Differential antimutagenicity of WR-1065 added after irradiation in L5178Y cell lines

Radiation Research

Volumn 151, Issue 4, 1999, Pages 391-397

  Evans, Helen H ^a   Horng, Min Fen ^a   Ricanati, Marlene ^a   McCoy, Elena C ^a,b  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CITY UNIVERSITY OF NEW YORK   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (3 AMINOPROPYLAMINO)ETHANETHIOL; ANTIMUTAGENIC AGENT; DOUBLE STRANDED DNA;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DNA REPAIR; DNA STRAND BREAKAGE; DRUG ACTIVITY; DRUG EFFECT; DRUG SCREENING; FLOW CYTOMETRY; IONIZING RADIATION; LEUKEMIA L 5178 Y; MOUSE; NONHUMAN; PRIORITY JOURNAL;

NASA DISCIPLINE RADIATION HEALTH; NON-NASA CENTER;

ANIMALS; ANTIMUTAGENIC AGENTS; DNA; DNA REPAIR; LEUKEMIA L5178; MERCAPTOETHYLAMINES; MICE; MICE, INBRED DBA; THYMIDINE KINASE; TUMOR CELLS, CULTURED;

ANIMALIA;

EID: 0033039253     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.2307/3579825     Document Type: Article

References (46)

