T-STAR/ETOILE: A novel relative of SAM68 that interacts with an RNA-binding protein implicated in spermatogenesis

Human Molecular Genetics

Volumn 8, Issue 6, 1999, Pages 959-969

  Venables, J P ^a   Vernet, C ^b   Chew, S L ^a,c   Elliott, D J ^d   Cowmeadow, R B ^b   Wu, J ^b   Cooke, H J ^d   Artzt, K ^b   Eperon, I C ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^c QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^d WESTERN GENERAL HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; GREEN FLUORESCENT PROTEIN; RNA BINDING PROTEIN;

ANIMAL CELL; ARTICLE; CELL NUCLEUS; CHROMOSOME 15; GERM CELL; HELA CELL; HUMAN; HUMAN CELL; MALE; MALE INFERTILITY; MEIOSIS; MOLECULAR CLONING; MOUSE; NONHUMAN; NUCLEOLUS; NUCLEOTIDE SEQUENCE; ONCOGENE SRC; PRIORITY JOURNAL; RAT; SEQUENCE HOMOLOGY; SPERMATOGENESIS; TESTIS; Y CHROMOSOME;

3T3 CELLS; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID SEQUENCE; ANIMALS; BLOTTING, NORTHERN; CELL NUCLEUS; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 8; COS CELLS; DNA, COMPLEMENTARY; DNA-BINDING PROTEINS; GENE EXPRESSION; HELA CELLS; HUMANS; MALE; MICE; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; MURIDAE; PLASMIDS; PROTEIN BINDING; RATS; RNA; RNA, MESSENGER; RNA-BINDING PROTEINS; SACCHAROMYCES CEREVISIAE; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; SPERMATOGENESIS; TISSUE DISTRIBUTION; TUMOR SUPPRESSOR PROTEIN P53;

ANIMALIA; MAMMALIA;

EID: 0033047312     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: 10.1093/hmg/8.6.959     Document Type: Article

References (71)

