Nitric oxide modulation of the growth hormone-releasing activity of Hexarelin in young and old dogs

Metabolism: Clinical and Experimental

Volumn 48, Issue 2, 1999, Pages 176-182

  Rigamonti, Antonello E ^a   Cella, Silvano G ^a   Marazzi, Nicoletta ^a   Müller, Eugenio E ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ERYTHRITYL TETRANITRATE; GROWTH HORMONE; HEXARELIN; INDOMETACIN; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; PROSTAGLANDIN SYNTHASE; PROSTAGLANDIN SYNTHASE INHIBITOR;

ANIMAL EXPERIMENT; ARTICLE; CONCENTRATION RESPONSE; DOG; DRUG ACTIVITY; DRUG POTENTIATION; FEMALE; GROWTH HORMONE BLOOD LEVEL; GROWTH HORMONE RELEASE; HORMONAL REGULATION; HORMONE ACTION; HORMONE RESPONSE; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL;

EID: 0033044560     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0026-0495(99)90030-6     Document Type: Article

References (35)

1. Ceccatelli S, Hulting A, Zhang X, et al: Nitric oxide synthase in the rat anterior pituitary gland and the role of nitric oxide in regulation of luteinizing hormone secretion. Proc Natl Acad Sci USA 90:11292-11296, 1993
2. Costa A, Trainer P, Besser M, et al: Nitric oxide modulates the release of corticotropin-releasing hormone from the rat hypothalamus in vitro. Brain Res 605:187-192, 1993
3. Chiodera P, Volpi R, Coiro V: Inhibitory control of nitric oxide on the arginine-vasopressin and oxytocin response to hypoglycaemia in normal men. Neuroreport 5:1822-1824, 1994
4. Duvilanski BH, Zambruno C, Seilicovich A, et al: Role of nitric oxide in control of prolactin release by the adenohypophysis. Proc Natl Acad Sci USA 92:170-174, 1995
5. Kato M: Involvement of nitric oxide in growth hormone (GH)-releasing hormone-induced GH secretion in rat pituitary cells. Endocrinology 131:2133-2138, 1992
6. Aguila MC: Growth hormone-releasing factor increases somatostatin release and mRNA levels in the rat periventricular nucleus via nitric oxide by activation of guanylate cyclase. Proc Natl Acad Sci USA 91:782-786, 1994
7. Korbonits M, Trainer PJ, Fanciulli G, et al: L-Arginine is unlikely to exert neuroendocrine effects in humans via the generation of nitric oxide. Eur J Endocrinol 135:543-547, 1996
8. Tena-Sempere M, Leonor P, Gonzalez D, et al: Involvement of endogenous nitric oxide in the control of pituitary responsiveness to different elicitors of growth hormone release in prepubertal rats. Neuroendocrinology 64:146-152, 1996
9. Volpi R, Chiodera P, Caffarri G, et al: Influence of nitric oxide on hypoglycemia- or angiotensin II-stimulated ACTH and GH secretion in normal men. Neuropeptides 30:528-532, 1996
10. Moncada S, Higgs FA The L-arginine-nitric oxide pathway. N Engl J Med 329:2002-2012, 1993
11. Knowles RG, Moncada S: Nitric oxide synthases in mammals. Biochem J 258:249-258, 1994
12. Bredt DS, Hwang PM, Snyder SH: Localization of nitric oxide synthase indicating a neuronal role for nitric oxide. Nature 347:768-770, 1990
13. Bhat G, Mahesh VB, Aguan K, et al: Evidence that brain nitric oxide synthase is the major nitric oxide synthase isoform in the hypothalamus of the adult female rat and that nitric oxide potently regulates hypothalamic cGMP levels. Neuroendocrinology 64:93-102, 1996
14. Rettori V, Gimeno M, Lyson K, et al: Nitric oxide mediates norepinephrine-induced prostaglandin E2 release from the hypothalamus. Proc Natl Acad Sci USA 89 11543-11546, 1992
15. Salvemini D: Regulation of cyclooxygenase enzymes by nitric oxide. Cell Mol Life Sci 53:576-582, 1997
