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Volumn 33, Issue 2-3, 1999, Pages 199-215

Characterization of phenytoin-resistant kindled rats, a new model of drug-resistant partial epilepsy: Influence of experimental and environmental factors

Author keywords

Atmospheric pressure; Kindling parameters; Limbic seizures; Pharmacoresistance; Seasonal influence

Indexed keywords

PHENYTOIN;

EID: 0033045047     PISSN: 09201211     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0920-1211(98)00086-2     Document Type: Article
Times cited : (21)

References (46)
  • 1
    • 0019258125 scopus 로고
    • Development of a new pharmacological seizure model: Effects of anticonvulsants on cortical and amygdala-kindled seizures in the rat
    • Albright P.S., Burnham W.M. Development of a new pharmacological seizure model: effects of anticonvulsants on cortical and amygdala-kindled seizures in the rat. Epilepsia. 21:1980;681-689.
    • (1980) Epilepsia , vol.21 , pp. 681-689
    • Albright, P.S.1    Burnham, W.M.2
  • 2
    • 0021748805 scopus 로고
    • Hippocampal calcium-binding protein during commissural kindling-induced epileptogenesis: Progressive decline and effects of anticonvulsants
    • Baimbridge K.G., Miller J.J. Hippocampal calcium-binding protein during commissural kindling-induced epileptogenesis: progressive decline and effects of anticonvulsants. Brain Res. 324:1984;85-90.
    • (1984) Brain Res. , vol.324 , pp. 85-90
    • Baimbridge, K.G.1    Miller, J.J.2
  • 3
    • 0028370563 scopus 로고
    • Seasonality of pineal melatonin production in the rat: Possible synchronization by the geomagnetic field
    • Bartsch, H., Bartsch, C., Mecke, D., Lippert, T.H., 1994. Seasonality of pineal melatonin production in the rat: possible synchronization by the geomagnetic field. Chronobiol. Int. 11, 21-26.
    • (1994) Chronobiol. Int. , vol.11 , pp. 21-26
    • Bartsch, H.1    Bartsch, C.2    Mecke, D.3    Lippert, T.H.4
  • 4
    • 0021921141 scopus 로고
    • Limbic seizure and brain damage produced by kainic acid mechanisms and relevance to human temporal lobe epilepsy
    • Ben-Ari Y. Limbic seizure and brain damage produced by kainic acid mechanisms and relevance to human temporal lobe epilepsy. Neuroscience. 14:1985;375-403.
    • (1985) Neuroscience , vol.14 , pp. 375-403
    • Ben-Ari, Y.1
  • 5
    • 0029053325 scopus 로고
    • Decreased latency for limbic seizures induced in rats by lithium pilocarpine occurs when daily average geomagnetic activity exceeds 20 nanoTesla
    • Bureau Y.R.J., Persinger M.A. Decreased latency for limbic seizures induced in rats by lithium pilocarpine occurs when daily average geomagnetic activity exceeds 20 nanoTesla. Neurosci. Lett. 192:1995;142-144.
    • (1995) Neurosci. Lett. , vol.192 , pp. 142-144
    • Bureau, Y.R.J.1    Persinger, M.A.2
  • 6
    • 0018952226 scopus 로고
    • Pharmacological modification of amygdaloid-kindled seizures
    • Callaghan D.A., Schwark W.S. Pharmacological modification of amygdaloid-kindled seizures. Neuropharmacology. 19:1980;1131-1136.
    • (1980) Neuropharmacology , vol.19 , pp. 1131-1136
    • Callaghan, D.A.1    Schwark, W.S.2
  • 7
    • 0025744912 scopus 로고
    • Decrease of GABA-immunoreactive neurons in the amygdala after electrical kindling in the rat
    • Callahan P.M., Paris J.M., Cunningham K.A., Shinnick-Gallagher P. Decrease of GABA-immunoreactive neurons in the amygdala after electrical kindling in the rat. Brain Res. 555:1991;335-339.
