Pathophysiology of variceal bleeding

Gastrointestinal Endoscopy Clinics of North America

Volumn 9, Issue 2, 1999, Pages 167-174

  Roberts, L R ^a   Kamath, P S ^a  

^a MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON MONOXIDE; ENDOTHELIN; GLUCAGON; INDOMETACIN; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; OCTREOTIDE; PROSTAGLANDIN; PROSTAGLANDIN SYNTHASE INHIBITOR; TUMOR NECROSIS FACTOR ALPHA; VASOCONSTRICTOR AGENT;

ABDOMINAL PRESSURE; ASCITES; BLEEDING; BLOOD CLOTTING DISORDER; ENDOTHELIUM CELL; ESOPHAGUS VARICES; HEPATORENAL SYNDROME; HUMAN; LIVER CIRRHOSIS; LIVER SINUSOID; MOLECULAR BIOLOGY; NONHUMAN; PORTAL HYPERTENSION; PORTAL VEIN BLOOD FLOW; PORTAL VEIN BLOOD PRESSURE; PRIORITY JOURNAL; REVIEW; SPLANCHNIC BLOOD FLOW; STOMACH VARICES; VARICOSIS; VASCULAR RESISTANCE; VASODILATATION; VEIN RUPTURE; VEIN TONE;

EID: 0033046445     PISSN: 10525157     EISSN: None     Source Type: Journal    
DOI: 10.1016/s1052-5157(18)30201-0     Document Type: Review

References (30)

1. Abelmann W.H. Hyperdynamic circulation in cirrhosis: A historical perspective Hepatology 20 1994 1356
2. Asbert M. Gines A. Gines P. Circulatory levels of endothelin in cirrhosis Gastroenterology 104 1993 1485
3. Bhathal P.S. Grossman H.J. Reduction of the increased portal vascular resistance of the isolated perfused cirrhotic rat liver by vasodilators J Hepatol 1 1985 325
4. Bomzon A. Blendis L.M. The nitric oxide hypothesis and the hyperdynamic circulation in cirrhosis Hepatology 20 1995 1343
5. Bosch J. Pizcueta P. Feu F. Pathophysiology of portal hypertension Gastroenterol Clin North Am 21 1992 1
6. Bruix J. Bosch J. Kravetz D. Effects of prostaglandin inhibition on systemic and hepatic hemodynamics in patients with cirrhosis of the liver Gastroenterology 88 1985 430
7. Claria J. Jimenez W. Ros J. Pathogenesis of arterial hypotension in cirrhotic rats with ascites: Role of endogenous nitric oxide Hepatology 15 1992 343
8. Fernandez M. Garcia-Pagan J.C. Casadevall M. Acute and chronic cyclooxygenase blockage in portal-hypertensive rats: Influence in nitric oxide biosynthesis Gastroenterology 110 1996 1529
9. Garcia-Pagan J.C. Feu F. Castells A. Circadian variations of portal pressure and variceal hemorrhage in patients with cirrhosis Hepatology 19 1994 595
10. Gondo K. Ueno T. Skamoto M. The endothelin-1 binding site in rat liver tissue: Light- and electron-microscopic autoradiographic studies Gastroenterology 104 1993 1745
11. Groszmann R.J. Hyperdynamic circulation of liver disease 40 years later: Pathophysiology and clinical consequences Hepatology 20 1994 1359
12. Hartleb M. Moreau R. Cailmail S. Vascular hyporesponsiveness to endothelin-1 in rats with cirrhosis Gastroenterology 107 1994 1085
13. Hou M.C. Cahill P.A. Zhang S. Enhanced cyclooxygenase-1 expression within the superior mesenteric artery of portal hypertensive rats: Role in the hyperdynamic circulation Hepatology 27 1998 20
14. Housset C. Rockey D.C. Bissell D.M. Endothelin receptors in rat liver: Lipocytes as a contractile target for endothelin 1 Proc Natl Acad Sei USA 90 1993 9266
15. Kamath P.S. Grabau C. Ward L. Increased intrahepatic resistance in portal hypertension is mediated by endothelin Hepatology 18 1993 A901
16. Kiel J.W. Pitts V. Benoit J.N. Reduced vascular sensitivity to norepinephrine in portal-hypertensive rats Am J Physiol 248 1985 G192
17. Kravetz D. Arderiu M. Bosch J. Hyperglucagonemia and hyperkinetic circulation after portacaval shunt in the rat Am J Physiol 252 1987 G257
18. Lebrec D. Methods to evaluate portal hypertension Gastroenterol Clin North Am 21 1992 41
19. Lopez-Talavera J.C. Cadelina G. Olchowski J. Thalidomide inhibits tumor necrosis factor alpha, decreases nitric oxide synthesis, and ameliorates the hyperdynamic circulatory syndrome in portal-hypertensive rats Hepatology 23 1996 1616
20. Lopez-Talavera J.C. Merrill W.W. Groszmann R.J. Tumor necrosis factor α: A major contributor to the hyperdynamic circulation in prehepatic portal hypertensive rats Gastroenterology 108 1995 761
21. Malesci A. Tacconi M. Valentini A. Octreotide long-term treatment in patients with portal hypertension: Persistent inhibition of postprandial glucagon response without major changes in renal function J Hepatol 26 1997 816
22. Martin P.-Y.M. Gines P. Schrier R.W. Nitric oxide as a mediator of hemodynamic abnormalities and sodium and water retention in cirrhosis N Engl J Med 339 1998 533
23. Martin P.-Y.M. Xu D.L. Niederberger M. Upregulation of endothelial constitutive NOS: A major role in the increased NO production in cirrhotic rats Am J Physiol 270 1996 F494
24. Moore K. Wendon J. Frazer M. Plasma endothelin immunoreactivity in liver disease, and the hepatorenal syndrome N Engl J Med 327 1992 1774
25. Morales-Ruiz M. Jimenez W. Perez-Sala D. Increased nitric oxide synthase expression in arterial vessels of cirrhotic rats with ascites Hepatology 24 1996 1481
26. Pak J.-M. Lee S.S. Glucagon in portal hypertension J Hepatol 20 1994 825
27. Rockey D.C. Fouassier L. Chung J.J. Cellular localization of endothelin-1 and increased production in liver injury in the rat: Potential for autocrine and paracrine effects on stellate cells Hepatology 27 1998 472
28. Sieber C.C. Groszmann R.J. In vitro hyporeactivity to methoxamine in portal hypertensive rats: Reversal by nitric oxide blockade Am J Physiol 262 1992 G996
29. Sieber C.C. Lopez-Talavera J.C. Groszmann R.J. Role of nitric oxide in the in vitro splanchnic vascular hyporeactivity in ascitic cirrhotic rats Gastroenterology 104 1993 1750
30. Sitzmann J.V. Li S.S. Adkinson N.F. Evidence for role of prostacyclin as a systemic hormone in portal hypertension Surgery 109 1991 149