Melatonin treatment of sleep-wake cycle disorders in children and adolescents

Developmental Medicine and Child Neurology

Volumn 41, Issue 7, 1999, Pages 491-500

  Jan, James E ^a,b   Freeman, Roger D ^a   Fast, Diane K ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b BC CHILDREN S HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

MELATONIN; MELATONIN RECEPTOR; SEDATIVE AGENT;

CAREGIVER; CIRCADIAN RHYTHM; CONFUSION; DRUG ABSORPTION; DRUG COST; DRUG HALF LIFE; ENVIRONMENTAL FACTOR; HEADACHE; HUMAN; INSOMNIA; JET LAG; NAUSEA; NERVOUS SYSTEM DEVELOPMENT; ORAL DRUG ADMINISTRATION; PINEAL BODY; PRIORITY JOURNAL; PRURITUS; RESTLESSNESS; REVIEW; SEDATION; SIDE EFFECT; SLEEP DISORDER; SLEEP PATTERN; SLEEP WAKING CYCLE; SUSTAINED RELEASE PREPARATION; TACHYCARDIA;

ADOLESCENT; CHILD; CIRCADIAN RHYTHM; FEMALE; FREE RADICAL SCAVENGERS; HUMANS; MALE; MELATONIN; SLEEP; SLEEP DISORDERS;

EID: 0033036549     PISSN: 00121622     EISSN: None     Source Type: Journal    
DOI: 10.1017/S0012162299001061     Document Type: Review

References (191)

1. Lerner AB, Case JD. (1960) Melatonin. Federation Proceedings 19: 590-2.
2. Anton-Tay F, Diaz JL, Fernández-Guardiola A. (1971) On the effect of melatonin upon human brain: its possible therapeutic implications. Life Sciences 10: 841-50.
3. Dahlitz M, Alvarez B, Vignau J, English J, Arendt J, Parkes JD. (1991) Delayed sleep phase syndrome response to melatonin. Lancet 333: 1121-4.
4. Stankov B, Fraschini F, Oldani A. (1994) Melatonin and delayed sleep phase syndrome. Ambulatory polygraphic evaluation. Neuroreport 6: 132-4.
5. Oldani A, Ferini-Strambi L, Zucconi M, Stankov B, Fraschini F, Smirne S. (1994) Melatonin and delayed sleep phase syndrome: ambulatory polygraphic evaluation. Neuroreport 6: 132-4.
6. Dagan Y, Yovel I, Hallis D, Eisenstein M, Raichik I. (1998) Evaluating the role of melatonin in the long-term treatment of delayed sleep phase syndrome (DSPS). Chronobiology International 15: 181-90.
7. Folkard S, Arendt J, Aldhous M, Kennet H. (1990) Melatonin stabilises sleep onset time in a blind man without entrainment of cortisol or temperature rhythms. Neuroscience Letters 113: 193-8.
8. Folkard S, Arendt J, Clark M. (1993) Can melatonin improve shift workers' tolerance of the night shift? Some preliminary findings. Chronobiology International 10: 315-20.
9. Dawson D, Encel N, Lushington K. (1995) Improving adaptation to simulated night shift: timed exposure to bright light versus daytime melatonin administration, Sleep 18: 11-21.
10. Lewy J, Ahmed S, Latham Jackson J, Sack R. (1992) Melatonin shifts human circadian rhythms according to phase curve. Chronobiology International 9: 380-92.
11. Petrie K, Dawson AG, Thompson L, Brook R. (1993) A double-blind trial of melatonin as a treatment in international cabin crew. Biological Psychiatry 33: 526-30.
12. Lino A, Silvy S, Rusconi A. (1993) Melatonin and jet lag: treatment schedule. Biological Psychiatry 34: 587-8.
13. Arendt J, Deacon S. (1997) Treatment of circadian rhythm disorders-melatonin. Chronobiology International 14: 185-204.
14. Cramer H, Rudolph J, Kandfel K. (1974) On the effects of melatonin on sleep and behavior in man. Advances in Biochemical Psychopharmacology 11: 187-91.
15. MacFarlane JG, Cleghom JM, Brown GM, Streiner DL. (1991) The effects of exogenous melatonin on the total sleep time and daytime alertness of chronic insomniacs: a preliminary study. Biological Psychiatry 30: 371-6.
16. Dawson D, Encel N. (1993) Melatonin and sleep in humans. Journal of Pineal Research 15: 1-12.
17. Dollins AB, Zhadanova IV, Wurtman RJ, Lynch HJ, Deng MH. (1994) Effect of inducing nocturnal serum melatonin concentrations in daytime on sleep, mood, body temperature and performance. Proceedings of the National Academy of Sciences of the United States of America 91: 1824-8.
18. Singer C, Wild K, Sack R, Lewy A. (1994) High dose melatonin is well tolerated by the elderly. Sleep Research 23: 86. (Letter.)
