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Volumn 58, Issue 3, 1999, Pages 487-492

9-[2-(phosphonomethoxy)ethyl]adenine diphosphate (PMEApp) as a substrate toward replicative DNA polymerases α, δ, ε, and ε*

Author keywords

Adefovir; PMEA excision; PMEA insertion; pol ; pol ; pol

Indexed keywords

9 [2 (PHOSPHONOMETHOXY)ETHYL]ADENINE DIPHOSPHATE; ADEFOVIR; CYCLINE; DEOXYADENOSINE PHOSPHATE; DEOXYADENOSINE TRIPHOSPHATE; DNA POLYMERASE; EXONUCLEASE; ISOENZYME; UNCLASSIFIED DRUG;

EID: 0033043577     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(99)00118-5     Document Type: Article
Times cited : (26)

References (28)
  • 3
    • 0028130055 scopus 로고
    • Inhibitory effects of acyclic nucleoside phosphonates on human hepatitis B virus and duck hepatitis B virus infections in tissue culture
    • Heijtink RA, Kruining J, De Wilde GA, Baizarini J, De Clercq E and Schalm SW, Inhibitory effects of acyclic nucleoside phosphonates on human hepatitis B virus and duck hepatitis B virus infections in tissue culture. Antimicrob Agents Chemother 38: 2180-2182, 1994.
    • (1994) Antimicrob Agents Chemother , vol.38 , pp. 2180-2182
    • Heijtink, R.A.1    Kruining, J.2    De Wilde, G.A.3    Baizarini, J.4    De Clercq, E.5    Schalm, S.W.6
  • 5
    • 0031036704 scopus 로고    scopus 로고
    • HPMPC (cidofovir), PMEA (adefovir) and related acyclic nucleoside phosphonate analogues: A review of their pharmacology and clinical potential in the treatment of viral infections
    • Naesens L, Snoeck R, Andrei G, Balzarini J, Neyts J and De Clercq E, HPMPC (cidofovir), PMEA (adefovir) and related acyclic nucleoside phosphonate analogues: A review of their pharmacology and clinical potential in the treatment of viral infections. Antiviral Chem Chemother 8: 1-23, 1997.
    • (1997) Antiviral Chem Chemother , vol.8 , pp. 1-23
    • Naesens, L.1    Snoeck, R.2    Andrei, G.3    Balzarini, J.4    Neyts, J.5    De Clercq, E.6
  • 6
    • 0028797327 scopus 로고
    • Transport of 9-(2-phosphonomethoxyethyl)adenine across plasma membrane of HeLa S3 cells is protein mediated
    • Cihlář T, Rosenberg I, Votruba I and Holý A, Transport of 9-(2-phosphonomethoxyethyl)adenine across plasma membrane of HeLa S3 cells is protein mediated. Antimicrob Agents Chemother 39: 117-124, 1995.
    • (1995) Antimicrob Agents Chemother , vol.39 , pp. 117-124
    • Cihlář, T.1    Rosenberg, I.2    Votruba, I.3    Holý, A.4
  • 8
    • 0026441170 scopus 로고
    • Phosphorylation of 9-(2-phosphonomethoxyethyl)adenine and 9-(S)-(3-hydroxy-2-phosphonomethoxypropyl)adenine by AMP(dAMP) kinase from L1210 cells
    • Merta A, Votruba I, Jindřich J, Holý A, Cihlář T, Rosenberg I, Otmar M and Herve TY, Phosphorylation of 9-(2-phosphonomethoxyethyl)adenine and 9-(S)-(3-hydroxy-2-phosphonomethoxypropyl)adenine by AMP(dAMP) kinase from L1210 cells. Biochem Pharmacol 44: 2067-2077, 1992.
    • (1992) Biochem Pharmacol , vol.44 , pp. 2067-2077
    • Merta, A.1    Votruba, I.2    Jindřich, J.3    Holý, A.4    Cihlář, T.5    Rosenberg, I.6    Otmar, M.7    Herve, T.Y.8
  • 9
    • 0025324881 scopus 로고
    • Inhibition of herpes simplex virus DNA polymerase by diphosphates of acyclic phosponylmethoxyalkyl nucleotide and analogues
