Enhancement of low density lipoprotein catabolism by non-steroidal anti-inflammatory drugs in cultured HepG2 cells

European Journal of Pharmacology

Volumn 372, Issue 3, 1999, Pages 311-318

  Al Rayyes, O ^a   Ahren, B ^a   Floren, C H ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Cyclosporine; Flufenamic acid; Fluvastatin; Indomethacin; Low density lipoprotein; Peroxisome proliferator activated receptor

Indexed keywords

ACETYLSALICYLIC ACID; CYCLOSPORIN; FLUFENAMIC ACID; FLUINDOSTATIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; IBUPROFEN; INDOMETACIN; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR; NONSTEROID ANTIINFLAMMATORY AGENT; PARACETAMOL; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR;

ARTICLE; ATHEROSCLEROSIS; CONTROLLED STUDY; DEGRADATION; DRUG EFFECT; HEPATOMA CELL; HUMAN; HUMAN CELL; LIPOPROTEIN METABOLISM; PRIORITY JOURNAL; RECEPTOR UPREGULATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 0033029081     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(99)00246-0     Document Type: Article

References (26)

1. Afifi, A.A., Azen, S.P., 1997. Statistical analysis, A computer oriented approach, 2nd edn., Academic Press, New York.
2. O Al Rayyes C.-H Florén Troglitazone up-regulates low density lipoprotein receptor activity in HepG2 cells Diabetes 47 1998 1193 1198
3. O Al Rayyes A Wallmark C.-H Florén Cyclosporine inhibits catabolism of low-density lipoproteins in HepG2 cells by 25% Heptology 24 1996 613 619
4. O Al Rayyes A Wallmark C.-H Florén Additive inhibitory effect of hydrocortisone and cyclosporine on low-density lipoprotein receptor activity in cultured HepG2 cells Hepatology 26 1997 967 971
5. Ausubel, M.A., Bernt, R., Kingston, R.E., Moore, D.D., Seidman, J.G., Smith, J.A., Struhl, K., 1993. Preparation and analysis of RNA. Current protocols in molecular biology. Green Publishing Associates and Wiley, Cambridge, MA, 1:4.0.1–4.10.9.
6. E.L Bierman O Stein Y Stein Lipoprotein uptake and metabolism by aortic smooth muscle cells in tissue culture Circ. Res. 35 1974 136 150
7. V Dhawan N.K Ganguly S Majumdar R.N Chakavarti Effect of indomethacin on serum lipids, lipoproteins, prostaglandins and the extent and severity of atherosclerosis in rhesus monkeys Can. J. Cardiology 8 1992 306 312
8. A.M Elneihoum P Falke B Hedblad F Lindgarde K Ohlsson Leukocyte activation in atherosclerosis: correlation with risk factors Atherosclerosis 131 1997 79 84
9. P.S Foxworthy D.N Perry P.I Eacho Induction of peroxisomal β-oxidation by nonsteroidal anti-inflammatory drugs Toxicol. Appl. Pharmacol. 118 1993 271 274
10. R.T Gansevoort J.E Heeg F.D Dikkeschei D De Zeeuw P.E De Jong R.P.F Dullaart Symptomatic antiproteinuric treatment decreases serum lipoprotein (a) concentration in patients with glomerular proteinuria Nephrol. Dial. Transplant. 9 1994 244 250
11. R.J Havel H.A Eder J.H Bragdon The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum J. Clin. Invest. 34 1955 1345 1353
12. M.C Hochberg NSAIDs mechanisms and pathways of action Hosp. Pract. 15 1989 185 198
13. M Iwanishi M Kobayashi Effect of pioglitazone on insulin receptors of skeletal muscles from high-fat-fed rats Metabolism 42 1993 1017 1021
14. C Jiang A.T Ting B Seed PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines Nature 391 1998 82 86
15. E.W Kraegen D.E James A.B Jenkins D.J Chisholm L.H Storlien A potent in vivo effect of ciglitazone on muscle insulin resistance induced by high fat feeding of rats Metabolism 38 1989 1089 1093
16. A.M Lefebvre J Peinado-Onsurbe I Leitersdorf M.R Briggs L.R Paterniti J.C Fruchart C Fievet J Auwerx B Staels Regulation of lipoprotein metabolism by thiazolidinediones occurs through a distinct but complementary mechanism relative to fibrates Arterioscler. Thromb. Vasc. Biol. 17 1997 1756 1764
17. J.M Lehmann J.M Lenhard B.B Oliver G.M Ringold S.A Kliewer Peroxisome proliferator-activated receptors α and γ are activated by indomethacin and other non-steroidal anti-inflammatory drugs J. Biol. Chem. 272 1997 3406 3410
18. O.H Lowry N.J Rosebrough A.L Farr R.J Randall Protein measurements with folin phenol reagents J. Biol. Chem. 193 1951 265 275
19. A.S McFarlane Efficient trace-labelling of proteins with iodine Nature 182 1958 53
20. Norusis, M.J., 1993. SPSS for Windows, rel. 6.0. SPSS, Chicago.
21. K.S Park T.P Ciaraldi L Abrams-Carter S Mudaliar S.E Nikoulina R.R Henry PPAR-γ gene expression is elevated in skeletal muscle of obese and type II diabetes subjects Diabetes 46 1997 1230 1234
22. A.M Salter J Saxton D Brindley Characterization of the binding of human low density lipoprotein to primary monolayer cultures of rat hepatocytes Biochem. J. 240 1986 549 557
23. K Schoonjans G Martin B Staels J Auwerx Peroxisome proliferator-activated receptors, orphans with ligands and functions Curr. Opin. Lipidol. 8 1997 66 159
24. R.A.K Srivastava H Ito M Hess N Srivastava G Schonfeld Regulation of low density lipoprotein receptor gene expression in HepG2 and Caco2 cells by palmitate, oleate, and 25-hydroxycholesterol J. Lipid. Res. 36 1995 1434 1446
25. D.K Stoller C.B Ground V Michalek H Buchwald Reduction of atherosclerosis with nonsterolidal anti-inflammatory drugs J. Surg. Res. 54 1993 7 11
26. A.J Vidal-Puig R.V Considine M Jimenez-Linan A Werman W.J Pories J.F Caro J.S Flier Peroxisome proliferator-activated receptor gene expression in human tissues. Effect of obesity, weight loss, and regulation by insulin and glucocorticoids J. Clin. Invest 99 1997 2416 2422