    • (1991) Brain Res. , vol.555 , pp. 335-339
    • Callahan, P.M.1    Paris, J.M.2    Cunningham, K.A.3    Shinnick-Gallagher, P.4
  • 8
    • 0028286992 scopus 로고
    • Neuronal loss induced in limbic pathways by kindling: Evidence for induction of hippocampal sclerosis by repeated brief seizures
    • Cavazos, J.E., Das, I., Sutula, T.P., 1994. Neuronal loss induced in limbic pathways by kindling: evidence for induction of hippocampal sclerosis by repeated brief seizures. J. Neurosci. 14, 3106-3121.
    • (1994) J. Neurosci. , vol.14 , pp. 3106-3121
    • Cavazos, J.E.1    Das, I.2    Sutula, T.P.3
  • 9
    • 0030027461 scopus 로고    scopus 로고
    • Methods for determining numbers of cells and synapses: A case for more uniform standards of review
    • Coggeshall R.E., Lekan H.A. Methods for determining numbers of cells and synapses: a case for more uniform standards of review. J. Comp. Neurol. 364:1996;6-15.
    • (1996) J. Comp. Neurol. , vol.364 , pp. 6-15
    • Coggeshall, R.E.1    Lekan, H.A.2
  • 10
    • 0343624542 scopus 로고
    • Intractable epilepsy: Introduction
    • In: Schmidt, D., Morselli, P.L. (Eds.) Raven Press, New York
    • Dam, M., 1986. Intractable epilepsy: introduction. In: Schmidt, D., Morselli, P.L. (Eds.), Intractable Epilepsy: Experimental and Clinical Aspects. Raven Press, New York, pp. 1-3.
    • (1986) Intractable Epilepsy: Experimental and Clinical Aspects , pp. 1-3
    • Dam, M.1
  • 11
    • 0027972615 scopus 로고
    • Sex differences in the anticonvulsant efficacy of phenytoin in amygdala-kindled rats
    • Ebert U., Rundfeldt C., Löscher W. Sex differences in the anticonvulsant efficacy of phenytoin in amygdala-kindled rats. Brain Res. 638:1994;45-52.
    • (1994) Brain Res. , vol.638 , pp. 45-52
    • Ebert, U.1    Rundfeldt, C.2    Löscher, W.3
  • 12
    • 0030929440 scopus 로고    scopus 로고
    • Phenytoin's effect on the spread of seizure activity in the amygdala kindling model
    • Ebert U., Cramer S., Löscher W. Phenytoin's effect on the spread of seizure activity in the amygdala kindling model. Naunyn-Schmiedeberg's Arch. Pharmacol. 356:1997;341-347.
    • (1997) Naunyn-Schmiedeberg's Arch. Pharmacol. , vol.356 , pp. 341-347
    • Ebert, U.1    Cramer, S.2    Löscher, W.3
  • 13
    • 0344628691 scopus 로고    scopus 로고
    • Characterization of phenytoin-resistant amygdala-kindled rats, a new model of drug-resistant partial epilepsy: Influence of genetic factors
    • Ebert, U., Löscher, W., 1999. Characterization of phenytoin-resistant amygdala-kindled rats, a new model of drug-resistant partial epilepsy: influence of genetic factors. Epilepy Res. 33, 217-226.
    • (1999) Epilepy Res. , vol.33 , pp. 217-226
    • Ebert, U.1    Löscher, W.2
  • 14
    • 0018917862 scopus 로고
    • Effects of phenytoin on amygdaloid kindled seizures in the rat
    • Ehle A.L. Effects of phenytoin on amygdaloid kindled seizures in the rat. Electroencephalogr. Clin. Neurophysiol. 48:1980;102-105.
