Methotrexate compared with mercaptopurine for early induced abortion

Obstetrics and Gynecology

Volumn 93, Issue 6, 1999, Pages 904-909

  Davis, Anne R ^a   Miller, Leslie ^b   Tamimi, Hisham ^b   Gown, Allen ^b  

^a PH 16 Columbia University ^*  (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CHORIONIC GONADOTROPIN BETA SUBUNIT; COCODAMOL; IBUPROFEN; IMMUNOGLOBULIN; KI 67 ANTIGEN; MERCAPTOPURINE; METHOTREXATE;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; FETUS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INDUCED ABORTION; INTRAMUSCULAR DRUG ADMINISTRATION; ORAL DRUG ADMINISTRATION; PAIN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

6-MERCAPTOPURINE; ABORTIFACIENT AGENTS; ABORTION, INDUCED; ADULT; FEMALE; FETUS; HUMANS; KI-67 ANTIGEN; METHOTREXATE; PLACENTA; PREGNANCY; PREGNANCY TRIMESTER, FIRST;

EID: 0033036479     PISSN: 00297844     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0029-7844(98)00569-9     Document Type: Article

References (23)

1. Riddle JM. Contraception and abortion from the ancient world to the Renaissance. Cambridge, Massachusetts: Harvard University Press, 1994:16-24.
2. Etziony MD. The physician's creed; an anthology of medical prayers, oaths, and codes of ethics written and recited by medical practitioners through the ages. Springfield, Illinois: Thomas, 1973.
3. Thiersch JB, Philips FS. Effect of 4-amino-pteroylglutamic acid (aminopterin) on early pregnancy. Proc Soc Exp Biol Med 1950;74: 204-8.
4. Thiersch JB. Therapeutic abortions with a folic acid antagonist, 4-aminopteroylglutamic acid (4-amino PGA) administered by the oral route. Am J Obstet Gynecol 1952;63:1298-304.
5. Tanaka T, Hayashi H, Kutsuzawa T, Fujimoto S, Ichinoe K. Treatment of interstitial ectopic pregnancy with methotrexate: Report of a successful case. Fertil Steril 1982;37:851-2.
6. Stovall TG, Ling FVV. Single-dose methotrexate: An expanded clinical trial. Am J Obstet Gynecol 1993;168:1759-65.
7. Creinin MD. Methotrexate for abortion at days gestation. Contraception 1993;48:519-25.
8. Hausknecht RU. Methotrexate and misoprostol to terminate early pregnancy. N Engl J Med 1995;333:537-40.
9. Ulman A, Silvestre L, Chemama L, Rezvani Y, Renault M, Aguillaume CJ, et al. Medical termination of early pregnancy with mifepristone (RU 486) followed by a prostaglandin analogue. Acta Obstet Gynecol Scand 1992;71:278-83.
10. World Health Organization (WHO), Task Force on Postovulatory Methods for Fertility Regulation. Pregnancy termination with mifepristone and gemeprost: A multicenter comparison between repeated doses and a single dose of mifepristone. Fertil Steril 19916:32-40.
11. American Hospital Formulary Service drug information 1997. Bethesda, Maryland: American Society of Health System Pharmacists, Inc., 1997.
12. Bagshau'e KD. Trophoblastic tumours: Chemotherapy and developments. BMJ 1963;2:1303-7.
13. Hung-Chao S, Pao-Chen W, Ts'ui-Hua H. Treatment of choriocarcinoma and chorioadenoma destruyens with 6-mercaptopurine and surgery. Chin Med J 1963;82:24-38.
14. Schammel DP, Blockage T. p53, PCNA, and Ki-67 in hydropic molar and nonmolar placentas: An immunohistochemical study. Int J Gynecol Pathol 1996;15:158-66.
15. Du Bois D, Du Bois EF. A formula to estimate the approximate surface area if the height and weight be known. Arch Intern Med 1916;17:863-71.
16. Cattoretti G, Becker MH, Key G, Duchrow M, Schluter C, Galle J, Monoclonal anti-bodies against recombinant parts of the Ki-67 antigen (MIB 1 and MIB 3) detect proliferating cells in microwaveprocessed and formalin-fixed paraffin sections. J Pathol 1992;168: 357-63.
17. Gown AM, deVVever N, Battifora H. Microwave-based antigenic unmasking: A revolutionary new technique for routine immunohistochemistry. Appl Immunohistochem 1993;l:256-66.
18. Hsu SM, Raine L, Fanger H. Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques-a comparison between ABC and unlabelled antibody (PAP) procedures. J Histochem Cytochem 1981;29:577-8.
19. Lehr HA, Hansen KD, Coltrera MD, RUSS JC, Gown AM. Photoshop-based image analysis for the semiautomated assessment of Ki-67-defined proliferative activity in the routine diagnosis of breast cancer. Appl Immunohistochem 1996;4:117-27.
20. Schaff EA, Penmetsa U, Eisinger SH, Franks P. Methotrexate. A single agent for early abortion. J Reprod Med 1997;42:56-60.
21. Creinin MD, Damey PD. Methotrexate and misoprostol for early abortion. Contraception 1993;48:339-48.
22. Isaccs JD, McGehee RP, Cowan BD. Life-threatening neutropenia following methotrexate treatment of ectopic pregnancy: A report of two cases. Obstet Gynecol 1996;88:694-6.
23. Winikoff B. Acceptability of medical abortion in early pregnancy. Farn Plann Perspect 1995;27:142-8.