19. Brown GM. (1995) Melatonin in psychiatric and sleep disorders. Therapeutic implication. CNS Drugs 3: 209-26.
20. Haimov I, Lavie P, Laudon M, Herer P, Vigder C, Zisapel N. (1995) Melatonin replacement therapy of elderly insomniacs. Sleep 18: 598-603.
21. Zhdanova IV, Wurtman RJ, Schomer DI. (1995) Sleep-inducing effects of low doses of melatonin ingested in the evening. Clinical Pharmacology and Therapeutics 57: 552-8.
22. Zhdanova IV, Wurtman RJ, Morabito C, Piotrovska VR, Lynch HJ. (1996) Effects of low oral doses of melatonin, given 2-4 hours before habitual bedtime, on sleep in normal young humans. Sleep 19: 423-31.
23. Attenburrow MEJ, Cowen PJ, Shapley AL. (1996) Low dose melatonin improves sleep in healthy middle-aged subjects. Psychopharmacology 126: 179-81.
24. Zhdanova IV, Wurtman RJ. (1997) Efficacy of melatonin as a sleep-promoting agent. Journal of Biological Rhythms 12: 644-50.
25. Palm L, Blennow G, Wetterberg L. (1991) Correction of non-24-hour sleep wake cycle by melatonin in a blind, retarded boy. Annals of Neurology 29: 336-9.
26. Tzischinsky O, Pal I, Epstein R, Dagan Y, Lavie P. (1992) The importance of timing in melatonin administration in a blind man. Journal of Pineal Research 12: 105-8.
27. Jan JE, Espezel H, Appleton RE. (1994) The treatment of sleep disorders with melatonin. Developmental Medicine & Child Neurology 36: 97-107.
28. Tomoda A, Miike T, Uezono K, Kawasaki. (1994) A school refusal case with biological rhythm disturbance and melatonin therapy. Brain and Development 16: 71-6.
29. Jan JE, Abroms IF, Freeman RD, Brown GM, Espezel H, Connolly MB. (1994) Rapid cycling in severely multidisabled children: a form of bipolar affective disorder? Pediatric Neurology 10: 34-9.
30. Nagtegaal JE, Smits MG, Hemmes AM. (1994) Effects of melatonin in a child with delayed sleep phase syndrome. Sleep-wake Research in The Netherlands 5: 117-8.
31. Lapierre O, Dumont M. (1995) Melatonin treatment of a non-24-hour sleep-wake cycle in a blind retarded child. Biological Psychiatry 38: 119-22.
32. Etzioni A, Luboshitzky R, Tiosano D, Ben-Harush M, Goldsher D, Lavie P. (1996) Melatonin replacement corrects sleep disturbance in a child with pineal tumor. Neurology 46: 261-3.
33. Jan JE, O'Donnell ME. (1996) Use of melatonin in the treatment of paediatric sleep disorders. Journal of Pineal Research 21: 193-9.
34. Zhdanova IV, Wagstaff J, Wurtman RJ. (1996) Melatonin and sleep in Angelman syndrome children. Paper presented at the American Professional Sleep Societies 10th Annual Meeting. Washington, DC. 1996 (Abstract.)
35. Espezel H, Jan JE, O'Donnell ME, Milner R. (1996) The use of melatonin to treat sleep-wake rhythm disorders in children who are visually impaired. Journal of Visual Impairment and Blindness 90: 34-50.
36. Camfield P, Gordon K, Dooley J, Camfield C. (1996) Melatonin appears ineffective in children with intellectual deficits and fragmented sleep. Six "N of 1" trials. Journal of Child Neurology 11: 341-3.
37. Palm L, Blennow G, Wetterberg L. (1997) Long-term melatonin treatment in blind children and young adults with circadian sleep-wake disturbances. Developmental Medicine & Child Neurology 39: 319-25.
38. Robertson JM, Tanguay PE. (1997) The use of melatonin in a boy with refractory bipolar disorder. Journal of the American Academy of Child and Adolescent Psychiatry 38: 822-5.
39. Horrigan JP, Barnhill LJ. (1997) Journal of the American Academy of Child and Adolescent Psychiatry 36: 8. (Letter.)
40. Tanaka H, Araki A, Ito J, Tasaki T, Miyamoto A, Cho K. (1997) Improvement of hypertonus after treatment for sleep disturbances in three patients with severe brain damage. Brain and Development 19: 240-4.
41. Schmitt-Mechelke TH, Steinlin M, Bolthauser E. (1997) Melatonin in the treatment of sleep problems in neuropediatric patients. Schweiz Medizinische Wochenschrift 127: (Suppl. 87) 9.
42. Hung JCC, Appleton RE, Nunn AJ, Rosenbloom L. (1998) The use of melatonin in the treatment of sleep disturbances in children with neurological or behavioural disorders. Journal of Pediatric Pharmacy Practice 3: 250-6.
