Erythroid gene expression is differentially regulated by erythropoietin, haemin and delta-aminolaevulinic acid in UT-7 cells

British Journal of Haematology

Volumn 104, Issue 4, 1999, Pages 829-837

  McHale, Cliona M ^a   Winter, Paul C ^a   Lappin, Terence R J ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

Differentiation; Erythroid; Erythropoietin; Haemin; aminolaevulinic acid

Indexed keywords

AMINOLEVULINIC ACID; BETA GLOBIN; ERYTHROPOIETIN; GLYCOPHORIN; HEMIN; PHORBOL 13 ACETATE 12 MYRISTATE;

ARTICLE; CELL DIFFERENTIATION; CELL MATURATION; CELL PROLIFERATION; CELL SURVIVAL; DRUG EFFECT; ERYTHROID CELL; ERYTHROPOIESIS; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MEGAKARYOCYTE; PRIORITY JOURNAL; STEM CELL;

EID: 0033045053     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.1999.01269.x     Document Type: Article

References (52)

1. Aplan P.D., Nakahara, K., Orkin. S.H. & Kirsch, I.R. (1992) The SCL gene product: a positive regulator of erythroid differentiation. EMBO Journal, 11, 4073-4081.
2. Begley, C.G., Aplan, P.D., Denning, S.M., Haynes, B.F., Waldmann, T.A. & Kirsch, I.R. (1989) The gene SCL is expressed during early hematopoiesis and encodes a differentiation-related DNA-binding motif. Proceedings of the National Academy of Sciences of the United States of America, 86, 10128-10132.
3. Blair, D.G., Athanasiou, M., Watson, D. & Clausen, P. (1996) Evidence that specific members of the ets family of transcription factors function in a lineage-specific fashion in erythroid and megakaryocytic differentiation. Blood, 88, 193a.
4. Briegel, K., Lim, K.C., Plank, C., Beug, H., Engel, J.D. & Zenke, M. (1993) Ectopic expression of a conditional GATA-2/estrogen receptor chimera arrests erythroid differentiation in a hormone-dependent manner. Genes and Development, 7, 1097-1109.
5. Busfield, S.J., Chappel, D.S., Jennings, G., Trengrove, N.J., Riches, K.J., Callus, B.A., Tilbrook, P.A. & Klinken, S.P. (1995a) Erythropoietin exerts transcriptional and translational control over globin synthesis in J2E cells. Cell Growth and Differentiation, 6, 429-437.
6. Busfield, S.J. & Klinken, S.P. (1992) Erythropoietin-induced stimulation of differentiation and proliferation in J2E cells is not mimicked by chemical induction. Blood, 80, 412-419.
7. Busfield, S.J., Spadaccini, A., Riches, K.H., Tilbrook, P.A. & Klinken, S.P. (1995b) The major erythroid DNA-binding protein GATA-1 is stimulated by erythropoietin but not by chemical inducers of differentiation. European Journal of Biochemistry, 230, 475-480.
8. Chomczynski, P. & Sacchi, N. (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Analytical Biochemistry, 162, 165-159.
9. Dai, W. & Murphy, M.J. (1993) Downregulation of GATA-1 expression during phorbol myristate acetate induced megakaryocytic differentiation of human erythroleukemia cells. Blood, 81, 1214-1221.
10. Debili, N., Coulombel, L., Croisille, L., Katz, A., Guichard, J., Breton-Gorius, J. & Vainchenker, W. (1996) Characterization of a bipolent erythro-megakaryocytic progenitor in human bone marrow. Blood, 1988, 1284-1296.
11. De Sauvage, F.J., Hass, P.E., Spencer, S.D., Malloy, B.E., Gurney, A.L., Spencer, S.A., Darbonne, W.C., Henzel, W.J., Wong, S.C., Kuang, W-J., Oles, K.J., Hultgren, B., Solberg, L.A., Jr, Groeddel, D.V. & Eaton, D.L. (1994) Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-MPL ligand. Nature, 369, 533-538.
12. Fibach, E., Kollia, P., Schecter, A.N., Noguchi, C.T. & Rodgers, G.P. (1995) Hemin-induced acceleration of hemoglobin production in immature cultured erythroid cells: preferential enhancement of fetal hemoglobin. Blood, 85, 2967-2974.
13. Fibach, E., Konijn, A.M., Bauminger, R.E., Ofer, S. & Rachmilewitz, E.A. (1987) Effect of extracellular hemin on hemoglobin and ferritin content of erythroleukemia cells. Journal of Cellular Physiology, 130, 460-465.
14. Fibach, E., Manor, D., Oppenheim, A. & Rachmilewitz, E.A. (1989) Proliferation and maturation of human erythroid progenitors in liquid culture. Blood, 73, 100-103.
