Melatonin treatment of non-epileptic myoclonus in children

Developmental Medicine and Child Neurology

Volumn 41, Issue 4, 1999, Pages 255-259

  Jan, James E ^c   Connolly, Mary B C ^d   Hamilton, Don ^d   Freeman, Roger D ^a   Laudon, Moshe ^b  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b NEURIM PHARMACEUTICALS LTD   (Israel)

^c BC CHILDREN S HOSPITAL   (Canada)

^d NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANTICONVULSIVE AGENT; MELATONIN; PINEAL BODY HORMONE;

ARTICLE; CASE REPORT; CHILD; DRUG EFFICACY; FEMALE; HUMAN; MALE; MYOCLONUS; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; SLEEP; SLEEP DISORDER;

ANTICONVULSANTS; CHILD; CHILD, PRESCHOOL; FEMALE; HUMANS; INFANT; MALE; MELATONIN; MYOCLONUS; SLEEP DISORDERS; TREATMENT OUTCOME;

EID: 0032895835     PISSN: 00121622     EISSN: None     Source Type: Journal    
DOI: 10.1017/S0012162299000535     Document Type: Article

References (48)

1. Albertson TE, Peterson SL, Stark LG, Lakin ML, Winters WD. (1981) The anticonvulsant properties of melatonin on kindled seizures in rats. Neuropharmacology 20: 61-6.
2. Aldhous M, Franey C, Wright J, Arendt J. (1985) Plasma concentrations of melatonin in man following oral absorption of different preparations. British Journal of Clinical Pharmacology 4: 517-21.
3. Antón-Tay F. (1974) Melatonin: effects on brain function. Advances in Biochemical Psychopharmacology. Vol. 11. New York: Raven Press, p 315-24.
4. -Diaz JL, Fernandez-Guardiol A. (1971) On the effect of melatonin upon human brain. Its possible therapeutic implications. Life Sciences (Part I) 10: 841-50.
5. Arendt J, Skene DJ, Middleton B, Lockley SW, Deacon S. (1997) Efficacy of melatonin treatment in jet lag, shift work, and blindness. Journal of Biological Rhythms 12: 604-17.
6. Brailowsky S. (1976) Effects of melatonin on the photosensitive epilepsy of the baboon, Papio papio. Electroencephalography and Clinical Neurophysiology 11: 314-9.
7. Brown P, Thompson PD, Rothwell JC, Day BL, Marsden CD. (1991) Axial myoclonus of propriospinal origin. Brain 114: 197-214.
8. Brueske V, Allen J, Kepic T, Meissner W, Lee R, Vaughan G, Weinburg U. (1981) Melatonin inhibition of seizure activity in man. Electroencephalography and Clinical Neurophysiology 51: 209. (Abstract.)
9. Cajochen C, Krüuchi K, von Arx M-A, Möri D, Graw P, Wirz-Justice A. (1996) Daytime melatonin administration enhances sleepiness and theta/alpha activity in the waking EEG. Neuroscience Letters 207: 209-13.
10. Champney TH. (1990) Noradrenergic involvement in pinealectomy induced convulsions in gerbils. Neuroscience Letters 120: 245-8.
11. -Champney JC. (1992) Novel anticonvulsant action of chronic melatonin in gerbils. NeuroReports 3: 1152-4.
12. -Peterson SL. (1993) Circadian, seasonal, pineal and melatonin influences on epilepsy. In: Yu H-S, Reiter RJ, editors. Melatonin. Biosynthesis, Physiological Effects and Clinical Applications. London: CRC Press, p 478-94.
13. -Hanneman WH, Legare ME, Appel K. (1996) Acute and chronic effects of melatonin as an anticonvulsant in male gerbils. Journal of Pineal Research 20: 79-83.
14. -Sanchez-Forte H, Munóz-Hoyos A, Molina-Carballo A, Morino-Madrid F, Acuna-Castroviejo D. (1995) Anticonvulsant effects of melatonin in humans. Paper presented at the Society for Neuroscience Annual Meeting, San Diego, California, 11th-12th November 1995.
15. Dawson D, Gibbon S, Singh P. (1996) The hypothermic effect of melatonin on core body temperature: is more better? Journal of Pineal Research 20: 192-7.
16. Deacon S, Arendt J. (1995) Melatonin induces temperature suppression and its acute phase-shifting effects correlate in a dose dependent manner in humans. Brain Research 688: 77-85.
17. Degan R. (1980) A study of the diagnostic value of waking and sleep EEGs after sleep deprivation in epileptic patients on anticonvulsant therapy. Electroencephalograpby and Clinical Neurophysiology 49: 577-84.
18. Deuschl G, Toro C, Valls-Sole J, Zeffiro T, Zee DS, Hallett M. (1994) Symptomatic and palatal tremor. I. Clinical, physiological and MRI analysis. Brain 117: 775-88.
19. Fariello RG, Bubenik GA, Brown GM, Grota LJ. (1977) Epileptogenic action on intraventricularly injected antimelatonin antibody. Neurology 27: 567-70.
20. Fejerman N. (1997) Non-epileptic neurologic paroxysmal disorders and episodic symptoms in infants. In: Engel J, Pedley TA, editors. Epilepsy: A Comprehensive Textbook. Philadelphia: Lippincott-Raven. p 2745-54.
21. Floreani M, Franceschini D, Petroni M, Giusti P. (1996) Melatonin protection against kainate neurotoxicity. Paper presented at the 2nd Locarno Meeting on Neuroendocrinoimmunology: therapeutic potential of the pineal hormone melatonin, Locarno, Switzerland, 5th-8th May, 1996.
