Synovial fluid transforming growth factor β inhibits dendritic cell-T lymphocyte interactions in patients with chronic arthritis

Arthritis and Rheumatism

Volumn 42, Issue 3, 1999, Pages 507-518

  Summers, Kelly L ^a   O'Donnell, John L ^a   Heiser, Axel ^a   Highton, John ^b   Hart, Derek N J ^a  

^a CHRISTCHURCH HOSPITAL   (New Zealand)

^b UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; CD86 ANTIGEN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR;

ANTIGEN PRESENTING CELL; ARTICLE; CHRONIC ARTHRITIS; CROSS LINKING; DENDRITIC CELL; HUMAN; HUMAN CELL; IMMUNE RESPONSE; LIGAND BINDING; LYMPHOCYTE FUNCTION; LYMPHOCYTE PROLIFERATION; MEMBRANE BINDING; MONONUCLEAR CELL; PRIORITY JOURNAL; RECEPTOR UPREGULATION; SYNOVIAL FLUID LEVEL; T LYMPHOCYTE ACTIVATION;

ANTIBODIES, MONOCLONAL; ANTIGENS, CD; ANTIGENS, CD14; ANTIGENS, CD3; ANTIGENS, CD80; ANTIGENS, CD86; ARTHRITIS, RHEUMATOID; B-LYMPHOCYTES; CELL COMMUNICATION; CELL LINE, TRANSFORMED; CELLS, CULTURED; CHRONIC DISEASE; CYTOTOXICITY TESTS, IMMUNOLOGIC; DENDRITIC CELLS; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; HUMANS; INTERLEUKIN-2; LYMPHOCYTE ACTIVATION; MEMBRANE GLYCOPROTEINS; RECEPTORS, IGG; SYNOVIAL FLUID; T-LYMPHOCYTES; TRANSFORMING GROWTH FACTOR BETA;

EID: 0033044187     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/1529-0131(199904)42:3<507::AID-ANR16>3.0.CO;2-Y     Document Type: Article

References (54)

