Dimethylarginine dimethylaminohydrolase (DDAH) as a nerve-injury-associated molecule: MRNA localization in the rat brain and its coincident up-regulation with neuronal NO synthase (nNOS) in axotomized motoneurons

European Journal of Neuroscience

Volumn 11, Issue 6, 1999, Pages 2160-2166

  Nakagomi, S ^a   Kiryu Seo, S ^a   Kimoto, M ^b   Emson, P C ^c   Kiyama, H ^a  

^a ASAHIKAWA MEDICAL COLLEGE   (Japan)

^b OKAYAMA PREFECTURAL UNIVERSITY   (Japan)

^c BABRAHAM INSTITUTE   (United Kingdom)

Author keywords

cDNA library; Hypoglossal motor neuron; Methylarginine; Nitric oxide; Regeneration

Indexed keywords

DIMETHYLARGININASE; MESSENGER RNA; NITRIC OXIDE SYNTHASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE DEHYDROGENASE;

ANIMAL TISSUE; ARTICLE; GENE CONTROL; MALE; MOTONEURON; NERVE FIBER TRANSECTION; NERVE INJURY; NERVE REGENERATION; NONHUMAN; PRIORITY JOURNAL; RAT;

AMIDOHYDROLASES; ANIMALS; AXOTOMY; BRAIN; HYDROLASES; HYPOGLOSSAL NERVE; MALE; MOTOR NEURONS; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE I; RATS; RATS, WISTAR; RNA, MESSENGER; TISSUE DISTRIBUTION; WOUNDS, PENETRATING;

EID: 0033047187     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1460-9568.1999.00634.x     Document Type: Article

References (12)

1. Beckman, J.S. & Koppenol, W.H. (1996) Nitric oxide, Superoxide, and peroxynitrite: the good, the bad, and ugly. Am. J. Physiol., 271, C1424-1437.
2. Bredt, D.S., Hwang, P.M. & Snyder, S.H. (1990) Localization of nitric oxide synthase indicating a neural role for nitric oxide. Nature, 347, 768-770.
3. Dawson, T.M. & Dawson, V.L. (1996a) Nitric oxide synthase: role as a transmitter/mediator in the brain and endocrine system. Annu. Rev. Med., 47, 219-227.
4. Dawson, V.L. & Dawson, T.M. (1996b) Nitric oxide actions in neurochemistry. Neurochem. Int., 29, 97-110.
5. Estevez, A.G., Spear, N., Manuel, S.M., Radi, R., Henderson, C.E., Barbeito, L. & Beckman, J.S. (1998) Nitric oxide and Superoxide contribute to motor neuron apoptosis induced by trophic factor deprivation. J. Neurosci., 18, 923-931.
6. Hecker, M., Sessa, W.C., Harris, H.J., Anggard, E.E. & Vane, J.R. (1990) The metabolism of L-arginine and its significance for the biosynthesis of endothelium-derived relaxing factor: cultured endothelial cells recycle L-citrulline to L-arginine. Proc. Natl Acad. Sci. USA, 87, 8612-8616.
7. Hibbs, J.B. Jr, Taintor, R.R. & Vavrin, Z. (1987a) Macrophage cytotoxicity: role for L-arginine deiminase and imino nitrogen oxidation to nitrite. Science, 235, 473-476.
8. Hibbs, J.B. Jr, Vavrin, Z. & Taintor, R.R. (1987b) L-arginine is required for expression of the activated macrophage effector mechanism causing selective metabolic inhibition in target cells. J. Immunol., 138, 550-565.
9. Hökfelt, T., Zhang, X. & Wiessenfeld-Hallin, Z. (1994) Messenger plasticity in primary sensory neurons following axotomy and its functional implications. Trends Neurosci., 17, 22-30.
10. Holscher, C. (1997) Nitric oxide, the enigmatic neuronal messenger: its role in synaptic plasticity Trends Neurosci., 20, 298-303.
11. Huang, Z., Huang, P.L., Panahian, N., Dalkara, T., Fishman, M.C. & Moskowitz, M.A. (1994) Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase. Science, 265, 1883-1885.
12. Iwase, K., Iyama, K., Akagi, K., Yano, S., Fukunaga, K., Miyamoto, E., Mori, M. & Takiguchi, M. (1998) Precise distribution of neuronal nitric oxide synthase mRNA in the rat brain revealed by non-radioisotopic in situ hybridization. Mol. Brain Res., 53, 1-12.