β1-Integrin mediates cell adhesion, haptotaxis, and chemokinesis of hepatoma cells

Medical Molecular Morphology

Volumn 32, Issue 1, 1999, Pages 2-10

  Torimura, Takuji ^a   Ueno, Takato ^a   Kin, Motoaki ^a   Sakisaka, Shotaro ^a   Tanikawa, Kyuichi ^b   Sata, Michio ^a  

^a KURUME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b International Institute for Liver Research   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CELL ADHESION MOLECULE; INTEGRIN;

BASEMENT MEMBRANE; CANCER INVASION; CELL ADHESION; CELL MIGRATION; CHEMOKINESIS; CHEMOTAXIS; CYTOSKELETON; HEPATOMA CELL; HUMAN; LIVER CELL CARCINOMA; METASTASIS; PRIORITY JOURNAL; REVIEW;

EID: 0033035574     PISSN: 18601480     EISSN: 18601499     Source Type: Journal    
DOI: 10.1007/s007950050002     Document Type: Review

References (35)

1. Biscegli AM, Rustgo VK, Hoofnagle JM, Dusheiko GM, Lotze MT (1988) Hepatocellular carcinoma. Ann Intern Med 108: 390-401
2. Oda T, Tsuda H, Scarpa A, Sakamoto M, Hirohashi S (1992) Mutation pattern of the p53 gene as a diagnostic marker for multiple hepatocellular carcinoma. Cancer Res 52: 3674-3678
3. Arakawa M, Kage N, Sugihara S, Nakashima T, Suenaga M, Okuda K (1986) Emergence of malignant lesions within an adenomatous hyperplastic nodule in a cirrhotic liver: observation in five cases. Gastroenterology 91: 198-208
4. Kondo Y, Wada K (1991) Intrahepatic metastasis of hepatocellular carcinoma. A histopathologic study. Hum Pathol 22: 125-130
5. Wiler DL, Wood PA, Willett FM (1944) Primary cancer of the liver. Ann Intern Med 20: 454-485
6. McDonald RA (1957) Primary carcinoma of the liver. Arch Intern Med 99: 266-279
7. Edmondson HA, Steiner PE (1954) Primary carcinoma of the liver. A study of 100 among 48, 900 necropsies. Cancer (Phila) 7: 462-503
8. Fidler IJ (1989) Origin and biology of cancer metastasis. Cytometry 10: 673-680
9. Liotta LA (1986) Tumor invasion and metastasis - role of the extracellular matrix: roads memorial award lecture. Cancer Res 46: 1-7
10. Thompson EW, Torri J, Sabol M, Sommers CL, Byers S, Valverius EM, Martin GR, Lippman ME, Stampfer MR, Dickson RB (1994) Oncogene-induced basement membrane invasiveness in human mammary epithelial cells. Clin Exp Metastasis 12: 181-194
11. Weinel RJ, Rosendahl A, Pinschmidt E, Kisker O, Simon B, Santoso S (1995) The α6-integrin receptor in pancreatic carcinoma. Gastroenterology 108: 523-532
12. Matrisian LM, Bowden GT (1990) Stromelysin/transin and tumor progression. Semin Cancer Biol 1: 107-115
13. Liotta LA, Steeg PS, Stetler-Stevenson WG (1991) Cancer metastasis and angiogenesis: an imbalance of positive and negative regulation. Cell 64: 327-336
14. Liotta LA (1986) Tumor invasion and metastasis - role of the extracellular matrix. Cancer Res 46: 1-7
15. Albelda SM (1993) Biology of disease: role of integrins and other cell adhesion molecules in tumor progression and metastasis. Lab Invest 68: 4-17
16. Torimura T, Ueno T, Kin M, Inuzuka S, Sugawara H, Tamaki S, Tsuji R, Sujaku K, Sata M, Tanikawa K (1997) Coordinated expression of integrin α6β1 and laminin in hepatocellular carcinoma. Hum Pathol 28: 1131-1138
17. Helmer ME (1990) VLA protein in the integrin family: structure, functions and their role on leukocytes. Annu Rev Immunol 8: 365-400
