Potent inhibition of cytochrome P-450 2D6-mediated dextromethorphan O- demethylation by terbinafine

Drug Metabolism and Disposition

Volumn 27, Issue 7, 1999, Pages 770-775

  Abdel Rahman, Susan M ^a,b,c   Marcucci, Kenda ^a   Boge, Thomas ^c   Gotschall, R Russell ^a   Kearns, Gregory L ^a,b,c   Leeder, J Steven ^a,b,c  

^a CHILDREN S MERCY HOSPITAL   (United States)

^b UNIVERSITY OF MISSOURI KANSAS CITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF MISSOURI KANSAS CITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 METHOXY 4,5 METHYLENEDIOXYAMPHETAMINE; 3,4 NAPHTHYLENE DIOL; 5,6 NAPHTHYLENE DIOL; AJMALICINE; CYTOCHROME P450 INHIBITOR; DEBRISOQUINE 4 HYDROXYLASE; DEXTROMETHORPHAN; DEXTRORPHAN; QUINIDINE; TERBINAFINE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DEMETHYLATION; DRUG POTENCY; DRUG STRUCTURE; ENZYME INHIBITION; ENZYME KINETICS; HUMAN; HUMAN TISSUE; LIVER MICROSOME; MOLECULAR MODEL; PHARMACOPHORE; PRIORITY JOURNAL;

CYTOCHROME P-450 CYP2D6; DEXTROMETHORPHAN; ENZYME INHIBITORS; HUMANS; METHYLATION; MICROSOMES, LIVER; MODELS, MOLECULAR; NAPHTHALENES;

EID: 0033028843     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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