43. Jan JE, Espezel H, Goulden KJ. (1998) Melatonin in sleep disorders of children with neurodevelopmental disabilities. In: Shafii M, Shafii SL, editors. Melatonin in Psychiatric and NeoplasticDisorders. Progress in Psychiatry (No. 55). Washington, DC: American Psychiatric Press, p 169-88.
44. Ross C, Whitehouse W, Khin-Maung-Zaw F. (1997) Use of melatonin to normalize disturbed sleep pattern: semi-objective quantification of benefit by parent-completed sleep diaries. DevelopmentalMedicine & Child Neurology 39: (Suppl. 77) p31.
45. McArthur AJ, Budden SB. (1998) Sleep dysfunction in Rett syndrome: a trial of exogenous melatonin treatment. DevelopmentalMedicine & Child Neurology 40: 186-92.
46. Pillar G, Etzioni A. Shahar E, Lavie P. (1998) Melatonin treatment in an institutionalised child with psychomotor variation and an irregular sleep-wake pattern. Archives of Disease in Childhood 79: 63-64.
47. Arendt J. (1988) Melatonin. Clinical Endocrinology 29: 205-29.
48. Arendt J. (1996) Melatonin: claims made in the popular media are mostly nonsense. British Medical Journal 312: 1242-3.
49. Young SN. (1996) Melatonin, sleep, aging and the Health Protection Branch. Journal of Psychiatry and Neurosciences 21: 161-4.
50. Cahill GM, Grace MS, Besharse JC. (1991) Rhythmic regulation of retinal melatonin: metabolic pathways, neurochemical mechanisms, and the ocular circadian clock. Cellular and Molecular Neurobiology 11: 529-60.
51. Zawilska JB, Nowak JZ. (1992) Regulatory mechanisms in melatonin biosynthesis in retina. Neurochemistry International 20: 23-36.
52. Denis P, Nordmann JP, Elena PP, Dussaillant M, Seraux H, Lapalus P. (1993) Physiological roles of dopamine and neuropeptides in the retina. Fundamental and Clinical Pharmacology 7: 293-304.
53. Lee PF, Pang SF. (1993) Melatonin and its receptors in the gastrointestinal tract. Biological Signals 2: 181-93.
54. Bhanu I. (1996) The peripheral melanocytes and photoperiodism: a network for all seasons. Paper presented at the proceedings of 2nd Locarno Meeting on Neuroendocrinoimmunology, Locarno, Switzerland. May 5-8, 1996. p 68. (Abstract.)
55. Pang SF, Brown GM. (1983) Regional concentration of melatonin in the rat brain in the light and dark period. Life Sciences 33: 1199-204.
56. Huether G. (1993) The contribution of extrapineal sites of melatonin synthesis to circulating melatonin levels in higher vertebrates. Experientia 15: 665-70.
57. Hattori A, Migitakia H, Iigo M, Itoh M, Yamamoto K, Ohtani-Kandro R, Hara M, Suzuki T, Reiter R. (1995) Identification of melatonin in plants and its effects on plasma melatonin levels and binding to melatonin receptors in vertebrates. Biochemistry and Molecular Biology International 35: 627-34.
58. Dubbels R, Reiter RJ, Klemke E, Goebel A, Schankenberg E, Ehlers C, Schiwara HW, Schlot W. (1995) Melatonin in edible plants identified by radioimmunoassay and high performance lipid chromatography-gas spectrometry. Journal of Pineal Research 18: 28-31.
59. Ebadi M, Govitrapong P. (1986) Orphan transmitters and their receptor sites in the pineal gland. In: Reiter RJ, editor. Pineal Research Reviews. Vol 4. New York: Alan R Liss. p 1-54.
60. Dubocovich ML. (1988) Pharmacology and function of melatonin receptors. FASEB Journal 2765-73.
61. Morgan PJ, Barrett P, Howell HE, Helliwell R. (1994) Melatonin receptors: localization, molecular pharmacology and physiological significance. Neurochemistry International 24: 101-46.
62. Dubocovich ML. (1991) Melatonin receptors in the central nervous system. Advances in Experimental Medicine and Biology 294: 255-65.
63. Stankov B, Fraschini F, Reiter RJ. (1991) Melatonin binding sites in the central nervous system. Brain Research Brain Research Reviews 16: 245-56.
64. Liu C, Weaver DR, Jin X, Shearman LP, Pieschi RL, Gribkoff VK, Reppert SM. (1997) Molecular dissection of two distinct actions of melatonin on the suprachiasmatic circadian clock. Neuron 19: 91-102.
65. Reppert SM. (1997) Melatonin receptors: molecular biology of a new family of G protein-coupled receptors. Journal of Biological Rhythms 12: 528-31.
66. Dubocovich ML. (1990) Presynaptic receptors in the visual system. Annals of the New York Academy of Sciences 604: 82-95.
67. 125I) iodomelatonin binding sites in the lung and heart: a line between the photoperiodic signal, melatonin and cardiopulmonary system. Biological Signals 2: 228-36.