18. Hynes RO (1992) Integrins: Versatility, modulation, and spreading in cell adhesion. Cell 69: 11-25
19. Yamada KM, Geiger B (1997) Molecular interactions in cell adhesion complexes. Curr Opin Cell Biol 9: 76-85
20. Kassner PD, Kawaguchi S, Hemler (1994) Minimum α-chain cytoplasmic tail sequence needed to support integrin-mediated adhesion. J Biol Chem 269: 19859-19867
21. LaFlamme S, Thomas L, Yamada S, Yamada K (1994) Single subunit chimeric integrins as mimics and inhibitors of endogenous integrin functions in receptor localization, cell spreading and imigration, and matrix assembly. J Cell Biol 126: 1287-1298
22. Yamada KM (1997) Integrin signaling. Matrix Biol 16: 137-141
23. Ishizaki T, Maekawa M, Fujisawa K, Okawa K, Iwamatsu A, Fujita A, Watanabe N, Saito Y, Kakizuka A, Morii N, Narumiya S (1996) The small GTP-binding protein Rho binds to and activates a 160-kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase. EMBO J 15: 1885-1893
24. Leung T, Manser E, Tan L, Lim L (1995) A novel serine/threonine kinase binding the Ras-related Rho A GTPase which translocates the kinase to peripheral membranes. J Biol Chem 270: 29051-29054
25. Matsui T, Amano M, Yamamoto t, Chihara K, Nakatuku M, Ito N, Nakano T, Okawa K, Iwamatsu A, Kaibuchi K (1996) Rhoassociated kinase, a novel serine/threonine kinase, as a putative target for the small GTP binding protein Rho. EMBO J 15: 2208-2216
26. O'Toole TE, Katagiri Y, Faull RJ, Peter K, Tamura R, Quaranta V, Loftus JC, Shattil SJ, Ginsberg MH (1994) Integrin cytoplasmic domains mediate inside-out signal transduction. J Cell Biol 124: 1047-1059
27. Otey CA, Pavalko FM, Burridge K (1990) An interaction between α-actinin and the β1-integrin subunit in vitro. J Cell Biol 111: 721-729
28. Clark EA, Brugge JS (1995) Integrins and signal transduction pathways: the road taken. Science 268: 233-239
29. Torimura T, Ueno T, Kin M, Inuzuka S, Sugawara H, Tamaki S, Ogata R, Sujaku K, Sata M, Tanikawa K (1997) Coordinated expression of integrin α6β1 and laminin in hepatocellular carcinoma. Hum Pathol 28: 1131-1138
30. Martigez-Herrandez A, Amenta PS (1983) The basement membrane in pathology. Lab Invest 48: 656-677
31. Ogata R (1988) Type IV collagen and laminin enhance the motility, adhesion, and proliferation of hepatoma cells. KMJ 45: 11-20
32. Mitchison TJ, Cramer LP (1996) Actin-based cell motility and cell locomotion. Cell 84: 371-379
33. Carloni V, Romanelli RG, Mercurio AM, Pinzani M, Laffi G, Cotrrozzi G, Gentilini P (1998) Knockout of α6β1-integrin expression reverses the transformed phenotype of hepatocarcinoma cells. Gastroenterology 115: 433-442
34. Torimura T, Ueno T, Kin M, Ogata R, Inuzuka S, Sugawara H, Kuromatsu R, Shimada M, Sata M, Yano H, Kojiro M, Tanikawa K (1994) Integrin α6β1 plays the most significant role in the attachment of hepatoma cells to laminin (abstract). Hepatology 20: 276A
35. Ogata R, Torimura T, Kin M, Ueno T, Tateishi Y, Kuromatsu R, Shimauchi Y, Sakamoto M, Tamaki S, Sata M, Tanikawa K. Increased expression of membrane-type I matrix metalloproteinase and matrix metalloproteinase-2 with tumor de-differentiation in hepatocellular carcinoma. Hum Pathol (in press)