    • (1980) Electroencephalogr. Clin. Neurophysiol. , vol.48 , pp. 102-105
    • Ehle, A.L.1
  • 16
    • 0019854869 scopus 로고
    • The effect of interstimulation interval on the assessment and stability of kindled seizure threshold
    • Freeman F.G., Jarvis M.F. The effect of interstimulation interval on the assessment and stability of kindled seizure threshold. Brain Res. Bull. 7:1981;629-633.
    • (1981) Brain Res. Bull. , vol.7 , pp. 629-633
    • Freeman, F.G.1    Jarvis, M.F.2
  • 17
    • 0021260688 scopus 로고
    • Anticonvulsant effect of primidone in the gerbil. Time course and significance of the active metabolites
    • Frey H.H., Löscher W., Reiche R., Schultz D. Anticonvulsant effect of primidone in the gerbil. Time course and significance of the active metabolites. Pharmacology. 28:1984;329-335.
    • (1984) Pharmacology , vol.28 , pp. 329-335
    • Frey, H.H.1    Löscher, W.2    Reiche, R.3    Schultz, D.4
  • 18
    • 0016721610 scopus 로고
    • Effect of age, height, weight and sex on serum phenytoin concentration in epileptic patients
    • Houghton G.W., Richens A., Leighton M. Effect of age, height, weight and sex on serum phenytoin concentration in epileptic patients. Br. J. Clin. Pharmacol. 2:1975;251-256.
    • (1975) Br. J. Clin. Pharmacol. , vol.2 , pp. 251-256
    • Houghton, G.W.1    Richens, A.2    Leighton, M.3
  • 19
    • 0002734928 scopus 로고
    • Amygdaloid kindling in the rat: Regional differences and general properties
    • In: Wada, J.A. (Ed.), Raven Press, New York
    • Le Gal La Salle, G., 1981. Amygdaloid kindling in the rat: regional differences and general properties. In: Wada, J.A. (Ed.), Kindling 2. Raven Press, New York, pp. 31-47.
    • (1981) Kindling 2 , pp. 31-47
    • Le Gal La Salle, G.1
  • 20
    • 0031870728 scopus 로고    scopus 로고
    • Amygdala-kindling induces a lasting reduction of GABA-immunoreactive neurons in a discrete area of the ipsilateral piriform cortex
    • in press
    • Lehmann, H., Ebert, U., Löscher, W., 1998. Amygdala-kindling induces a lasting reduction of GABA-immunoreactive neurons in a discrete area of the ipsilateral piriform cortex. Synapse (in press).
    • (1998) Synapse
    • Lehmann, H.1    Ebert, U.2    Löscher, W.3
  • 21
    • 0030248323 scopus 로고    scopus 로고
    • The role of technical, biological and pharmacological factors in the laboratory evaluation of anticonvulsant drugs. VI. Seasonal influences on maximal electroshock and pentylenetetrazol seizure thresholds
    • Löscher W., Fiedler M. The role of technical, biological and pharmacological factors in the laboratory evaluation of anticonvulsant drugs. VI. Seasonal influences on maximal electroshock and pentylenetetrazol seizure thresholds. Epilepsy Res. 25:1996;3-10.
    • (1996) Epilepsy Res. , vol.25 , pp. 3-10
    • Löscher, W.1    Fiedler, M.2
  • 22
    • 0026075949 scopus 로고
    • Kindling as a model of drug-resistant partial epilepsy: Selection of phenytoin-resistant and non-resistant rats
    • Löscher W., Rundfeldt C. Kindling as a model of drug-resistant partial epilepsy: selection of phenytoin-resistant and non-resistant rats. J. Pharmacol. Exp. Ther. 258:1991;483-489.
    • (1991) J. Pharmacol. Exp. Ther. , vol.258 , pp. 483-489
    • Löscher, W.1    Rundfeldt, C.2
  • 23
    • 0023897574 scopus 로고
    • Which animal models should be used in the search for new antiepileptic drugs? A proposal based on experimental and clinical considerations
    • Löscher W., Schmidt D. Which animal models should be used in the search for new antiepileptic drugs? A proposal based on experimental and clinical considerations. Epilepsy Res. 2:1988;145-181.