68. Viswanathan M, Laitinen JT, Saavedra JM. (1993) Vascular melatonin receptors. Biological Signals 2: 221-7.
69. 125I) iodomelatonin in the adrenal gland. Biological Signals 3: 91-8.
70. Pang SF, Dubocovich ML, Brown GM. (1993) Melatonin receptors in peripheral tissues: a new area of melatonin research. Biological Signals 2: 177-80.
71. Davis FC. (1997) Melatonin: role in development. Journal of Biological Rhythms 12: 498-508.
72. Reiter RJ. (1991) Pineal melatonin: cell biology of its synthesis and of its physiological interaction. Endocrine Reviews 12: 151-80.
73. Cajochen C, Kräuchi K, von Arx M-A, Möri D, Graw P, Wirz-Justice A. (1996) Daytime melatonin administration enhances sleepiness and theta/alpha activity in the waking EEG. Neuroscience Letters 207: 209-13.
74. Waldhauser F, Dietzel M. (1985) Daily and annual rhythm in human melatonin secretion: role in puberty control. Annals of New York Academy of Sciences 453: 205-14.
75. Waldhauser F, Weiszenbacher G, Tatzer E, Gisinger B, Waldhauser M, Schemper M, Frisch H. (1988) Alterations in nocturnal serum melatonin levels in humans with growth and aging. Journal of Clinical Endocrinology and Metabolism 66: 648-52.
76. Waldhauser F, Ehrhart B, Forster E. (1993) Clinical aspects of the melatonin action: impact of development, aging and puberty, involvement of melatonin in psychiatric disease and importance of neuroimmunoendocrine interactions. Experientia 49: 671-81.
77. Cavallo A, Ritschel WA. (1996) Pharmacokinetics of melatonin in human sexual maturation. Journal of Clinical Endocrinology and Metabolism 81: 1882-6.
78. Puig-Domingo M, Reiter R, De Leiva A. (1992) II Brief report: melatonin-related hypogonadotropic hypogonadism. New England Journal of Medicine 357: 1356-9.
79. Cavallo A. (1993) Melatonin and human puberty: current perspectives. Journal of Pineal Research 15: 115-21.
80. Cavallo A, Dolan LM. (1996) 6-hydroxymelatonin sulfate excretion in human puberty. Journal of Pineal Research 21: 225-30.
81. Lam RW, Berkowitz AL, Berga SL, Clark CM, Kripke DF, Gillin JC. (1990) Melatonin suppression in bipolar and unipolar mood disorders. Psychiatry Research 33: 129-34.
82. Haimov I, Laudon M, Zisapel N, Souronjon M, Nof D, Shlitner A, Herer P, Tzischinsky O, Lavie P. (1994) Impaired 6-sulfatoxymelatonin rhythms in the elderly: coincidence with sleep disorders. British Medical Journal 309: 167.
83. Nair NPV, Hariharasubramanian N, Pilapil C, Issac I, Thavundayil JX. (1986) Plasma melatonin-an index of brain aging in humans. Biological Psychiatry 21: 141-50.
84. Aldhous M, Franey C, Wright J, Arendt J. (1985) Plasma concentrations of melatonin in man following oral absorption of different preparations. British Journal of Clinical Pharmacology 4: 517-21.
85. Arendt J. (1994) Melatonin and the Mammalian Pineal Gland. London: Chapman Hall.
86. Weaver DR. (1998) The suprachiasmatic nucleus: a 25 year retrospective. Journal of Biological Rhythms 13: 100-12.
87. Rusak B, Zucker I. (1979) Neural regulation of circadian rhythms. Physiological Review 59: 449-526.
88. Cohen RA, Albers HE. (1991) Disruption of human circadian and cognitive regulation following a discrete hypothalamic lesion: a case study. Neurobiology 41: 726-9.
89. Czeisler CA, Shanahan TL, Klerman EB, Martens H, Brotman DJ, Emens JS, Klein T, Rizzo JF. (1995) Suppression of melatonin secretion in some blind patients by exposure to bright light. New England Journal of Medicine 332: 6-11.
90. Moore RY. (1990) The circadian system and sleep-wake behavior. In: Montplaisir J, Godbout R, editors. Sleep and Biological Rhythms. New York: Oxford University Press. p 3-10.
91. Klein DC, Weller JL. (1970) Indole metabolism in the pineal gland: a circadian rhythm in N-acetyltransferase. Science 169: 1093-5.
92. Lewy AJ, Wehr TA, Goodwin FK, Newsome DA, Markey SP. (1980) Light suppresses melatonin secretion in humans. Science 210: 1267-9.
93. Roberts JE. (1995) Visible light induces changes in the immune response through an age-brain mechanism (photoneuroimmunology). Journal of Photochemistry and Photobiology 29: 3-15.
94. Cassone VM, Warren WS, Brooks DS, Lu J. (1993) Melatonin, the pineal gland and the circadian rhythm. Journal of Biological Rhythms 8: (Suppl.) 73-81.