1. Hecht, N.B. (1995) The making of a spermatozoon: a molecular perspective. Dev. Genet., 16, 95-103.
2. Sassone-Corsi, P. (1997) Transcriptional checkpoints determining the fate of male germ cells. Cell, 88, 163-166.
3. Willison, K. and Ashworth, A. (1987) Mammalian spermatogenic gene expression. Trends Genet., 3, 351-355.
4. Hargreave, T.B. (ed.) (1997) Male Infertility. Springer Verlag, pp. 1-16.
5. Pryor, J.L., KentFirst, M., Muallem, A., VanBergen, A.H., Nolten, W.E., Meisner, L. and Roberts, K.P. (1997) Microdeletions in the Y chromosome of infertile men. N. Engl. J. Med., 336, 534-539.
6. Elliott, D.J. and Cooke, H.J. (1997) The molecular genetics of male infertility. Bioessays, 19, 801-809.
7. Tiepolo, L. and Zuffardi, O. (1976) Localisation of factors controlling spermatogenesis in the non-fluorescent portion of the human Y chromosome long arm. Hum. Genet., 34, 119-124.
8. Ma, K., Inglis, J.D., Sharkey, A., Bickmore, W.A., Hill, R.E., Prosser, E.J., Speed, R.M., Thomson, E.J., Jobling, M., Taylor, K., Wolfe, J., Cooke, H.J., Hargreave, T.B. and Chandley, A.C. (1993) A Y-chromosome gene family with RNA-binding protein homology: candidates for the azoospermia factor AZF controlling human spermatogenesis. Cell, 75, 1287-1295.
9. Reijo, R., Lee, T.Y., Salo, P., Alagappan, R., Brown, L.G., Rosenberg, M., Rozen, S., Jaffe, T., Straus, D., Hovatta, O., Delachapelle, A., Silber, S. and Page, D.C. (1995) Diverse spermatogenic defects in humans caused by Y-chromosome deletions encompassing a novel RNA-binding protein gene. Nature Genet., 10, 383-393.
10. Delbridge, M.L., Harry, J.L., Toder, R., O'Neill, R.J.W., Ma, K., Chandley, A.C. and Graves, J.A.M. (1997) A human candidate spermatogenesis gene, RBM1, is conserved and amplified on the marsupial Y chromosome. Nature Genet., 15, 131-136.
11. Cooke, H.J., Lee, M., Kerr, S. and Ruggiu, M. (1996) A murine homolog of the human DAZ gene is autosomal and expressed only in male and female gonads. Hum. Mol. Genet., 5, 513-516.
12. Reijo, R., Seligman, J., Dinulos, M.B., Jaffe, T., Brown, L.G., Disteche, C.M. and Page, D.C. ( 1996) Mouse autosomal homolog of DAZ, a candidate male-sterility gene in humans, is expressed in male germ cells before and after puberty. Genomics, 35, 346-352.
13. Seboun, E., Barbaux, S., Bourgeron, T., Nishi, S., Algonik, A., Egashira, M., Nikkawa, N., Bishop, C., Fellous, M., McElreavey, K. and Kasahara, M. (1997) Gene sequence, localization, and evolutionary conservation of DAZLA, a candidate male sterility gene. Genomics, 41, 227-235.
14. Birney, E., Kumar, S. and Krainer, A.R. (1993) Analysis of the RNA-recognition motif and RS and RGG domains: conservation in metazoan pre-mRNA splicing factors. Nucleic Acids Res., 21, 5803-5816.
15. Ruggiu, M., Speed, R., Taggart, M., McKay, S.J., Kilanowski, F., Saunders, P., Dorin, J. and Cooke, H.J. ( 1997) The mouse Dazla gene encodes a cytoplasmic protein essential for gametogenesis. Nature, 389, 73-77.
16. Elliott, D.J., Oghene, K., Makarov, G., Makarova, O., Hargreave, T.B., Chandley, A.C., Eperon, I.C. and Cooke, H.J. (1998) Dynamic changes in the subnuclear organisation of pre-mRNA splicing proteins and RBM during human germ cell development. J. Cell Sci., 111, 1255-1265.
17. Soulard, M., Dellavalle, V., Siomi, M.C., Pinolroma, S., Codogno, P., Bauvy, C., Bellini, M., Lacroix, J.C., Monod, G., Dreyfuss, G. and Larsen, C.J. ( 1993) HnRNP G: sequence and characterization of a glycosylated RNA-binding protein. Nucleic Acids Res., 21, 4210-4217.
