Complementarity determining region residues aspartic acid at H55, serine at H95 and tyrosines at H97 and L96 play important roles in the B72.3 antibody-TAG72 antigen interaction

Protein Engineering

Volumn 9, Issue 6, 1996, Pages 539-543

  Xiang, Jim ^a   Sha, Yuhua ^a   Prasad, Lata ^a   Delbaere, Louis T J ^a  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

Author keywords

Antigen binding affinity; CDR residues; Site directed mutagenesis; TAG72 antigen

Indexed keywords

ASPARTIC ACID; SERINE; TYROSINE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANTIBODY COMBINING SITE; ANTIGEN ANTIBODY REACTION; ANTIGEN BINDING; ARTICLE; BINDING AFFINITY; COMPLEMENTARITY DETERMINING REGION; HUMAN; IMMUNOGLOBULIN STRUCTURE; PRIORITY JOURNAL; RADIOIMMUNOASSAY;

EID: 0029744928     PISSN: 02692139     EISSN: None     Source Type: Journal    
DOI: 10.1093/protein/9.6.539     Document Type: Article

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