1. Stastny P. Association of the B-cell alloantigen DRw4 with rheumatoid arthritis. N Engl J Med 1978;298:869-71.
2. Hart DNJ. Dendritic cells: unique leukocyte populations which control the primary immune response. Blood 1997;90:3245-87.
3. Janeway CA Jr, Bottomly K. Signals and signs for lymphocyte responses. Cell 1994;76:275-85.
4. Guinan EC, Gribben JG, Boussiotis VA, Freeman GJ, Nadler LM. Pivotal role of the B7:CD28 pathway in transplantation tolerance and tumor immunity. Blood 1994;84:3261-82.
5. Linsley PS, Brady W, Grosmaire L, Aruffo A, Damle NK, Ledbetter JA. Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation. J Exp Med 1991;173:721-30.
6. Hart DNJ, Starling GC, Calder VL, Fernando NJ. B7/BB-1 is a leucocyte differentiation antigen on human dendritic cells induced by activation. Immunology 1993;79:616-20.
7. McLellan AD, Starling GC, Williams LA, Hock BD, Hart DNJ. Activation of human peripheral blood dendritic cells induces the CD86 co-stimulatory molecule. Eur J Immunol 1995;25:2064-8.
8. Summers KL, O'Donnell JL, Williams LA, Hart DNJ. Expression and function of CD80 and CD86 costimulator molecules on synovial dendritic cells in chronic arthritis. Arthritis Rheum 1996; 39:1287-91.
9. McLellan AD, Sorg RV, Williams LA, Hart DNJ. Human dendritic cells activate T lymphocytes via a CD40:CD40 ligand-dependent pathway. Eur J Immunol 1996;26:1204-10.
10. Summers KL, O'Donnell JL, Hart DNJ. Co-expression of the CD45RA and CD45RO antigens on T lymphocytes in chronic arthritis. Clin Exp Immunol 1994;97:39-44.
11. Pitzalis C, Kingsley G, Murphy J, Panayi G. Abnormal distribution of the helper-inducer and suppressor-inducer T-lymphocyte subsets in the rheumatoid joint. Clin Immunol Immunopathol 1987; 45:252-8.
12. Kohem CL, Brezinschek RI, Wisbey H, Tortorella C, Lipsky PE, Oppenheimer-Marks N. Enrichment of differentiated CD45RBdim,CD27- memory T cells in the peripheral blood, synovial fluid, and synovial tissue of patients with rheumatoid arthritis. Arthritis Rheum 1996;39:844-54.
13. Allen ME, Young SP, Michell RH, Bacon PA. Altered T lymphocyte signaling in rheumatoid arthritis. Eur J Immunol 1995;25: 1547-54.
14. Kitas GD, Salmon M, Farr M, Young SP, Bacon PA. T-cell functional defects in chronic rheumatoid-arthritis: intrinsic or extrinsic. J Autoimmun 1988;1:339-51.
15. Combe B, Pope RM, Fischbach M, Darnell B, Baron S, Talal N. Interleukin-2 in rheumatoid arthritis: production of and response to interleukin-2 in rheumatoid synovial fluid, synovial tissue and peripheral blood. Clin Exp Immunol 1985;59:520-8.
16. Firestein GS, Alvaro-Gracia JM, Maki R. Quantitative analysis of cytokine gene expression in rheumatoid arthritis. J Immunol 1990;144:3347-53.
17. Mirza NM, Relias V, Yunis EJ, Pachas WN, Dasgupta JD. Defective signal transduction via T-cell receptor-CD3 structure in T cells from rheumatoid arthritis patients. Hum Immunol 1993; 36:91-8.
18. Summers KL, Daniel PB, O'Donnell JL, Hart DNJ. Dendritic cells in synovial fluid of chronic inflammatory arthritis lack CD80 surface expression. Clin Exp Immunol 1995;100:81-9.
19. Buelens C, Willems F, Delvaux A, Pierard G, Delville J, Velu T, et al. Interleukin-10 differentially regulates B7-1 (CD80) and B7-2 (CD86) expression on human peripheral blood dendritic cells. Eur J Immunol 1995;25:2668-72.
20. Mitra RS, Judge TA, Nestle FO, Turka LA, Nickoloff BJ. Psoriatic skin-derived dendritic cell function is inhibited by exogenous IL-10: differential modulation of B7-1 (CD80) and B7-2 (CD86) expression. J Immunol 1995;154:2668-77.
21. Brennan FM, Maini RN, Feldmann M. Cytokine expression in chronic inflammatory disease. In: Saklatvala J, Walport MJ, editors. British medical bulletin. Vol. 51. Edinburgh: Churchill Livingstone; 1995. p. 368-84.
22. Cush JJ, Splawski JB, Thomas R, McFarlin JE, Schulze-Koops H, Davis LS, et al. Elevated interleukin-10 levels in patients with rheumatoid arthritis. Arthritis Rheum 1995;38:96-104.
23. Brennan FM, Chantry D, Turner M, Foxwell B, Maini R, Feldmann M. Detection of transforming growth factor-beta in rheumatoid arthritis synovial tissue: lack of effect on spontaneous cytokine production in joint cell cultures. Clin Exp Immunol 1990;81:278-85.
24. Lotz M, Kekow J, Carson DA. Transforming growth factor-β and cellular immune responses in synovial fluids. J Immunol 1990;144: 4189-94.
25. Bucht A, Larsson P, Weisbrot L, Thorne C, Pisa P, Smedegard G, et al. Expression of interferon-gamma (IFN-γ), IL-10, IL-12 and transforming growth factor-beta (TGF-β) mRNA in synovial fluid cells from patients in the early and late phases of rheumatoid arthritis (RA). Clin Exp Immunol 1996;103:357-67.
26. Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988;31:315-24.
27. Hock BD, Starling GC, Daniel PB, Hart DNJ. Characterisation of CMRF-44, a novel monoclonal antibody to an activation antigen expressed by the allostimulatory cells within peripheral blood, including dendritic cells. Immunology 1994;83:573-81.