18. Chien, C.T., Bartel, P.L., Sternglanz, R. and Fields, S. (1991) The 2-hybrid system: a method to identify and clone genes for proteins that interact with a protein of interest. Proc. Natl Acad. Sco. USA, 88, 9578-9582.
19. Fumagalli, S., Totty, N.F., Hsuan, J.J. and Courtneidge, S.A. (1994) A target for Src in mitosis. Nature, 368, 871-874.
20. Taylor, S.J. and Shalloway, D. (1994) An RNA-binding protein associated with Src through its SH2 and SH3 domains in mitosis. Nature, 368, 867-871.
21. Resnick, R.J., Taylor, S.J., Lin, Q. and Shalloway, D. (1997) Phosphorylation of the Src substrate Sam68 by Cdc2 during mitosis. Oncogene, 15, 1247-1253.
22. Lin, Q., Taylor, S.J. and Shalloway, D. (1997) Specificity and determi-nants of Sam68 RNA binding: implications for the biological function of K homology domains. J. Biol. Chem., 272, 27274-27280.
23. Vernet, C. and Artzt, K. (1997) STAR, a gene family involved in signal transduction and activation of RNA. Trends Genet., 13, 479-484.
24. Di Fruscio, M., Chen, T. and Richard, S. (1999) Characterization of Sam68-like mammalian proteins SLM-1 and SLM-2: SLM-1 is a Src substrate during mitosis. Proc. Natl Acad. Sci. USA, 96, 2710-2715.
25. Ashley, C.T., Wilkinson, K.D., Reines, D. and Warren, S.T. (1993) FMR1 protein: conserved RNP family domains and selective RNA binding. Science, 262, 563-566.
26. Siomi, H., Matunis, M.J., Michael, W.M. and Dreyfuss, G. (1993) The pre-messenger RNA-binding K protein contains a novel evolutionarily conserved motif. Nucleic Acids Res., 21, 1193-1198.
27. Siomi, H., Choi, M.Y., Siomi, M.C., Nussbaum, R.L. and Dreyfuss, G. (1994) Essential role for KH domains in RNA-binding - impaired RNA-binding by a mutation in the KH domain of FMR1 that causes fragile-X syndrome. Cell, 77, 33-39.
28. Musco, G., Stier, G., Joseph, C., Morelli, M., Nilges, M., Gibson, T.J. and Pastore, A. (1996) 3-Dimensional structure and stability of the KH domain - molecular insights into the fragile-X syndrome. Cell, 85, 237-245.
29. Jones, A.R. and Schedl, T. (1995) Mutations in gld-1, a female germ cell-specific tumor-suppressor gene in Caenorhabditis elegans, affect a conserved domain also found in Src-associated protein Sam68. Genes Dev., 9, 1491-1504.
30. Chen, T.P., Damaj, B.B., Herrera, C., Lasko, P. and Richard, S. (1997) Self-association of the single-KH-domain family members Sam68, GRP33, GLD-1, and Qk1: role of the KH domain. Mol. Cell. Biol., 17, 5707-5718.
31. Rickles, R.J., Botfield, M.C., Weng, Z.G., Taylor, J.A., Green, O.M., Brugge, J. and Zoller, M.J. (1994) Identification of Src, Fyn, Lyn, P13K and Abl SH3 domain ligands using phage display libraries. EMBO J., 13, 5598-5604.
32. Ishidate, T., Yoshihara, S., Kawasaki, Y., Roy, B.C., Toyoshima, K. and Akiyama, T. (1997) Identification of a novel nuclear localization signal in Sam68. FEBS Lett., 409, 237-241.
33. Ghetti, A., Pinolroma, S., Michael, W.M., Morandi, C. and Dreyfuss, G. (1992) HnRNP I, the polypyrimidine tract-binding protein: distinct nuclear localization and association with hnRNAs. Nucleic Acids Res., 20, 3671-3678.
34. Matera, G. and Wolin, S. (1995) A perinucleolar compartment contains several RNA-polymerase III transcripts as well as the polypyrimidine tract-binding protein, hnRNP I. J. Cell Biol., 130, 497-500.
35. Huang, S., Deerinck, T.J., Ellisman, M.H. and Spector, D.L. (1997) The dynamic organization of the perinucleolar compartment in the cell nucleus. J. Cell. Biol., 137, 965-974.
36. Matunis, M.J., Michael, W.M. and Dreyfuss, G. (1992) Characterization and primary structure of the poly (C)-binding heterogeneous nuclear ribo-nucleoprotein complex K-protein. Mol. Cell. Biol., 12, 164-171.