15. Fukuda, Y., Fujita, H., Garbaczewski, L. & Sassa, S. (1994) Regulation of β-globin mRNA by heme in DMSO-sensitive and DMSO-resistant murine erythroleukemia cells. Blood, 83, 1662-1667.
16. Green, A.R., Rockman, S., De Luca, E. & Begley, C.G. (1993) Induced myeloid differentiation of K562 cells with downregulation of erythroid and megakaryocytic transcription factors: a novel experimental model for hemopoietic lineage restriction. Experimental Hematology, 21, 525-531.
17. Green, A.R., Salvaris, E. & Begley, C.G. (1991) Erythroid expression of the 'helix-loop-helix' gene, SCL. Oncogene, 6, 475-479.
18. Griflin, M.O., Nelson, J.C. & Abraham, N.G. (1990) Early protooncogene expression during hemin-induced differentiation of human erythroleukemic cells. Leukemia Research, 14, 997-1006.
19. Harigae, H., Yamamoto, M., Fujita, H., Weinstock, P. & Sassa, S. (1998) In vitro differentiation of ES cells lacking the erythroid-specific δ-aminolevulinate synthase gene. Blood, 86, 496a.
20. Hermine, O., Mayeux, P., Titeux, M., Mitjavila, M.-T., Casadevall, N., Guichard, J., Komatsu, N., Suda, T., Miura, Y., Vainchenker, W. & Breton-Gorius, J. (1992) Granulocyte-macrophage colony-stimulating factor and erythropoietin act competitively to induce two different programs of differentiation in the human pluripotent cell line UT-7. Blood, 80, 3060-3069.
21. Kastan, M.B., Slamon, D.J. & Civin, C.I. (1989) Expression of protooncogene c-myb in normal human hematopoietic cells. Blood, 73, 1444-1451.
22. Kawasaki, N., Morimoto, K., Tanomoto, T. & Hayakawa, T. (1996) Control of hemoglobin synthesis in erythroid differentiating K562 cells. Archives of Biochemistry and Biophysics, 328, 289-294.
23. Klinken, S.P., Nicola, N.A. & Johnson, G.R. (1988) In vitro-derived leukemic erythroid cell lines induced by raf- and myc-containing retrovirus differentiate in response to erythropoietin. Proceedings of the National Academy of Sciences of the United States of America, 85, 8506-8510.
24. Komatsu, N., Nakauchi, H., Miuwa, N., Ishihara, T., Eguchi, M., Moroi, M., Okada, M., Sato, H., Wada, H., Yawata, Y., Suda, T. & Miura, Y. (1991) Establishment and characterization of a human leukemic cell line with megakaryocytic features: dependency on granulocyte-macrophage colony-stimulating factor, interleukin 3 or erythropoietin for growth and survival. Cancer Research, 51, 341-348.
25. Komatsu, N., Yamamoto, M., Fujita, H., Miwa, A., Hataki, K., Endo, T., Okano, H., Katsube, T., Fukumaki, Y., Sassa, S. & Miura, Y. (1993) Establishment and characterization of an erythropoietin-dependent subline, UT-7/Epo, derived form human leukemia cell line, UT-7. Blood, 82, 456-464.
26. Kondo, T., Sakai, M., Isobe, H., Taniguchi, N., Nishi, S. & Kawakami, Y. (1991) Induction of carbonic anhydrase I isozyme precedes the globin synthesis during erythropoiesis in K562 cells. American Journal of Hematology, 38, 201-206.
27. Labbaye, C., Valtieri, M., Barberi, T., Meccia, E., Maseela, B., Pelosi, E., Condorelli, G.I., Testa, V. & Peshle, C. (1995) Differential expression and functional role of GATA-2, NF-E2 and GATA-1 in normal adult hematopoiesis. Journal of Clinical Investigation, 95, 2346-2358.
28. Laskey, J.D., Ponka, P. & Schulman, H.M. (1986) Control of heme synthesis during Friend cell differentiation: role of iron and transferrin. Journal of Cellular Physiology, 124, 185-192.
29. Leonard, M., Brice, M., Engel, J.D. & Papayannopoulou, T. (1993) Dynamics of GATA transcription factor expression during erythroid differentiation. Blood, 82, 1071-1079.
30. Lin, C.-S., Lim, S.-K., D'Agati, V. & Constantini, F. (1996) Differential effects of an erythropoietin receptor gene disruption on primitive and definitive erythropoiesis. Genes and Development, 10, 154-164.
31. Loken, M.R., Virendra, O.S., Dattilio, K.L. & Civin, C.L. (1987) Flow cytometric analysis of human bone marrow. I. Normal erythroid development. Blood, 69, 255-265.
32. Lozzio, C.B. & Lozzio, B.B. (1975) Human chronic myelogenous leukemia cell line with positive Philadelphia chromosome. Blood, 45, 321-334.