95. Dawson D, Gibbon S, Singh P. (1996) The hypothermic effect of melatonin on core body temperature: is more better? Journal of Pineal Research 20: 192-7.
96. Sack RL, Hughes RJ, Edgar DM, Lewy AJ. (1997) Sleep promoting effects of melatonin: at what dose, in whom, under what conditions, and by what mechanisms. Sleep 20: 908-15.
97. Lavie P, Haimov I, Shochat T. (1997) Melatonin-shutting off the wakefulness system. In: Maestroni GJM, Conti A, Reiter RJ, editors. Therapeutic Potential of Melatonin. New York: Karger. p 149-60.
98. Dubocovich ML, Yun K, Al-Ghoul WM, Benloucif S, Masana MI. (1998) Selective MT2 melatonin receptor antagonists block melatonin-mediated phase advances of circadian rhythms. FASEB Journal 12: 1211-20.
99. Lewy AJ, Sack RL, Blood ML, Bauer VK, Cutler, NL, Thomas KH. (1995) Melatonin marks circadian phase position and resets the endogenous circadian pacemaker in humans. Ciba Foundation Symposium 183: 303-17.
100. Shochat T, Luboshitzky R, Lavie P. (1997) Nocturnal melatonin onset is phase locked to the primary sleep gate. American Journal of Physiology 273: 364-70.
101. Tzischinsky O, Lavie P. (1994) Melatonin possesses a time-dependent hypnotic effect. Sleep 17: 638-45.
102. Middleton B, Arendt J, Stone BM. (1997) Complex effects of melatonin on human circadian rhythms in constant dim light. Journal of Biological Rhythms 12: 467-77.
103. Middleton B, Stone BM, Arendt J. (1996) Melatonin and fragmented sleep patterns. Lancet 348: 551-2.
104. Dunlap JC. (1993) Genetic analysis of circadian clocks. Annual Review of Physiology 55: 683-728.
105. Hastings M. (1995) Circadian rhythms: peering into the molecular clockwork. Journal of Neuroendocrinology 7: 331-40.
106. Arendt J. (1993) Some effects of light and melatonin on human rhythms. In: Wetterberg L, editor. Light and Biological Rhythms in Man. Oxford: Pergamon. p 203-15.
107. Dahl RE. (1996) The regulation of sleep and arousal. Development and Psychobiology 8: 3-27.
108. McIntyre IM, Norman TR, Burrows GD, Armstrong SM. (1993) Alterations to plasma melatonin and cortisol after evening alprazolam administration in humans. Chronobiology International 10: 205. (Abstract.)
109. Reiter RJ, Robinson J. (1995) Drugs that deplete melatonin. In: Your Body's Natural Wonder Drug Melatonin. New York: Bantam. p 181-91.
110. Ibuka N, Inouye S-I, Kawamura H. (1997) Analysis of sleep-wakefulness rhythms in male rats after suprachiasmatic nucleus lesions and ocular enucleation. Brain Research 122: 33-47.
111. Klein DC. (1993) The mammalian melatonin rhythm generating system. In: Wetterberg L, editor. Light and Biological Rhythms in Man. Oxford, UK: Pergamon. p 55-71.
112. Neuwelt EA, Glasberg M, Frankel E, Clark WK. (1979) Malignant pineal region tumors. Journal of Neurosurgery 51: 597-607.
113. Packer RJ, Sutton LN, Rosenstock JG, Rorke LB, Bilaniuk LT. (1984) Pineal region tumors in childhood. Pediatrics 74: 97-102.
114. Petterborg LJ, Thalen BE, Kjellman BF, Wetterberg L. (1991) Effect of melatonin replacement on serum hormone rhythms in a patient lacking endogenous melatonin. Brain Research Bulletin 27: 181-5.
115. McArthur AJ, Lewy AJ, Sack RL. (1996) Non 24-hour sleep-wake syndrome in a sighted man: circadian studies and efficacy of melatonin treatment. Sleep 19: 544-53.
116. Wever RA. (1979) The Circadian System of Man. New York: Springer-Verlag.
117. Kennaway DJ, Van Dorp CF. (1991) Free-running rhythms of melatonin, cortisol, electrolytes and sleep in humans in Antarctica. American Journal of Physiology 260: 1137-44.
118. Whitson PA, Putcha L, Chen YM, Baker E. (1995) Melatonin and cortisol assessment of circadian shifts in astronauts before flight. Journal of Pineal Research 18: 141-7.
119. Oren DA, Giesen HA, Wehr TA. (1997) Restoration of detectable melatonin after entrainment to a 24 hour schedule in a 'free-running' man. Psychoneuroendocrinology 22: 39-52.
120. Kullmann G, Neri F, Bertolini M. (1996) Lack in light/dark rhythm of the pineal hormone melatonin in autistic children: a therapeutic potential of melatonin. Paper presented at the 2nd Locarno Meeting on Neuroendocrinoimmunology, Locarno, Switzerland. May 5-8, 1996. p 49. (Abstract.)
