Design of protease inhibitors on the basis of substrate stereospecificity

Biopolymers - Peptide Science Section

Volumn 51, Issue 1, 1999, Pages 3-8

  Kim, Dong ^a  

^a Pohang University of Science and Technology (POSTECH)   (South Korea)

Author keywords

A chymotrypsin; Inhibitor design; Papain; Stereochemical approach; Substrate stereospecificity

Indexed keywords

CATALYST ACTIVITY; CATALYST DEACTIVATION; CHEMICAL BONDS; ENZYME KINETICS; ESTERS; MATHEMATICAL MODELS; MOLECULAR ORIENTATION; MOLECULAR STRUCTURE;

CHYMOTRYPSIN; STEREOSPECIFICITY;

ENZYME INHIBITION;

2 BENZYL 3,4 EPOXYBUTANOIC ACID METHYL ESTER; CHYMOTRYPSIN A; PAPAIN; PROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; DRUG CONFORMATION; DRUG DESIGN; DRUG PROTEIN BINDING; ENZYME ACTIVE SITE; ENZYME INACTIVATION; ENZYME SPECIFICITY; NONHUMAN; PROTEINASE INHIBITION; STEREOSPECIFICITY; STRUCTURE ACTIVITY RELATION;

BINDING SITES; CHYMOTRYPSIN; DRUG DESIGN; PAPAIN; PROTEASE INHIBITORS; STEREOISOMERISM; SUBSTRATE SPECIFICITY;

EID: 0033037117     PISSN: 00063525     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0282(1999)51:1<3::AID-BIP2>3.0.CO;2-Q     Document Type: Article

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