Effects of cachexia due to cancer on whole body and skeletal muscle protein turnover

Cancer

Volumn 82, Issue 1, 1998, Pages 42-48

  Dworzak, Federica ^b   Ferrari, Paola ^c   Gavazzi, Cecilia ^a   Maiorana, Carmen ^a   Bozzetti, Federico ^a  

^a NATIONAL CANCER INSTITUTE   (Italy)

^b DEPARTMENT OF NEUROSURGERY   (Italy)

^c JOINT RESEARCH CENTRE   (Italy)

Author keywords

Cancer cachexia; Gastric carcinoma; Phenylalanine kinetics; Protein metabolism; Skeletal muscle protein turnover; Whole body protein turnover

Indexed keywords

MUSCLE PROTEIN;

ADULT; ADVANCED CANCER; AGED; ARTICLE; CACHEXIA; CASE REPORT; CONTROLLED STUDY; FEMALE; HUMAN; MALE; PRIORITY JOURNAL; PROTEIN METABOLISM; PROTEIN SYNTHESIS; SKELETAL MUSCLE; STOMACH CARCINOMA; WASTING SYNDROME;

ADULT; AGED; BLOOD PROTEINS; CACHEXIA; CARBON ISOTOPES; CARCINOMA; DEUTERIUM; FEMALE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; MALE; MIDDLE AGED; MUSCLE, SKELETAL; NUTRITION DISORDERS; PHENYLALANINE; PROTEIN BIOSYNTHESIS; PROTEINS; RADIOPHARMACEUTICALS; STOMACH NEOPLASMS; TYROSINE;

EID: 0031918561     PISSN: 0008543X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0142(19980101)82:1<42::AID-CNCR5>3.0.CO;2-M     Document Type: Article

References (47)