121. Cavallo A, Holt KG, Hejazi MS, Richards GS, Meyer WJ. (1987) Melatonin circadian rhythm in childhood depression. Journal of the American Academy of Child and Adolescent Psychiatry 26: 395-9.
122. Kennedy SH, Garfinkel PE, Parientic V, Costa D, Brown GM. (1989) Changes in melatonin levels but not cortisol levels are associated with depression in patients with eating disorders. Archives of General Psychiatry 46: 73-8.
123. Brown GM. (1992) Day-night rhythm disturbance, pineal function and human disease. Hormone Research 37: (Suppl. 3) 105-11.
124. Garfinkel D, Laudon M, Nof D, Zisapel N. (1995) Improvement of sleep quality in elderly people by controlled-release melatonin. Lancet 346: 541-4.
125. Hajak G, Rodenbeck A, Staedt J, Bandelow B, Huether G, Ruther E. (1995) Nocturnal plasma melatonin levels in patients suffering from chronic primary insomnia. Journal of Pineal Research 19: 116-22.
126. Middleton B, Arendt J, Stone BM. (1996) Human circadian rhythms in constant dim light (8 lux) with knowledge of clock time. Journal of Sleep Research 5: 69-76.
127. Duffy JF, Kronauer RE, Czeisler CA. (1996) Phase-shifting human circadian rhythms: influence of sleep timing, social contact and light exposure. Journal of Physiology 495: 289-97.
128. Miles LE, Wilson MA. (1977) High incidence of cyclic sleep/wake disorders. Sleep Research 6: 192.
129. Miles LE, Raynal DM, Wilson MA. (1977) Blind man living in normal society has circadian rhythm of 24.9 hours. Science 198: 421-3.
130. Lewy AJ, Newsome DA. (1980) Different types of melatonin circadian secretory rhythms in some blind subjects. Journal of Clinical Endocrinology and Metabolism 56: 1103-7.
131. Okawa M, Takahashi K, Sasaki H. (1986) Disturbance of circadian rhythms in severely brain-damaged patient correlated with CT findings. Journal of Neurology 233: 274-82.
132. Sack RL, Lewy AJ, Blood ML, Stevenson J, Keith LD. (1991) Melatonin administration to blind people: phase advances and entrainment. Journal of Biological Rhythms 6: 249-61.
133. Aldhous ME, Arendt J. (1991) Assessment of melatonin rhythms and sleep-wake cycle in blind subjects. Advances in Pineal Research 5: 307-9.
134. Sack RL, Lewy AJ, Blood ML, Keith LD, Nakagawa H. (1992) Circadian rhythm abnormalities in totally blind people: incidence and clinical significance. Journal of Clinical Endocrinology and Metabolism 75: 127-34.
135. Nakagawa H, Isaki K, Sack RL, Lewy AJ. (1992) Free-running melatonin, sleep propensity, cortisol and temperature rhythm in a totally blind person. Japanese Journal of Psychiatry and Neurology 46: 210-2.
136. Tzischinsky O, Skene R, Epstein R, Dagan Y, Lavie P. (1991) Circadian rhythms in 6-sulphatoxymelatonin and nocturnal sleep in blind children. Chronobiology International 8: 168-75.
137. Sasaki H, Nakata H, Murakami S, Uesugi B, Harada S, Teranishi M. (1992) Circadian sleep-waking rhythm disturbance in blind adolescents. Japanese Journal of Psychiatry and Neurology 46: 209.
138. Leger D, Guilleminault C, Defranoe R, Domont A, Paillard M. (1996) Blindness and sleep patterns. Lancet 348: 830-1.
139. Arendt J, Skene DJ, Middleton B, Lockley SW, Deacon S. (1997) Efficacy of melatonin treatment in jet lag, shift work, and blindness. Journal of Biological Rhythms 12: 604-17.
140. Mindell JS, Moline ML, Zendell SM, Brown LW, Fry JW. (1994) Pediatricians and sleep disorders: training and practice. Pediatrics 94: 194-200.
141. Bramble D. (1997) Rapid-acting treatment for a common sleep problem. Developmental Medicine & Child Neurology 39: 543-7.
142. Chilcott LA, Shapiro CM. (1996) The socioeconomic impact of insomnia. An overview. Pharmacoeconomics 10: (Suppl. 1) 1-14.
143. Torsvall L, Akerstedt T, Gillander K, Knutsson A. (1989) Sleep on the night shift: 24-hour EEG monitoring of spontaneous sleep/wake behavior. Psychophysiology 26: 352-8.
144. Marcus C, Loughlin G. (1996) Effect of sleep deprivation on driving safety in housestaff. Sleep 19: 763-6.
145. Smith C. (1995) Sleep states and memory processes. Behavioral Brain Research 69: 137-45.
146. Piazza CC, Fisher W, Kiesewetter K, Bowman L, Moser H. (1990) Aberrant sleep pattern in children with Rett Syndrome. Brain and Development 12: 488-93.