22. Fountain NB, Kim JS, Lee SI. (1998) Sleep deprivation activates epileptiform discharges independent of the activating effects of sleep. Journal ofClinicalNeurophysiology 15: 69-75.
23. Garcia-Rill E. (1991) The pedunculopontine nucleus. Progress in Neurobiology 36: 363-89
24. Gastaut H. (1968) Sámiologie des myoclonies et nosologie analytique des syndromes myocloniques. In: Bonduelle M, Gastaut H, editors. Les Myoclonies. Paris: Masson and Co. p 1-30.
25. Golombek DA, Duque DF, De Brito Sánchez MG, Burin L. (1992) Time dependent anticonvulsant activity of melatonin in hamsters. European Journal of Pharmacology 210: 253-8.
26. International League Against Epilepsy Commission report. (1997) Myoclonus and epilepsy in childhood. Epilepsia 38: 1251-4.
27. Jan JE, Espezel H, Appleton RE. (1994) The treatment of sleep disorders with melatonin. Developmental Medicine and Child Neurology 36: 97-107.
28. -O'Donnell ME. (1996) Use of melatonin in the treatment of paediatric sleep disorders. Journal of Pineal Research 21: 193-9.
29. Kunz D, Bes F. (1997) Melatonin effects in a patient with severe REM sleep behavior disorder: case report and theoretical considerations. Neuropsychobiology 36: 211-4.
30. Lavie P, Haimov I, Shochat T. (1997) Melatonin - shutting off the wakefulness system. In: Maestroni GJM, Conti A, Reiter RJ, editors. Therapeutic Potential of Melatonin. New York: Karger. p 149-60.
31. Lombroso CT, Fejerman N. (1997) Benign myoclonus of early infancy. Annals of Neurology 1: 138-48.
32. Liu C, Weaver DR, Jin X, Shearman LP, Pieschl RL, Gribkoff VK, Reppert SM. (1997) Molecular dissection of two distinct actions of melatonin on the suprachiasmatic circadian clock. Neuron 19: 91-102.
33. Maurizi CP. (1985) Could supplementary dietary tryptophan and taurine prevent epileptic seizures. Neuroscience Letters 150: 112-16.
34. Middleton B, Arendt J, Stone BM. (1997) Complex effects of melatonin on human circadian rhythms in constant dim light. Journal of Biological Rhythms 12: 467-77.
35. Molina-Carballo A, Munoz-Hoyos A, Reiter RJ, Sanchez-Forte M, Moreno-Madrid F, Rufo-Campos M, Molina-Font JA, Acuna-Castroviejo D. (1997) Utility of high doses of melatonin as adjunctive anticonvulsant therapy in a child with severe myoclonic epilepsy: two years' experience. Journal of Pineal Research 23: 97-105.
36. Montagna P, Provini F, Plazzi G, Liguori R, Lugaresi E. (1997) Propriospinal myoclonus upon relaxation and drowsiness: a cause of severe insomnia. Movement Disorders 12: 66-72.
37. Munoz-Hoyos A, Sánchez-Forte M, Molina-Carballo A, Escames G, Martin-Medina E, Reiter RJ, Molina-Font JA, Acuña-Castroviejo D. (1998) Melatonin's role as an anticonvulsant and neuronal protector: experimental and clinical evidence. Journal of Child Neurology 13: 501-9.
38. Pang SF, Brown GM. (1983) Regional concentration of melatonin in the rat brain in the light and dark period. Life Sciences 33: 1199-204.
39. Reiter RJ, Morgan W. (1972) Attempts to characterize the convulsive response of parathyroidectomized rats to pineal gland removal. Physiology and Behaviour 9: 203-8.
40. Reiter RJ, Blask DE, Talbot JA, Barnett MP. (1973) Nature and time course of seizures associated with surgical removal of the pineal gland from parathyroidectomized rats. Experimental Neurology 38: 386-97
41. Resnick RJ, Moshé SL, Perotta L, Chambers HJ. (1986) Benign neonatal sleep myoclonus: relationship to sleep states. Archives of Neurology 43: 266-8.
42. Sack RL, Hughes RJ, Edgar DM, Lewy AJ. (1997) Sleep promoting effects of melatonin: at what dose, in whom, under what conditions and by what mechanisms. Sleep 20: 908-15.
43. Sheldon SH. (1998) Pro-convulsant effects of oral melatonin in neurologically disabled children. Lancet 351: 1254. (Letter.)
44. Shouse MN, Martins da Silva A, Sammaritano M. (1996) Circadian rhythm, sleep, and epilepsy. Journal of Clinical Neurophysiology 13: 32-50.
45. Sugden D. (1983) Psychopharmacological effects of melatonin in mouse and rat. Joumal of Pharmacology and Experimental Therapy 227: 587-91.
46. Tanaka H, Araki A, Ito J, Tasaki T, Miyamoto A, Cho K. (1997) Improvement of hypertonus after treatment for sleep disturbances in three patients with severe brain damage. Brain and Development 19: 240-4.
47. Walters AS, Picchietti DL, Ehrenberg BL, Wagner ML. (1994) Restless legs syndrome in childhood and adolescence. Pediatric Neurology 11: 241-5.
48. Yamamoto H, Tang HW. (1996) Antagonistic effect of melatonin against cyanide-induced seizures and acute lethality in mice. Toxicology Letters 87: 19-24.