Hepatocytic differentiation in retiform Sertoli-Leydig cell tumors: Distinguishing a heterologous element from Leydig cells

Human Pathology

Volumn 30, Issue 6, 1999, Pages 611-617

  Mooney, Eoghan E ^a   Nogales, Francisco F ^b   Tavassoli, Fattaneh A ^b  

^a NATIONAL MATERNITY HOSPITAL   (Ireland)

^b NONE

Author keywords

Endoderm; Hepatocytes; Immunohistochemistry; Leydig cells; Retiform; Sertoli Leydig cell tumor

Indexed keywords

ALBUMIN; ALPHA 1 ANTITRYPSIN; ALPHA FETOPROTEIN; FERRITIN; INHIBIN; KERATIN; VIMENTIN;

ANDROBLASTOMA; ARTICLE; CELL DIFFERENTIATION; CELL ULTRASTRUCTURE; CONTROLLED STUDY; DISEASE ASSOCIATION; ENDODERM; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LEYDIG CELL; LIVER CELL; SEX CORD TUMOR; YOLK SAC TUMOR;

EID: 0033029754     PISSN: 00468177     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0046-8177(99)90083-7     Document Type: Article

References (41)

1. Young RH, Scully RE: Ovarian Sertoli-Leydig cell tumors: A clinicopathological analysis of 207 cases. Am J Surg Pathol 9:543-569, 1985
2. Benfield GFA, Tapper-Jones L, Stout TV: Androblastoma and raised serum α-fetoprotein with familial multinodular goitre: Case report. Br J Obstet Gynaecol 89:323-326, 1982
3. Young RH, Perez-Atayde AR, Scully RE: Ovarian Sertoli-Leydig cell tumor with retiform and heterologous components: Report of a case with hepatocytic differentiation and elevated serum alpha-fetoprotein. Am J Surg Pathol 8:709-718, 1984
4. Sekiya S, Inaba N, Iwasawa H, et al: AFP-producing Sertoli-Leydig cell tumor of the ovary. Arch Gynecol 236:187-196, 1985
5. Tetu B, Ordonez NG, Silva EG: Sertoli-Leydig cell tumor of the ovary with α-fetoprotein production. Arch Pathol Lab Med 110:65-68, 1986
6. Mann WJ, Chumas J, Rosenwaks Z, et al: Elevated serum α-fetoprotein associated with Sertoli-Leydig cell tumors of the ovary. Obstet Gynecol 67:141-144, 1986
7. Tiltman A, Dehaeck K, Soeters R, et al: Ovarian Sertoli-Leydig cell tumor with raised serum alpha fetoprotein. Virchows Arch A 410:107-112, 1986
8. Talerman A: Ovarian Sertoli-Leydig cell tumor (androblastoma) with retiform pattern: A clinicopathologic study. Cancer 60:3056-3064, 1987
9. Chadha S, Honnebier WJ, Schaberg A: Raised serum α-fetoprotein in Sertoli-Leydig cell tumor (androblastoma) of ovary: Report of two cases. Int J Gynecol Pathol 6:82-88, 1987
10. Motoyama T, Watanabe H, Gotoh A, et al: Ovarian Sertoli-Leydig cell tumor with elevated serum alpha-fetoprotein. Cancer 63:2047-2053, 1989
11. Gagnon S, Tetu B, Silva EG, et al: Frequency of α-fetoprotein production by Sertoli-Leydig cell tumors of the ovary: An immunohistochemical study of eight cases. Mod Pathol 2:63-67, 1989
12. Larsen WG, Felmar EA, Wallace ME, et al: Sertoli-Leydig cell tumor of the ovary: A rare cause of amenorrhea. Obstet Gynecol 79:831-833, 1992
13. Amato G, Izzo G, Izzo A: A paradoxical inhibition of androgenic hyperproduction by a Sertoli-Leydig cell tumor [of the] ovary. Hum Reprod 10:2967-2969, 1995
14. Hammad A, Jasnoz KM, Olson PR: Expression of alpha-fetoprotein by ovarian Sertoli-Leydig cell tumors: Case report and review of the literature. Arch Pathol Lab Med 119:1075-1079, 1995
15. Singh ZN, Singh MK, Chopra P: Sertoli Leydig cell tumor with malignant heterologous elements and raised alpha-fetoprotein: A case report. J Obstet Gynaecol Res 22:595-598, 1996
16. Golbang P, Khan A, Scurry J, et al: Cervical sarcoma botryoides and ovarian Sertoli-Leydig cell tumor. Gynecol Oncol 67:102-106, 1997
17. Talerman A, Haije WG, Baggerman L: Serum alphafetoprotein (AFP) in patients with germ cell tumors of the gonads and extragonadal sites: Correlation between endodermal sinus (yolk sac) tumor and raised serum AFP. Cancer 46:380-385, 1980
18. Perrone T, Steeper TA, Dehner LP: Alpha-fetoprotein localization in pure ovarian teratoma: An immunohistochemical study of 12 cases. Am J Clin Pathol 88:713-717, 1987