1. C. L. Greenstock, Redox processes in radiation biology and cancer. Radiat. Res. 86, 196-211 (1981).
2. T. J. Slaga, A. J. P. Klein-Szanto, L. L Triplett, L. P. Yotti and J. E. Trosko, Skin tumor-promoting activity of benzoyl peroxide, a widely used free radical-generating compound. Science 213, 1023-1025 (1981).
3. R. C. Fahey, Protection by thiols. Pharmacol. Ther. 39, 101-108 (1988).
4. D. J. Grdina, B. Nagy, C. K. Hill, R. L. Wells and C. Peraino, The radioprotector WR 1065 reduces radiation-induced mutations at the hypoxanthine-guanine phosphoribosyl transferase locus in V79 cells. Carcinogenesis 6, 929-931 (1985).
5. D. J. Grdina, P. Sigdestad and B. A. Carnes, Protection by WR 1065 and WR 151326 against fission-neutron-induced mutations at the HGPRT locus in V79 cells. Radiat. Res. 117, 500-510 (1989).
6. D. J. Grdina, B. Nagy and P. J. Meechan, Effect of an aminothiol (WR-1065) on radiation-induced mutagenesis and cytotoxicity in two repair-deficient mammalian cell lines. In Anticarcinogenesis and Radiation Protection 2 (O. F. Nygaard and A. C. Upton, Eds.), pp. 287-295. Plenum Press, New York, 1991.
7. P. J. Meechan, A. Vaughan and D. J. Grdina, WR-1065 association with CHO AA8 cells, nuclei and nucleoids. Radiat. Res. 125, 152-157 (1991).
8. D. B. Rubin, E. A. Drab, H. J. Kang, F. E. Baumann and E. R. Blazek, WR-1065 and radioprotection of vascular endothelial cells. I. Cell proliferation, DNA synthesis and damage. Radiat. Res. 145, 210-216 (1996).
9. E. Riklis, M. Green, A. Proger, R. Marko and M. Mintsberg, Increased radioprotection attained by DNA repair enhancement. Pharmacol. Ther. 39, 311-322 (1988).
10. E. Riklis, DNA repair as a probe of radiosensitivity and radioprotection. In Radiaprotectors and Anticarcinogens (O. F. Nygaard and M. G. Simic, Eds.), pp. 363-380. Academic Press, New York, 1983.
11. D. J. Grdina, N. Shigematsu, P. Dale, G. L. Newton, J. A. Aguilera and R. F. Fahey, Thiol and disulfide metabolites of the radiation protector and potential chemopreventive agent WR-2771 are linked to both its anti-cytotoxic and anti-mutagenic mechanisms of action. Carcinogenesis 16, 767-774 (1995).
12. 60Co gamma-ray irradiation. Carcinogenesis 7, 665-668 (1986).
13. E. K. Balcer-Kubiczek, G. H. Harrison, C. K. Hill and W. F. Blakely, Effects of WR-1065 and WR-151326 on survival and neoplastic transformation in C3H/10T1/2 cells exposed to TRIGA or JANUS fission neutrons. Int. J. Radiat. Biol. 63, 37-46 (1993).
14. C. Savoye, C. Swenberg, S. Hugot, D. Sy, R. Sabattier, M. Charlier and M. Spotheim-Maurizot, Thiol WR-1065 and disulphide WR-33278, two metabolites of the drug Ethyol (WR-2721), protect DNA against fast neutron-induced strand breakage. Int. J. Radiat. Biol. 71, 193-202 (1997).
15. N. Shigematsu, J. L. Schwartz and D. J. Grdina, Protection against radiation-induced mutagenesis at the hprt locus by spermine and N,N″-(dithiodi-2,1-ethanediyl)bis-1,3-propanediamine (WR-33278). Mutagenesis 9, 355-360 (1994).
16. B. W. Corn, H. L. Liber and J. B. Little, Differential effects of radical scavengers on X-ray-induced mutation and cytotoxicity in human cells. Radiat. Res. 109, 100-108 (1987).
17. L. S. Clark, R. J. Albertini and J. A. Nicklas, The aminothiol WR-1065 protects T lymphocytes from ionizing radiation-induced deletions of the HPRT gene. Cancer Epidemiol. Biomarkers Prev. 6, 1033-1037 (1997).
18. C. P. Sigdestad, W. Guilford, J. Perrin and D. J. Grdina, Cell cycle redistribution of cultured cells after treatment with chemical radiation protectors. Cell Tissue Kinet. 21, 193-200 (1988).
19. C. P. Sigdestad, B. L. Bergquist and D. J. Grdina, The effect of chemical radiation protectors on cell cycle progression alter gamma or neutron irradiation. Cell Prolif. 24, 271-280 (1991).
20. 2 phase following exposure to WR-1065. Radiat. Res. 126, 223-228 (1991).
21. R. L. Warters, J. C. Roberts, B. H. Wilmore and L. L. Kelley, Modulation of radiation-induced apoptosis by thiolamines. Int. J. Radiat. Biol. 72, 439-448 (1997).
22. P. E. Brown, Mechanism of action of aminothiol radio-protectors. Nature 213, 363-364 (1967).
23. S. E. Bresler, L. A. Noskin, I. M. Stepanova and N. A. Kuzovleva, Mechanism of the radioprotecting action of chemical compounds on Escherichia coli cells. Mol. Gen. Genet. 163, 75-85 (1978).