    • Merta A, Votruba I, Rosenberg I, Otmar M, Hřebabecký H, Bernaerts R and Holý A, Inhibition of herpes simplex virus DNA polymerase by diphosphates of acyclic phosponylmethoxyalkyl nucleotide and analogues. Antiviral Res 13: 209-218, 1990.
    • (1990) Antiviral Res , vol.13 , pp. 209-218
    • Merta, A.1    Votruba, I.2    Rosenberg, I.3    Otmar, M.4    Hřebabecký, H.5    Bernaerts, R.6    Holý, A.7
  • 10
    • 0025336166 scopus 로고
    • Inhibition of avian myeloblastosis virus reverse transcriptase by diphosphates of acyclic phosphonylmethyl nucleotide analoges
    • Votruba I, Trávníček M, Rosenberg I, Otmar M, Merta A, Hřebabecký H and Holý A, Inhibition of avian myeloblastosis virus reverse transcriptase by diphosphates of acyclic phosphonylmethyl nucleotide analoges. Antiviral Res 13: 287-293, 1990.
    • (1990) Antiviral Res , vol.13 , pp. 287-293
    • Votruba, I.1    Trávníček, M.2    Rosenberg, I.3    Otmar, M.4    Merta, A.5    Hřebabecký, H.6    Holý, A.7
  • 11
    • 0029022494 scopus 로고
    • Kinetic interaction of the diphosphates of 9-(2-phosphonomethoxyethyl)adenine and other anti-HIV active purine congeners with HIV reverse transcriptase and human polymerases α, βand γ
    • Cherrington JM, Allen SJW, Bischofberger N and Chen MS, Kinetic interaction of the diphosphates of 9-(2-phosphonomethoxyethyl)adenine and other anti-HIV active purine congeners with HIV reverse transcriptase and human polymerases α, βand γ. Antiviral Chem Chemother 6: 217-221, 1995.
    • (1995) Antiviral Chem Chemother , vol.6 , pp. 217-221
    • Cherrington, J.M.1    Allen, S.J.W..2    Bischofberger, N.3    Chen, M.S.4
  • 12
    • 0029941879 scopus 로고    scopus 로고
    • Different inhibitory potencies of acyclic phosphonomethoxyalkyl nucleotide analogs toward DNA polymerases α, δ, and ε
    • Kramata P, Votruba I, Otová B and Holý A, Different inhibitory potencies of acyclic phosphonomethoxyalkyl nucleotide analogs toward DNA polymerases α, δ, and ε. Mol Pharmacol 49: 1005-1011, 1996.
    • (1996) Mol Pharmacol , vol.49 , pp. 1005-1011
    • Kramata, P.1    Votruba, I.2    Otová, B.3    Holý, A.4
  • 13
    • 0001855814 scopus 로고
    • Synthesis of potential prodrugs and metabolities of 9-(S)-(3-hydroxy-2-phosphonylmethoxypropyl)adenine
    • Rosenberg I and Holý A, Synthesis of potential prodrugs and metabolities of 9-(S)-(3-hydroxy-2-phosphonylmethoxypropyl)adenine. Collect Czech Chem Commun 52: 2792-2800, 1987.
    • (1987) Collect Czech Chem Commun , vol.52 , pp. 2792-2800
    • Rosenberg, I.1    Holý, A.2
  • 14
    • 0001153009 scopus 로고
    • Synthesis of N-(2-phosphonylmethoxyethyl) derivatives of heterocyclic bases
    • Holý A, Rosenberg I and Dvořáková H, Synthesis of N-(2-phosphonylmethoxyethyl) derivatives of heterocyclic bases. Collect Czech Chem Commun 52: 2801-2809, 1987.
    • (1987) Collect Czech Chem Commun , vol.52 , pp. 2801-2809
    • Holý, A.1    Rosenberg, I.2    Dvořáková, H.3
  • 15
    • 0001613474 scopus 로고
    • DNA-polymerases α, δ, ε from T-cell spontaneous lymphoblastic leukemia of Sprague-Dawley inbred rat: Isolation and characterization
