Light-chain framework region residue Tyr71 of chimeric B72.3 antibody plays an important role in influencing the TAG72 antigen binding

Protein Engineering

Volumn 12, Issue 5, 1999, Pages 417-421

  Xiang, Jim ^a   Prasad, Lata ^a   Delbaere, Louis T J ^a   Jia, Zongchao ^a,b  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

^b QUEEN S UNIVERSITY   (Canada)

Author keywords

Binding affinity; FR residues; Site directed mutagenesis; TAG72 antigen

Indexed keywords

ARGININE; CHIMERIC PROTEIN; GUANIDINE; IMMUNOGLOBULIN LIGHT CHAIN; MONOCLONAL ANTIBODY B.72.3; PHENYLALANINE; THREONINE; TYROSINE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANTIBODY STRUCTURE; ANTIGEN BINDING; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CRYSTALLOGRAPHY; HYDROGEN BOND; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS;

EID: 0033033423     PISSN: 02692139     EISSN: None     Source Type: Journal    
DOI: 10.1093/protein/12.5.417     Document Type: Article

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