37. Segade, F., Hurle, B., Claudio, E., Ramos, S. and Lazo, P.S. (1996) Molecular cloning of a mouse homolog for the Drosophila splicing regulator Tra2. FEBS Lett., 387, 2-3.
38. Dauwalder, B., Amayamanzanares, F. and Mattox, W. (1996) A human homolog of the Drosophila sex determination factor transformer-2 has conserved splicing regulatory functions. Proc. Natl Acad. Sci. USA, 93, 9004-9009.
39. Beil, B., Screaton, G. and Stamm, S. (1997) Molecular cloning of hTra2-beta-1 and hTra2-beta-2, two human homologs of Tra-2 generated by alternative splicing. DNA Cell Biol., 16, 679-690.
40. Screaton, G.R., Caceres, J.F., Mayeda, A., Bell, M.V., Plebanski, M., Jackson, D.G., Bell, J.I. and Krainer, A.R. (1995) Identification and characterization of 3 members of the human SR family of pre-mRNA splicing factors. EMBO J., 14, 4336-4349.
41. Cavaloc, Y., Popielarz, M., Fuchs, J.P., Gattoni, R. and Stévenin, J. (1994) Characterization and cloning of the human splicing factor 9G8: a novel 35 kDa factor of the serine/arginine protein family. EMBO J., 13, 2639-2649.
42. Zorn, A.M. and Krieg, P.A. (1997) The KH domain protein encoded by quaking functions as a dimer and is essential for notochord development in Xenopus embryos. Genes Dev., 11, 2176-2190.
43. Bomsztyk, K., VanSeuningen, I., Suzuki, H., Denisenko, O. and Ostrowski, J. (1997) Diverse molecular interactions of the hnRNP K protein. FEBS Lett., 403, 113-115.
44. Lamond, A.I. and Earnshaw, W.C. (1998) Structure and function in the nucleus. Science, 280, 547-553.
45. Liu, Q. and Dreyfuss, G. (1996) A novel nuclear structure containing the survival of motor neurons protein. EMBO J., 15, 3555-3565.
46. Pombo, A., Cuello, P., Schul, W., Yoon, J.-B., Roeder, G.R., Cook, P.R. and Murphy, S. (1998) Regional and temporal specialization in the nucleus: a transcriptionally-active nuclear domain rich in PTF, Oct1 and PIKA antigens associates with specific chromosomes early in the cell cycle. EMBO J., 17, 1768-1778.
47. Wong, G., Muller, O., Clark, R., Conroy, L., Moran, M.F., Polakis, P. and McCormick, F. (1992) Molecular cloning and nucleic acid binding properties of the GAP-associated tyrosine phosphoprotein p62. Cell, 69, 551-558.
48. Weng, A.S., Thomas, S.M., Rickles, R.J., Taylor, J.A., Brauer, A.W., Seidel-Dugan, C., Michael, W.M., Dreyfuss, G. and Brugge, J.S. (1994) Identification of Src, Fyn and Lyn SH3-binding proteins: implications for a function of SH3 domains. Mol. Cell. Biol., 14, 4509-4521.
49. Richard, S., Yu, D.Y., Blumer, K.J., Hausladen, D., Olszowy, M.W., Connelly, P.A. and Shaw, A.S. (1995) Association of p62, a multifunctional SH2-domain and SH3-domain binding-protein, with Src family tyrosine kinases, Grb2, and phospholipase-C-gamma-1. Mol. Cell. Biol., 15, 186-197.
50. Lawe, D.C., Hahn, C. and Wong, A.J. (1997) The Nek SH2/SH3 adaptor protein is present in the nucleus and associates with the nuclear protein SAM68. Oncogene, 14, 223-231.
51. Maa, M.C., Leu, T.H., Trandel, B.J., Chang, J.H. and Parsons, S.J. (1994) A protein that is highly related to GTPase-activating protein-associated p62 complexes with phospholipase C-gamma. Mol. Cell. Biol., 14, 5466-5473.
52. Chen, T.P. and Richard, S. (1998) Structure-function analysis of Qk1: a lethal point mutation in mouse quaking prevents homodimerization. Mol. Cell. Biol., 18, 4863-4871.
53. Wang, L.L., Richard, S. and Shaw, A.S. (1995) p62 association with RNA is regulated by tyrosine phosphorylation. J. Biol. Chem., 270, 2010-2013.