147. Piazza CC, Fisher W, Moser M. (1991) Behavioral treatment of dysfunction in patients with Rett Syndrome. Brain and Development 13: 232-7.
148. Vaughan GM. (1993) New sensitive serum melatonin radioimmunoassay employing the Kennaway G 280 antibody: Syrian hamster morning adrenergic response. Journal of Pineal Research 15: 88-103.
149. Voultsios A, Kennaway DJ, Dawson D. (1997) Salivary melatonin as a circadian phase marker: validation and comparison to plasma melatonin. Journal of Biological Rhythms 12: 457-66.
150. Aldhous ME, Arendt J. (1988) Radioimmunoassay for 6-sulphatoxymelatonin in urine using an iodinated tracer. Annals of Clinical Biochemistry 25: 298-303.
151. Alvarez B, Dahlitz MJ, Vignau J, Parkes JD. (1992) The delayed sleep-phase syndrome: clinical and investigative findings in 14 subjects. Journal of Neurology, Neurosurgery and Psychiatry 55: 665-70.
152. Kaplan BJ, McNicol J, Conte RA, Moghadam HK. (1987) Sleep disturbance in preschool-aged hyperactive and nonhyperactive children. Pediatrics 80: 839-44.
153. Marcotte AC, Thacker PV, Butters M, Bortz J, Acebo C, Carskadon MA. (1998) Parental report of sleep problems in children with attentional and learning disorders. Developmental and Behavioral Pediatrics 19: 178-86.
154. Laurant MW, Nagtegaal JE, Coenen AML, Smits MG. (1997) Quality of life before and after treatment with melatonin in patients with delayed sleep phase syndrome. Sleep-wake Research in the Netherlands 8: 83-6.
155. Lockley SW, Skene DJ, Tabandeh HJ, Bird AC, Defrance R, Arendt J. (1997) Relationship between napping and melatonin in the blind. Journal of Biological Rhythms 12: 16-25.
156. Deacon S, Arendt J. (1995) Melatonin induces temperature suppression and its acute phase-shifting effects correlate in a dose dependent manner in humans. Brain Research 688: 77-85.
157. Chase JE, Gidal BE. (1997) Melatonin: therapeutic use in sleep disorders. Annals of Pharmacotherapy 31: 1218-26.
158. Voordouw BCG, Euser R, Verdonk, RER, Alberda BT, De Jong FH, Drogendijk AC, Fauser BCMJ, Cohen M. (1992) Melatonin and melatonin-progestin combinations alter pituitary-ovarian function in women, and can inhibit ovulation. Journal of Clinical Endocrinology and Metabolism 74: 108-17.
159. Maestroni GJ. (1993) The immunoneuroendocrine role of melatonin. Journal of Pineal Research 14: 1-10.
160. McElhinny AS, Davis FC, Warner CM. (1996) The effects of melatonin on cleavage rate on C57BL/6 and CBA/Ca preimplantation embryos cultured in vitro. Journal of Pineal Research 21: 44-8.
161. Mirmiran M. Pevet P. (1986) Effects of melatonin and 5-methoxytryptamine on sleep wake patterns in the male rat. Journal of Pineal Research 3: 135-41.
162. Steriade M, Paré D. (1990) Brainstem genetics and thalamic transfer of internal signals during dreaming sleep: cellular data and hypothesis. In: Montplaisir J, Godbout R, editors. Sleep and Biological Rhythms. New York: Oxford University Press.p 148-62.
163. Hubain P, VanVeeren C, Staner I, Mendlewicz J, Linkowski P. (1996) Neuroendocrine and sleep variables in major depressed inpatients: role of severity. Psychiatry Research 63: 83-92.
164. Leibenluft E, Albert PS, Rosenthal NE, Wehr TA. (1996) Relationship between sleep and mood in patients with rapid-cycling bipolar disorder. Psychiatry Research 63: 161-8.
165. Lieberman HR, Waldhauser F, Garfield G, Lynch HJ, Wurtman RJ. (1984) Effects of melatonin on human mood and performance. Brain Research 323: 201-7.
166. deVries MW, Peeters FPML. (1997) Melatonin as a therapeutic agent in the treatment of sleep disturbance in depression. Journal of Nervous and Mental Disease 185: 201-2.
167. Carman JS, Post RM, Buswell R, Goodwin FK. (1976) Negative effects of melatonin on depression. American Journal of Psychiatry 133: 1181-6.
168. Ryan ND, Puig-Antich J, Rabinovich H, Robinson D, Ambrosini PJ, Nelson B, Iyengar S. (1987) The clinical picture of major depression in children and adolescents. Archives of General Psychiatry 44: 854-61.
169. Shafii M, MacMillan DR, Key MP, Derrick AM, Kaufman N, Nahinsky ID. (1996) Nocturnal serum melatonin profile in major depression in children and adolescents. Archives of General Psychiatry 53: 1009-13.