    • Kramata P, Černý J, Birkuš G, Votruba I, Otová B and Holý A, DNA-polymerases α, δ, ε from T-cell spontaneous lymphoblastic leukemia of Sprague-Dawley inbred rat: Isolation and characterization. Collect Czech Chem Commun 60: 1555-1572, 1995.
    • (1995) Collect Czech Chem Commun , vol.60 , pp. 1555-1572
    • Kramata, P.1    Černý, J.2    Birkuš, G.3    Votruba, I.4    Otová, B.5    Holý, A.6
  • 16
    • 0032396186 scopus 로고    scopus 로고
    • Nonproteolyzed form of DNA-polymerase ε from T-cell spontaneous lymphoma of Sprague-Dawley inbred rat: Isolation and characterization
    • Birkuš G, Kramata P, Votruba I, Otová B, Otmar M and Holý A, Nonproteolyzed form of DNA-polymerase ε from T-cell spontaneous lymphoma of Sprague-Dawley inbred rat: Isolation and characterization. Collect Czech Chem Commun 63: 723-731, 1998.
    • (1998) Collect Czech Chem Commun , vol.63 , pp. 723-731
    • Birkuš, G.1    Kramata, P.2    Votruba, I.3    Otová, B.4    Otmar, M.5    Holý, A.6
  • 17
    • 0026543506 scopus 로고
    • Identification of replication factor C from Saccharomyces cerevisiae: A component of the leadingstrand DNA replication complex
    • Fien K and Stillman B, Identification of replication factor C from Saccharomyces cerevisiae: a component of the leadingstrand DNA replication complex. Mol Cell Biol 12: 155-163, 1992.
    • (1992) Mol Cell Biol , vol.12 , pp. 155-163
    • Fien, K.1    Stillman, B.2
  • 18
    • 0024851541 scopus 로고
    • Multiple replication factors augment DNA synthesis by the two eukaryotic DNA polymerases, α, δ
    • Tsurimoto T and Stillman B, Multiple replication factors augment DNA synthesis by the two eukaryotic DNA polymerases, α, δ. EMBO J. 8: 3883-3889, 1989.
    • (1989) δ. EMBO J , vol.8 , pp. 3883-3889
    • Tsurimoto, T.1    Stillman, B.2
  • 19
    • 0022966781 scopus 로고
    • An auxiliary protein for DNA polymerase-δ from fetal calf thymus
    • Tan CK, Castillo C, So AG and Downey KM, An auxiliary protein for DNA polymerase-δ from fetal calf thymus. J Biol Chem 261: 12310-12316, 1986.
    • (1986) J Biol Chem , vol.261 , pp. 12310-12316
    • Tan, C.K.1    Castillo, C.2    So, A.G.3    Downey, K.M.4
  • 20
    • 0025826051 scopus 로고
    • Eukaryotic DNA polymerases
    • Wang TS-F, Eukaryotic DNA polymerases. Annu Rev Biochem 60: 513-552, 1991.
    • (1991) Annu Rev Biochem , vol.60 , pp. 513-552
    • Wang, T.S.-F.1
  • 21
    • 0023665197 scopus 로고
    • DNA polymerase insertion fidelity: Gel assay for site-specific kinetics
    • Boosalis MS, Petruska J and Goodman MF, DNA polymerase insertion fidelity: Gel assay for site-specific kinetics. J Biol Chem 262: 14689-14696, 1987.
    • (1987) J Biol Chem , vol.262 , pp. 14689-14696
    • Boosalis, M.S.1    Petruska, J.2    Goodman, M.F.3
  • 22
    • 0025222838 scopus 로고
    • Human immunodeficiency virus reverse transcriptase: Substrate and inhibitor kinetics with thymidine 5′-triphosphate and 3′-azido-3′-deoxythymidine 5′-triphosphate
    • Reardon JE and Miller WH, Human immunodeficiency virus reverse transcriptase: Substrate and inhibitor kinetics with thymidine 5′-triphosphate and 3′-azido-3′-deoxythymidine 5′-triphosphate. J Biol Chem 265: 20302-20307, 1990.
    • (1990) J Biol Chem , vol.265 , pp. 20302-20307
    • Reardon, J.E.1    Miller, W.H.2