1. Dewys WD, Begg C, Lavin PT, Band PR, Bennett JM, Bertino JR, et al. Prognostic effect of weight loss prior to chemotherapy in cancer patients. Am J Med 1980;69:491-7.
2. Hickman DM, Miller RD, Rombeau JL, Twomey PL, Frey C. Serum albumin and body weight as predictors of post-operative course in colorectal cancer. JPEN 1980;4:314-6.
3. Daly JM, Dudrick SJ, Copeland EM. Evaluation of nutritional indices as prognostic indicators in the cancer patient. Cancer 1979;43:925-31.
4. Warren S. The immediate causes of death in cancer. Am J Med Sci 1932;184:610-5.
5. Ambrus JL, Ambrus CM, Mink IB. Causes of death in cancer patients. J Med 1975;6:61-4.
6. Inagaki J, Rodriguez V, Bodey GP. Causes of death in cancer patients. Cancer 1974;33:568-73.
7. Klastersky J, Daneau D, Verhest A. Causes of death in patients with cancer. Eur J Cancer 1972;8:149-54.
8. Cohn SH, Gartenhaus W, Sawitsky A, Rai K, Zanzi I, Vasvani A, et al. Compartmental body composition of cancer patients by measurement of total body nitrogen, potassium, and water. Metabolism 1981;30:222-9.
9. 5] phenylalanine model. Am J Physiol 1989;256:631-9.
10. Abumrad NN, Rabin D, Diamond MP, Lacy WW. Use of a heated superficial hand vein as an alternative site for the measurement of amino acid concentration and for the study of glucose and alanine kinetics in man. Metabolism 1981;30:936-40.
11. 15N] leucine as the tracer. Clin Sci 1987;73:241-6.
12. Sumner DS. Noninvasive diagnostic techniques in vascular disease. In: Bernstein EF, editor. St. Louis: CV Mosby, 1978:126-47.
13. Tourian A, Goddard J, Puck TT. Phenylalanine hydroxylase activity in mammalian cells. J Cell Physiol 1969;73:159-70.
14. Grau CR, Steele R. Phenylalanine and tyrosine utilisation in normal and phenylalanine deficient mice. J Nutr 1953;53:59-71.
15. 13C] leucine. Am J Physiol 1980;238:E473-9.
16. Munro HN, Fleck A. Analysis of tissues and body fluids from nitrogenous constituents. In: Munro HN, editor. Mammalians protein metabolism. vol. 3. New York: Academic, 1969:423-5.
17. Maughan RJ, Watson JS, Weir J. The relative proportions of fat, muscle and bone in the normal human forearm as determined by computed tomography. Clin Sci Lond 1984;66:583-9.
18. Rennie MJ, Edwards RHT, Halliday D, Matthews DE, Wolman SL, Millward DJ. Muscle protein synthesis measured by stable isotope techniques: the effects of feeding and fasting. Clin Sci Lond 1982;63:519-23.
19. Bozzetti F, Migliavacca S, Scotti A, Bonaluni MG, Scarpa D, Baticci F. et al. Impact of cancer, type site, stage and treatment on the nutritional status of patients. Ann Surg 1982;196:170-9.
20. Bozzetti F, Agradi E, Ravera E. Anorexia in cancer patients: prevalence and impact on the nutritional status. Clin Nutr 1989;8:35-43.
21. Emery PW, Edwards RHT, Rennie MJ, Souhami RL, Halliday D. Protein synthesis in muscle measured in vivo in cachectic patients with cancer. Br Med J 1984;289:584-6.
22. Shaw JHF, Humberstone DA, Douglas RG, Koea J. Leucine kinetics in patients with benign disease, now-weight-losing cancer, and cancer cachexia: studies at the whole-body and tissue level and the response to nutritional support. Surgery 1991;109:37-50.
23. Heslin MJ, Newman E, Wolf RF, Pisters PWT, Brennan MF. Effect of systemic hyperinsulinemia in cancer patients. Cancer Res 1992;52:3845-50.
24. Waterhouse C, Mason J. Leucine metabolism in patients with malignant disease. Cancer 1981;48:939-44.
25. Heber D, Chlebowski RT, Ishibashi DE, Herrold JN, Block JB. Abnormalities in glucose and protein metabolism in non-cachetic lung cancer patients. Cancer Res 1982;42:4815-9.
26. Edén E, Ekman L, Bennegård K, Lindmark L, Lundholm K. Whole-body tyrosine flux in relation to energy expenditure in weight-losing cancer patients. Metabolism 1984;33:1020-7.
27. Norton JA, Stein TP, Brennan MF. Whole body protein synthesis and turnover in normal man and malnourished patients with and without known cancer. Ann Surg 1981;194:123-8.
28. Jeevanandam M, Horowitz GD, Lowry SF, Brennan MF. Cancer cachexia and protein metabolism. Lancet 1984;1:1423-6.
29. Melville S, McNurlan MA, Calder AG, Garlick PJ. Increased protein turnover despite normal energy metabolism and responses to feeding in patients with lung cancer. Cancer Res 1990;50:1125-31.
30. 14C] leucine. Clin Sci Mol Med 1977;53:277-88.
31. Welle S, Thornton C, Jozefowicz R, Statt M. Myofibrillar protein synthesis in young and old men. Am J Physiol 1993;264, E693-8.
32. Lundholm K, Schersten T. Leucine incorporation into proteins and cathepsin-D activity in human skeletal muscles: the influence of the age of the subject. Exp Gerontol 1975;10:155-9.
33. Fukagawa NK, Minaker KL, Young VR, Matthews DE, Bier DM, Rowe JW. Leucine metabolism in ageing humans: effects of insulin and substrate availability. Am J Physiol 1989;256:E288-94.
34. 13C-leucine in healthy young and elderly adults. J Gerontol 1984;39:673-81.
35. Newman E, Heslin MJ, Wolf RF, Pisters PWT, Brennan MF. The effect of insulin on glucose and protein metabolism in the forearm of cancer patients. Surg Oncol 1992;1:257-67.
36. Lundholm K, Bylund AC, Holm J, Scherstén T. Skeletal muscle metabolism in patients with malignant tumour. Eur J Cancer 1976;12:465-73.
37. Heymsfield SB, McManus CB. Tissue components of weight loss in cancer patients: a new method of study and preliminary observations. Cancer 1985;55:238-49.
38. Lundholm K, Ekman L, Edström S, Karlberg I, Jagenburg R, Schersten T, et al. Protein synthesis in liver tissue under the influence of methylcholantrene induced sarcoma in mice. Cancer Res 1979;39:4657-61.
39. Lundholm K, Edstrom S, Ekman L. A comparative study of the influence of malignant turnover on host metabolism in mice and man. Cancer 1978;42:453-61.
40. Pain VM, Randall DP, Garlick PJ. Protein synthesis in liver and skeletal muscle of mice bearing an ascites tumour. Cancer Res 1984;44:1054-7.
41. Falconer JS, Fearon KCH, Plester CE, Ross JA, Carter DC, et al. Cytokines, the acute-phase response, and resting-energy expenditure in cachectic patients with pancreatic cancer. Ann Surg 1994;219:325-31.
42. MacFie J, Burkinshaw L. Body composition in malignant disease. Metabolism 1987;36:290-4.
43. Walser M. Creatinine excretion as measure of protein nutrition in adults of varying age. JPEN 1987;11:73S-8.
44. Bistrian RB, Blackburn GL, Sherman M, Scrimshaw NS. Therapeutic index of nutritional depletion in hospitalized patients. Surg Gynecol Obstet 1975;141:512-6.
45. Bistrian RB. Nutritional assessment and therapy of protein calories malnutrition in the hospital. J Am Diet Assoc 1977;71:393-7.
46. Rowe JW, Andres R, Tobin JD. The effect of age on creatinine clearance in men: a cross sectional and longitudinal study. J Gerontol 1976;31:155-63.
47. Imbembo AL, Walser M. Nutritional assessment. In: Walser M, Imbembo AL, Margolis S, Elpert GA, editors. Nutritional management. The Johns Hopkins handbook. Philadelphia: WB Saunders, 1984:9-30.