    • (1988) Epilepsy Res. , vol.2 , pp. 145-181
    • Löscher, W.1    Schmidt, D.2
  • 24
    • 0022455261 scopus 로고
    • Is amygdaloid kindling in rats a model for drug-resistant partial epilepsy?
    • Löscher W., Jäckel R., Czuczwar S.J. Is amygdaloid kindling in rats a model for drug-resistant partial epilepsy? Exp. Neurol. 93:1986;211-226.
    • (1986) Exp. Neurol. , vol.93 , pp. 211-226
    • Löscher, W.1    Jäckel, R.2    Czuczwar, S.J.3
  • 25
    • 0027163791 scopus 로고
    • Transmitter amino acid levels in rat brain regions after amygdala-kindling or chronic electrode implantation without kindling: Evidence for a pro-kindling effect of prolonged electrode implantation
    • Löscher W., Hörstermann D., Hönack D., Rundfeldt C., Wahnschaffe U. Transmitter amino acid levels in rat brain regions after amygdala-kindling or chronic electrode implantation without kindling: evidence for a pro-kindling effect of prolonged electrode implantation. Neurochem. Res. 18:1993;775-781.
    • (1993) Neurochem. Res. , vol.18 , pp. 775-781
    • Löscher, W.1    Hörstermann, D.2    Hönack, D.3    Rundfeldt, C.4    Wahnschaffe, U.5
  • 26
    • 0010352450 scopus 로고
    • Pharmacological characterization of phenytoin-resistant amygdala-kindled rats, a new model of drug-resistant partial epilepsy
    • Löscher W., Rundfeldt C., Hönack D. Pharmacological characterization of phenytoin-resistant amygdala-kindled rats, a new model of drug-resistant partial epilepsy. Epilepsy Res. 9:1993;11-18.
    • (1993) Epilepsy Res. , vol.9 , pp. 11-18
    • Löscher, W.1    Rundfeldt, C.2    Hönack, D.3
  • 27
    • 0028922382 scopus 로고
    • Susceptibility of different cell layers of the anterior and posterior part of the piriform cortex to electrical stimulation and kindling: Comparison with the basolateral amygdala and 'area tempestas'
    • Löscher, W., Ebert, U., Wahnschaffe, U., Rundfeldt, C., 1995a. Susceptibility of different cell layers of the anterior and posterior part of the piriform cortex to electrical stimulation and kindling: comparison with the basolateral amygdala and 'area tempestas'. Neuroscience 66, 265-276.
    • (1995) Neuroscience , vol.66 , pp. 265-276
    • Löscher, W.1    Ebert, U.2    Wahnschaffe, U.3    Rundfeldt, C.4
  • 28
    • 0028799166 scopus 로고
    • Does prolonged implantation of depth electrodes predispose the brain to kindling?
    • Löscher W., Wahnschaffe U., Hönack D., Rundfeldt C. Does prolonged implantation of depth electrodes predispose the brain to kindling? Brain Res. 697:1995;197-204.
    • (1995) Brain Res. , vol.697 , pp. 197-204
    • Löscher, W.1    Wahnschaffe, U.2    Hönack, D.3    Rundfeldt, C.4
  • 29
    • 0025832850 scopus 로고
    • Intraperitoneal phenytoin suppresses kindled responses: Effects on motor and electrographic seizures
    • Lothman E.W., Williamson J.M., Van Landingham K.E. Intraperitoneal phenytoin suppresses kindled responses: effects on motor and electrographic seizures. Epilepsy Res. 9:1991;11-18.