  • 23
    • 0030969223 scopus 로고    scopus 로고
    • Incorporation of selected nucleoside phosphonates and anti-human immunodeficiency virus nucleotide analogues into DNA by human DNA polymerases α, β and γ
    • Cihlář T and Chen MS, Incorporation of selected nucleoside phosphonates and anti-human immunodeficiency virus nucleotide analogues into DNA by human DNA polymerases α, β and γ. Antiviral Chem Chemother 8: 187-195, 1997.
    • (1997) Antiviral Chem Chemother , vol.8 , pp. 187-195
    • Cihlář, T.1    Chen, M.S.2
  • 24
    • 0026793636 scopus 로고
    • Selective action of 2′,3′-didehydro-2′,3′-dideoxythymidine triphosphate on human immunodeficiency virus reverse transcriptase and human DNA polymerases
    • Huang P, Farquhar D and Plunkett W, Selective action of 2′,3′-didehydro-2′,3′-dideoxythymidine triphosphate on human immunodeficiency virus reverse transcriptase and human DNA polymerases. J Biol Chem 267: 2817-2822, 1992.
    • (1992) J Biol Chem , vol.267 , pp. 2817-2822
    • Farquhar D, H.P.1    Plunkett, W.2
  • 25
    • 0026604666 scopus 로고
    • Interactions of azidothymidine triphosphate with the cellular DNA polymerases α, δ, and ε and with DNA primase
    • Nickel W, Austerman S, Bialek G and Grosse F, Interactions of azidothymidine triphosphate with the cellular DNA polymerases α, δ, and ε and with DNA primase. J Biol Chem 267: 848-854, 1992.
    • (1992) J Biol Chem , vol.267 , pp. 848-854
    • Nickel, W.1    Austerman, S.2    Bialek, G.3    Grosse, F.4
  • 26
    • 0027332447 scopus 로고
    • Cytostatic effect of 9-(2-phosphonomethoxyethyl)adenine (PMEA). I. Lymphatic leukemia KHP-Lw-I in Lewis rats
    • Otová B, Sladkź M, Votruba I, Holý A, and Krěn V, Cytostatic effect of 9-(2-phosphonomethoxyethyl)adenine (PMEA). I. Lymphatic leukemia KHP-Lw-I in Lewis rats. Folia Bio (Praha) 39: 136-141, 1993.
    • (1993) Folia Bio (Praha) , vol.39 , pp. 136-141
    • Otová, B.1    Sladkź, M.2    Votruba, I.3    Holý, A.4    Krěn, V.5
  • 27
    • 0027433229 scopus 로고
    • Cytostatic effect of 9-(2-phosphonomethoxyethyl)adenine (PMEA). II. Lymphatic leukemia in Sprague-Dawley rats
    • Otová B, Sladká M, Blažek K, Schramlová J, Votruba I and Holý A, Cytostatic effect of 9-(2-phosphonomethoxyethyl)adenine (PMEA). II. Lymphatic leukemia in Sprague-Dawley rats. Folia Biol (Praha) 39: 142-149, 1993.
    • (1993) Folia Biol (Praha) , vol.39 , pp. 142-149
    • Otová, B.1    Sladká, M.2    Blažek, K.3    Schramlová, J.4    Votruba, I.5    Holý, A.6
  • 28
    • 0027374683 scopus 로고
    • Antimitotic and teratogenic effects of acyclic nucleotideanalogues 1-(S)-(3-hydroxy-2-phosphonomethoxypropyl)cytosine (HPMPC) and 9-(2-phosphonomethoxyethyl)adenine (PMEA)
    • Bilá V, Otová B, Jelinek R, Sladká M, Mejsnarová B, Holý A and Křen V, Antimitotic and teratogenic effects of acyclic nucleotideanalogues 1-(S)-(3-hydroxy-2-phosphonomethoxypropyl)cytosine (HPMPC) and 9-(2-phosphonomethoxyethyl)adenine (PMEA). Folia Biol (Praha) 39: 150-160, 1993.
    • (1993) Folia Biol (Praha) , vol.39 , pp. 150-160
    • Bilá, V.1    Otová, B.2    Jelinek, R.3    Sladká, M.4    Mejsnarová, B.5    Holý, A.6    Křen, V.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.