170. Ford DE, Kamerow D. (1989) Epidemiological studies of sleep disturbances and psychiatric disorders: an opportunity for prevention? Journal of the American Medical Association 262: 1479-84.
171. Wu JC, Bunney WE. (1990) The biological basis of an antidepressant response to sleep deprivation and relapse: review and hypothesis. American Journal of Psychiatry 147: 14-21.
172. Morton DJ. (1986) Effects of anticonvulsant drugs in vivo on rat pineal n-acetyltransferase (EC 2.3.1.5) and hydroxyindole-o-pineal transferase (EC 2.1.1.4) Journal of Pineal Research 3: 181-6.
173. Monteleone P, Tortorella A, Borriello R, Natale M, Cassandro P, Maj M. (1997) Suppression of nocturnal plasma melatonin levels by evening administration of sodium valproate in healthy humans. Biological Psychiatry 41: 336-41.
174. Zisapel N, Garfinkel D. (1997) Use of controlled-release melatonin for insomnia in older persons. Clinical Geriatrics 5: 17-26.
175. Valcavi R, Zini M, Maestrani G, Conti A. (1993) Melatonin stimulates growth hormone secretion through pathways other than the growth hormone-releasing hormone. Clinical Endocrinology 39: 193-9.
176. Maestroni GJ, Conti A, Pierpaoli W. (1988) Pineal melatonin, its fundamental immunoregulatory role in aging and cancer. Annals of New York Academy of Sciences 521: 140-8.
177. Reiter RJ, Melchiorri D, Sawerynek E, Poeggeler B, Barlow-Walden L, Chuang JI, Ortiz GG, Acuña-Castroviejo D. (1995) A review of the evidence supporting melatonin's role as an antioxidant. Journal of Pineal Research 18: 1-11.
178. Gupta D. (1991) Melatonin, immunity and cancer in humans. In: Franschini F, Reiter RJ, editors. Role of Melatonin and Pineal Peptides in Neuroimmunomodulation. NATO ASI Series. New York: Plenum. p 253-61.
179. Bartsch C, Bartsch H, Lippert TH. (1992) The pineal gland and cancer: facts, hypotheses and perspectives. Cancer Journal 5: 194-9.
180. Brzezinski A. (1997) Melatonin in humans. New England Journal of Medicine 336: 186-95.
181. Shouse MN, Martins da Silva A, Sammaritano M. (1996) Circadian rhythm, sleep and epilepsy. Journal of Clinical Neurophysiology 13: 32-50.
182. Sheldon SH. (1998) Pro-convulsant effects of oral melatonin in neurologically disabled children. Lancet 351: 1254.
183. Jan JE, Connolly MBC, Hamilton D, Freeman RD, Laudon M. (1999) Melatonin treatment of nonepileptic myoclonus in children. Developmental Medicine & Child Neurology 41: 255-9.
184. Muñoz-Hoyos A, Sanchez-Forte M, Molina-Carballo A, Escames G, Martin-Medina E, Reiter RJ, Molina-Front JA, Acuña-Castroviejo D. (1998) Melatonin's role as an anticonvulsant and neuronal protector: experimental and clinical evidence. Journal of Child Neurology 13: 501-9.
185. Reiter RJ, Morgan W. (1972) Attempts to characterize the convulsive response of parathyroidectomized rats to pineal gland removal. Psychology and Behaviour 9: 203-8.
186. Fariello RG, Bubenik GA, Brown GM, Grota LJ. (1977) Epileptogenic action on intraventricularly injected anti-melatonin antibody. Neurology 27: 567-70.
187. Albertson TE, Peterson SL, Stark LG, Lakin ML, Winters WD. (1981) The anticonvulsant properties of melatonin on kindled seizures in rats. Neuropharmacology 20: 61-6.
188. Champney TH, Hanneman WH, Legare ME, Appel K. (1996) Acute and chronic effects of melatonin as an anticonvulsant in male gerbils. Journal of Pineal Research 20: 79-83.
189. Brueske V, Allen J, Kepic T, Meissner W, Lee R, Vaughan G, Weinburg U. (1981) Melatonin inhibition of seizure activity in man. Electroencephalography and Clinical Neuropsychology 51: 209. (Abstract.)
190. Champney TH, Sanchez-Forte H, Muñoz-Hoyos A, Molina-Carballo A, Moreno-Madrid F, Acuña-Castroviejo D. (1995) Anticonvulsant effects of melatonin in humans. Paper presented at the Society for Neuroscience Annual Meeting. San Diego, California, 11th-12th November, 1995.
191. Molina-Carballo A, Muñoz-Hoyos, A, Reiter RJ, Sanchez-Forte M, Moreno-Madrid F, Rufo-Campos M, Molina-Font JA, Acuna-Castroviejo D. (1997) Utility of high doses of melatonin as adjunctive anticonvulsant therapy in a child with severe myoclonic epilepsy: two years' experience. Journal of Pineal Research 23: 97-105.