Whole body protein kinetics using Phe and Tyr tracers: An evaluation of the accuracy of approximated flux values

American Journal of Physiology - Endocrinology and Metabolism

Volumn 276, Issue 6 39-6, 1999, Pages

  Short, Kevin R ^a   Meek, Shon E ^a   Moller, Niels ^a   Ekberg, Karin ^b   Nair, K Sreekumaran ^a  

^a MAYO CLINIC   (United States)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Protein metabolism; Stable isotopes

Indexed keywords

PHENYLALANINE; TYROSINE;

ACCURACY; ADULT; AMINO ACID TRANSPORT; ANALYTICAL ERROR; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HYDROXYLATION; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN INFUSION; ISOTOPE LABELING; MALE; MATHEMATICAL MODEL; MEASUREMENT; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN SYNTHESIS; TRANSPORT KINETICS;

EID: 0033043391     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.1999.276.6.e1194     Document Type: Article

References (19)

1. Bland, J. M., and D. G. Altman. Statistical methods for assessing agreement between two methods of clinical measurement. Lancet 1: 307-310, 1986.
2. Clark, S. E., C. A. Karn, J. A. Ahlrichs, J. Wang, C. A. Leitch, E. A. Liechty, and S. C. Denne. Acute changes in leucine and phenylalanine kinetics produced by parenteral nutrition in premature infants. Pediatr. Res. 41: 568-574, 1997.
3. 13C]tyrosine in the postabsorptive state. Metabolism 31: 999-1005, 1982.
4. Daley, S. E., A. D. J. Pearson, A. W. Craft, J. Kernahan, R. A. Wyllie, L. Price, C. Brock, C. Hetherington, D. Halliday, and K. Bartlett. Whole body protein metabolism in children with cancer. Arch. Dis. Child 75: 273-281, 1996.
5. Denne, S. C., C. A. Karn, J. A. Ahlrichs, A. R. Dorotheo, J. Wang, and E. A. Liechty. Proteolysis and phenylalanine hydroxylation in response to parenteral nutrition in extremely premature and normal newborns. J. Clin. Invest. 97: 746-754, 1996.
6. Dworzak, F., P. Ferrari, C. Gavazzi, C. Maiorana, and F. Bozzetti. Effects of cachexia due to cancer on whole body and skeletal muscle protein turnover. Cancer 82: 42-48, 1998.
7. Kilani, R. A., F. S. Cole, and D. M. Bier. Phenylalanine hydroxylase activity in preterm infants: is tyrosine a conditionally essentially amino acid? Am. J. Clin. Nutr. 61: 1218-1223, 1995.
8. Krempf, M., R. A. Hoerr, L. Marks, and V. R. Young. Phenylalanine flux in adult men: estimates with different tracers and routes of administration. Metabolism 39: 560-562, 1990.
9. Meek, S. E., M. Persson, G. C. Ford, and K. S. Nair. Dose effect of insulin on protein dynamics: differential responses of splanchnic and skeletal muscle beds in healthy human subjects. Diabetes 47: 1824-1835, 1998.
10. Munro, H. N., and A. Fleck. Analysis of tissues and body fluids for nitrogenous constituents. In: Mammalian Protein Metabolism, edited by H. N. Munro. New York: Academic, 1969, p. 423-525.
11. Nair, K. S. Assessment of protein metabolism in diabetes. In: Clinical Research in Diabetes and Obesity, Part I: Methods, Assessment, and Metabolic Regulation, edited by B. Draznin and R. Rizza. Totowa, NJ: Humana, 1997, p. 137-170.
12. Nair, K. S., G. C. Ford, K. Ekberg, E. Fernqvist-Forbes, and J. Wahren. Protein dynamics in whole body and in splanchnic and leg tissues in type I diabetic patients. J. Clin. Invest. 95: 2926-2937, 1995.
13. Pacy, P. J., G. M. Price, D. Halliday, M. R. Quevedo, and D. J. Millward. Nitrogen homeostasis in man: the diurnal responses of protein synthesis and degradation and amino acid oxidation to diets with increasing protein intakes. Clin. Sci. (Colch.) 86: 103-118, 1994.
14. 5]phenylalanine methodologies. Clin. Sci. (Colch.) 80: 345-352, 1991.
15. Shortland, G. J., J. H. Walter, P. J. Fleming, and D. Halliday. Phenylalanine kinetics in sick preterm neonates with respiratory distress syndrome. Pediatr. Res. 36: 713-718, 1994.
16. 5]phenylalanine model. Am. J. Physiol. 256 (Endocrinol. Metab. 19): E631-E639, 1989.
17. 5]phenylalanine model. Am. J. Physiol. 256 (Endocrinol. Metab. 19): E631-E639, 1989.
18. Treacy, E., J. J. Pitt, K. Seller, G. N. Thompson, S. Ramus, and R. G. H. Cotton. In vivo disposal of phenylalanine in phenylketonuria: a study of two siblings. J. Inherited Metab. Dis. 19: 595-602, 1996.
19. Widdowson, E. M., D. A. Southgate, and E. N. Hey. Body composition of the fetus and infant. In: Fifth Nutricia Symposium: Nutrition and Metabolism of the Fetus and Infant, edited by H. K. A. Visser. The Hauge: Martinus Nijhoff, 1979, p. 169-177.