33. Martin, D.I.K., Zon, L.I., Mutler, G. & Orkin, S.H. (1990) Expression of an erythroid transcription factor in megakaryocytic and mast cell lineages. Nature, 344, 444-446.
34. Martin, P. & Papayannopoulou, T. (1982) HEL cells: a new human erythroleukemia cell line with spontaneous and induced globin expression. Science, 216, 1233-1235.
35. Mayeux, P., Felix, J.-M., Billat, C. & Jacquot, R. (1986) Induction by hemin and proliferation and differentiation of progenitor erythroid cells responsible for erythropoietin. Experimental Hematology, 14, 801-808.
36. McDonald, T.P. & Sullivan, P.S. (1993) Megakaryocytic and erythrocytic cell lines share a common precursor. Experimental Hematology, 21, 1316-1320.
37. Mouthon, M.A., Bernard, O., Mitjavila, M.T., Romeo, PH., Vainchenker, W. & Mathieu-Mahul, D. (1993) Expression of tal-1 and GATA-binding proteins during human hematopoiesis. Blood, 81, 647-655.
38. Murate, T., Kagami, Y., Hotta, T., Yoshida, T., Saito, H. & Yoshida, S. (1990) Terminal differentiation of human erythroleukemia cell line K562 induced by aphidicolin. Experimental Cell Research, 191, 45-50.
39. Murate, T., Saga, S., Hotta, T., Asano, H., Ito, T., Kato, K., Tsushita, K., Kinoshita, T., Ichiwaka, A., Yoshida, S. & Saito, H. (1993) The close relationship between DNA replication and the selection of differentiation lineages of human erythroleukemia cell lines K562, HEL, and TF1 into either erythroid or megakaryocytic lineages. Experimental Cell Research, 208, 35-43.
40. Ponka, P. & Schulman, H.M. (1985) Acquisition of iron from transferrin regulates heme synthesis. Journal of Biological Chemistry, 260, 14717-14721.
41. Pope, S.H., Fibach, E., Kim, H.J. & Rodgers, G.P. (1996) Kinetics of expression of genes for globins, transcription factors and cytokine receptors during maturation of adult normal human erythroid cells. Blood, 88 SI, 190a.
42. Robb, L., Elwood, N.J., Elefanty, A.G., Kontgen, F., Li, R., Barnett, L.D. & Begley, C.G. (1996) The sc1 gene product is required for the generation of all hematopoietic lineages in the adult mouse. EMBO Journal, 15, 4123-4129.
43. Robb, L., Lyons, I., Li, R., Hartley, L., Kontgen, F., Harvey, R.P., Metclaf, D. & Begley, C.G. (1995) Absence of yolk sac hematopoiesis from mice with a targeted disruption of the sc1 gene. Proceedings of the National Academy of Sciences of the United States of America, 92, 7075-7079.
44. Romeo, P.H., Pradini, M.H., Joulin, V., Mignotte, M., Prenant, W., Vainchenker, G., Marguerie, G. & Uzan, G. (1990) Megakaryocytic and erythrocytic lineages share transcription factors. Nature, 344, 447-449.
45. Ross, J. & Sauntner, D. (1976) Induction of globin mRNA accumulation by hemin in cultured erythroleukemic cells. Cell, 8, 513-520.
46. Rouault, T., Rao, K., Harford, J., Mattia, E. & Klausner, R.D. (1985) Hemin, chelatable iron, and the regulation of transferrin receptor biosynthesis. Journal of Biological Chemistry, 260, 14862-14866.
47. Spivak, J.L., Pham, T., Isaacs, M. & Hankins, W.D. (1991) Erythropoietin is both a mitogen and a survival factor. Blood, 77, 1228-1233.
48. Spriggs, L.L., Hill, S.M. & Jeter, J.R.J. (1992) Proliferation is required for induction of terminal differentiation of Friend erythroleukemia cells. Biochemistry and Cell Biology, 70, 555-564.
49. Tsuyoka, R., Takahashi, T., Suzuki, A., Sasaki, Y., Nakamura, K., Fukumoto, M., Ohmori, K., Ohno, Y. & Nakao, K. (1995) A newly established megakaryoblastic/erythroid cell line that differentiates to red cells in the prsence of erythropoietin and produces platelet-like particles. Stem Cells, 13, 54-64.
50. Visvader, J., Begley, C. & Adams, J. (1991) Differential expression of the LYL, SCL, and E2A helix-loop-helix genes. Oncogene, 6, 187-194.
51. Weiss, G., Houston, T., Kastner, S., Johrer, K., Grunewald, K. & Brock, J. (1997) Regulation of cellular iron metabolism by erythropoietin: activation of iron-regulatory protein and upregulation of transferrin receptor expression in erythroid cells. Blood, 89, 680-687.
52. Wu, H., Liu, X., Jaenisch, R. & Lodish, H.F. (1995) Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or erythropoietin receptor. Cell, 85, 59-67.