19. Nogales FF, Ruiz Avila I, Concha A, et al: Immature teratoma of the ovary: Embryologic correlations and immunohistochemistry. HUM PATHOL 24:364-370, 1993
20. Sekiya S, Inaba N, Takamizawa H, et al: Human chorionic gonadotrophin and alpha-fetoprotein in sera and tumor cells of a patient with pure dysgerminoma of the ovary. Acta Obstet Gynaecol Scand 66:75-78, 1987
21. Hsu SM, Raine L, Fanger H: Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: Comparison between ABC and unlabelled antibody (PAP) procedures. J Histochem Cytochem 29:577-580, 1981
22. Nogales FF: The pathology of the human yolk sac, in Fox H, Wells M (eds): Haines and Taylor's Obstetrical and Gynaecological Pathology (ed 4). Edinburgh, Scotland, Churchill Livingstone, 1995, pp 1677-1688
23. Parkash V, Carcangiu ML: Transformation of ovarian dysgerminoma to yolk sac tumor: Evidence for a histogenetic continuum. Mod Pathol 8:881-887, 1995
24. Nogales FF, Concha A, Plata C, et al: Granulosa cell tumor of the ovary with diffuse true hepatic differentiation simulating stromal luteinization. Am J Surg Pathol 17:85-90, 1993
25. Seidman JD, Abbondanzo SL, Bratthauer GL: Lipid cell (steroid cell) tumor of the ovary: Immunophenotype with analysis of potential pitfall due to endogenous biotin-like activity. Int J Gynecol Pathol 14:331-338, 1995
26. McCluggage WG, Maxwell P, Patterson A, et al: Immunohistochemical staining of hepatocellular carcinoma with monoclonal antibody against inhibin. Histopathology 30:518-522, 1997
27. Salazar H, Kanbour A, Tobon H, et al: Endoderm cell derivatives in embryonal carcinoma of ovary: An electron microscopic study of two cases. Am J Pathol 74:108A, 1974
28. Prat J, Bhan AK, Dickersin GR, et al: Hepatoid yolk sac tumor of the ovary (endodermal sinus tumor with hepatoid differentiation): A light microscopic, ultrastructural and immunohistochemical study of seven cases. Cancer 50:2355-2368, 1982
29. Nakashima N, Fukatsu T, Nagasaka T, et al: The frequency and histology of hepatic tissue in germ cell tumors. Am J Surg Pathol 11:682-692, 1987
30. Takeda A, Ishizuka T, Goto T, et al: Polyembryoma of the ovary producing alpha-fetoprotein and HCG: Immunoperoxidase and electron microscopic study. Cancer 49:1878-1889, 1982
31. Ishikura H, Scully RE: Hepatoid carcinoma of the ovary: A newly described tumor. Cancer 60:2775-2784, 1987
32. Cohen MB, Friend DS, Molnar JJ, et al: Gonadal endodermal sinus (yolk sac) tumor with pure intestinal differentiation: A new histologic type. Pathol Res Pract 182:609-616, 1987
33. Masson P, Thériault JP: Une forme inhabituelle de tumeur ovarienne: Épiteliome bilio-hépatoïde. Ann Anat Pathol (Paris) 1:7-18, 1956
34. Konishi I, Fujii S, Kataoka N, et al: Ovarian mucinous cystadenocarcinoma producing α-fetoprotein. Int J Gynecol Pathol 7:182-189, 1988
35. Nomura K, Miyasaka Y, Murae M, et al: Ovarian mucinous cystadenocarcinoma producing alpha-fetoprotein: A case report. Acta Pathol Jpn 42:372-375, 1992
36. Young RH, Prat J, Scully RE: Ovarian Sertoli-Leydig cell tumors with heterologous elements. 1. Gastrointestinal epithelium and carcinoid: A clinicopathological analysis of thirty-six cases. Cancer 50:2448-2456, 1982
37. Alison M, Golding M, Lalani EN, et al: Wholesale hepatocytic differentiation in the rat from ductular oval cells, the progeny of biliary stem cells. J Hepatol 26:343-352, 1997
38. Roskams T, De Vos R, Desmet V: 'Undifferentiated progenitor cells' in focal nodular hyperplasia of the liver. Histopathology 28:291-299, 1996
39. Smith PG, Tee LBG, Yeoh GCT: Appearance of oval cells in the liver of rats after long-term exposure to ethanol. Hepatology 23:145-154, 1996
40. Chandran R, Rahman H, Gebbie D: Composite mucinous and granulosa-theca-cell tumor of the ovary: An unusual neoplasm. Aust N Z J Obstet Gynaecol 33:437-439, 1993
41. Young RH, Scully RE: Ovarian Sertoli-Leydig cell tumors with a retiform pattern: A problem in histopathologic diagnosis: A report of 25 cases. Am J Surg Pathol 7:755-771, 1983