    • (1991) Epilepsy Res. , vol.9 , pp. 11-18
    • Lothman, E.W.1    Williamson, J.M.2    Van Landingham, K.E.3
  • 30
    • 0021815424 scopus 로고
    • Role of female gonadal hormones in the CNS: Clinical and experimental aspects
    • Maggi A., Perez J. Role of female gonadal hormones in the CNS: clinical and experimental aspects. Life Sci. 37:1985;893-906.
    • (1985) Life Sci. , vol.37 , pp. 893-906
    • Maggi, A.1    Perez, J.2
  • 31
    • 0024448524 scopus 로고
    • Development of new pharmacological agents for epilepsy: Lessons from the kindling model
    • McNamara J.O. Development of new pharmacological agents for epilepsy: lessons from the kindling model. Epilepsia. 30(Suppl. 1):1989;S13-18.
    • (1989) Epilepsia , vol.30 , Issue.1 SUPPL. , pp. 13-18
    • McNamara, J.O.1
  • 32
    • 0024457284 scopus 로고
    • Intravenous phenytoin is an effective anticonvulsant in the kindling model
    • McNamara J.O., Rigsbee L.C., Butler L.S., Shin C. Intravenous phenytoin is an effective anticonvulsant in the kindling model. Ann. Neurol. 26:1989;675-678.
    • (1989) Ann. Neurol. , vol.26 , pp. 675-678
    • McNamara, J.O.1    Rigsbee, L.C.2    Butler, L.S.3    Shin, C.4
  • 33
    • 0023773223 scopus 로고
    • Sex-specific distinctions in audiogenic convulsions exhibited by severe seizure genetically epilepsy-prone rats (GEPR-9s)
    • Mishra P.K., Dailey J.W., Reigel C.E., Tomsic M.L., Jobe P.C. Sex-specific distinctions in audiogenic convulsions exhibited by severe seizure genetically epilepsy-prone rats (GEPR-9s). Epilepsy Res. 2:1988;309-316.
    • (1988) Epilepsy Res. , vol.2 , pp. 309-316
    • Mishra, P.K.1    Dailey, J.W.2    Reigel, C.E.3    Tomsic, M.L.4    Jobe, P.C.5
  • 34
    • 0030001026 scopus 로고    scopus 로고
    • Differential sensitivity of various temporal lobe structures in the rat to kindling and status epilepticus induction
    • Mohapel P., Dufresne C., Kelly M.E., McIntyre D.C. Differential sensitivity of various temporal lobe structures in the rat to kindling and status epilepticus induction. Epilepsy Res. 23:1996;179-187.
    • (1996) Epilepsy Res. , vol.23 , pp. 179-187
    • Mohapel, P.1    Dufresne, C.2    Kelly, M.E.3    McIntyre, D.C.4
  • 36
    • 0030239465 scopus 로고    scopus 로고
    • Enhancement of limbic seizures by nocturnal application of magnetic fields that simulate the magnitude and morphology of increases in geomagnetic activity
    • Persinger M.A. Enhancement of limbic seizures by nocturnal application of magnetic fields that simulate the magnitude and morphology of increases in geomagnetic activity. Int. J. Neurosci. 86:1996;271-280.
    • (1996) Int. J. Neurosci. , vol.86 , pp. 271-280
    • Persinger, M.A.1
  • 37
    • 0015309163 scopus 로고
    • Modification of seizure activity by electrical stimulation. II. Motor seizure
    • Racine R.J. Modification of seizure activity by electrical stimulation. II. Motor seizure. Electroencephalogr. Clin. Neurophysiol. 32:1972;281-294.
    • (1972) Electroencephalogr. Clin. Neurophysiol. , vol.32 , pp. 281-294
    • Racine, R.J.1
  • 38
    • 0025050694 scopus 로고
    • Antiepileptic drugs: Pharmacological mechanisms and clinical efficacy with considerations of promising developmental stage compounds
    • Rogawski M.A., Porter R.J. Antiepileptic drugs: pharmacological mechanisms and clinical efficacy with considerations of promising developmental stage compounds. Pharmacol. Rev. 42:1990;223-286.