28. Fearnley DB, McLellan AD, Mannering SI, Hock BD, Hart DNJ. Isolation of human blood dendritic cells using the CMRF-44 monoclonal antibody: implications for studies on antigen presenting cell function and immunotherapy. Blood 1997;89:3708-16.
29. McLellan AD, Starling GC, Hart DNJ. Isolation of human blood dendritic cells by discontinuous Nycodenz gradient centrifugation. J Immunol Methods 1995;184:81-9.
30. Inaba K, Steinman RM. Accessory cell-T lymphocyte interactions: antigen-dependent and -independent clustering. J Exp Med 1986; 163:247-61.
31. Stagg AJ, Harding B, Hughes RA, Keat A, Knight SC. Peripheral blood and synovial fluid T cells differ in their response to alloantigens and recall antigens presented by dendritic cells. Clin Exp Immunol 1991;84:72-7.
32. Verwilghen J, Corrigall V, Pope RM, Rodrigues R, Panayi GS. Expression and function of CDS and CD28 in patients with rheumatoid arthritis. Immunology 1993;80:96-102.
33. Hernández-Garcia C, Fernández-Gutiérrez B, Morado IC, Bañares AA, Jover JA. The CD69 activation pathway in rheumatoid arthritis synovial fluid T cells. Arthritis Rheum 1996;39:1277-86.
34. Cella M, Scheidegger D, Palmer-Lehmann K, Lane P, Lanzavecchia A, Alber G. Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation. J Exp Med 1996;184:747-52.
35. Kang K, Kubin M, Cooper KD, Lessin SR, Trinchieri G, Rook AH. IL-12 synthesis by human Langerhans cells. J Immunol 1996;156:1402-7.
36. Wang F, Sengupta TK, Zhong Z, Ivashkiv LB. Regulation of the balance of cytokine production and the signal transducer and activator of transcription (STAT) transcription factor activity by cytokines and inflammatory synovial fluids. J Exp Med 1995;182: 1825-31.
37. Fava R, Olsen N, Keski-Oja J, Moses H, Pincus T. Active and latent forms of transforming growth factor β activity in synovial effusions. J Exp Med 1989;169:291-6.
38. Clark DA, Flanders KC, Hirte H, Dasch JR, Coker R, McAnulty RJ, et al. Characterization of murine pregnancy decidua transforming growth factor beta. Biol Reprod 1995;52:1380-8.
39. Lipscomb MF, Pollard AM, Yates JL. A role for TGF-beta in the suppression by murine bronchoalveolar cells of lung dendritic cell initiated immune responses. Reg Immunol 1993;5:225-30.
40. Lang AK, Searle RF. The immunomodulatory activity of human amniotic fluid can be correlated with transforming growth factor-beta 1 (TGF-β1) and β2 activity. Clin Exp Immunol 1994;97:158-63.
41. Meert KL, Ofenstein JP, Genyea C, Sarnaik AP, Kaplan J. Elevated transforming growth factor-β concentration correlates with posttrauma immunosuppression. J Trauma 1996;40:901-6.
42. Yuan L, Kuramitsu Y, Li Y, Kobayashi M, Hosokawa M. Restoration of interleukin-2 production in tumor-bearing rats through reducing tumor-derived transforming growth factor β by treatment with bleomycin. Cancer Immunol Immunother 1995;41:355-62.
43. Wahl SM, Allen JB, Welch GR, Wong HL. Transforming growth factor-β in synovial fluids modulates FcγRIII (CD16) expression on mononudear phagocytes. J Immunol 1992;148:485-90.
44. + T lymphoblastoid cell line. Immunol Invest 1996;25:129-51.
45. Salmon M, Gaston JS. The role of T-lymphocytes in rheumatoid arthritis. In: Saklatvala J, Walport MJ, editors. British medical bulletin. Vol. 51. Edinburgh: Churchill Livingstone; 1995. p. 332-45.
46. Chu CQ, Field M, Abney E, Zheng RQH, Allard S, Feldmann M, et al. Transforming growth factor-β1 in rheumatoid synovial membrane and cartilage/pannus junction. Clin Exp Immunol 1991;86:380-6.
47. Thomas R, Davis LS, Lipsky PE. Rheumatoid synovium is enriched in mature antigen-presenting dendritic cells. J Immunol 1994;153:2613-23.
48. McLellan AD, Hart DNJ. Induction of dendritic cell co-stimulation molecule expression is suppressed by T cells in absence of antigen specific signalling: role of cluster formation. CD40 and HLA-class II for DC activation. Submitted for publication.
49. Alderson MR, Smith CA, Tough TW, Davis-Smith T, Armitage RJ, Falk B, et al. Molecular and biological characterization of human 4-1BB and its ligand. Eur J Immunol 1994;24:2219-27.
50. Walunas TL, Lenschow DJ , Bakker CY, Linsley PS, Freeman GJ, Green JM, et al. CTLA-4 can function as a negative regulator of T cell activation. Immunity 1994; 1:405-13.
51. Zhou LJ, Tedder TF. A distinct pattern of cytokine gene expression by human CD83+ blood dendritic cells. Blood 1995;86:3295-301.
52. Robertson SE, Young SP, Viner NJ, Bacon PA. Enhanced co-stimulatory ability of synovial fluid accessory cells in rheumatoid arthritis. Br J Rheumatol 1997;36:413-9.
53. Schlaak JF, Pfers I, Meyer Zum Buschenfelde KH, Marker-Hermann E. Different cytokine profiles in the synovial fluid of patients with osteoarthritis, rheumatoid arthritis and seronegative spondylarthropathies. Clin Exp Rheumatol 1996;14:155-62.
54. Wahl SM, Allen JB, Costa GL, Wong HL, Dasch JR. Reversal of acute and chronic synovial inflammation by anti-transforming growth factor β. J Exp Med 1993; 177:225-30.