum interferon-α by dissociation-enhanced lanthanide fluoroimmunoasay. PMIS 105, 531-536.