16. Salvemini D, Misko TP, Masferrrer JL, et al: Nitric oxide activates cyclooxygenase enzymes. Proc Natl Acad Sci USA 90:7240-7244, 1993
17. Ojcda SR, Negro-Vilar A, McCann SM, et al. Release of prostaglandins by hypothalamic tissue: Evidence for their involvement in catecholamine-induced lutemizing hormone-releasing hormone release. Endocrinology 104:617-624, 1979
18. Sobel DO: Characterization of PGE2 inhibition of corticotropin releasing factor-mediated ACTH release. Brain Res 411:102-107, 1987
19. Sonntag WE, Steger RW, Forman LJ, et al: Decreased pulsatile release of growth hormone in old rats. Endocrinology 107:1875-1879, 1977
20. Zadik Z, Chalew SA, McCarter RJ, et al: The influence of age on the twenty-four-hour integrated concentration of growth hormone in normal individuals. J Clin Endocrinol Metab 60:513-516, 1985
21. Shibasaki T, Shizume K, Makahara M, et al: Age-related changes in plasma growth hormone response to growth hormone-releasing factor in man. J Clin Endocrinol Metab 58:212-214, 1984
22. Cocchi D, Calderini G, Ganzetti I, et al: Aspects of the control of prolactin and growth hormone secretion in aging, in Muller EE, MacLeod RM (eds): Neuroendocrine Perspectives, vol 5 Amsterdam, The Netherlands. Elsevier, 1986, pp 191-204
23. Arvat E, Gianotti L, Grottoli S, et al: Arginine and growth hormone-releasing hormone restore the blunted growth hormone-releasing activity of Hexarelin in elderly subjects. J Clin Endocrinol Metab 79, 1440-1443, 1994
24. Cella SG, Locatelli V, Poratelli M, et al: Hexarelin, a potent GHRP analogue: Interactions with GHRH and clonidine in young and aged dogs. Peptides 16:81-86, 1995
25. Muller EE, Cella SG, De Gennaro Colonna V, et al: Aspects of the neuroendocrine control of growth hormone secretion in ageing mammals. J Reprod Fertil Suppl 43:99-114, 1993
26. Müller EE, Cella SG, Parenti M, et al: Somatotropic dysregulation in old mammals. Horm Res 43:39-45, 1995
27. Robertson RM, Robertson D. Drugs used for the treatment of myocardial ischemia, in Hardman JG, Limbird LE, Molinoff PB, et al (eds): Goodman & Gilman's The Pharmacological Basis of Therapeutics (ed 9). New York, NY. McGraw-Hill, 1996. pp 759-767
28. Korbonits M, Grossman AB: Growth hormone-releasing peptide and its analogues. Trends Endocrinol Metab 6:43-46, 1995
29. Torsello A, Grilli R, Luoni M, et al: Mechanism of action of Hexarelin. Growth hormone-releasing activity in the rat. Eur J Endocrinol 135:481-488, 1996
30. Rees DD, Palmer RMJ, Sculz R, et al: Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo. Br J Pharmacol 101:746-752, 1990
31. Roudbaraki MM, Drouhault R, Bacquart T, et al: Arachidonic acid-induced release in somatotropes: Involvement of calcium. Neuroendocrinology 63:244-256, 1996
32. Anhnfelt-Ronne I, Agerholm PC, Bistrup HN: Indomethacin pretreatment reduces GHRP-6-induced GH release in rats. Second International Symposium on Growth Hormone Secretagogues, Tampa, FL, February 13-17, 1997
33. DeGennaro Colonna V, Rossoni G, Bernareggi M, et al: Cardiac ischemia and impairment of vascular endothelium function in hearts from growth hormone-deficient rats. Protection by Hexarelin. Eur J Pharmacol 334:201-207, 1997
34. Ghigo E, Arvat E, Muccioli G, et al: Growth hormone-releasing peptides. Eur J Endocrinol 136:445-460, 1997
35. Smith RG, Cheng K, Schoen WR, et al: A nonpeptidyl growth hormone secretagogue. Science 260:1640-1643, 1993