Intrathymic and intrasplenic oxidative stress mediates thymocyte and splenocyte damage in acutely exercised mice

Journal of Applied Physiology

Volumn 86, Issue 6, 1999, Pages 1823-1827

  Azenabor, A A ^a   Hoffman Goetz, L ^a  

^a UNIVERSITY OF WATERLOO   (Canada)

Author keywords

Catalase; Membrane lipid peroxide; Splenocytes; Superoxide dismutase; Thymocytes

Indexed keywords

CATALASE; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ARTICLE; BIOCHEMICAL OXYGEN DEMAND; ENZYME ACTIVATION; ENZYME ACTIVITY; EXERCISE; FEMALE; LIPID PEROXIDATION; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; SPLEEN CELL; THYMOCYTE;

EID: 0033039894     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.1999.86.6.1823     Document Type: Article

References (26)

1. Azenabor, A. A., and J. B. Mahony. Generation of reactive oxygen species (ROS) and formation of merabrance lipid peroxides in cells infected with Chlamydia trachomatis. Int. J. Infect. Dis. In press.
2. Briehl, M. M., A. Baker, L. M. Siemankowski, and J. Morreale. Modulation of antioxidant defenses during apoptosis. Oncol. Res. 9: 281-285, 1997.
3. Camus, G., G. Deby-Dupont, J. Duchateau, C. Deby, J. Pincemail, and M. Lamy. Are similar inflammatory factors involved in strenuous exercise and sepsis? Intens. Care Med. 20: 602-610, 1994.
4. Concordet, J. P., and A. Ferry. Physiological programmed cell death in thymocytes is induced by physical stress (exercise). Am. J. Physiol. 265 (Cell Physiol. 34): C626-C269, 1993.
5. Ferry, A., P. Rieu, F. Laziri, C. Y. Guezennec, A. El Herbazi, C. LePage, and M. Rieu. Immumomodulations of thymocytes in trained rats. J. Appl. Physiol. 71: 815-850, 1991.
6. Ferry, A., B. L. Weill, and M. Rieu. Immunomodulations induced in rats by exercise on a treadmill. J. Appl. Physiol. 69: 1912-1915, 1990.
7. Hartmann, A., U. Plappert, K. Radatz, L. Grunert-Fuchs, and G. Speit. Does physical activity induce DNA damage? Mutagenesis 9: 269-272, 1994.
8. Hoffman-Goetz, L., and B. K. Pedersen. Exercise and the immune system: a model of the stress response? Immunol. Today 15: 382-387, 1994.
9. Hoffman-Goetz, L., S. Zajchowski, and A. Aldred. Impact of treadmill exercise on early apoptotic cells in mouse thymus and spleen. Life Sci. 64: 191-200, 1998.
10. Ji, L. L., and S. Leichtweis. Exercise and oxidative stress: sources of free radicals and their impact on antioxidant system. Age 20: 91-106, 1997.
11. Kitamura, Y., S. Shimohama, W. Kamoshima, T. Ota, Y. Matsuoka, Y. Nomura, M. A. Smith, G. Perry, P. J. White-house, and T. Taniguchi. Alteration of proteins regulating apoptosis, Bcl-2, Bcl-x, Bax, Bak, Bad, ICH-I and CPP32, in Alzheimers' disease. Brain Res. 780: 260-269, 1998.
12. Kontes, H.-A., E. P. Wei, J. T. Povlishock, and C. W. Christman. Oxygen radicals mediate the cerebral anteriolar dilation from arachidonate and bradykinin in cats. Circ. Res. 55: 295-303, 1984.
13. Lin, T., T. Brunner, B. Tietz, J. Madsen, E. Bonfoco, M. Reaves, M. Huflet, and D. R. Green. Fas ligand-mediated killing by intestinal intraepithelial lymphocytes. Participation in intestinal graft-versus-host disease. J. Clin. Invest. 101: 570-574, 1998.
14. Liu, D., T. E. Sybert, H. Qian, and J. Liu. Superoxide production after spinal injury detected by micro perfusion of cytochrome-c. Free Radic. Biol. Med. 25: 298-304, 1998.
15. Lorenzen, J., J. Thiel, and R. Fischer. The mummified Hodgkin cell: cell death in Hodgkin's disease. J. Pathol. 182: 288-298, 1997.
16. MacNeil, B., L. Hoffman-Goetz, A. Kendall, and M. Houston. Exercise and blood lymphocyte functional responses: intensity, duration, and subject fitness effects. J. Appl. Physiol. 70: 179-185, 1990.
17. McCormick, D. B. Vitamins: methods for the determination of ascorbic acid. In: Textbook of Clinical Chemistry, edited by N. W. Tietz. Philadelphia, PA: Saunders, 1986, p. 960-962.
18. Niess, A. M., A. Hartmann, A. Grunert-Fuchs, B. Poch, and G. Speit. DNA damage after exhaustive treadmill running in trained and untrained men. Int. J. Sports Med. 17: 397-403, 1996.
19. Pereira, B., L. F. B. Costa Rosa, D. A. Safi, M. H. G. Medeiros, R. Curi, and E. J. H. Bechara. Superoxide dismutase, catalase, and glutathione peroxidase activities in muscle and lymphoid organs of sedentary and exercise-trained rats. Physiol. Behav. 56: 1095-1099, 1994.
20. Peter, W., M. Benten, M. Lieberherr, G. Geise, and F. Wunderlich. Estradiol binding to cell surface raises cytosolic free calcium in T cells. FEBS Lett. 422: 349-353, 1998.
21. Rice-Evans, C. A., A. Diplock, and M. C. R. Symons. Techniques in free radical research In: Laboratory Techniques in Biochemistry and Molecular Biology, edited by R. H. Burdon and P. H. Vanknippenberg, Amsterdam: Elsevier, 1991, vol. 22, p. 185-206.
22. Rock, R. C., W. G. Walker, and C. D. Jennings. Nitrogen metabolites and renal function: enzymatic method of uric acid analysis. In: Textbook of Clinical Chemistry, edited by N. W. Tietz. Philadelphia, PA: Saunders, 1986, p. 1286-1288.
23. Smith, P. K., R. I. Krohn, G. T. Hermansan, A. K. Mallia, F. H. Gartner, M. D. Provenzano, E. K. Fujimoto, N. M. Goeke, B. J. Olson, and D. C. Klenk. Measurement of protein using bicinchoninic acid. Anal. Biochem. 150: 76-85, 1985.
24. Surh, C. D., and J. Sprent. T-cell apoptosis detected in situ during positive and negative selection in the thymus. Nature 372: 100-103, 1994.
25. Tankersley, C. G., W. R. Nicholas, D. R. Deaver, D. Mikilta, and W. L. Kenney. Estrogen replacement in middle-aged women: thermoregulatory responses to exercise in heat. J. Appl. Physiol. 73: 1238-1245, 1992.
26. + LAK cells. Virology 241: 169-180, 1998.