24. V. G. Petin and V. L. Matrenina, Radioprotecting action of chemical compounds on γ-irradiated yeast cells of various genotypes. Mol. Gen. Genet. 183, 152-157 (1981).
25. J. W. Hülsewede and D. Schulte-Frohlinde, Radiation protection of E. coli strains by cysteamine in the presence of oxygen. Int. J. Radiat. Biol. 50, 861-869 (1986).
26. G. L. Newton, J. A. Aguilera, J. F. Ward and R. C. Fahey, Binding of radioprotective thiols and disulfides in Chinese hamster V79 cell nuclei. Radiat. Res. 146, 298-305 (1996).
27. X. Zhang, P. P. Lai and Y. C. Taylor, Differential radioprotection of cultured human diploid fibroblasts and fibrosarcoma cells by WR 1065. Int. J. Radiat. Oncol. Biol. Phys. 24, 713-719 (1992).
28. A. T. M. Vaughan, D. J. Grdina, P. J. Meechan, A. E. Milner and D. J. Gordon, Conformational changes in chromatin structure induced by the radioprotective aminothiol WR-1065. Br. J. Cancer 60, 893-896 (1989).
29. G. A. Fischer, Studies of the culture of leukemic cell in vitro. Ann. NY Acad. Sci. 76, 673-680 (1958).
30. P. Alexander and Z. B. Mikulski, Mouse lymphoma cells with different radiosensitivities. Nature 192, 572-573 (1961).
31. H. H. Evans, J. Mencl, M-F. Horng, M. Ricanati, C. Sanchez and J. Hozier, Locus specificity in the mutability of L5178Y mouse lymphoma cells: The role of multilocus lesions. Proc. Natl. Acad. Sci. USA 83, 4379-4383 (1986).
32. H. H. Evans, M. Ricanati, M-F. Horng and J. Mencl, Relationship between topoisomerase II and radiosensitivity in mouse L5178Y lymphoma strains. Mutat. Res. 217, 53-63 (1989).
33. H. H. Evans, M. Ricanati, C. Di Salvo, M-F. Horng and J. Mencl, Induction of multilocus lesions by UVC radiation in mouse L5178Y lymphoblasts. Mutat. Res. 251, 79-90 (1991).
34. D. Clive and P. Voytek, Evidence for chemically-induced gene mutations at the thymidine kinase locus in cultured L5178Y mouse lymphoma cells. Mutat. Res. 44, 269-278 (1977).
35. M. M. Moore, Genotoxicity of γ-irradiation in L5178Y mouse lymphoma cells. Mutat. Res. 174, 149-154 (1986).
36. +/- cell line is heterozygous for a codon 170 mutation in the p53 tumor suppressor gene. Mutat. Res. 373, 157-165 (1997)
37. K. J. Schimenti and J. W. Jacobberger, Fixation of mammalian cells for flow cytometric evaluation of DNA content and nuclear immunofluoresence. Cytometry 13, 48-59 (1992).
38. B. Rydberg, M. Löbrich and P. K. Cooper, DNA double-strand breaks induced by high-energy neon and iron ions in human fibroblasts. I. Pulsed-field gel electrophoresis method. Radiat. Res. 139, 133-141 (1994).
39. H. H. Evans, M. Ricanati and M-F. Horng, Deficiency in DNA repair in mouse lymphoma strain L5178Y-S. Proc. Natl. Acad. Sci. USA 84, 7562-7566 (1987).
40. D. Wlodek and W. N. Hittelman, The repair of double-strand DNA breaks correlates with radiosensitivity of L5178Y-S and LY5178Y-R cells. Radiat. Res. 112, 146-155 (1987).
41. L. S. Clark, R. J. Albertini and J. A. Nicklas, Hprt mutations in human T-lymphocytes reflect radioprotective effects of the aminothiol, WR-1065. Carcinogenesis 17, 2647-2653 (1996).
42. G. E. Woloschak, T. Paunesku, C. M. Chang-Liu and D. J. Grdina, Expression of thymidine kinase messenger RNA and a related transcript is modulated by radioprotector WR 1065. Cancer Res. 55, 4788-4792 (1995).
43. C. P. Sigdestad, S. H. Treacy, L. A. Knapp and D. J. Grdina, The effects of 2-[(aminopropyl)amino] ethanethiol (WR 1065) on radiation-induced DNA double-strand damage and repair in V79 cells. Br. J. Cancer 55, 477-482 (1987).
44. J. L. A. Mitchell, G. G. Judd, R. R. Diveley, Jr., C-Y. Choe and A. Leyser, Involvement of the polyamine transport system in cellular uptake of the radioprotectants WR-1065 and WR-33278. Carcinogenesis 16, 3063-3068 (1995).
45. G. D. Smoluk, R. C. Fahey, P. M. Calabro-Jones, J. A. Aguilera and J. F. Ward, Radioprotection of cells in culture by WR-2721 and derivatives: Form of the drug responsible for protection. Cancer Res. 48, 3641-3647 (1988).
46. D. J. Grdina, N. Shigematsu, P. Dale, G. L. Newton, J. A. Aguilera and R. C. Fahey, Thiol and disulfide metabolites of the radiation protector and potential chemopreventive agent WR-2721 are linked to both its anticytotoxic and antimutagenic mechanisms of action. Carcinogenesis 16, 767-774 (1995).