54. Xiao, S.H. and Manley, J.L. (1997) Phosphorylation of the ASF/SF2 RS domain affects both protein-protein and protein-RNA interactions and is necessary for splicing. Genes Dev., 11, 334-344.
55. Tacke, R., Chen, Y. and Manley, J.L. (1997) Sequence-specific RNA binding by an SR protein requires RS domain phosphorylation: creation of an SRp40-specific splicing enhancer. Proc. Natl Acad. Sci. USA, 94, 1148-1153.
56. Jan, E., Motzny, C.K., Graves, L.E. and Goodwin, E.B. (1999) The STAR protein, GLD-1, is a transitional regulator of sexual identity in Caenorhabditis elegans. EMBO J., 18, 258-269.
57. Jan, E., Loushin, C., Punkay, E., Artzt, K. and Goodwin, E.B. (1999) The STAR protein, QUAKING-6, is a translational repressor. Proc. Natl Acad. Sci. USA, in press.
58. Arning, S., Gruter, P., Bilbe, G. and Kramer, A. (1996) Mammalian splicing factor SF1 is encoded by variant cDNAs and binds to RNA. RNA, 2, 794-810.
59. Rain, J.C., Rafi, Z., Rhani, Z., Legrain, P. and Kramer, A. (1998) Conservation of functional domains involved in RNA binding and protein-protein interactions in human and Saccharomyces cerevisiae pre-mRNA splicing factor SF1. RNA, 4, 551-565.
60. Abovich, N. and Rosbash, M. (1997) Cross-intron bridging interactions in the yeast commitment complex are conserved in mammals. Cell, 89, 403-412.
61. Berglund, J.A., Chua, K., Abovich, N., Reed, R. and Rosbash, M. (1997) The splicing factor BBP interacts specifically with the pre-mRNA branchpoint sequence UACUAAC. Cell, 89, 781-787.
62. Berglund, J.A., Fleming, M.L. and Rosbash, M. (1998) The KH domain of the branchpoint sequence binding protein determines specificity for the pre-mRNA branchpoint sequence. RNA, 4, 998-1006.
63. Geliebter, J. ( 1987) Dideoxynucleotide sequencing of RNA and uncloned cDNA. Focus, 9, 5-6.
64. Elliott, D.J., Millar, M.R., Oghene. K., Ross, A., Kiesewetter, F., Pryor, J., McIntyre, M., Hargreave, T.B., Saunders, P., Vogt, P.H., Chandley, A.C. and Cooke, H. (1997) Expression of RBM in the nuclei of human germ cells is dependent on a critical region of the Y chromosome long arm. Proc. Natl Acad. Sci. USA, 94, 3848-3853.
65. Rowe, L.B., Nadeau, J.H., Turner, R., Frankel, W.N., Letts, V.A., Eppig, J.T., Kos, M.S., Thurston, S.J. and Birkenmeier, E.H. (1994) Maps from two interspecific backcross DNA panels available as a community genetic mapping resource. Mamm. Genome, 5, 253-274.
66. Swanson, M.S. and Dreyfuss, G. (1988) Classification and purification of proteins of heterogeneous nuclear ribonucleoprotein-particles by RNA-binding specificities. Mol. Cell. Biol., 8, 2237-2241.
67. Spector, D.L., Goldman, R.D. and Leinwand, L.A. (1998) Cells: A Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
68. Lerner, E.A., Lerner, M.R., Janeway, C.A. and Sleitz, J.A. (1980) Monoclonal antibodies to nucleic acid-containing cellular constituents: probe for molecular biology and autoimmune disease. Proc. Natl Acad. Sci. USA, 78, 2737-2741.
69. Raska, I., Andrade, L., Ochs, R.L., Chan, E., Chang, C.M., Roos, G. and Tan, E.M. (1991) Immunological and ultrastructural studies of the nuclear coiled body with autoimmune antibodies. Exp. Cell Res., 195, 27-37.
70. Haefner, B., Baxter, R., Fincham, V.J., Downes, C.P. and Frame, M.C. (1995) Cooperation of Src homology domains in the regulated binding of phosphatidylinositol-3-kinase: a role for the Src homology-2 domain. J. Biol. Chem., 270, 7937-7943.
71. Mayeda, A. and Krainer, A.R. (1992) Regulation of alternative pre-mRNA splicing by hnRNP A1 and splicing factor SF2. Cell, 68, 365-375.