    • (1990) Pharmacol. Rev. , vol.42 , pp. 223-286
    • Rogawski, M.A.1    Porter, R.J.2
  • 39
    • 0027362902 scopus 로고
    • Anticonvulsant efficacy and adverse effects of phenytoin during chronic treatment in amygdala-kindled rats
    • Rundfeldt C., Löscher W. Anticonvulsant efficacy and adverse effects of phenytoin during chronic treatment in amygdala-kindled rats. J. Pharmacol. Exp. Ther. 266:1993;216-223.
    • (1993) J. Pharmacol. Exp. Ther. , vol.266 , pp. 216-223
    • Rundfeldt, C.1    Löscher, W.2
  • 40
    • 0025168396 scopus 로고
    • Phenytoin potently increases the threshold for focal seizures in amygdala-kindled rats
    • Rundfeldt C., Hönack D., Löscher W. Phenytoin potently increases the threshold for focal seizures in amygdala-kindled rats. Neuropharmacology. 29:1990;845-851.
    • (1990) Neuropharmacology , vol.29 , pp. 845-851
    • Rundfeldt, C.1    Hönack, D.2    Löscher, W.3
  • 41
    • 0022625903 scopus 로고
    • The influence of seizure type on the efficacy of plasma concentrations of phenytoin, phenobarbital and carbamazepine
    • Schmidt D., Einicke I., Haenel F. The influence of seizure type on the efficacy of plasma concentrations of phenytoin, phenobarbital and carbamazepine. Arch. Neurol. 43:1986;263-265.
    • (1986) Arch. Neurol. , vol.43 , pp. 263-265
    • Schmidt, D.1    Einicke, I.2    Haenel, F.3
  • 43
    • 0028338409 scopus 로고
    • Stimulation-dependent effect of antiepileptic drugs in amygdala kindled rats on both seizure score and duration of afterdischarges
    • Voits M., Frey H.H. Stimulation-dependent effect of antiepileptic drugs in amygdala kindled rats on both seizure score and duration of afterdischarges. Pharmacol. Toxicol. 75:1994;54-61.
    • (1994) Pharmacol. Toxicol. , vol.75 , pp. 54-61
    • Voits, M.1    Frey, H.H.2
  • 44
    • 84909694052 scopus 로고
    • Seasonal influences on biological rhythms of standardized laboratory animals
    • Von Mayersbach H. Seasonal influences on biological rhythms of standardized laboratory animals. Chronobiologia. 8:1981;87-91.
    • (1981) Chronobiologia , vol.8 , pp. 87-91
    • Von Mayersbach, H.1
  • 45
    • 0029877361 scopus 로고    scopus 로고
    • Microdialysis study of the neuropharmacokinetics of phenytoin in rat hippocampus and frontal cortex
    • Walker M.C., Alavijeh M.S., Shorvon S.D., Patsalos P.N. Microdialysis study of the neuropharmacokinetics of phenytoin in rat hippocampus and frontal cortex. Epilepsia. 37:1996;421-427.
    • (1996) Epilepsia , vol.37 , pp. 421-427
    • Walker, M.C.1    Alavijeh, M.S.2    Shorvon, S.D.3    Patsalos, P.N.4
  • 46
    • 0027445071 scopus 로고
    • The role of technical, biological, and pharmacological factors in the laboratory evaluation of anticonvulsant drugs. V. Lack of seasonal influences on amygdala kindling in rats
    • Wlaz P., Löscher W. The role of technical, biological, and pharmacological factors in the laboratory evaluation of anticonvulsant drugs. V. Lack of seasonal influences on amygdala kindling in rats. Epilepsy Res. 16:1993;131-136.
    • (1993) Epilepsy Res. , vol.16 , pp. 131-136
    • Wlaz, P.1    Löscher, W.2


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